With the dramatic increase in e-cigarette use among adolescents over the past 5 years,1 and the legalization of cannabis in many states,2 preventing adolescent substance misuse and substance use disorders (SUD) can feel like an uphill battle for child and adolescent psychiatrists. A team effort is certainly required, and Jessica Lahey’s book, The Addiction Inoculation: Raising Healthy Kids in a Culture of Dependence, is a ray of sunshine in the darkened landscape of the pandemic. This resource helps parents and caregivers understand the risks associated with adolescent substance use and provides guidance for implementing prevention strategies at home.