Introduction: The present study was carried out to assess the value of routine histopathological examination of appendectomy specimens An attempt is made to review the histopathological spectrum of appendectomy over a period of 2 years and 3 months. aims and objectives: To study the spectrum of histopathological lesions in appendectomy specimens and special emphasis is made to highlight the unusual lesions observed in surgically resected appendicectomies and appendices in medicolegal autopsies. material and methods: The study was carried out on appendectomy specimens received in the department of pathology Mahadevappa Rampure Medical College during a period of 2 years and 3 months from Jan 2019 to March 2021. Clinical data collected from records of corresponding appendectomy specimens were processed. Sections studied various histopathological patterns with an emphasis on unusual findings. results: A total of 500 specimens were analyzed among which 298 were males and 202 were females with M: F 1.4:1. The histopathological examination showed Acute appendicitis (57.4%), Acute ulcerative appendicitis (0.8%), Recurrent/Eosinophilic appendicitis (03%), Acute necrotizing appendicitis (1.6%), Acute appendicitis with periappendicitis (1.4%), Acute suppurative appendicitis (2.4%), Gangrenous appendicitis (0.8%), Healed appendicitis (2.2%), Chronic appendicitis (25.2%) and Chronic sclerosing appendicitis (1.0%). The unusual fngings were observed in 22 cases (4.4%) which include Tubercular appendicitis (1.0%), Foreign body granuloma (0.8%), Xanthogranulomatous appendicitis (0.2%), Enterobiusvermicularis (0.8%), Round worm (0.2%), Retention mucocele (0.4%), Carcinoid tumor (0.4%), Mucinous adenocarcinoma (0.4%) and Metastatic adenocarcinoma (0.2%). conclusion: Though the present study revealed usual findings of appendicitis and variants in most of the cases, the observation of unusual findings like granulomas, parasites, and neoplasms warrants a careful study of all appendectomy specimens received in the pathology department with emphasis on relevant clinical and laboratory findings thus modulating the management and follow up.