Objective: There is a growing trend towards social media health information and education. The objective of this study was to assess the quality of YouTube® videos as a form of health education for core vascular conditions. Methods: A cross-sectional study was performed on YouTube® videos focusing on six core vascular conditions: abdominal aortic aneurysm, carotid artery disease, peripheral arterial disease, lower limb amputation, varicose veins, and deep vein thrombosis. One hundred videos for each vascular condition were recorded by a single clinician rater. Videos were coded in terms of country, year and source of upload. Other parameters included category, target audience, and viewer interaction. Video quality was evaluated using three validated assessment tools: DISCERN, HONcode, and Global Quality Scale (GQS). Results: Six hundred videos were reviewed within their vascular condition. Varicose vein and amputation videos were the most popular conditions receiving the highest mean number of views (286 233 and 167 651 respectively). Physician/Healthcare professionals (PHs) were the source of the majority of YouTube® videos: 68% of AAA videos and 72% of carotid videos. Videos targeting students achieved the highest level of viewer interaction. PH videos achieved the highest mean GQS score across all six vascular conditions (p < .001). Civilian uploaded videos were found to have the highest level of bias and a mean GQS score of 2 indicating “poor” quality information. Conclusion: Physicians and healthcare professionals should consider increasing their engagement and upload more high quality videos to YouTube® in order to counteract the “misleading” and “poor quality” patient information that currently exists.