Saturated And Unsaturated Research Articles

Pyrolysis mechanism of α-CPP and β-CPP fuels by ReaxFF molecular dynamics

Novel fuel molecules with high density and high specific impulse are ideal alternatives for aerospace fuels, and understanding their combustion or pyrolysis chemistry is desired for successful applications. In this work, the pyrolysis of the novel fuel molecules cyclopropanated α-pinane (α-CPP) and cyclopropanated β-pinane (β-CPP) was investigated using ReaxFF MD. The results showed that the initial pyrolysis of fuel molecules is mainly completed through three steps: the cleavage of the CC bond in ternary rings to form diradicals, four-membered ring undergoes a ring-opening reaction to form diradicals with cyclic structure and double bonds inside, and six-membered ring opening to triolefin molecules or diradicals with unsaturated bonds. In the initial reaction of α-CPP and β-CPP, C11H18 → •CH3 + •C10H15 and C11H18 → •C6H9 + •C5H9 are dominant respectively. Further analysis revealed that C5H9 and C6H9 radicals are important intermediates in the pyrolysis process. Kinetic calculations showed that the activation energies of α-CPP and β-CPP molecules are 51.44 kcal/mol and 49.14 kcal/mol, respectively, which are smaller than those of JP-10, RP-1 and other fuels. This work provides a theoretical basis for revealing the overall reaction mechanism of α-CPP and β-CPP pyrolysis of high-energy fuel molecules at the atomic level.

1‐Alkynylphosphorus Compounds in Organic Synthesis，2010‐2024

Since the review of Yorimitsu and Oshima in 2010, the past 15 years have witnessed significant progresses in the application of 1‐alkynylphosphorus compounds in organic synthesis. Owing to the reactive carbon‐carbon triple bond in association with the electron‐withdrawing phosphoryl group, they easily undergo transition metal‐catalyzed nucleophilic addition reactions at the β‐position with carbon‐ and heteroatom‐based nucleophiles to afford structurally diverse 1‐alkenyl phosphorus compounds. Especially, when 1‐alkynylphosphonates or phosphinates are used, intramolecular substitution reactions on P‐atom might occur in some cases, which would result in the formation of P‐based heterocycles. In addition, the existing triple bond makes them prone to go through addition reaction initiated cyclization reactions and [2+2], [2+3], [2+4], [2+5] and [2+2+2] cycloaddition reactions with other unsaturated bonds, which provides an efficient access to various P‐based heterocycles and phosphorylated carbon‐ and heterocycles.

Metallic Impurities in Electrolysis: Catalytic Effect of Pb Traces in Reductive Amination and Acetone Reduction.

The electrochemical hydrogenation (e-hydrogenation) of unsaturated compounds like imines or carbonyls presents a benign reduction method. It enables direct use of electrons as reducing agent, water as proton source, while bypassing the need for elevated temperatures or pressures. In this contribution, we discuss the nature of active sites in electrocatalytic reductive amination with the transformation of acetone and methylamine as model reaction. Surprisingly, lead impurities in the ppm-range proved to possess a significant effect in e-hydrogenation. Accordingly, the influence of applied potential and cathode material in presence of 1 ppm Pb was investigated. Finally, we transferred the insights to the reduction of acetone manifesting comparable observations as for imine reduction. The results suggest that previous studies on electrochemical reduction in the presence of lead electrodes should be re-evaluated.

Palladium-Catalyzed γ-C–H Arylation of Unsaturated Carbonyl Compounds: An Emerging Remote Buchwald–Hartwig–Miura Arylation

AbstractAs an important complement to the Buchwald–Hartwig–Miura arylation, Pd-catalyzed γ-C–H arylations, including γ-C(sp3)–H and γ-C(sp2)–H arylations, provide a more direct route to install an aryl group on the less reactive γ-site of unsaturated carbonyl compounds, and have attracted considerable interest from the chemistry community in recent years. This review summarizes the applications of this method with both cyclic and linear unsaturated carbonyl compounds (aldehydes, ketones, esters, amide, and nitriles), as well as in the total synthesis of natural products (NPs), natural product skeletons, and bioactive analogues.1 Introduction2 γ-C–H Arylation of Cyclic Unsaturated Carbonyl Substrates2.1 Exocyclic γ-Arylation2.1.1 Unsaturated Ketones and the Corresponding Silyl-Dienol Ethers2.1.2 Unsaturated Lactones2.2 Endocyclic γ-C–H Arylation2.2.1 Unsaturated Ketones and the Corresponding Silyl-Dienol Ethers2.2.2 Unsaturated Lactones2.2.3 Unsaturated Nitriles3 γ-C–H Arylation of Linear Unsaturated Carbonyl Substrates3.1 Unsaturated Aldehydes3.2 Unsaturated Ketones3.3 Unsaturated Amides3.4 Unsaturated Nitriles3.5 Silyl Ketene Acetals of α,β-Unsaturated Esters4 Conclusion

