Research Update Research Articles

An update in recent research on nicotine contamination and nicotine-degrading microorganisms.

Nicotine is a toxic and addictive alkaloid found in tobacco and tobacco products that is harmful to human health and is an environmental pollutant. Nicotine-degrading microorganisms are unique microorganisms with the ability to use nicotine molecules as their sole source of nitrogen and carbon needed for growth. They are capable of degrading nicotine into less toxic or non-toxic metabolites. This review describes the environment's primary nicotine contamination sources and potential hazards. It also summarizes various types of nicotine-degrading microorganisms, their optimal culture conditions, and degradation efficiency. Four different catabolic pathways of nicotine in microorganisms are discussed, and the applications of nicotine-degrading microorganisms in different fields, such as the tobacco, pharmaceutical, and environmental protection industries, are outlined. This review describes the hazards of nicotine and the current research and application of nicotine-degrading microorganisms. It provides a theoretical reference for future research on nicotine-degrading microorganisms and their applications.

Hydrochemical regime of some lakes of Kokshetau upland

The hydrochemical indicators of lakes Imantau, Shalkar (North-Kazakhstan region), Zerenda, Kopa (Akmola region) located on the Kokshetau upland for 2022-2023 are shown in the article. Lake Zerenda, Imantau, Shalkar - the largest water reservoir of STNP "Kokshetau". Lake Kopa is located in the center of Kokshetau, in the most urbanized area of the region. Between the studied years, there is a change in some indicators, as well as indicators exceeding the MPC. In connection with the increase in anthropogenic load on water bodies, it is important to update research annually, and hydrobiological research with hydrochemical parameters is also conducted. An increase in the amount of ammonium ions is noted in lakes Zerendа, Kopa, Imantau and Shalkar, which is a sign of pollution by organic substances. In addition, sharp changes in the chemical composition of water are observed in Lake Shalkar, where a sharp increase in mineralization is observed, which requires further studies of the state of the reservoir. The chemical composition of Lake Zerendа is relatively stable, but there is a high concentration of sodium and potassium exceeding the MPC. The levels of magnesium and calcium are also higher than normal, which indicates a higher level of minerals in the water.

Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis

Breast cancer is a cancer with global prevalence and a surge in the number of cases with each passing year. With the advancement in science and technology, significant progress has been achieved in the prevention and treatment of breast cancer to make ends meet. The scientific intradisciplinary subject of “metabolomics” examines every metabolite found in a cell, tissue, system, or organism from different sources of samples. In the case of breast cancer, little is known about the regulatory pathways that could be resolved through metabolic reprogramming. Evidence related to the significant changes taking place during the onset and prognosis of breast cancer can be obtained using metabolomics. Innovative metabolomics approaches identify metabolites that lead to the discovery of biomarkers for breast cancer therapy, diagnosis, and early detection. The use of diverse analytical methods and instruments for metabolomics includes Magnetic Resonance Spectroscopy, LC/MS, UPLC/MS, etc., which, along with their high-throughput analysis, give insights into the metabolites and the molecular pathways involved. For instance, metabolome research has led to the discovery of the glutamate-to-glutamate ratio and aerobic glycolysis as biomarkers in breast cancer. The present review comprehends the updates in metabolomic research and its processes that contribute to breast cancer prognosis and metastasis. The metabolome holds a future, and this review is an attempt to amalgamate the present relevant literature that might yield crucial insights for creating innovative therapeutic strategies aimed at addressing metastatic breast cancer.

Development and validation of social issues advocacy scale 2-short form

ABSTRACT The Social Issues Advocacy Scale (SIAS) was published in 2011 as a tool to assess attitudes and behaviors associated with social justice advocacy. The scale was later revised to reflect updated theories and research, resulting in the 78-item scale, SIAS-2. Given the length of SIAS-2, this article reports on three studies with the aims to shorten the number of items and provide reliability and validity data. In Study 1, we developed SIAS-2 Short Form, consisting of 38 items and 8 subscales, measuring different aspects of social justice advocacy, replicating the scale structure of SAIS-2. In Study 2, we confirmed the scale structure, using confirmatory factor analysis, and examined construct validity. As expected, SIAS-2 SF was positively associated with political engagement, cultural openness, social justice self-efficacy, and engagement, and negatively associated with belief in a just world and cultural dominance. Total scale Cronbach’s alpha was .94 (subscale alphas: .74–.87). As in Study 3, we examined test–retest reliability, with a score of r = .84 for the total scale score. The results revealed a 38-item scale with 8 subscales that appears valid and presents with good to excellent internal reliability. Limitations and implications are addressed.

