Unpublished Work Research Articles

The Solutions for The Conflict of Laws Relating to Copyright and Its Exploitation" A Comparative Study"

Determining the applicable law for copyright is a complex issue in the jurisprudence of private international law. This is because it is an intangible moral property, meaning that the nature of the subject to which the right is attributed differs from other material rights. In addition, most legislations have not established specific attribution rules for moral rights, making it difficult to determine the applicable law for copyright. Hence, the research problem is embodied in the absence of explicit and clear texts that address the issue of conflict of laws if it relates to the author’s topics moving between the scope of more than one law, which leads to an overlap in the scope of the applications of the law that related to those rights, raising the issue of which law should apply and which one is more accurate in achieving justice. The importance of this research is evident in raising the awareness among rights holders of the existence of a legal organization that protects the copyright, which may ease their minds due to their prior knowledge of the existence of a law that protects the product of their mind on the one hand and deters the aggressor on the other hand. Moreover, this study aimed to demonstrate the validity of the laws referred to by the traditional attribution rules to resolve conflicts of laws in matters related to copyright. It must be noted that the study adopted the analytical and descriptive comparative approach between Jordanian law and Iraqi law and the role of each in resolving problems arising from conflicts of laws.The study found that the Jordanian legislator specifically addressed unpublished works in Article 57 of the Copyright Protection Law, clarifying whether they fall under the law's provisions. However, we did not find an explicit provision in the Iraqi Copyright Protection Law regulating the issue of unpublished works. However, the researcher recommended that the Jordanian legislator conclude new bilateral or regional agreements in addition to joining international agreements due to the inadequacy or inappropriateness of traditional agreements related to judicial cooperation to rule on what arises from a conflict of legislative jurisdiction regarding copyright.

Blood pressure targets for hypertension in people with chronic renal disease.

Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease, development of end-stage renal disease, and all-cause mortality. It affects around 10% of the population worldwide. The prevalence of hypertension in people with CKD ranges from 22% in stage 1 to 80% in stage 4. Elevated arterial blood pressure is one of the major independent risk factors for adverse cardiovascular events. Thereby, reducing blood pressure to below standard targets may be beneficial but could also increase the risk of adverse events. The optimal blood pressure target in people with hypertension and CKD remains unknown. Primary: to compare the effects of standard and lower-than-standard blood pressure targets for hypertension in people with chronic kidney disease on mortality and morbidity outcomes. Secondary: to assess the magnitude of reductions in systolic and diastolic blood pressure, the proportion of participants reaching blood pressure targets, and the number of drugs necessary to achieve the assigned target. We used standard, extensive Cochrane search methods. We searched the Cochrane Hypertension Specialized Register, CENTRAL, MEDLINE, Embase, one other database, and two trial registers up to 8 February 2023. We also contacted authors of relevant papers regarding further published and unpublished work. We applied no language restrictions. We included randomized controlled trials (RCTs) in people with hypertension and CKD that provided at least twelve months' follow-up. Eligible interventions compared lower targets for systolic/diastolic blood pressure (130/80 mmHg or lower) to standard targets for blood pressure (140 to 160/90 to 100 mmHg or lower). Participants were adults with CKD and elevated blood pressure documented in a standard way on at least two occasions, or already receiving treatment for elevated blood pressure. We used standard Cochrane methods. Our critical outcomes were: total mortality, total serious adverse events, total cardiovascular events, cardiovascular mortality, and progression to end-stage renal disease. Important outcomes were: participant withdrawals due to adverse effects, and number of participants with a doubling of serum creatinine level or at least a 50% reduction in the glomerular filtration rate (GFR) at the end of the study. We used GRADE to assess the certainty of the evidence for the critical outcomes. This review received no funding. We included six RCTs that contributed data for meta-analysis, involving 7348 participants overall (range 840 to 4733 people per study). The mean follow-up was 3.6 years (range 1.0 to 8.0 years). Three studies were publicly funded, two were privately funded, and one had both public and private funding. All RCTs provided individual participant data. None of the included studies blinded participants or clinicians because of the need to titrate antihypertensive drugs to reach a specific blood pressure target. However, an independent committee blinded to group allocation assessed clinical events in all studies. Critical outcomes. Compared with standard blood pressure targets, lower targets likely result in little to no difference in total mortality (risk ratio (RR) 0.90, 95% confidence interval (CI) 0.76 to 1.06; 6 studies, 7348 participants), total serious adverse events (RR 1.01, 95% CI 0.94 to 1.08; 6 studies, 7348 participants), and total cardiovascular events (RR 1.00, 95% CI 0.87 to 1.15; 5 studies, 6508 participants), all with moderate-certainty evidence. Compared with standard blood pressure targets, lower targets may result in little to no difference in cardiovascular mortality (RR 0.90, 95% CI 0.70 to 1.16; 6 studies, 7348 participants) and progression to end-stage renal disease (RR 0.94, 95% CI 0.80 to 1.11; 4 studies, 4788 participants), both with low-certainty evidence. Important outcomes. We found little to no differences in: participant withdrawals due to adverse effects; and the number of participants with a doubling of serum creatinine level, or at least a 50% reduction in GFR at the end of the study. Exploratory outcomes. Compared to the standard blood pressure target groups, participants in the lower target groups achieved lower systolic and diastolic blood pressure values after one year, and required a higher number of antihypertensive drugs at the end of the studies. A higher proportion of participants in the standard blood pressure target groups achieved the targets they were assigned than did participants in the intensive target groups. Compared to a standard blood pressure target, lower blood pressure targets probably result in little to no difference in total mortality, total serious adverse events, and total cardiovascular events, and may result in little to no difference in total cardiovascular mortality or in the progression to end-stage renal disease in people with hypertension and CKD. However, the evidence underpinning these conclusions has several limitations. All studies were open design, blood pressure measurement was performed at a medical office, and there was scant information about adverse events. Future research should include high-quality adverse event data, report results for people with different levels of proteinuria, and consider out-of-office blood pressure monitoring. Several studies are ongoing, and may provide new evidence for this topic in the near future.

