Unusual Forms Research Articles

Prenatal diagnostic errors in hemoglobin Bart's hydrops fetalis caused by rare genetic interactions of α-thalassemia.

To describe rare genetic interactions of α-thalassemia alleles causing Hb H disease and Hb Bart's hydrops fetalis which could lead to diagnostic errors in a routine practice. Hematological and molecular characterization were carried out in a Thai family with a risk of having fetus with Hb Bart's hydrops fetalis. Both parents were found to be the thalassemia intermedia patients associated with unusual forms of Hb H disease. DNA analysis of common α-thalassemia mutations in Thailand identified α+-thalassemia (-α3.7 kb del) and unknown α0-thalassemia in the father and α0-thalassemia (--SEA) with unknown α+-thalassemia in the mother. Fetal DNA analysis unlikely identified a homozygosity for α0-thalassemia (--SEA/--SEA). Further analysis identified that the father carried a rare South African α0-thalassemia in combination with α+-thalassemia (--SA/-α), whereas the mother was a patient with Hb H-Queens Park disease (--SEA/ααQP). The fetus was, in fact, a compound heterozygote for (--SA/--SEA). As shown in this study, routine screening for α-thalassemia at prenatal diagnosis in the region should include both common and rare α0-thalassemia alleles found in the population to effectively prevent a fatal condition of Hb Bart's hydrops fetalis syndrome.

The Incidence and Characteristics of Pelvic-Origin Varicosities in Patients with Complex Varices Evaluated by Ultrasonography.

The purpose of this study was to evaluate the incidence of gonadal vein refluxes associated with lower-extremity varicose veins with Doppler ultrasonography (DUS). A total of 6279 patients with venous disease-related symptoms of the lower extremity were evaluated with DUS in the vascular lab. Gonadal vein reflux using abdominal ultrasound was further evaluated in patients with unusual varices, defined as varices in the inguinal, inner or upper thigh and the vulvar area without refluxes in the saphenofemoral junction (SPJ). Those patients who showed gonadal vein reflux were diagnosed as having pelvic-origin varicosity. Unusual varices were found in a total of 237 patients (3.8%), and of these patients, pelvic-origin varicosity was discovered with transabdominal ultrasound in 156 (65.8%). A total of 66.7% (n = 38/57) of unusual varix patients with pelvic pain had gonadal vein reflux. The measurement of gonadal vein diameter was larger in ultrasonography than CT scans (8.835 vs. 8.81, p < 0.001). Two patients with severe symptoms but no obstructive venous diseases were treated with gonadal vein embolization. The incidence of pelvic-origin varicosities was 2.5% (n = 156/6279). However, more than half of the patients with unusual varices had gonadal vein reflux and 24.4% of these patients also presented with pelvic pain. The evaluation of pelvic-origin varicosities should be performed in patients who present with unusual forms of varices of the lower extremity.

The End of the Beginning of Mechanical Stereochemistry.

ConspectusStereochemistry has played a key role in the development of synthetic chemistry for the simple reason that the function and properties of most molecules, from medicine to materials science, depend on their shape and thus the stereoisomer used. However, despite the potential for rotaxanes and catenanes to display unusual forms of stereochemistry being identified as early as 1961, this aspect of the mechanical bond remained underexplored and underexploited; until 2014 it was only possible to access chiral rotaxanes and catenanes whose stereoisomerism is solely attributable to the mechanical bond using chiral stationary phase high performance liquid chromatography, which limited their production on scale and thus inhibited the investigation of their properties and applications. Furthermore, the stereogenic units of such molecules and analogues were often poorly described, which made it hard to fully articulate both what had been achieved in the field and what problems were left to solve. Relatively recently, methods to access rotaxanes and catenanes that display mechanical stereochemistry selectively have been developed, making these intriguing structures available for study in a range of prototypical applications including catalysis, sensing, and as chiral luminophores.In this Account, we briefly discuss the history of mechanical stereochemistry, beginning in 1961 when the potential for mechanical stereoisomerism was first identified, before defining how mechanical stereochemistry arises from a structural point of view. Building on this, using simple stereochemical arguments, we confirm that the complete set of unique stereogenic units of two-component rotaxanes and catenanes have finally been identified and categorized unambiguously, with the last being identified only in 2024. After pausing to discuss some of the stereochemical curiosities that arise when molecules contain both covalent and mechanical stereogenic units, and the potential for stereoisomerism to arise due to co-conformational movement, we use our stereochemical framework to summarize our efforts to develop conceptually general approaches to [2]catenanes and [2]rotaxanes containing all of the possible mechanical stereogenic units. In particular, we highlight how the nature of a mechanical stereogenic unit affects the available strategies for their stereoselective synthesis. We finish by highlighting recent prototypical chemical applications of interlocked molecules that rely on their mechanical stereochemistry, before discussing future directions and challenges.Taken together, we propose that the transition of such molecules from being hard to make and poorly described, to being available in high stereopurity using clearly articulated methodological and stereochemical concepts suggests that the field is finally maturing. Thus, we are now coming to the end of the beginning of mechanical stereochemistry. The stage is now set for such molecules to play a functional role in a range of areas, indeed in any chemical or physical application where control over molecular shape is required.