Complications following miniplate insertion in maxillofacial fractures: a systematic review

Background Maxillofacial fractures, frequently arising from road traffic incidents, falls, and acts of interpersonal aggression, are a considerable public health issue, exhibiting diverse epidemiological patterns according to demographic factors. The application of miniplates for fracture stabilization is a recognized technique, with innovative methods such as 3D plate systems emerging. Nonetheless, consequences including infections and hardware malfunctions persist. This systematic review seeks to present current evidence regarding the complications linked to miniplate placement in maxillofacial fractures over the last ten years. Methods A systematic review was performed in accordance with PRISMA principles. Databases such as the Cochrane Library, PubMed, and Scopus were examined from September 2014 to September 2024. Studies documenting problems related to miniplate placement were included, without language constraints. The ROBINS-I tool was utilized for non-randomized studies, whereas the Cochrane risk of bias tool was applied to randomized controlled trials. Results From 2,289 initially found studies, 56 satisfied the inclusion criteria. Among these, 28 employed interventional designs, whilst the remaining 28 were observational research. The predominant problems documented in several investigations encompassed infection, wound dehiscence, malocclusion, paraesthesia, malunion/non-union, segment movement, hardware failure, and palpable hardware. Advanced methodologies such as 3D plate systems and locking mechanisms were linked to diminished complication rates. Conclusion This systematic analysis presents a decade of updated research about problems associated with miniplate placement in maxillofacial fractures. Novel methodologies such as 3D plate systems and locking mechanisms demonstrate promise in mitigating problems relative to conventional techniques. These findings can facilitate informed decision-making in clinical practice. Additional study utilizing standardized outcomes and prospective designs is essential to enhance comprehension of the long-term effects of miniplate utilization.

An Overview of Metallic Nanoparticles: Classification, Synthesis, Applications, and their Patents.

Nanotechnology has gained enormous attention in pharmaceutical research. Nanotechnology is used in the development of nanoparticles with sizes ranging from 1-100 nm, with several extraordinary features. Metallic nanoparticles (MNPs) are used in various areas, such as molecular biology, biosensors, bio imaging, biomedical devices, diagnosis, pharmaceuticals, etc., for their specific applications. For this study, we have performed a systematic search and screening of the literature and identified the articles and patents focusing on various physical, chemical, and biological methods for the synthesis of metal nanoparticles and their pharmaceutical applications. A total of 174 references have been included in this present review, of which 23 references for recent patents were included. Then, 29 papers were shortlisted to describe the advantages, disadvantages, and physical and chemical methods for their synthesis, and 28 articles were selected to provide the data for biological methods for the formulation of metal NPs from bacteria, algae, fungi, and plants with their extensive synthetic procedures. Moreover, 27 articles outlined various clinical applications of metal NPs due to their antimicrobial and anticancer activities and their use in drug delivery. Several reviews are available on the synthesis of metal nanoparticles and their pharmaceutical applications. However, this review provides updated research data along with the various methods employed for their development. It also summarizes their various advantages and clinical applications (anticancer, antimicrobial drug delivery, and many others) for various phytoconstituents. The overview of earlier patents by several scientists in the arena of metallic nanoparticle preparation and formulation is also presented. This review will be helpful in increasing the current knowledge and will also inspire to innovation of nanoparticles for the precise and targeted delivery of phytoconstituents for the treatment of several diseases.

Using Cannabis and CBD to Sleep: An Updated Review.

Cannabis sativa and constituent cannabinoids are in widespread use for the treatment of sleep disorders where many patients desire pharmacotherapy. Previous reviews highlight a lack of high-quality evidence to support the efficacy and long-term safety of cannabinoids in various conditions. We aim to provide an update of recent original research evaluating cannabinoid-based therapeutics in sleep disorders. We identified twenty-one recent studies of cannabinoids for insomnia, subjective sleep impairment, obstructive sleep apnoea, rapid eye movement sleep behaviour disorder, and restless legs syndrome. We note trends towards the use of minor cannabinoids, studies using decentralised approaches and increased utilisation of objective measures in clinical trials. The evidence-base does not match widespread use of cannabinoids for the treatment of sleep disorders. There is a growing need for adequately funded well-designed clinical trials with longer treatment durations and decent sample sizes to inform both the clinician and patient.

