Uplift wind-induced responses and failure criteria of high-vertical standing seam metal cladding systems (SSMCSs) are of paramount importance for evaluating their wind resistance performance. This paper proposes an efficient evaluation method that combines a highly efficient finite element (FE) model for structural response analysis with reasonable failure criteria, based on experimental and numerical investigation. The FE model incorporating the developed equivalent spring model is established with the calibrated stiffness from tensile tests and validated through the wind uplift resistance experiments conducted on large-scale prototype structures. The recorded structural responses from the experiments validate the feasibility of the FE model in simulating the geometric and material nonlinearities of the systems. To evaluate the wind resistance performance, the failure criteria are developed based on the observed pullout mechanisms and failure modes from the experiments. These criteria take the relative deformation of standing webs and the pullout resistance strength of seam connections as critical parameters, and the relationship between them is calibrated through a series of tensile tests using a self-designed fixture. Tensile test results show notable variability in the pullout resistance strength of seam connections, with a mean value decreasing as the relative rotational angle of the standing webs increases. According to the developed failure criteria, the ultimate uplift pressures evaluated from the FE analysis exhibit minimal positive deviations of 5.3 % and 7.3 % from the experimental results for different failure modes, respectively. This highlights the effectiveness of the proposed method in evaluating the wind resistance performance of high-vertical SSMCSs.