РАЗВИТИЕ КРЕАТИВНОГО ТУРИЗМА В РЕСПУБЛИКЕ ТАТАРСТАН С ИСПОЛЬЗОВАНИЕМ ТУРИСТСКО-РЕКРЕАЦИОННОГО ПОТЕНЦИАЛА

Recently, the widespread digitalization of society and the development of the creative economy have led to changes in the structure and value of the goods and services provided. The basis of the creative economy is innovation. To create any new ideas, it is necessary to use a non-standard approach and solutions. The development of creative industries, in turn, has a beneficial effect on economic growth and raises the interaction between consumers and producers to a new level. Creative technologies in tourism are a relatively new direction, as they focus on unique and unusual forms of travel and entertainment. The article discusses the main forms and directions of creative tourism, and also focuses on cultural features that may also interest and attract tourists. The basis for the development of creative tourism on the territory of the Republic of Tatarstan is the tourism and recreational potential, which makes it possible to organize completely new routes and fully reflect the rich culture of the republic. Also, the development of creative industries, combined with its potential, will have a beneficial effect on the development of local crafts and deeper mutual understanding and respect for culture and traditions. The article analyzes the tourism and recreational potential using the scoring method of Yu.A. Khudenkikh and assesses the degree of his influence on the development of creative tourism in the Republic of Tatarstan. An analysis is given of existing events that can have an impact and attract new tourists to the territory of the republic.

ТЕХНОЛОГИЯ РЕАЛИЗАЦИИ СТРУКТУРНО-СОДЕРЖАТЕЛЬНЫХ ПАРАМЕТРОВ МЕТОДОЛОГИЧЕСКОГО КОМПОНЕНТА В УСЛОВИЯХ ОБУЧЕНИЯ БУРЯТСКОМУ ЯЗЫКУ КАК ВТОРОМУ УЧАЩИХСЯ НАЧАЛЬНЫХ КЛАССОВ

This article is devoted to the technology for implementing the structural and content parameters of the methodological component in the lessons of Buryat as a second language in primary school. To increase the efficiency of the process of teaching Buryat as a second language through new teaching content in primary grades, it is proposed to develop a technology for this process, which allows identifying gaps in training, adjusting the pedagogical process and planning further training, as well as developing recommendations for eliminating the situation of failure in the learning process. First of all, it is necessary to define such concepts as “technology” from the point of view of pedagogical sciences. The authors elaborated on the concept of “pedagogical technology”. However, there are great discrepancies in the understanding and use of the concept of “educational technology”. The technology for developing students' sociocultural competence can be presented through the use of interactive teaching methods: role-playing game, business game, round table. Information and communication technologies (ICT) is a general concept that describes various devices, mechanisms, methods, and algorithms for processing information. The article examined various interactive educational learning platforms, and also provided a typology of preparatory exercises with its own examples. The authors come to the conclusion that the use of ICT in lessons of Buryat as a second language is necessary and advisable, because Students' motivation to learn increases, thanks to unusual forms of lesson delivery and not boring exercises in the textbook, but conducting them in a playful way; a favorable psychological climate is created in the lesson, fatigue is reduced, language activity is activated, communication skills are developed, and vocabulary is replenished.

