Unpredictable Times Research Articles

Becoming a new parent during the pandemic: experiences of pregnancy, birth, and the postnatal period

New parenthood in ordinary times can be a vulnerable and unpredictable time. The Covid-19 pandemic brought additional, unprecedented changes to policy and practice that drastically impacted on the experiences of parents. This study aimed to enhance our understanding of the experiences of new parents during the pandemic by qualitatively analysing their experiences. New parents from the UK (N = 303; female = 296; male = 7) responded to a survey conducted between 2021–2022 asking about experiences of pregnancy, birth and the postnatal period. Responses were analysed thematically, taking an interpretivist approach, and drawing across the three time periods. Parents reported conflicting feelings, negative feelings and silver linings cutting across eight themes, including: impacts on well-being, feeling without a village, changes to healthcare, atypical social experiences as a new parent, differential impacts on financial and working lives, conflicting feelings around digital technology, anger and worry regarding contradictory government guidance and recommendations for other parents. The findings offer much needed insights into the experiences of new parents during this time and provide some context to the documented elevated levels of perinatal mental health difficulties in new parents during the pandemic. We suggest key recommendations going forwards in the care of new parents now, and in times of future national crisis.

Nonlinear Dynamic Analysis Using Harmonic Balance Method

There is a high demand for nonlinear structural dynamics in implicit Finite Element Analysis (FEA). Although such methods are available, there are several obstacles to use them daily. One is their extreme and unpredictable computation time, which makes it often impossible to get results in time. Another point is the restriction of the methods to the time domain, which is often in contrary to the usual design rules based on frequency domain results. The Harmonic Balance Method (HBM) is a solution for an important sub-class of analysis cases, which resolves the two mentioned obstacles. As a starting point, we define HBM as a frequency response analysis with local nonlinearities. This allows to solve contact problems or mounting problems with nonlinear force-deflection curves. The primary results of HBM are in frequency domain. For all calculated frequencies, a solution in time domain is also available for a periodic response. A simplified radiator is used as industrial example. To prove the validity of HBM, a comparison with a linear frequency response analysis is performed, which shows same results. Then, rubber bushes and contact are added to the model as nonlinearities. Key results of stress and fatigue are presented, and the computation times are analysed to demonstrate the feasibility of the HBM implementation for applications in research and industry. All simulations are performed with the FEA software PERMAS, which contains the HBM among many other analysis methods in structural dynamics.

A Swot Analysis of AI – Powered Chatbots in English Language Education

An essential tool for businesses to evaluate their position in the market and handle unpredictable times is a SWOT analysis. It looks at four key elements: the strengths, weaknesses, opportunities, and threats of using AI-powered chatbots in educational settings. 14 students were chosen for the qualitative descriptive based on their prior interactions with chatbots driven by artificial intelligence. Open-ended questions from an interview guide were used in semi-structured interviews to learn more about participants’ perceptions, experiences, and difficulties using AI-powered chatbots. Following ethical study norms, digital voice recorders were utilized to guarantee precise transcription and analysis while protecting participant privacy and confidentiality. To learn more about the experiences and viewpoints of the participants, this method entailed finding, examining, and summarizing patterns or themes in the data collection. Significant strengths of AI-powered chatbots in the educational context include quick and tailored replies, improved accessibility, and ongoing assistance. They encourage self-directed learning and increase learning efficiency. Nonetheless, difficulties include managing intricate inquiries, a lack of empathy, an excessive dependence on technology, and worries over data security and privacy. Maximizing the promise of AI-powered chatbots while addressing their limits to enhance instructional practice and results requires striking a balance between these strengths and weaknesses

Diet Quality in Patients with Breast Cancer: Results of a Single Cohort Study in a Midwestern US Population