Validation of American College of Radiology Bone Reporting and Data System (Bone-RADS) Version 2023 for diagnosis of malignant tumors of appendicular bone on conventional radiographs

PurposeTo evaluate the diagnostic performance of the American College of Radiology(ACR) Bone Reporting and Data System (Bone-RADS) in diagnosis of malignant tumors of the appendicular bone on conventional radiographs. MethodsPrimary and secondary tumors of appendicular bone in patients who underwent radiographic and MRI examinations were classified into benign, intermediate, and malignant using a reference standard of histopathology, imaging follow-up, or clinical-radiologic consensus. Two radiologists assessed five radiographic features (margin, periosteal reaction, endosteal erosion, pathologic fracture, and extra-osseous mass), scored point total (points from radiographic features and a history of cancer), and assigned Bone-RADS categories. The diagnostic performance of Bone-RADS and interreader agreements were calculated. ResultsA total of 778 patients (507 benign, 45 intermediate, and 226 malignant tumors) were included. Bone-RADS showed high discrimination performance, with areas under the receiver-operating characteristics curve of 0.940–0.957 for point total and 0.895–0.900 for categorization. Bone-RADS had high sensitivity (95.2 %–99.1 %) and negative predictive value (NPV) (96.4 %–99.5 %), but relatively low specificity (65.0 %–68.6 %) and positive predictive value (PPV) (53.7 %–61.9 %). Interreader agreements were good to excellent for Bone-RADS point total (ICC = 0.850), categorization (k = 0.739), and most of the radiographic features (k = 0.621–0.822), except for endosteal erosion (k = 0.537) and extra-osseous mass (k = 0.234). ConclusionIn diagnosis of malignant bone tumors, ACR Bone-RADS showed high discrimination performance, with high sensitivity and NPV, but relatively low specificity and PPV. Nevertheless, relatively low interobserver agreement in some radiographic features and the consensus-based points system in Bone-RADS warrant further research and possible updates.

Research Updates and Advances on Flavonoids Derived from Dandelion and Their Antioxidant Activities.

As a common medicinal and edible plant, dandelion plays a crucial and significant role in the fields of traditional Chinese medicines, functional foods, healthcare products, daily chemicals, and feed additives, which are closely related to its rich chemical constituents and remarkable biological activities. Modern studies have demonstrated that dandelion contains all kinds of bioactive constituents, including flavonoids, amino acids, fatty acids, organic acids, phenolic acids, coumarins, lignans, polysaccharides, phytosterols, terpenes, glycoproteins, oligosaccharides, alkaloids, etc. Meanwhile, dandelion has been proven to possess antioxidant, antibacterial, anti-inflammatory, antitumor, antivirus, hypoglycemic, and hypolipidemic properties, as well as the ability to regulate hormone levels and protect some visceral organs. Among them, flavonoids derived from dandelion and their antioxidant activities have received considerable attention. This study reviews dandelion flavonoids and their in vitro and in vivo antioxidant activities by consulting and organizing relevant domestic and international works of literature to provide a scientific and theoretical basis for further research, development, and utilization of dandelion.

Case Salience in the State Supreme Courts: A Research Update

Abstract In this research, we update the measure of case salience for state supreme courts originally developed by Vining and Wilhelm (2011). The original measure was compatible with the Brace-Hall State Supreme Court Data Project (SSCDP) and covered 1995 through 1998. Our updated measure is now compatible with the Hall–Windett Data on State Supreme Court Outcomes (2013), a more contemporary source for state supreme court information. Here we discuss the new dataset of salient cases from 1995 to 2019 and provide descriptive statistics.

HIV Clinical Providers' Awareness, Attitudes, and Willingness to Support Patient Outreach Efforts for HIV Cure-Directed Research in Philadelphia, United States.