First Report of Pitaya Virus X Infecting Lophocereus schottii f. mieckleyanus (Thin-Stemmed Totem Pole Cactus) in the United States.

Lophocereus is a genus of three species of columnar cacti native to Arizona and Mexico (Lodi, 2015). These cacti produce several tall, ascending, columnar stems that branch at the base in a candelabra-like arrangement. The most common species, L. schottii is known as the senita cactus. Several unusual knobby-stemmed spineless forms of senita cactus have been found in nature in Baja California, Mexico, which are collectively known as totem pole cacti. The thin-stemmed totem pole cactus, L. schottii f. mieckleyanus is an important part of landscapes in southern Arizona. Cacti are clonally propagated which makes viral infections of economic importance in the ornamental/nursery industry. In February 2023, virus-like symptoms, such as mosaic and chlorotic spots were observed on the stems of L. schottii f. mieckleyanus grown in a nursery in Phoenix, AZ, USA. Total RNA was extracted from two symptomatic cacti (YPHC-61 A & B) following the protocol by Tzanetakis et al. (2007), and cDNA was synthesized using the Superscript IV Reverse Transcriptase (Invitrogen, Vilnius, Lithuania). Reverse transcription polymerase chain reaction (RT-PCR) performed with cactus virus X specific primers (Kim et al. 2016) targeting the coat protein (CP) gene failed to generate any amplicon, while potexvirus-replicase primers, Potex 2RC and Potex 5 (van der Vlugt and Berendsen 2002) targeting RNA-dependent RNA polymerase (RdRp) gene amplified an expected amplicon of ~580 bp from both the samples. One of the amplicons was Sanger sequenced and showed 90.7% nucleotide (nt) identity with pitaya virus X (PiVX) in the GenBank (MN982522). Sequence was submitted in the GenBank under the accession number OR425049. PiVX is a new species of the genus Potexvirus and is named after its origin from pitaya (Hylocereus spp.). Further, RT-PCR was conducted with PiVX-specific primers, CP 110F/CP 604R targeting CP gene (Bae and Park 2022) and RdRp gene (RdRp F 5' GCGTGGGCCCTGGAAAA-3'/RdRp R 5' CTAAGATTCATCAATTCACCTCTCC-3') (this study). Amplicons of ~500 and 1100 bp were obtained using primers, CP 110F/CP 604R and RdRp F/RdRp R, respectively. A BLAST search revealed 90.5% nt identity to PiVX CP sequences (OM802135 and OM802134) and 87.3% nt identity to RdRp sequences (MN982523 and LC654699) in the GenBank. Sequences of isolates YPHC-61A and YPHC-61B were submitted in the GenBank under accession numbers, OQ915350 and PP182358 (CP gene) and OQ915351 and PP209539 (RdRp gene). Phylogenetic analysis based on the combined sequence datasets of CP and RdRp genes also grouped YPHC-61A and YPHC-61B with PiVX isolates and separated from other potexviruses species. For a bioassay of the virus, sap extract from symptomatic cactus was mechanically inoculated onto indicator plant species, i.e., beans, alfalfa, and melon. Ten days post- inoculation, chlorotic lesions were observed on beans and alfalfa plants, while melon and mock-inoculated plants did not show any symptoms. Similarly, L. schottii f. mieckleyanus plants grafted with infected cactus showed chlorotic spots after 30 days post grafting. Mechanically inoculated beans, alfalfa, and cactus plants were found to be positive for PiVX based on RT-PCR and Sanger sequencing. PiVX has earlier been detected on Notocactus leninghausii f. cristatus (Park et al. 2018) and dragon fruit (Selenicereus undatus) plants in South Korea (Bae and Park 2022). To our knowledge, this is the first report of PiVX on L. schottii f. mieckleyanus in the United States and worldwide.

Unusual forms of diffuse parenchymal lung disease worth knowing about

Unusual forms of diffuse parenchymal lung disease worth knowing about

A novel likely pathogenetic variant p.(Cys235Arg) of the MEN1 gene in multiple endocrine neoplasia type 1 with multifocal glucagonomas.

