This paper explores the potential of an Integrated Sensing and Communication (ISAC) system to enhance search-and-rescue operations. While prior research has explored ISAC capabilities in Unmanned Aerial Vehicles (UAVs), our study focuses on addressing the specific challenges posed by modern communication standards (e.g., power, frequency, and bandwidth limitations) in the context of search-and-rescue missions. The paper details effective methods for processing echoed signals generated by downlink transmissions and evaluates key performance indicators, including Noise Equivalent Sigma Zero (NESZ) and channel capacity. Additionally, we utilize synchronization uplink signals transmitted by User Equipment (UE) to improve target detection and classification of possible victims by fusing SAR imagery with triangulation results from uplink signals. An experimental campaign validates the proposed setup by integrating SAR images of the environment with active localization results, both produced by a UAV equipped with a Software Defined Radio (SDR) payload. Our results demonstrate the system’s capability to detect and localize buried targets in avalanche scenarios, with localization errors ranging from centimeters to 10 m depending on environmental conditions. This successful integration highlights the practical applicability of our approach in challenging search-and-rescue missions.