On the History of the St. Petersburg Assyriological School: Rostislav Antonovich Gribov

The article is dedicated to the 90th anniversary of the remarkable Orientalist and teacher Rostislav Antonovich Gribov, who trained several generations of Russian Assyriologists. It contains a biography of the scholar, supplemented by characteristics of his scholarly and pedagogical activities. The main directions of R.A. Gribov’s activity are considered: the creation of a new methodology for teaching the cuneiform languages of Mesopotamia, a study of the socio-political history of the city of Mari, works on the history of Russian Assyriology. A list of published and unpublished works is attached to the article.

New insights on the origin of the Richardson-Richards equation

ABSTRACT The Richardson-Richards equation (RRE), despite known shortcomings especially in regard to preferential flow, provides the basis for the vast majority of unsaturated flow models in use today. L.F. Richardson published this equation in 1922, nine years before L.A. Richards. Whereas Richards approached this problem directly from the groundbreaking developments of Edgar Buckingham, Richardson, surprisingly, cited as his starting point only the earlier work of L.J. Briggs. Collectively, these four scientists’ published and unpublished work reveals that: (1) Briggs’ work, though qualitative, captured the essential physical principles needed for quantifying unsaturated flow; (2) Buckingham came very close to deriving the RRE and explained why he stopped short of doing so; (3) derivation of the RRE from the work of either Briggs or Buckingham required only modest developmental work; and (4) besides deriving the RRE, Richards carried through much of the experimental agenda that Buckingham considered a necessary precursor to mathematical treatment.