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine syndrome caused by pathogenic variants in MEN1 tumor suppressor gene. Diagnosis is commonly based on clinical criteria and confirmed by genetic testing. The objective of the present study was to report on a MEN1 case characterized by multiple pancreatic glucagonomas, with particular concern on the possible predisposing genetic defects. While conducting an extensive review of the most recent scientific evidence on the unusual glucagonoma familial forms, we analyzed the MEN1 gene in a 35-year-old female with MEN1, as well as her son and daughter, using Sanger and next-generation sequencing (NGS) approaches. We additionally explored the functional and structural consequences of the identified variant using in silico analyses. NGS did not show any known pathogenic variant in the tested regions. However, a new non-conservative variant in exon 4 of MEN1 gene was found in heterozygosity in the patient and in her daughter, resulting in an amino acid substitution from hydrophobic cysteine to hydrophilic arginine at c.703T > C, p.(Cys235Arg). This variant is absent from populations databases and was never reported in full papers: its characteristics, together with the high specificity of the patient's clinical phenotype, pointed toward a possible causative role. Our findings confirm the need for careful genetic analysis of patients with MEN1 and establish a likely pathogenic role for the new p.(Cys235Arg) variant, at least in the rare subset of MEN1 associated with glucagonomas.

The value of genome-wide analysis in craniosynostosis.

Background: This study assessed the diagnostic yield of high-throughput sequencing methods in a cohort of craniosynostosis (CS) patients not presenting causal variants identified through previous targeted analysis. Methods: Whole-genome or whole-exome sequencing (WGS/WES) was performed in a cohort of 59 patients (from 57 families) assessed by retrospective phenotyping as having syndromic or nonsyndromic CS. Results: A syndromic form was identified in 51% of the unrelated cases. A genetic cause was identified in 38% of syndromic cases, with novel variants detected in FGFR2 (a rare Alu insertion), TWIST1, TCF12, KIAA0586, HDAC9, FOXP1, and NSD2. Additionally, we report two patients with rare recurrent variants in KAT6A and YY1 as well as two patients with structural genomic aberrations: one with a 22q13 duplication and one with a complex rearrangement involving chromosome 2 (2p25 duplication including SOX11 and deletion of 2q22). Moreover, we identified potentially relevant variants in 87% of the remaining families with no previously detected causal variants, including novel variants in ADAMTSL4, ASH1L, ATRX, C2CD3, CHD5, ERF, H4C5, IFT122, IFT140, KDM6B, KMT2D, LTBP1, MAP3K7, NOTCH2, NSD1, SOS1, SPRY1, POLR2A, PRRX1, RECQL4, TAB2, TAOK1, TET3, TGFBR1, TCF20, and ZBTB20. Conclusion: These results confirm WGS/WES as a powerful diagnostic tool capable of either targeted in silico or broad genomic analysis depending on phenotypic presentation (e.g., classical or unusual forms of syndromic CS).

Bis(ethylenedithio)tetrathiafulvalene and dibenzotetrathiafulvalene salts with dicyanoiron(III) phthalocyanine anions

Electrooxidation of bis(ethylenedithio)tetrathiafulvelene (BEDT-TTF) and dibenzotetrathiafulvelene (DB-TTF) in the presence of dicyanoiron(II) phthalocyanine (Pc) dianions in form of the {Cryptand(K+)}2{FeII(CN)2Pc}2− salt has been studied in o-dichlorobenzene and acetonitrile solutions (where Cryptand is cryptand[2.2.2]). Initially iron(II) is oxidized to iron(III) and after that tetrathiafulvelenes are oxidized forming crystalline salts (BEDT-TTF+){FeIII(CN)2Pc}−·C6H4Cl2 (1) and (DB-TTF+){FeIII(CN)2Pc}−·C6H4Cl2 (2). Both salts contain closely packed 2D layers composed of the {FeIII(CN)2Pc}− anions and cationic layers containing solvent molecules. Since cations cannot partially oxidize Pc in these salts, two S = 1/2 spins are positioned on FeIII and the cations. The χMT values are 0.90 and 0.87 emu·K/mol per formula unit at 300 K. Antiferromagnetic coupling of spins is observed in 1 and 2 due to both Fe-Cation coupling of −0.4 and −3.5 cm−1 and Fe-Fe couplings of −3.5 and −7.9 cm−1, respectively. Due to its smaller size of DB-TTF+, complex 2 has denser packing of the components and shows stronger exchange couplings. An unusual compound forms when DB-TTF and {FeII(CN)2Pc}2− are oxidized together in acetonitrile: (DB-TTF0)2{Cryptand(K+)}{FeIII(CN)2Pc}− (3) where charges on DB-TTF and Fe are closer to zero and +3, respectively. The {FeIII(CN)2Pc}− anions form layers in 3 among which chains with short C,N…C,N contacts between Pc can be outlined. Only weak intermolecular antiferromagnetic coupling is manifested in 3 with estimated zJ value of −1.6 cm−1.

