This paper introduces an idea to enhance the thermal performance of helically coiled heat exchangers by integrating the effect of using a tube with an elliptical cross section shape with the effect of tube twisting. Numerical simulations showed that the combination of these two effects resulted in disrupting the growth of hydrodynamic and thermal boundary layers leading to better distributions of temperature, velocity, and turbulent kinetic energy compared with the untwisted model with a circular cross section. The Nusselt number was found to be increased significantly by decreasing the aspect ratio of the elliptical tube shape along with increasing the number of tube twisting turns. The average Nusselt number was increased by 29.24% when using aspect ratio of 0.3 with a twist ratio of 0.0327 m. The enhancement in the thermal performance is accompanied with an increase in the pressure drop due to the increased turbulence levels. Findings of this research reveal that this technique is promising in raising the performance of helically coiled heat exchangers. Detailed analysis provided may be useful for future researches on this topic.