Selective hydrogenation of nitro compounds to amines by coupled redox reactions over a heterogeneous biocatalyst

Cleaner synthesis of amines remains a key challenge in organic chemistry because of their prevalence in pharmaceuticals, agrochemicals and synthetic building blocks. Here, we report a different paradigm for chemoselective hydrogenation of nitro compounds to amines, under mild, aqueous conditions. The hydrogenase enzyme releases electrons from H2 to a carbon black support which facilitates nitro-group reduction. For 30 nitroarenes we demonstrate full conversion (isolated yields 78 – 96%), with products including pharmaceuticals benzocaine, procainamide and mesalazine, and 4-aminophenol – precursor to paracetamol (acetaminophen). We also showcase gram-scale synthesis of procainamide with 90% isolated yield. We demonstrate potential for extension to aliphatic substrates. The catalyst is highly selective for reduction of the nitro group over other unsaturated bonds, tolerant to a wide range of functional groups, and exhibits excellent stability in reactions lasting up to 72 hours and full reusability over 5 cycles with a total turnover number over 1 million, indicating scope for direct translation to fine chemical manufacturing.

Improvement of methane reforming Ni-based catalyst stability by controlling the unsaturated coordination aluminum in metakaolinite

Dry reformation of methane (DRM) is an attractive route to utilize greenhouse gases, which has significant environmental and economic benefits. Ni-based catalysts are one of the most important catalysts in DRM. However, their deactivation induced by sintering and coking remains a major challenge. In this work, a series of metakaolinite-supported Ni catalysts (Ni/MK) with varying content of unsaturated coordinated aluminum were prepared. It was found that the catalytic stability could be improved by controlling the unsaturated coordinated aluminum content. Ni/MK-800, with the highest unsaturated coordinated aluminum content, demonstrated at least 18 times enhanced stability duration compared with Ni/MK-600 with the lowest content. The increasing content of unsaturated coordinated aluminum enhanced the metal-support interaction, which subsequently improved the anti-sintering and anti-coking performance and thus improved the catalytic stability. This work provided an optional strategy for designing highly stable DRM catalysts by controlling the coordinative unsaturation degree of central ions in support.

Multiple strategies enhance visible-light photocatalytic degradation levofloxacin of Fe-doped MOF/AgCl Z-scheme heterojunction composites based on pyrazole carboxylic ligand

The construction of visible-light catalysts to degrade water pollutants is significant in environmental governance and solar energy conversion. In this work, a novel Zn-MOF with unsaturated coordination sites was constructed using 1-(Carboxymethyl)-pyrazole-4-carboxylic acid as the organic ligand. Its crystal structure was studied through single crystal X-ray diffraction. To enhance visible light catalytic performance, ZnFe-MOF/AgCl-x Z-scheme heterojunction composites were constructed. The optimized ZnFe-MOF/AgCl-50 material exhibits excellent photocatalytic performance, which can degrade 90.33 % of levofloxacin in 21 min. The results indicate that Fe doping and the construction of the ZnFe-MOF/AgCl-x Z-scheme heterojunction not only broaden the responsive range to visible light, but also effectively promote the internal and interfacial charges transfer efficiency, leading to a superior catalytic performance. In addition, the Ag nanoparticles (NPs) generated during the photocatalytic process can serve as a bridge, achieving rapid charge transfer in Z-scheme heterojunction. This work can offer an innovative perspective for the development of novel and efficient MOF-based Z-scheme heterojunction photocatalysts for wastewater treatment applications.