The reuse of Song Thrush (Turdus philomelos) nests by the Red-backed Shrike (Lanius collurio) in an intensive agricultural landscape: a coincidence or a new solution?

Nest site availability plays an important role in the ecology of the birds inhabiting intensive agricultural landscapes. The removal of trees and snags due to logging is one of the main threats and the cause of the observed decline in many birds living in an agricultural landscape. When nests are lost, nesting passerines typically rebuild them for a new clutch. Additionally, relocating nests after a brood loss is a prevalent strategy used to avoid predators and brood parasites. Such a strategy is common to the Red-backed Shrike, which builds successive nests for each brood. Interestingly, clutch replacement may occur in unusual forms. This study describe three cases of Song Thrush nests reused by Red-backed Shrikes during one breeding season. The time and energy-saving behaviour or possible deterrence of nest parasitism could explain why the nests have been reused. However, due to the limited observations as compared to the total number of nests, further research is necessary to clarify this phenomenon.

Urban form and daily mobility on the outskirts of Constantine (Algeria): Case of the new town of Ali Mendjeli

This article presents the results of research into the impact of urban form on mobility practices in the outskirts of Constantine, which has experienced spectacular urban growth in recent years. Like other Algerian cities, Ali Mendjeli is one of the most unusual urban forms to have arisen from the saturation of the mother city, and has undergone rapid urban expansion, marked by the concentration of major facilities and services. This has led to several urban dysfunctions, reflected in longer distances travelled, strong growth in the number of journeys and increased use of the car, resulting in saturation of the road network and the inefficiency of public transport, which can no longer cope with high demand, and the emergence of informal transport. In fact, the household travel survey carried out in 2020/2021 revealed that the distance between home and work increases with distance from the town center, with a correlation coefficient of R? = 0.78. In addition, the urban layout of Ali Mendjeli is difficult to navigate on foot, with the private car the most dominant modal share, and public transport is still in deficit due to the poor quality of its offer.

An Unusual Case of Mixed Superficial and Adenoid Basal Cell Carcinoma in a 57-year-old Filipino Female

Introduction: Basal cell carcinoma (BCC) is the most common cutaneous malignancy worldwide often occurring in sun-exposed areas. While the nodular variant accounts for the majority of cases, the adenoid type is extremely rare, comprising about 1.3% of all BCCs. Contrary to the typical presentation of BCC, adenoid BCC features a large sized lesion and a tendency to involve non-sun exposed areas such as the trunk. This case study presents a unique form of mixed superficial and adenoid BCC in a 57-year-old Filipino female. Case Report: A 57-year-old female presented with a 2-year history of a slowly enlarging bluish-black plaque with rolled borders on the left flank with noted bleeding, pain, and pruritus. Dermoscopy revealed arborizing vessels, leaf-like structures, blue gray globules, and white streaks, consistent with BCC. Histopathology showed a diagnosis of a superficial and adenoid type of BCC. Conclusion: Encounters with unusual forms of cutaneous carcinoma may arise in dermatologic practice. Dermoscopy serves as a powerful tool in identifying suspicious lesions and a pre-operative biopsy is done to correlate with the clinical diagnosis. Hence, the dermatologist will be able to decide the appropriate treatment option based on the clinical presentation and histopathologic type.

An Atypical Case of Myxedema Coma with Incidental Chilaiditi Syndrome

• Hypothyroidism is a prevalent condition in the general population.1 42 million people in India have thyroid disorders and hypothyroidism is the most common, affecting one in ten adults. • Myxedema coma is a rare and life threatening emergency with a high mortality rate.2 It results from severe hypothyroidism and affects almost every organ • Patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism.3 Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. • A high index of suspicions is needed among clinicians in order to rapidly recognize the condition and make an early diagnosis. Treatment should be commenced on clinical grounds while waiting for laboratory results. • Here, we present the case of a male who presented to the emergency department with altered mental status, Anasarca and in abilty to walk.