Emerging research underscores the relationship between diet quality in patients with breast cancer and their cardiovascular health. This study examines the role of diet quality in patients post-breast cancer diagnosis in a single cohort in the midwestern United States (US), along with barriers to the adoption of a healthy diet and willingness to change diet. This cross-sectional study surveyed 108 patients with breast cancer. Diet quality was assessed using the Rapid Assessment of Eating in Participants - Shortened version (REAP-S). Participants had an average total REAP-S Score of 28.44 on a scale of 13–39. This score is lower than that of the average omnivorous population of the US and remained so as time since diagnosis progressed despite participants’ overwhelming willingness to make changes toward a better quality diet. Several key barriers to healthier eating were identified, including unpredictable schedules and time constraints. Subaverage diet quality scores suggest that breast cancer patients elevate their future risk of adverse cardiovascular health and underscores the necessity for targeting interventions and reducing barriers to enhance diet quality.

An innovation potential and organizational performance: an integrative role of company’s dynamic capabilities

AbstractThe restaurant business plays a crucial role in the food economy and, like many industries, faces numerous challenges due to the rapid pace of change, driven by consumer trends and shifting demographics. In response to the pressure on businesses to adapt to these changing circumstances, new restaurant concepts, organizational structures and technologies have emerged in the hope of finding methods that are more agile during unpredictable times. The development of dynamic capabilities is a critical issue for both academics and practitioners, as it can enhance competitive advantages and improve organizational performance. The purpose of this paper is to examine the impact of dynamic capabilities on innovative potential and organizational performance. Through a literature review and the dynamic capability view, a theoretical model is proposed. This model was validated using the PLS-SEM technique, based on responses from 143 restaurants across eight of the largest Russian cities. The results indicate that dynamic capabilities related to the value proposition serve as a complete mediator in the relationship between a company's innovative potential and its performance in a highly volatile context. The proposed theoretical model is both unique and effective, demonstrating high explanatory power. This study enriches the existing literature on dynamic capabilities by addressing empirical research gaps and elucidating the mechanisms through which dynamic capabilities influence organizational performance.

Prosthetic Applications of Short Dental Implants in Limited Bone Height Cases: A Review Article.

The decision to rehabilitate insufficient alveolar bone height with short implants is considered an effective treatment. Complicated surgical procedures such as ridge augmentation, vestibuloplasty, and sinus lifting are usually accompanied by high risks such as membrane injury, hemorrhage, nerve affection, and increased time needed for implant treatment with unpredictable healing time. Short dental implants allow for faster treatment and decrease the need for complicated surgeries that are usually associated with standard dental implants, as in all four and all six concepts. A wide variety of short implants for replacing single, multiple, or even prosthetic rehabilitation of completely edentulous patients, either by using hybrid or overdenture prostheses, were documented by several studies. Further clinical investigations are needed to evaluate the improvement of short implant survival rate, the possibility of using short implants for patients with normal ridge height and contour, and also for patients who need maxillofacial prostheses.

THE INFLUENCE OF GREEN BANKING IMPLEMENTATION, ISLAMIC SOCIAL REPORTING AND COVID-19 CRISIS ON PROFITABILITY WITH BANK SIZE AS A MODERATING VARIABLE IN ISLAMIC GENERAL BANK PERIOD 2016-2023

This study uses bank size as a moderating variable to examine the effects of the Covid-19 crisis, Islamic social reporting, and the deployment of green banking on profitability in Indonesian Islamic commercial banks. In this work, panel data regression and moderated regression analysis are used as data analysis methods. Eleven Indonesian Islamic commercial banks that were registered with the OJK between 2016 and 2023 used as the study's sample. The study's findings show that Islamic commercial banks' profitability is significantly and favorably impacted by ISR. Profitability (ROE) is significantly impacted negatively by the Covid-19 situation, but not ROA. In the meantime, Islamic commercial banks' profitability is unaffected by green banking. The association between green banking and profitability may be moderated by the moderating variable of bank size. This research highlights how crucial risk management, responsibility, and openness are in a period of unpredictable economic times. In the context of Islamic banking, the impact of ISR procedures and reactions to financial crises like COVID-19 is quite significant. Islamic banks should see an improvement in their financial performance in the future by strengthening their ISR management and comprehending the implications of green banking.