Unraveling the role of anthropogenic and hydrologic drivers with respect to the optical and molecular properties of dissolved organic matter and organic phosphorus in a P-contaminated river

Anthropogenic and hydrological drivers are key factors influencing the fate of dissolved organic matter (DOM) and dissolved organic phosphorus (DOP) in river runoff. However, how anthropogenic disturbances and hydrological conditions jointly affect the composition and characteristics of DOM and DOP in river runoff remains unclear. This study used fluorescence spectroscopy, Fourier transform ion cyclotron resonance mass spectrometry, and the stable water isotopes to interpret the chemical composition and properties of DOM and DOP as well as their linkages to anthropogenic disturbances and hydrological conditions in a typical P-contaminated tributary to the central Yangtze River. The results show in the wet season, the average abundance of humic-like components in DOM exceeded 60 %, while the average abundance of tryptophan-like components in DOM exceeded 50 % in the dry season. During the dry season, hydrological conditions had a greater impact on highly unsaturated DOM compounds compared to anthropogenic disturbances because a decrease in precipitation reduced the transport of terrestrial DOM into aquatic systems and increased water retention time in the river, promoting the production of unsaturated compounds from photochemistry. The effects of the two factors were similar in the wet season because active agricultural activities and intense precipitation jointly facilitated the entry of exogenous humics into the runoff, leading to the similar relative abundance of highly unsaturated DOM compounds associated with both factors. Anthropogenic disturbances had a greater impact on aliphatic DOM and DOP than hydrological conditions, which was associated with intense human activities in the watershed, such as phosphate mining, agricultural cultivation, and domestic sewage discharge. This study provides new knowledge about the composition, properties and underlying mechanisms of DOM and DOP in the P-contaminated watershed runoff.

Parallel coupling of gas chromatography to mass spectrometry and solid deposition Fourier transform infrared spectroscopy: an innovative approach to address challenging identifications.

The request for novel hyphenated instruments and techniques, capable of affording exhaustive information and results, is a focus continuously watched out. In this context, the present work aimed at the development of an integrated system combining gas chromatographic (GC) separation with mass spectrometry (MS) and (solid deposition) Fourier transform infrared spectroscopy (FTIR) detection. An external transfer line was designed inthelab for the parallel coupling of the two detectors, in such a way toobtain complementary analytical information consisting of anMS spectrum, anIR spectrum and linear retention indices (LRI), within a single analysis. The instrument performance was demonstrated for the analysis of a commercial mixture consisting of 139 hydrocarbons, comprising linear, branched, unsaturated and aromatic compounds. A 100-m poly(dimethylsiloxane) column was employed for the separation, and the outlet flow was split 95:5 between the IR and MS detectors using two uncoated capillaries. The IR spectra were acquired from solid deposits on a zinc selenide disc (-90 °C), over a spot (detector area) of about 0.1 mm2, in the range of 4000-700 cm-1 and at a resolution of 4 cm-1. Final identification of the separated compounds by alibrary search was achieved by excluding incorrect results, sequentially using a three-filter approach (85% similarity against reference MS and IR library spectra and ±10 LRI unit tolerance). Based on these preliminary results, the GC-MS/sd-FTIR system is a promising tool for the characterization of complex matrix constituents, for which identification is cumbersome, by using only one detection technique.

Enhanced catalytic performance for aerobic dehydrogenation of N-heterocycles over bimetallic CoOX-CeO2 catalysts derived from Ce-based MOFs

N-heteroaromatics as one of cornerstones in chemical processes are in the limelight, so the synthesis of N-heteroaromatics have been attracted a great deal of attention. Among the elegant methods for the preparation of N-heteroaromatics, the direct oxidative dehydrogenation of saturated compounds affording N-heteroaromatics is a simple and efficient tactic. In this work, CoOX-CeO2 composites synthesized by the pyrolysis of Co/Ce-BTC MOFs as the precursor were employed as a heterogeneous catalyst for the dehydrogenation of N-heterocycles under aerobic conditions. CoOX-CeO2 composites were analyzed by diversified characterization techniques of SEM, TEM, BET, XRD, XPS, and ICP-OES. The characterization results demonstrate that abundant oxygen vacancies on the surface and the synergistic effect of CoOX-CeO2 composites remarkably enhance the catalytic performance of CoOX-CeO2 catalysts. Furthermore, the catalytic performance of CoOX-CeO2 composites remained excellent after six recycles. This catalytic system provides an alternative tool for the effective synthesis of aromatic compounds.

Stability of Medium-Ring Cyclic Unsaturated Carbonyl Compounds: Direct Access to Unsaturated Ketones with C-C Double Bonds at Distal Positions via Transfer Dehydrogenation of Alicyclic Ketones.