Ethical patient outreach is critical for engaging patients with HIV in HIV cure-directed research. We sought to examine HIV clinical providers' awareness of current HIV cure-directed research strategies investigated through the Martin Delaney Collaboratories (MDC) and providers' attitudes toward patient outreach for HIV cure-directed research and to identify opportunities for clinical provider education on MDC research strategies. We conducted a 1-time, cross-sectional, web-based survey with 64 HIV clinical providers (physicians, physician assistants, and nurses) in Philadelphia. A descriptive analysis was generated to determine clinical providers' awareness of MDC research strategies and attitudes toward patient outreach. Bivariate analyses were conducted to evaluate differences in awareness and attitudes by provider characteristics. Most providers were aware of MDC strategies, and nearly three-fourths of providers reported familiarity with 1 of the 2 Philadelphia MDC research programs. Providers overwhelmingly endorsed the need for clinicians to assist with patient outreach for HIV cure-directed research and were willing to recommend patients to participate. Enthusiasm for patient outreach waned if a study required a patient to undergo analytic treatment interruptions (ATIs). Providers identified preferred resources for receiving HIV cure-directed research updates, including webinars with continuing education credit and conferences. Our study's findings advocate for added investment toward developing resources that better engage clinical providers about HIV cure-directed research updates and ongoing studies, including the importance of ATIs. As gatekeepers to patient participation on HIV cure-directed studies, added efforts to increase provider knowledge of specific HIV cure-directed research will advance patient education and ethical outreach.

Cadmium (Cd) Tolerance and Phytoremediation Potential in Fiber Crops: Research Updates and Future Breeding Efforts

Heavy metal pollution is one of the most devastating abiotic factors, significantly damaging crops and human health. One of the serious problems it causes is a rise in cadmium (Cd) toxicity. Cd is a highly toxic metal with a negative biological role, and it enters plants via the soil–plant system. Cd stress induces a series of disorders in plants’ morphological, physiological, and biochemical processes and initiates the inhibition of seed germination, ultimately resulting in reduced growth. Fiber crops such as kenaf, jute, hemp, cotton, and flax have high industrial importance and often face the issue of Cd toxicity. Various techniques have been introduced to counter the rising threats of Cd toxicity, including reducing Cd content in the soil, mitigating the effects of Cd stress, and genetic improvements in plant tolerance against this stress. For decades, plant breeders have been trying to develop Cd-tolerant fiber crops through the identification and transformation of novel genes. Still, the complex mechanism of Cd tolerance has hindered the progress of genetic breeding. These crops are ideal candidates for the phytoremediation of heavy metals in contaminated soils. Hence, increased Cd uptake, accumulation, and translocation in below-ground parts (roots) and above-ground parts (shoots, leaves, and stems) can help clean agricultural lands for safe use for food crops. Earlier studies indicated that reducing Cd uptake, detoxification, reducing the effects of Cd stress, and developing plant tolerance to these stresses through the identification of novel genes are fruitful approaches. This review aims to highlight the role of some conventional and molecular techniques in reducing the threats of Cd stress in some key fiber crops. Molecular techniques mainly involve QTL mapping and GWAS. However, more focus has been given to the use of transcriptome and TFs analysis to explore the potential genomic regions involved in Cd tolerance in these crops. This review will serve as a source of valuable genetic information on key fiber crops, allowing for further in-depth analyses of Cd tolerance to identify the critical genes for molecular breeding, like genetic engineering and CRISPR/Cas9.

A Systematic Review of Sexual Assault Case Attrition in the United States from 2000 to 2020.

This article systematically reviewed research findings of five sexual assault case outcomes (founding, arrest, referral to prosecution, charging, and conviction) between 2000 and 2020. Records were collected from PsychINFO and ProQuest and had to report at least one quantitative criminal justice outcome, include data from a U.S. sample and involve original research. Thirty-six records (288,066 sexual assault cases) were analyzed. Results were stratified by reported cases, referred cases, charged cases, and victim age. Studies show that 72.09% to 92.66% of sampled cases are founded (M = 89.21%), 17.73% to 53.42% result in arrest (M = 27.25%), 13.60% to 69.57% result in referral (M = 31.36%), 3.28% to 83.16% result in charging (M = 19.58%), and only 1.86% to 40.31% result in conviction (M = 8.28%). This considerable variability in case outcomes is related to differences in cases included or excluded (e.g., age criterion, only sampling cases with sexual assault kits); thus, these studies are not reflective of all sexual assault cases. Studies were most likely to report arrest rates, followed by charging, referral, conviction, and founding. Overall, we have a good picture of what attrition looks like in adolescent-adult sexual assault cases from the 1980s to early 2010s in the Midwest and Southern CA. More updated research in the remaining parts of the country is needed, particularly from rural locales. Specific recommendations for more precise measurement and reporting methods are provided to improve our understanding of attrition and strengthen where, how, and with whom interventions are needed.

