The heat and mass transfer of the unsteady flow of a micropolar fluid over a curved stretching surface was considered in this study. The Brownian motion and thermophoresis effects were explored in this analysis. The effects of suction/injection cases on the curved surface were discussed. Under flow assumptions, a mathematical model was designed employing boundary layer approximations using partial differential equations. A suitable transformation was developed using the lie symmetry method. Partial differential equations were transformed into ordinary differential equations by suitable transformations. The dimensionless system was elucidated through a numerical technique, namely bvp4c. The involved physical parameters’ influences are described in the form of graphs as well as numerical results in the form of tables. Our current work is helpful in the engineering and industrial fields. The unsteadiness parameter increases which Nusselt number at increased but concentrations declined. The thermophoresis parameter increases when increasing the Nusselt number because the small number of nanoparticles enhances the heat transfer rate. The temperature profile declined due to increasing values of unsteadiness parameter for both cases of suction and injection cases.