МОБІЛЬНА АРХІТЕКТУРА ЯК СПОСІБ ВИРІШЕННЯ ПРОБЛЕМИ ЗАБЕЗПЕЧЕННЯ ВНУТРІШНЬО ПЕРЕМІЩЕНИХ ОСІБ ДОСТУПНИМ ЖИТЛОМ

The article highlights the problems of the creation and implementation of mobile housing for internally displaced persons in Ukraine, which provides people with a decent and comfortable shelter. In addition to social and cultural problems, refugees who are forced to relocate also deal with physical problems, where shelters are designed to meet the minimum needs of temporary accommodation. Designing emergency housing requires innovative and flexible thinking to ensure that housing is safe, healthy and comfortable. This would help improve the quality of housing for residents and surrounding communities. Portable architecture can help develop an industry-wide strategy that includes new materials, components, and construction methods. As a type of building project that must respond to relatively extreme operating parameters, it more often uses experimental and exploratory logistic and construction methods that may ultimately have more general significance. Portable buildings can do almost anything that permanent ones can, and they are also often able to perform other functions that would not be possible with other means. Portable buildings have a low environmental impact; they can be located in rural or urban areas with minimal long-term consequences. They can use a temporary identified address, which is valuable to both the operator and the visitor, as well-known locations can be used to increase the number of people reached over some time. Unusual forms of buildings that are temporarily placed in familiar settings can also change people's view of the environment and perhaps give them the impetus to recognize more clearly its positive and negative features.

SAT153 A Case Of Hypoglycemia-induced Chest Pain Secondary To Adult Nesidioblastosis: A Case Report

Abstract Disclosure: O.L. Medina Espitia: None. A. Quintero Altare: None. V.A. Clavijo: None. L.C. Martínez Delgado: None. The report of the present case in the medical literature is important in itself because of the infrequency of Nesidioblastosis. Additionally, it allows us to show unusual forms of presentation such as chest pain, and dynamic electrocardiographic changes in the ST segment with negative troponin, which coincide with episodes of hypoglycemia. At admission, the patient consulted the emergency department for a clinical presentation consisting of progressive retrosternal chest pain radiating to the left cervical region associated with dyspnea for medium exertion, palpitations, and dysautonomic symptoms, given by nausea. Due to episodes of chest pain, a coronary arteriography had been performed six months before admission without evidence of obstructive lesions. During hospitalization, episodes of hypoglycemia were observed. Remarkably, it was possible to document Dynamic ST changes in all EKG leads during episodes of hypoglycemia, as shown in Figure 1. Among the differential diagnoses, hypoglycemia secondary to adrenal or thyroid dysfunction was considered a first possibility, which was ruled out in the presence of normal paraclinical tests and medications that could generate hypoglycemia (negative sulfonylurea tests) were ruled out. A fasting test was performed with results showing endogenous hyperinsulinemic hyperinsulinemia with levels of insulin in 35.5 mg/dL, C-peptide 9.34 ng/dL and blood glucose 34 mm/dL. MRI of the abdomen without lesions. Due to a history of gastric bypass, endoscopic ultrasonography was not performed, therefore pancreatic calcium stimulation test was performed with evidence of a significant delta over the territory of the splenic artery. A distal pancreatectomy was obtained. Pathology report with findings suggestive of Nesidioblastosis (Figure 2.). There was a complete resolution of episodes of hypoglycemia and chest pain for two weeks. The recurrence of hypoglycemia episodes led to ambulatory treatment, with diazoxide with complete resolution of events. Presentation: Saturday, June 17, 2023

Multilevel allometric growth equations improve accuracy of carbon monitoring during forest restoration