Medium-ring cyclic compounds have characteristic distortions. For alicyclic enones, conjugated enones are known to be less stable than unconjugated enones. In this study, the relative stability of cycloalkenones with varied C-C double bond positions with C6-C12 rings was theoretically investigated to reveal that C8-C12 cycloalkenones prefer the unconjugated isomer. Furthermore, direct access to distal unsaturated cycloalkenones has been accomplished by transfer dehydrogenation of cycloalkanones catalyzed by iridium complexes.

Coordination Desymmetrization of Copper Single‐Atom Catalyst for Efficient Nitrate Reduction

AbstractCoordination engineering strategy for optimizing the catalytic performance of single‐atom catalysts (SACs) has been rapidly developed over the last decade. However, previous reports on copper SACs for nitrate reduction reactions (NO3RR) have mostly focused on symmetric coordination configurations such as Cu‐N4 and Cu‐N3. In addition, the mechanism in terms of the regulation of coordination environment and catalytic properties of SACs has not been well demonstrated. Herein, we disrupted the local symmetric structure of copper atoms by introducing unsaturated heteroatomic coordination of Cu−O and Cu−N to achieve the coordination desymmetrization of Cu‐N1O2 SACs. The Cu‐N1O2 SACs exhibit an efficient nitrate‐to‐ammonia conversion with a high FE of ~96.5 % and a yield rate of 3120 μg NH3 h−1 cm−2 at −0.60 V vs RHE. As indicated by in situ Raman spectra, the catalysts facilitate the accumulation of NO3− and the selective adsorption of *NO2, which were further confirmed by the theoretical study of surface dipole moment and orbital hybridization. Our work illustrated the correlation between the coordination desymmetrization and the catalytic performance of copper SACs for NO3RR.

Hydrogenolysis of Haloboranes: from Synthesis of Hydroboranes to Formal Hydroboration Reactions.

Hydroboranes are versatile reagents in synthetic chemistry, but their synthesis relies on energy-intensive processes. Herein, we report a new method for the preparation of hydroboranes from hydrogen and the corresponding haloboranes. Triethylamine (NEt3) form with dialkylchloroboranes a Frustrated Lewis Pair (FLP) able to split H2 and afford the desired hydroborane with ammonium salts. Unreactive haloboranes were unlocked using a catalytic amount of Cy2BCl, enabling the synthesis of commonly used hydroboranes such as pinacolborane or catecholborane. The mechanisms of these reactions have been examined by DFT studies, highlighting the importance of the base selection. Finally, the system's robustness has been evaluated in one-pot B-Cl hydrogenolysis/hydroboration reactions of C=C unsaturated bonds.

Hydrogenolysis of haloboranes: from synthesis of hydroboranes to formal hydroboration reactions

Hydroboranes are versatile reagents in synthetic chemistry, but their synthesis relies on energy‐intensive processes. Herein, we report a new method for the preparation of hydroboranes from hydrogen and the corresponding haloboranes. Triethylamine (NEt3) form with dialkylchloroboranes a Frustrated Lewis Pair (FLP) able to split H2 and afford the desired hydroborane with ammonium salts. Unreactive haloboranes were unlocked using a catalytic amount of Cy2BCl, enabling the synthesis of commonly used hydroboranes such as pinacolborane or catecholborane. The mechanisms of these reactions have been examined by DFT studies, highlighting the importance of the base selection. Finally, the system's robustness has been evaluated in one‐pot B‐Cl hydrogenolysis/hydroboration reactions of C=C unsaturated bonds.

Contrasting Metallic (Rh0) and Carbidic (2D-Mo2C MXene) Surfaces in Olefin Hydrogenation Provides Insights on the Origin of the Pairwise Hydrogen Addition.