Application of metabolomics in quality control of traditional Chinese medicines: a review.

Plant metabolites are the components endowing traditional Chinese medicine (TCM) with therapeutic effects, and, simultaneously, they are the primary targets for quality control. From germplasm selection and origin determination to field management, growth duration, harvesting and processing, and, finally, storage and transportation, each step profoundly influences TCM quality. The complexity of these plant or herb metabolites poses numerous quality control challenges. Metabolomics, as a comprehensive and systematic approach, has demonstrated value in this field. This technique not only meets the requirements for studying the complex mechanisms of TCM but also has significant advantages in identifying the TCM components, including active components. Therefore, in this article, several key factors affecting the chemical characteristics and quality traits of TCM, including their origin, harvesting period, medicinal parts, and processing methods, are researched. Additionally, the current challenges of integrating metabolomics with other omics technologies (transcriptomics, spatial metabolomics, etc.) are discussed. Furthermore, a future development trends and prospects are highlighted. With the continuous deepening of research and ongoing updates in technological capabilities, metabolomics will play an increasingly important role in the quality control of TCM, providing more scientific and robust support for quality assurance and safety evaluation.

Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions

Background. Peptidergic GPCR systems are broadly distributed in the human body and regulate numerous physiological processes by activating complex networks of intracellular biochemical events responsible for cell regulation and survival. Excessive stimulation, ill-function, or blockade of GPCRs produces cell disturbances that may cause disease should compensatory mechanisms not suffice. Methods and Results. Revision of updated experimental research provided an evident relationship associating peptidergic GPCR malfunction with tumor formation and maintenance resulting from uncontrolled cell proliferation and migration, colonization, inhibition of apoptosis or altered metabolism, and increased angiogenesis in tumoral tissues. Conclusion. Determination of the implication of GPCR peptide signaling in specific neoplasia is crucial to designing tailored pharmacological treatments to counteract or dismantle the origin of the signaling circuitry causing cellular disruption. In some cases, particular ligands for these receptors may serve as concomitant treatments to aid other pharmacological or physical approaches to eradicate neoplasias.

Faith and Reason: Reinventing Scholasticism in Postmodern Philippine Catholic Education

This paper aims to present the necessity of a new scholastic movement as an intellectual and religious movement and to reinvent it in the context of 21st Century Philippine Catholic Education. This reinvention of Scholasticism aims to design a curriculum for Senior high school students in order to equip them in understanding and defending the Catholic Faith and Teachings. Since the Catholic Church is facing the problems given by postmodernism and atheism, there is a need for another scholastic movement to counter these problems. This paper uses in-depth and comprehensive analysis of texts related to reinvention of scholastic movement in the 21st Century. The researcher used Purposive Sampling technique to carefully select the articles based on their relevance to the reinvention of scholastic movement. This paper uses updated and relevant research papers for analysis. In addition, to argue that there is a need for a new scholastic movement in Philippine Catholic education, the Hegelian dialectic was used, the idea of history repeating itself became the start point of this paper to argue that this is philosophical sound and valid. This paper examines the necessity of the 21st Century Philippine Catholic Education to the reinvented scholastic movement and it also offers a comprehensive curriculum design to reinvent scholasticism in education. Since, it aims to craft a curriculum which is anchored to apologetics and scholasticism, this proposed curriculum can equip the students to be effective Christians who will defend the church and its teachings. With this, the Religious Education for Grade 11 and Grade 12 will be a strong foundation of Catholic Faith in the 21st Century Philippine Education for Catholic schools.

A Needs-Based Assessment of Older Immigrants Experiencing Loneliness and Social Isolation and the Effectiveness of Interventions Responding to the Identified Needs: An Umbrella Review and Research Update

ABSTRACT This umbrella review and research update explores experiences of loneliness and social isolation in older immigrants to understand their support needs and the effectiveness of current interventions. Nine quantitative and qualitative studies discussing loneliness and/or social isolation in older immigrants were identified. Six key themes emerged: language and cultural barriers, life-course intersections, family relationships and obligations, meaningful opportunities as a counter-strategy, regaining self-esteem, and effectiveness of peer/community support. Assessment of needs was a central topic in the literature. Peer and community support is an effective intervention targeting loneliness and social isolation in older immigrants as it connects participants and creates meaningful relationships.