Impact of chronic constipation symptoms on work productivity and daily activity: A large-scale internet survey.

Chronic constipation negatively impacts work productivity and patients' quality of life. This retrospective study assessed the correlation between symptoms of chronic constipation and work/activity impairment with and without the use of laxative treatment. This cross-sectional, observational, web-based survey was conducted using the Work Productivity and Activity Impairment-Chronic Constipation Questionnaire and included Japanese patients with chronic constipation receiving prescribed medication. Outcomes of interest included total work productivity and activity impairment and their correlation with constipation symptoms. Among the 2351 analyzed patients (mean [SD] age, 51.7 [13.8] years), 80.7% were females, 63.3% had a disease duration of ≥10 years, and 1424 were working. The averages of total activity impairment, total work productivity impairment, presenteeism, and absenteeism were 39.2%, 33.9%, 31.2%, and 5.0%, respectively. The annual work productivity loss per patient was estimated to be 1.343 million Japanese Yen. Symptoms that had a statistically significant positive correlation with total work impairment (P < 0.05) were abdominal discomfort/nausea, abdominal pain, abdominal bloating, and unpredictable defecation timing. Total activity impairment was significantly (P < 0.05) affected by abdominal discomfort/nausea, abdominal bloating, abdominal pain, incomplete defecation, unpredictable defecation timing, loss of defecation desire, and straining. Work productivity and daily activity had improved in 71.2% and 72.6% of patients, respectively, after they received treatment. Symptoms of constipation, particularly abdominal symptoms and unpredictable defecation timing, can have a negative impact on work productivity and daily activity. Treatment focused on these symptoms may reduce the socio-economic burden of chronic constipation in Japan.

A feature-based qualitative assessment of smoking cessation mobile applications.

Understanding users' acceptance of smoking cessation interventions features is a precursor to mobile cessation apps' uptake and use. We gauged perceptions of three features of smoking cessation mobile interventions (self-monitoring, tailored feedback and support, educational content) and their design in two smoking cessation apps, Quit Journey and QuitGuide, among young adults with low socioeconomic status (SES) who smoke. A convenience sample of 38 current cigarette smokers 18-29-years-old who wanted to quit and were non-college-educated nor currently enrolled in a four-year college participated in 12 semi-structured virtual focus group discussions on GoTo Meeting. Discussions were audio recorded, transcribed verbatim, and coded using the second Unified Theory of Acceptance and Use of Technology (UTAUT2) constructs (i.e., performance and effort expectancies, hedonic motivation, facilitating conditions, social influence), sentiment (i.e., positive, neutral, negative), and app features following a deductive thematic analysis approach. Participants (52.63% female, 42.10% non-Hispanic White) expressed positive sentiment toward self-monitoring (73.02%), tailored feedback and support (70.53%) and educational content (64.58%). Across both apps, performance expectancy was the dominant theme discussed in relation to feature acceptance (47.43%). Features' perceived usefulness centered on the reliability of apps in tracking smoking triggers over time, accommodating within- and between-person differences, and availability of on-demand cessation-related information. Skepticism about features' usefulness included the possibility of unintended consequences of self-monitoring, burden associated with user-input and effectiveness of tailored support given the unpredictable timing of cravings, and repetitiveness of cessation information. All features were perceived as easy to use. Other technology acceptance themes (e.g., social influence) were minimally discussed. Acceptance of features common to smoking cessation mobile applications among low socioeconomic young adult smokers was owed primarily to their perceived usefulness and ease of use. To increase user acceptance, developers should maximize integration within app features and across other apps and mobile devices.