Scientific legacy of Prof. Evgenia N. Sinskaya, Doctor of Biological and Agricultural Sciences: commemorating her 135th birthday

In 2024, we celebrate the 135th birthday of Evgenia N. Sinskaya (1889–1965). A leading expert in the taxonomy, evolution, ecology and geography of cultivated plants and their wild relatives, Prof. E. N. Sinskaya occupies a well-deserved honorable place among the outstanding Russian biologists of the 20th century.Prof. Sinskaya was undoubtedly no less talented as a prominent scientist, but as a writer as well. We believe that Prof. Sinskaya’s scientific ideas would be best recognized through acquainting the readers with the published results of her unique research and reconsidering her theoretical works on the taxonomy, phylogeny, and the problem of populations of higher plants. Therefore, on the eve of her birthday celebration, we present a chronological list of her major publications. This list can be recommended to young Russian scientists whose scientific interests extend from theoretical issues of plant biology to practical challenges of crop cultivation. Besides, the editors of the journal Vavilovia supply a list of unpublished works by E. N. Sinskaya in an attempt to incorporate archival documents into scientific circulation, thus encouraging further detailed studies dedicated to the scientific legacy of one of VIR’s most renowned scientists.

Ольга и Борис Морозовы через Монголию в Китай (из семейного архива)

The publication is dedicated to the archival collection of Olga Alexandrovna (nee Kolosova, 1877–1968, Los Angeles) and Boris Ivanovich / Ioanovich (1902–1960, Lakewood, USA), who from Russia came to Mongolia,then emigrated to China (Tianjin and Shanghai), where they published their literary (autobiographical novel "Fate", "Irreversible" and "Nora") and scientific and educational works. In recent years they lived in the USA. An excerpt from the book by B.I. Morozov is published. "Mongolia: from a traveler’s notebook" (Tianjin: Knowledge, 1935). The last unpublished works of O.A. are noted. Morozova: "Notes about Tubabao" and "Cultural forces of Russian emigration." Materials for publication were identified from the personal collection of O.A. Morozova (3 boxes and an album of photographs. Inventory compiled by A. Shmelev), stored in the Museum of Russian Culture (MRC) in San Francisco and the Russian collection of the University of Hawaii. Illustrations from the author's personal collection were used.

Characteristics of natural environment use by occupational therapists working in mental health care: a scoping review.

The objective of this review was to identify and characterize the use of the natural environment/outdoor space by occupational therapists working in mental health care. This included consideration of the characteristics of the environment used, interventions, mental health conditions being treated, and the outcomes being used. Research has demonstrated the link between human health and the environment. The benefits appear to be particularly relevant to people with mental health conditions. Occupational therapists already consider the environment when assessing and developing interventions, and therefore are well placed to consider and use the natural environment in mental health practice. However, the use of the natural environment by occupational therapists working in mental health is unclear. The scoping review included any publication relating to the use of the natural environment/outdoor space in mental health occupational therapy practice. All forms of the natural environment or outdoor space were included, such as hospital gardens and local parks. There were no geographical, gender, or age restrictions. All mental health diagnoses were eligible for inclusion. Seven databases were searched: Embase (Ovid), Emcare (Ovid), MEDLINE (Ovid), PsycINFO (ProQuest), AMED (Ovid), Trip Database, and CINAHL (EBSCOhost). Gray literature was also searched using a selection of websites and digital repositories. Papers written in English were searched, with no time limit set on publication. Titles and abstracts were screened by 2 independent reviewers for assessment against the inclusion criteria, followed by a full-text review and data extraction. Data were extracted using the data extraction tool developed by the authors. Findings were presented in a tabular format, accompanied by a narrative summary describing how the results relate to the review objectives and question. Of peer-reviewed publications, 7 papers used qualitative methods and 7 used mixed methodology. The remaining sources included conference abstracts, unpublished works, a book chapter, and a website article. The environments used included forests, beaches, gardens, and parks. A variety of interventions were delivered in these environments, including gardening and nature-based activities, physical activities, and animal-assisted interventions. Such activity-focused interventions are largely delivered in a group context, thus providing a social element. A diverse range of mental health conditions were treated. Several methods were used to consider the outcomes on the individual, including both qualitative measures and quantitative outcome measurement tools. The review highlights many characteristics of how the natural environment is being used across mental health services by occupational therapists. A variety of conditions are targeted for such interventions, and several outcome measures have been used to understand impact. This review can support further development and implementation of nature-based approaches in mental health occupational therapy.

