Liver abscess (LA) is one of the most common cause of morbidity in children. Vietnam located in an area with a high infection incidence of fascioliasis in the world. LA due to fascioliasis is progressing in recent years. Objectives: To determine clinical and paraclinical features and results of treatment of LA. Subjects and research methods: This was a retrospective study. The duration was from January 2016 to January 2021. All the patients with LA were included in this study. Results: Clinical and paraclinical symptoms are in remission or returned to normal, especially liver damage on imaging. Results: There were 60 patients. Patients >5 years old account for 70.0%. LA due to parasitic, pyogenic,amoebic and unknown were 53.3, 5.1, 5.0 and 36.6%, respectively. The diameter of the LA is less than 5 cm accounting for a high rate (70%). Clinical manifestations with right upper quadrant pain, hepatomegaly, fever, nausea and vomiting were 95.0, 75.0, 25.0 and 25.0%, respectively. The values ofeosinophilia, C-reactive protein (CRP), and white blood cells were mostly increased in LA at 68.3, 65.0 and 65.0%, respectively. The rate of remission and cure is 95.0%. Conclusions: LA of unknown cause still accounts for a high proportion of research, so testing to find the agent should be early conducted, for timely treatment to bring the best effect to the patient.