Managing disturbed forests for climate mitigation and biodiversity requires monitoring the carbon (C) cycle consequences of replacing established exotic vegetation with native seedlings. Standard approaches rely on allometric growth equations with unexplored limitations for measuring C changes during restoration. Most plants lack species-specific allometric growth equations. Additionally, these equations may perform poorly for different growth forms, especially when applied to both mature trees and seedlings. To address these limitations, we generated and compared allometric growth equations for four woody species with different biogeographic origins and growth forms, including two high impact invasive species, Cupaniopisis anacardioides and Schinus terebinthifolia. By borrowing strength from sampling across species to reduce estimation error within species, Bayesian multilevel models generated more accurate estimates than either independent species-level models or generic equations, although improvements over independent species-level models were modest. Because errors systematically changed with plant size, especially for species with unusual growth forms, allometric growth equations from custom multilevel models generated higher baseline aboveground biomass estimates and lower post-restoration estimates, which has important implications for monitoring C consequences of invasive tree management.

Aesthetics of Non-Conformism in Design Of Stage Space by Daniel Lider (1965–1975)

The purpose of the article is to identify the specifics of the manifestation of non-conformism tendencies in the work of Danylo Lider, People's Artist of Ukraine, chief artist of the Ivan Franko National Academic Drama Theatre in Kyiv in 1965–1975. Research methodology. The article uses a typological method (to identify the peculiarities of non-conformism in accordance with the specifics of stage design); a functional and typological method, which helped to identify the specifics of non-conformism in D. Lider's plastic solutions; a method of art historical, figurative and stylistic, formal and stylistic analysis of the design of the stage space of performances developed by D. Lider in 1965-1975. Scientific novelty. Non-conformism as a method of artistic thinking in the context of the specifics of the design of theatrical art of Ukraine in the 1960s-1990s is studied. The specificity of the manifestation of non-conformist tendencies in the work of one of the leading Ukrainian theatre artists D. Lider is revealed. Based on the analysis of architectonic elements and features of the visual image of the stage space of the plays "Diary Page" by O. Korniichuk (directed by V. Lyzogub, 1965), "Yaroslav the Wise" by I. Kocherha (directed by B. Meshkis, 1970), "The Time of Yellow Leaves" by O. Kolomiiets (1973), "Hello, Pripiat!" by O. Levada (directed by S. Smiian, 1974) revealed the characteristic features of Danylo Lider's non-conformism. Conclusions. The non-conformism of national theatre artists, in particular D. Lider, has a number of specific features that distinguish it from non-conformism in literature and the visual arts. The artist expresses a huge ideological, spiritual and artistic protest by means of multidimentional metaphorisation. Using myths and the tendency of his own consciousness to deep philosophical mystification of reality, he creates amazing, fantastic worlds within a given stage space. A peculiar reaction to the limitations of positivist aesthetics and naturalistic tendencies of socialist realism in D. Lider's work was the play of metaphors and associations. Non-conformism in the design of D. Lider's stage art is manifested in a complex synthesis of the master's philosophical, ideologicall and aesthetic concepts with the actual searches for new artistic forms. Its characteristic features are: a tendency to an highly complex, symbolic portrayal of one's own ideas and impressions, to a sophisticated coding of artistic means; immersion in the spiritual world and unusual forms of expression of new psychological material obtained as a result of comprehending the literary source of the stage production; creation of a figurative and plastic structure of the performance that goes far beyond the dramatic material; destruction of the canons of traditional artistic design in the style of socialist realism in search of a new reality; emphasis on the nuances of the deep shades of human feelings. Key words: non-conformism, stage space design, D. Lider, architectonics, metaphorisation, symbolic representation.

Solitary pityriasis versicolor an uncommon presentation as a large single patch Report of three cases and review of unusual clinical forms

Pityriasis versicolor (PV) is a common disease, easy recognizable, that usually affects the trunk and upper limbs with multiple rounded scaly lesions which can vary in color from case to case. However, infrequent localizations have been reported, as well as diverse unusual clinical presentations, including atrophic, hyperkeratotic, annular, or inverse forms, among other. We describe 3 cases presenting with a single large lesion in the neck, which can hinder the diagnosis. No description of this form was found neither in large series of PV, nor in extensive reviews. This solitary variety would be just another atypical clinical presentation of PV. Clinicians should be aware of this variety in order to avoid unnecessary studies.

Unusual crystal forms to motif prediction from quasiracemic materials

Unusual crystal forms to motif prediction from quasiracemic materials