Research Update: Testing Chinese Fiber Hemp Varieties in North Carolina

Research Update: Testing Chinese Fiber Hemp Varieties in North Carolina

Slovenian Translation, Cross-Cultural Adaptation, and Content Validation of the Updated Oslo Sports Trauma Research Center Questionnaire on Health Problems (OSTRC-H2).

The updated Oslo Sports Trauma Research Questionnaire on Health Problems (OSTRC-H2) has been translated into a limited set of languages and lacks full validation of its new measures. To (1) translate, cross-culturally adapt, and evaluate the measurement properties of the OSTRC-H2 for the Slovenian population and (2) investigate the construct validity for the severity score and time lost due to a health problem. Cohort study (diagnosis); Level of evidence, 3. The OSTRC-H2 was translated from English to Slovenian (OSTRC-H2-SLO) according to international guidelines. A 15-week study was conducted among 188 elite athletes, with a test-retest performed in the 10th week. Internal consistency, reliability, content validity, feasibility, and potential ceiling effects were investigated. Internal consistency was measured using the Cronbach alpha coefficient, while reliability was measured with the intraclass correlation coefficient (ICC). Construct validity was measured with the Spearman rank correlation coefficient (r S). There was a 95% response rate and an 18% mean weekly prevalence of health problems. The OSTRC-H2-SLO showed excellent test-retest reliability (ICC, 0.94 [95% CI, 0.67-0.99]), with a Cronbach α of .93. A strong positive correlation was found between the OSTRC-H2-SLO severity score and days lost due to an acute injury (r S = 0.754), overuse injury (r S = 0.785), and illness (r S = 0.894) (P < .001 for all). Moderate to strong negative correlations were observed between severity score and total load (training and competition load in hours) as well as between days lost and total load (P < .001 for all). The OSTRC-H2-SLO was found to be valid, reliable, and well accepted among Slovenian athletes. The authors confirmed the questionnaire's construct validity and identified total load as an indicator of an increase in the severity score. NCT05471297 (ClinicalTrials.gov identifier).

Research Update on the Therapeutic Potential of Garden Cress (Lepidium sativum Linn.) with Threatened Status.

Garden cress (Lepidium sativum) has been used in India for medicinal purposes since the Vedic era. Garden cress, a native of Egypt and southwest Asia, is a small perennial edible herb that has been used to treat many diseases for centuries. The seeds, leaves as well as roots have medicinal properties. The seeds are rich in protein, fat, calcium, and iron and have high nutritional value. They are considered to be galactagogue, anticarcinogenic, antidiabetic, antiasthmatic and antidiarrheal. Leaves, seeds, and aerial parts extracts are found to have alkaloids, flavonoids, glycosides, polypeptides, vitamins, minerals, proteins, fats, and carbohydrates. Lepidium sativum is known for its pungent odor due to the several volatile oils and has been used to treat various conditions, including respiratory disorders, muscle pain, inflammation, and bone fractures in the past. Lepidium sativum is a fast-growing annual herb; in India, it is commonly known as Chandrasoor. Whole fruits or seeds are used, fresh or dried, as a seasoning with a peppery flavor. Boiled seeds are consumed in drinks by Arabs, either ground in honey or as an infusion in hot milk. The seed oil can be used for illumination and soap making. Additionally, limited awareness and conservation efforts have further contributed to its threatened status. Recognizing the importance of preserving this valuable plant species is crucial for maintaining biodiversity and ensuring its availability for future generations. Furthermore, this review explores the potential benefits of Lepidium sativum in different domains. Its nutritional value and health benefits make it a promising candidate for addressing malnutrition and improving overall well-being. The presence of bioactive compounds suggests its potential use in functional foods, pharmaceuticals, and natural medicines for various ailments. Moreover, Lepidium sativum exhibits antimicrobial and insecticidal properties, offering potential applications in agriculture and pest control. The current review discussed the nutritional, potential benefits and pharmacological effects of Lepidium sativum.