Serious adverse events reporting in recent randomised clinical trials in intensive care medicine - A methodological study protocol.

Serious adverse events (SAEs) are common in intensive care unit (ICU) patients. Reporting of SAEs in randomised clinical trials (RCTs) varies why underreporting is likely. We aim to describe the reporting of SAEs from 2020 onwards and to illustrate the recent reporting of SAEs published in major medical journals. We will conduct a methodological study assessing pharmacological interventions in RCTs including adult ICU patients. We will search 10 general medical and critical care journals in PubMed. We will include all RCTs published from 2020 onwards. The primary research question is how many RCTs report SAEs in the primary publication. Secondary research questions include how SAEs are reported in the primary publication either as (1) proportion of patients experiencing one or more SAE, (2) all single events occurred, or (3) both strategies combined. We will assess the association between the proportion of patients with reported SAEs and the following trial characteristics: multicentred versus single-centre RCTs, industry-sponsored versus academic-sponsored, published trial protocol versus unpublished work, blinding, trials sample size, and RCTs focusing on COVID-19 patients versus other populations. The outlined methodological study will provide important information on the reporting of SAEs in recent drug trials in adult ICU patients.

Social Values and Students Holistic Education among Selected Secondary Schools in Mbale District, Uganda

In many of the secondary schools today, much attention is put on achieving grades and numbers in the schools. There is little attention put to in the building of value-based learners and the environments that are materialistic and place a high value on the material world has taken precedence over the humanistic world. There is little emphasis on the advancement of children's ethical and spiritual growth, favoring individualism that stresses egoism, worldly success, and the pursuit of pleasure via lifestyle. This has led to the dehumanization process, in which material qualities are exalted while human values—such as moral, ethical, and religious—are diminished and abandoned. Unconsciously, educators give up on moral and spiritual principles since they are seen as antiquated, outmoded, not modern, and unsatisfactory. Instead, they are supplanted by the dominance of materialistic principles, which are ranked higher. Contrary to those views, a good and comprehensive education system creates the necessary human capital and knowledgeable workers to take our societies to greater heights. Holistic education focuses on representing core ideals for a more just world for people and other living things. It offers a means of advancing the discussion of resource distribution beyond the financial to include the philosophical significance of love in creating a more just society. It draws attention to the need for and change toward a more spiritual and holistic strategy for developing empathy and kindness. It offers forums for conversations about eschewing the competitive mindset fostering an inward journey of learning, kindness, compassion, and empathy. These days, the focus of the educational system is mostly on gaining a lot of knowledge, passing tests, and getting credentials for jobs in the future. A comprehensive education program is essential in the educational system to give students the human values and the hard and soft skills they need. This essay examines the types of values that serve as a potent stimulant for excellent teaching practices and, consequently, support learning that is holistic. It examines rationalizations and describes how values can be used to strengthen beneficial student outcomes in all 1 RODRIGUES, Zuleide Blanco. Education: A study based on the UNESCO report on the four pillars of knowledge domains of growth on all levels—intellectual, moral, social, emotional, and spiritual. The research design for the study was mixed methods, utilizing combines quantitative and qualitative methods. We as well utilized Questionnaires for collection views plus statistics from head teachers, facilitators (teachers), parents and other school stakeholders. Literature of published and unpublished works on social values and students’ holistic learning in Uganda and other countries was reviewed. In data analysis, both both numerical and qualitative data analysis methods were applied. The investigation drew upon collected superior data which focused on individual discourses regarding Students are taught moral and religious principles as part of the process of developing their character in school and how these values influenced them for social transformation into individuals with the ability to face obstacles in life with morality and direction. It was framed in the 4 foundations of learning according towards UNESCO's Knowledge: Jacques Delors in the Delors Commission Report (1966), wherein this report, Education is viewed as one of the main tools available to promote a deeper and more harmonious form of human development and, in turn, to lessen poverty, exclusion, ignorance, oppression, and war, rather than as a miraculous remedy or a magic formula that will open the door to a world in which all ideals will be realized. This lifelong education is built on the following principles: Learning to know, learning to do, learning to live together and learning to be1