Kinetic studies are vital for gathering mechanistic insights into heterogeneously catalyzed hydrogenation of unsaturated organic compounds (olefins), where the Horiuti-Polanyi mechanism is ubiquitous on metal catalysts. While this mechanism envisions nonpairwise H2 addition due to the rapid scrambling of surface hydride (H*) species, a pairwise H2 addition is experimentally encountered, rationalized here based on density functional theory (DFT) simulations for the ethene (C2H4) hydrogenation catalyzed by two-dimensional (2D) MXene Mo2C(0001) surface and compared to Rh(111) surface. Results show that ethyl (C2H5*) hydrogenation is the rate-determining step (RDS) on Mo2C(0001), yet C2H5* formation is the RDS on Rh(111), which features a higher reaction rate and contribution from pairwise H2 addition compared to 2D-Mo2C(0001). This qualitatively agrees with the experimental results for propene hydrogenation with parahydrogen over 2D-Mo2C1-x MXene and Rh/TiO2. However, DFT results imply that pairwise selectivity should be negligible owing to the facile H* diffusion on both surfaces, not affected by H* nor C2H4* coverages. DFT results also rule out the Eley-Rideal mechanism appreciably contributing to pairwise addition. The measurable contribution of the pairwise hydrogenation pathway operating concurrently with the dominant nonpairwise one is proposed to be due to the dynamic site blocking at higher adsorbate coverages or another mechanism that would drastically limit the diffusion of H* adatoms.

Revealing degradation pathways of soluble and dissolved organic matter in alluvial-lacustrine aquifer systems impacted by high levels of geogenic ammonium

The excessive presence of geogenic ammonium (NH4+) in groundwater poses a global environmental concern, commonly linked to the degradation of nitrogen-containing dissolved organic matter (DOM). However, there is a gap in systematic studies on the combination of soluble organic matter (SOM) in sediments and DOM in groundwater, with few indoor incubation experiments to validate their degradation pathways. This study utilized ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry to analyze the molecular characteristics of DOM and SOM in aquifer systems affected by geogenic NH4+. Subsequently, indoor incubation experiments spanning up to 140 d were conducted to verify the degradation pathways. The experimental results revealed a two-phase degradation process for both the DOM and SOM. The initial stage was characterized by the degradation of aliphatic compounds (ALC) with the production of polyphenols (PPE) and highly unsaturated compounds (HUC). The second stage was dominated by the degradation of PPE and HUC, accompanied by the re-consumption of some ALC, while more recalcitrant HUC persisted. Notably, the first stage of SOM degradation exceeded that of DOM degradation, indicating that SOM exhibited greater resistance to aging. This phenomenon may be attributed to a wider range of active enzymes in sediments, the rapid replenishment of SOM by organic matter in sediments, or the accelerated degradation of DOM. The experimental results aligned with the molecular characterization of DOM and SOM in actual aquifer systems. It is hypothesized that NH4+ produced through the direct mineralization of SOM may contribute more to the enrichment of NH4+ in groundwater than that produced through the mineralization of DOM. This study is the first to analyze DOM and SOM together in aquifer systems and validate their degradation pathways through incubation experiments, thereby providing novel insights into the enrichment of geogenic NH4+ in groundwater.

Geometric Tuning of Coordinatively Unsaturated Copper(I) Sites in Metal-Organic Frameworks for Ambient-Temperature Hydrogen Storage.

Porous solids can accommodate and release molecular hydrogen readily, making them attractive for minimizing the energy requirements for hydrogen storage relative to physical storage systems. However, H2 adsorption enthalpies in such materials are generally weak (-3 to -7 kJ/mol), lowering capacities at ambient temperature. Metal-organic frameworks with well-defined structures and synthetic modularity could allow for tuning adsorbent-H2 interactions for ambient-temperature storage. Recently, Cu2.2Zn2.8Cl1.8(btdd)3 (H2btdd = bis(1H-1,2,3-triazolo-[4,5-b],[4',5'-i])dibenzo[1,4]dioxin; CuI-MFU-4l) was reported to show a large H2 adsorption enthalpy of -32 kJ/mol owing to π-backbonding from CuI to H2, exceeding the optimal binding strength for ambient-temperature storage (-15 to -25 kJ/mol). Toward realizing optimal H2 binding, we sought to modulate the π-backbonding interactions by tuning the pyramidal geometry of the trigonal CuI sites. A series of isostructural frameworks, Cu2.7M2.3X1.3(btdd)3 (M = Mn, Cd; X = Cl, I; CuIM-MFU-4l), was synthesized through postsynthetic modification of the corresponding materials M5X4(btdd)3 (M = Mn, Cd; X = CH3CO2, I). This strategy adjusts the H2 adsorption enthalpy at the CuI sites according to the ionic radius of the central metal ion of the pentanuclear cluster node, leading to -33 kJ/mol for M = ZnII (0.74 Å), -27 kJ/mol for M = MnII (0.83 Å), and -23 kJ/mol for M = CdII (0.95 Å). Thus, CuICd-MFU-4l provides a second, more stable example of optimal H2 binding energy for ambient-temperature storage among reported metal-organic frameworks. Structural, computational, and spectroscopic studies indicate that a larger central metal planarizes trigonal CuI sites, weakening the π-backbonding to H2.