Multi-functional nanosonosensitizer-engineered bacteria to overcome tumor hypoxia for enhanced sonodynamic therapy

BackgroundUltrasound-triggered sonodynamic therapy (SDT), with high safety and acceptance, has become a promising tumor treatment. However, the dense stroma, hypoxic microenvironment of tumor, and the unpredictable treatment timing limit the effectiveness of sonosensitizers and the antitumor therapeutic effect. Thus, it is crucial to develop an imaging-guided sensitization strategy for hypoxic tumor sonosensitization to improve the efficacy of SDT. MethodsIn this study, we developed a biohybrid system CB@HPP, which genetically engineered bacteria to express catalase (CB) and modified nanosonosensitizers (HPP) to the surface of these bacteria. Tumor hypoxia relief, tumor targeting, biocompatibility, and antitumor efficacy were evaluated through in vitro and in vivo experiments. In addition, the photoacoustic (PA), ultrasound (US), and fluorescence (FL) imaging effects of CB@HPP were evaluated in vivo and in vitro. ResultsAfter intravenous injection, CB@HPP was able to target tumor tissue. CB@HPP possessed efficient catalase activity and successfully degraded hydrogen peroxide to produce oxygen. Increased oxygen levels relief intratumoral hypoxia, thereby enhancing CB@HPP-mediated. In addition, CB@HPP showed FL/PA/US multimodal imaging capabilities, which reflects the aggregation effect of CB@HPP in the tumor and suggest the timing of treatment. ConclusionThe biohybrid system CB@HPP significantly alleviates tumor hypoxia, and multimodal imaging-mediated oxygen-producing SDT effectively suppresses tumors. This integrated imaging and therapeutic biohybrid system provides a more efficient and attractive cancer treatment strategy for SDT. Statement of significanceThis study developed a sensitizing SDT strategy for imaging-guided drug-targeted delivery and in situ oxygen production. We designed a biohybrid system CB@HPP, which was hybridized by the engineered bacteria with catalytic oxygen production and nanosonosensitizer with multimodal imaging capability. CB@HPP significantly alleviates tumor hypoxia, and multimodal imaging-mediated oxygen-producing SDT effectively suppresses tumors. This integrated imaging and therapeutic biohybrid system provides a more efficient and attractive cancer treatment strategy for SDT.

Are Modern Market-Available Multi-Rotor Drones Ready to Automatically Inspect Industrial Facilities?

Industrial inspection is a well-known application area for unmanned aerial vehicles (UAVs), but are modern market-available drones fully suitable for inspections of larger-scale industrial facilities? This review summarizes the pros and cons of aerial large-scale facility inspection, distinguishing it from other inspection scenarios implemented with drones. Moreover, based on paper analysis and additionally performed experimental studies, it reveals specific issues related to modern commercial drone software and demonstrates that market-available UAVs (including DJI and Autel Robotics) more or less suffer from the same problems. The discovered issues include a Global Navigation Satellite System (GNSS) Real Time Kinematic (RTK) shift, an identification of multiple images captured from the same point, limitations of custom mission generation with external tools and mission length, an incorrect flight time prediction, an unpredictable time of reaching a waypoint with a small radius, deviation from the pre-planned route line between two waypoints, a high pitch angle during acceleration/deceleration, an automatic landing cancellation in a strong wind, and flight monitoring issues related to ground station software. Finally, on the basis of the paper review, we propose solutions to these issues, which helped us overcome them during the first autonomous inspection of a 2400 megawatts thermal power plant.

Implementasi Algoritma A* (A-Star) untuk Mencari Rute Terpendek dari Kelurahan Cibubur ke Perpustakaan Nasional Republik Indonesia

Traffic congestion is a major challenge in Indonesia's big cities, including Jakarta, causing unpredictable travel times, increased pollution and reduced quality of life. The causes of traffic jams in Jakarta include limited road infrastructure, an increase in the number of vehicles, and disorderly driver behavior. One solution is to utilize available alternative routes to reduce congestion and provide more efficient travel options. The National Library of the Republic of Indonesia in Jakarta, although it provides complete facilities to support learning and research activities, is often difficult to access due to traffic jams. Travel from the outskirts of cities such as Cibubur to the city center can be hampered by traffic jams at certain points. Therefore, an effective method is needed to find the closest and fastest route. The A* algorithm is an optimal and efficient route finding algorithm, often used in navigation and route planning. Implementation of the A* algorithm can help drivers find the fastest and shortest routes, reduce travel time, save fuel, and increase transportation efficiency. The research results show that of the three routes studied (Jl. Raya Bogor, Jl. DI Pandjaitan, and Jl. H.R. Rasuna Said), the DI Pandjaitan route is the fastest route with a distance of 1,561.5 km. The implementation of the A* method is expected to help find community routes quickly and overcome congestion problems and lack of knowledge about alternative routes.