쉼보르스카의 미공개 초기작에 나타난 주요 모티브 연구

Wisława Szymborska, winner of the 1996 Nobel Prize in Literature, is a poet who perceives the true essence of objects through a penetrating insight, based on the mind’s eye. She established a unique style as a poet, characterized by concise yet clear language that encapsulated contemplation and introspection. Published in 2014 The Black Songs (Czarna Piosenka) is a collection of unpublished poems from the poet's youth. After her death, a bundle of manuscripts was found in a drawer, containing her earliest works from her youth. The restoration of this collection fills the seven-year gap between her debut in 1945 and the publication of her first book of poetry in 1952. It has been also revealed why Szymborska’s poems about World War II, despite her belonging to the “the War Generation,” were scarcely published until now. This paper examines the main motifs, images and themes of Szymborska’s unpublished early works, focusing on the works from The Black Songs and analyzes their connections to her later poems.

Can Bisphosphonate Therapy Reduce Overall Mortality in Patients With Osteoporosis? A Meta-analysis of Randomized Controlled Trials.

For patients with osteoporosis, bisphosphonate therapy can reduce the risk of fractures, but its effect on reducing mortality remains unclear. Previous studies on this topic have produced conflicting results and generally have been too small to definitively answer the question of whether bisphosphonate therapy reduces mortality. Therefore, a meta-analysis may help us arrive at a more conclusive answer. In a large meta-analysis of placebo-controlled randomized controlled trials (RCTs), we asked: (1) Does bisphosphonate use reduce mortality? (2) Is there a subgroup effect based on whether different bisphosphonate drugs were used (zoledronate, alendronate, risedronate, and ibandronate), different geographic regions where the study took place (Europe, the Americas, and Asia), whether the study was limited to postmenopausal female patients, or whether the trials lasted 3 years or longer? We conducted a systematic review using multiple databases, including Embase, Web of Science, Medline (via PubMed), Cochrane Library, and ClinicalTrials.gov, with each database searched up to November 20, 2023 (which also was the date of our last search), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included randomized, placebo-controlled clinical trials with participants diagnosed with osteoporosis and receiving bisphosphonate treatment. We excluded papers posted to preprint servers, other unpublished work, conference abstracts, and papers that were registered on ClinicalTrials.gov but were not yet published. We collected 2263 records. After excluding records due to study type, study content not meeting the inclusion criteria, and duplicates, our meta-analysis included 47 placebo-controlled RCTs involving 59,437 participants. Data extraction, quality assessment, and statistical analyses were performed. The evaluation of randomized trials for potential bias was conducted using the revised Cochrane Risk of Bias tool. This assessment encompassed factors such as sequence generation, allocation concealment, subject blinding, outcome assessor blinding, incomplete outcome data, and reporting bias. Some studies did not provide explicit details regarding random sequence generation, leading to a high risk of selection bias. A few studies, due to their open-label nature, were unable to achieve double-blind conditions for both the subjects and the researchers, resulting in intermediate performance bias. Nevertheless, the overall study quality was high. Due to the low heterogeneity among the studies, as evidenced by the low statistical heterogeneity (that is, a low I2 statistic), we opted for a fixed-effects model, indicating that the effect size is consistent across the studies. In such cases, the fixed-effects model can provide more precise estimates. According to the results of the funnel plot, we did not find evidence of publication bias. The use of bisphosphonates did not reduce the overall risk of mortality in patients with osteoporosis (risk ratio 0.95 [95% CI 0.88 to 1.03]). Subgroup analyses involving different bisphosphonate drugs (zoledronate, alendronate, risedronate, and ibandronate), regions (Europe, the Americas, and Asia), diverse populations (postmenopausal female patients and other patients), and trials lasting 3 years or longer revealed no associations with reduced overall mortality. Based on our comprehensive meta-analysis, there is high-quality evidence suggesting that bisphosphonate therapy for patients with osteoporosis does not reduce the overall risk of mortality despite its effectiveness in reducing the risk of fractures. The primary consideration for prescribing bisphosphonates to individuals with osteoporosis should continue to be centered on reducing fracture risk, aligning with clinical guidelines. Long-term studies are needed to investigate potential effects on mortality during extended treatment periods. Level I, therapeutic study.