Kinetics, products and mechanisms of the OH radicals and Cl atoms reactions with trans-2-octene and cycloheptene

Relative rate coefficients for the gas-phase reactions of OH radicals and Cl atoms with trans-2-octene (k1-OH and k2-Cl) and cycloheptene (k3-OH and k4-Cl) have been determined by in situ Fourier Transform Infrared Spectroscopy (FTIR). The experiments were carried out at 298 ± 2 K and atmospheric pressure (760 ± 10) Torr using synthetic air as bath gas. The following rate coefficients (in units of cm3 molecule−1 s−1) were obtained for the reactions of trans-2-octene and cycloheptene with OH radicals and Cl atoms: k1-OH = (8.51 ± 1.86) × 10−11, k2-Cl = (4.47 ± 1.09) × 10−10, k3-OH = (7.84 ± 1.78) × 10−11, k4-Cl = (5.46 ± 1.01) × 10−10, respectively. This is the first kinetic study for the reactions of trans-2-octene with Cl atoms and the first rate coefficient determination for the title reactions by in situ FTIR spectroscopy. The kinetic data were compared with previously reported values for similar compounds and reactivity trends were developed. Complementary, products identification studies were performed in similar conditions to the kinetic experiments by the in situ FTIR and Gas Chromatography coupled to mass spectrometry (GC-MS). The atmospheric chemical mechanisms were postulated for the first time for both unsaturated compounds. In addition, the atmospheric implications of these reactions were assessed through the estimation of the tropospheric lifetimes, Photochemical Ozone Creation Potential (POCP) and fates of these compounds in the troposphere.

Construction of high-performance g-C3N4/MoS2 heterojunction humidity sensor and investigation of its application

In the paper, a g-C3N4/MoS2 humidity sensor with high response, low hysteresis and fast response/recovery for skin health status detection was prepared. The synthesis of g-C3N4/MoS2 heterojunction materials increases the interfacial barrier and improves the sensitivity of sensor. The edge unsaturated bonds and S defects of g-C3N4/MoS2 composites together enhance the adsorption of H2O, which in turn improves the sensitivity of sensor. The consequent acceleration of electron transfer between the material surface and water molecules led to an improvement in the response/recovery speed and humidity hysteresis. The N-H on the composite surface promotes the formation of physically adsorbed water layer and enhances the sensor recovery capability. The g-C3N4/MoS2 sensor shows high sensitivity (204875 Ω/%RH), fast response/recovery speed (11/9 s), and low hysteresis (2.0 %) at the 11 %-95 % RH range. In this study, the sensors were successfully used for the detection of skin health conditions, providing a viable solution for skin detection.

Exploring the Potential of Oleanolic Acid Dimers-Cytostatic and Antioxidant Activities, Molecular Docking, and ADMETox Profile.

The presented work aimed to explore the potential of oleanolic acid dimers (OADs): their cytostatic and antioxidant activities, molecular docking, pharmacokinetics, and ADMETox profile. The cytostatic properties of oleanolic acid (1) and its 14 synthesised dimers (2a-2n) were evaluated against 10 tumour types and expressed as IC50 values. Molecular docking was performed with the CB-Dock2 server. Antioxidant properties were evaluated with the CUPRAC method. ADMETox properties were evaluated with the ADMETlab Manual (2.0) database. The results indicate that the obtained OADs can be effective cytostatic agents, for which the IC50 not exceeded 10.00 for many tested cancer cell lines. All OADs were much more active against all cell lines than the mother compound (1). All dimers can inhibit the interaction between the 1MP8 protein and cellular proteins with the best results for compounds 2f and 2g with unsaturated bonds within the linker. An additional advantage of the tested OADs was a high level of antioxidant activity, with Trolox equivalent for OADs 2c, 2d, 2g-2j, 2l, and 2m of approximately 0.04 mg/mL, and beneficial pharmacokinetics and ADMETox properties. The differences in the DPPH and CUPRAC assay results obtained for OADs may indicate that these compounds may be effective antioxidants against different radicals.