PENGATURAN PEMBUKTIAN TERBALIK TERBALIK DALAM UNDANG-UNDANG KORUPSI

The criminal act of corruption not only harms state finances, but also constitutes a violation of the social and economic rights of society at large, so that the criminal act of corruption needs to be classified as a crime whose eradication must be carried out in an extraordinary manner, to further guarantee legal certainty, avoid diversity of legal interpretations and providing protection for the social and economic rights of the community, as well as fair treatment in eradicating criminal acts of corruption. The statutory regulations that regulate criminal acts of corruption are Law no. 28 of 1999 concerning the Administration of a State that is Clean and Free from KKN, Law no. 31 of 1999 in conjunction with Law no. 20 of 2001 concerning Eradication of Corruption Crimes, Law no. 30 of 2002 concerning the Corruption Eradication Commission, and finally with the ratification of the United Nations Convention Against Corruption, 2003 (United Nations Convention Against Corruption, 2003) through Law no. 7 of 2006. The theories used to support the preparation of this book are the Theory of the Rule of Law, the Hierarchy Theory of Legal Norms, the Theory of Authority, the Concept of Corruption and Corruption Crimes and the Concept of Reverse Evidence. The approaches used in preparing this book are: statutory approach, conceptual research approach, case approach. Legal Materials use primary legal materials, in the form of secondary law and other legal materials. Primary legal materials include court decisions that have permanent legal force and laws related to corruption. Secondary legal materials are books, unpublished scientific works, journals and newspapers. Other legal materials are internet sites regulating the reverse evidence system in the provisions of Article 12B of Law Number 20 of 2001, Articles 37, 37A and 38B of Law Number 31 of 1999 in conjunction with Law No. 20 of 2001 and the Criminal Procedure Code. is limited or balanced, and uses a negative proof system according to law (negatief wettelijk overtuiging). The Public Prosecutor is still obliged to prove his charges. In the future, it is necessary to carry out an evaluation of the regulation of Corruption Crimes, it is necessary to strictly regulate the substance of the legal system of reverse evidence so that its application can be implemented effectively and is not just a rule contained in the norms.

Recent Trends in the Study of Springs in Nepal: A Review

Springs, a component of groundwater systems, are a vital source of fresh water for fulfilling people's demand for drinking water, household uses, and irrigation, especially in the Middle Hill region of Nepal. Springs provide water for base flows and lifelines for many rivers originating from the Middle Hill regions. The present study reviews a recent trend of spring studies and investigations in Nepal through a systematic search of published and unpublished works related to springs, which are freely available. The results show 47 publications, out of 30 are published, and 17 are unpublished. The origin of published work is mainly related to project-related works, whereas unpublished works come from the academic sector for fulfilling academic criteria for thesis research. According to the physiographical division of Nepal, the study area falls in the Middle Hills of Nepal, with the maximum area located in Bagmati Province. Most of the studies that qualitative rather than quantitative information of springs. Studies are not linked with spring source and their seasonal dynamics. However, clearly available data, attributes and information about springs from 47 reviewed documents are noted. Systematic data generation and a standard framework for data collection are also missing. Nevertheless, out of 47 studies, including 11 published and 4 unpublished, the total number of springs per sq. km. in the Middle Hill region of Nepal is estimated as 2.57, which can be integrated after more research on future springs–related work.

帝国主義下のマッドサイエンス――蘭郁二郎「宇宙爆撃」試論―― Mad-Science under Imperialism: Ran Ikujirō’s “Space Bombing”

This paper discusses the critiques of the imperial world image in Ikujirō Ran’s unpublished work Space Bombing. In this work, the researcher Murao, who works at the Borneo branch of the Institute of Magnetics, studies a “microscopic world” in which microscopic humans live in an atomic structure. He falls into the delusion that there are a minimal world within the atomic structure and a larger world where Earth is considered as a single atom. This paper argues that Murao’s perception was based on the scientific knowledge of the scientist Hantarō Nagaoka. The cosmology reflects the wartime image of the world, and we argue that the larger world implies the Western world, the human world implies Japan, and the minimal world implies the colonial world. Moreover, we suggest that Murao’s mad science indicates that the imperial world's configuration is not an absolute domination vs.no-domination relationship, but merely a relative relationship, and that the clashes between civilizations are able to be interpreted as insane.

Mary Main's written legacy: a bibliometric analysis

ABSTRACT Mary Main’s written work profoundly changed the direction of attachment research through her publications and through her teachings. The current study describes the scientific impact of her her published and unpublished work. We identified 85 such works. Web of Sciences contained k = 7,571 citations to these works from by 13,398 unique authors. The topics of citing work clustered around clinical psychological research, early dyadic relationships, romantic attachment, traumatic experiences, and the adult attachment interview itself. Based on co-citation patterns, Main shared an intellectual space with authors known for developmental psychopathology and child development, parent–child relationships, adult attachment, psychodynamic theorizing, and reciprocity in interaction and infant mental health. We discuss the impact of the “move to the level of representation” and how new ties with researchers unfamiliar with these ideas will be important to realize unused potential in the ideas and methods given to the field by Mary Main.

Construction of Jacobi forms using adjoint of the Jacobi–Serre derivative

In the article, we study the Oberdieck derivative defined on the space of weak Jacobi forms. We prove that the Oberdieck derivative maps a Jacobi form to a Jacobi form. Moreover, we study the adjoint of the Oberdieck derivative of a Jacobi cusp form with respect to the Petersson scalar product defined on the space of Jacobi forms. As a consequence, we also obtain the adjoint of the Jacobi–Serre derivative (defined in an unpublished work of Oberdieck). As an application, we obtain certain relations among the Fourier coefficients of Jacobi forms.

Abstract PO-012: Gain-of-function small molecules to reprogram oncogenic transcription in lymphoma

Abstract Conventional pharmacotherapy in oncology centers on target-centric silencing of aberrant protein function through small molecule inhibitors, degraders, or CRISPR/RNAi. In contrast, here we leverage induced proximity to develop pharmacology that activates dominant signaling pathways for a therapeutic effect. To develop this concept, we describe a new class of bivalent small molecules that reprogram cancer-driving gene expression to activate cell death signaling in diffuse large B cell lymphomas (DLBCL). These molecules, called Transcriptional Chemical Inducers of Proximity (TCIPs), operate at fractional occupancy of their protein targets, without genomic modifications to the cell or organism. The first TCIPs transiently re-localized elongation factors such as BRD4 (TCIP1, PMID 37495688) to loci regulated by the transcription factor BCL6, inducing the expression of pro-apoptotic genes regulated by BCL6. In new, unpublished work, CDK-TCIPs have been made to re-direct the activity of transcriptional elongation kinases such as CDK9, CDK12, or CDK13 to induce the expression of pro-apoptotic BCL6-target genes. Profiling in ∼900 barcoded cancer cell lines show that the molecules exhibit potent cell killing potency in a highly DLBCL lineage-restricted manner. Cytotoxicity to healthy lymphocytes is 100- to 10,000-fold lower, although germinal center B cells are ablated in a dose-dependent manner consistent with the role of BCL6 in the germinal center. Biochemical, cell biological, proteomic, and genomic studies demonstrate that CDK-TCIPs operate via a gain-of-function mechanism reliant on the ternary complex formed by the bivalent molecule. Instead of global enzyme inhibition or degradation, CDK-TCIPs borrow and re-localize a fraction of total CDK activity to BCL6-bound chromatin, producing pharmacology from the induction of pro-apoptotic gene transcription. The findings suggest a path to rational design of new gain-of-function chemotherapeutic strategies to rewire cell signaling using induced proximity. Citation Format: Sai Gourisankar, Roman Sarott, Basel Karim, Sabin Nettles, Haopeng Yang, Brendan Dwyer, Juste Simanauskaite, Jason Tse, Hind Abuzaid, Stephen M Hinshaw, Michael R Green, Gerald R Crabtree, Nathanael S Gray. Gain-of-function small molecules to reprogram oncogenic transcription in lymphoma [abstract]. In: Proceedings of the Fourth AACR International Meeting on Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2024 Jun 19-22; Philadelphia, PA. Philadelphia (PA): AACR; Blood Cancer Discov 2024;5(3_Suppl):Abstract nr PO-012.

Resistentes y resistencias a la campaña vasca de inoculación de viruelas de 1771

This work is an attempt to identify and analyse some of the acts of resistance faced by the smallpox inoculation campaign of the Basque provinces of Spain started at 1771. First, the author describes the main features of said campaign. Second, he focuses on the unpublished work Impugnación contra algunos médicos de Guipúzcoa y Vizcaya sobre materia de viruelas y inoculación, written by the antiinoculationist priest Francisco Ygnacio López de Luzuriaga. Third, he outilnes other acts of resistance that help to put the work into context. Overall, the work offers a historical approach to those who opposed the inoculation of smallpox.

90 years of Gödel’s incompleteness theorems: Logic and computation

Abstract This volume is one of two special issues collecting articles by invited speakers of the conference ‘Celebrating 90 Years of Gödel’s Incompleteness Theorems’ held in Nürtingen (Germany) in July 2021. The conference was organized by the Carl Friedrich von Weizsäcker Center at the University of Tübingen with support by the ERC-funded project Gödel Enigma: Rediscovering Kurt Gödel through his unpublished works at the University of Helsinki and by the Kurt Gödel Society in Vienna.

Artistic Forms of Shaping Ukrainian National Identity by Leon Getz

Abstract The article deals with the phenomenon of shaping Ukrainian national identity in artistic works of autobiographical nature, created at the time of life crisis and oppressive sociopolitical situation, using Leon Getz as an example. Getz (1896–1971) was a painter who was raised in a Polish-Ukrainian family in Lviv but made a decision to identify nationally with the Ukrainian minority, oppressed both in pre- and postwar Poland. After WWII, he was subjected to surveillance by the Polish Security Office because of his Ukrainian identification. That led him and his wife (also a Ukrainian) to attempt suicide—unsuccessful in the case of the artist, fatal in the case of his wife. Getz wrote down his memoirs twice: the first time in the 1930s, the second time after his wife’s death in the 1950s. The first memoirs expressed his loneliness in an environment dominated by Poles, and they were drawn up openly, though for the author’s needs only. The second memoirs presented his personal tragedy and were kept in secret because the Security Office sought to intercept Getz’s notes as documents incriminating the officers. However, the author hoped to make the text public in the future. The subject of the analysis is constituted by memoirs read in the context of the artist’s other personal documents and works. They present the formation of his Ukrainian national identity as the chosen one and at the same time as the one that, in his opinion, was related to his and his wife’s tragedy. I interpret these memoirs in two different but complimentary ways: first, as life writing at the time of a man’s personal life crisis and, second, as life writing in a situation of oppression by the authoritarian and after WWII totalitarian state, under surveillance by the Security Office, whose moves put the very subjectivity of an individual in crisis. Both interpretations highlight the process of building Getz’s self-identification not as a discovered preexisting nationality, but as a deliberate—and nonobvious—choice of national path. The article is based on Getz’s unpublished memoirs and works, which are held in archives in Cracow (Poland) and Rome (Italy).