Spatial memory obviates following behaviour in an information centre of wild fruit bats.

According to the information centre hypothesis (ICH), colonial species use social information in roosts to locate ephemeral resources. Validating the ICH necessitates showing that uninformed individuals follow informed ones to the new resource. However, following behaviour may not be essential when individuals have a good memory of the resources' locations. For instance, Egyptian fruit bats forage on spatially predictable trees, but some bear fruit at unpredictable times. These circumstances suggest an alternative ICH pathway in which bats learn when fruits emerge from social cues in the roost but then use spatial memory to locate them without following conspecifics. Here, using an unique field manipulation and high-frequency tracking data, we test for this alternative pathway: we introduced bats smeared with the fruit odour of the unpredictably fruiting Ficus sycomorus trees to the roost, when they bore no fruits, and then tracked the movement of conspecifics exposed to the manipulated social cue. As predicted, bats visited the F. sycomorus trees with significantly higher probabilities than during routine foraging trips (of >200 bats). Our results show how the integration of spatial memory and social cues leads to efficient resource tracking and highlight the value of using large movement datasets and field experiments in behavioural ecology. This article is part of the theme issue 'The spatial-social interface: a theoretical and empirical integration'.

Sports event quality and athlete’s behavioural intentions at the World Wrestling Championship

Abstract The COVID-19 pandemic caused unpredictable times and led to changes in tourism, sporting society, and events organisations. Sports events were postponed or cancelled. Indeed, there was a need to reconstruct the event circumstances for safety reasons. Therefore, this study aimed to provide insights into relationships between sports event quality, satisfaction, and behavioural intentions (repeated destination visits, positive word-of-mouth communication) during the implementation of COVID-19 security risk measures. The sample included 150 athletes from the U23 World Wrestling Championship organised in Belgrade, Serbia, in 2021. The sport event quality, satisfaction, and behavioral intentions were measured with a questionnaire. The proposed model was assessed using a confirmatory factor analysis with structural equation modeling using Smart PLS, SPSS, and AMOS. Results revealed a significant direct effect of the sport event quality (core dimension) and an indirect effect across satisfaction (tangibles and COVID-19 risk measures) on the athletes’ behavioural intentions. As wrestlers lived in a „bubble” and competed without spectators during the competition, it is not a surprise that the core dimension of service quality, including the competition itself, the opening ceremony, organisation, time schedule, medal ceremonies, and the total quality of the event, has a significant impact for wrestlers’ likelihood of coming back to the city or the country and to recommend the destination to others. Thisstudy contributes to advancing the general scientific knowledge concerning understanding sports events from the aspect of sports tourism and event organisation, especially in the post-COVID-19 era.

Strategizing green marketing in times of uncertainty: does it pay off?

PurposeThis study aims to investigate the impact of green marketing strategy (GMS) and firms’ decision to invest in or divest from green marketing activities during a crisis on business performance.Design/methodology/approachThe study collected survey data from 245 Greek firms during the 2015 Eurozone crisis to investigate the impact of GMS and green marketing investments on firm resilience during crisis. Time-lagged, objective performance data for a subset of these firms helped examine the impact of GMS on postcrisis financial performance.FindingsPursuing a GMS builds resilience, especially for companies that decided not to reduce resources allocated to green marketing activities during a recession. Beyond resilience, firms investing in GMS during the crisis experienced improved financial performance in the long run. Finally, this research proposes a typology of GMS responses during a crisis.Research limitations/implicationsThis study does not specify which types of green marketing activities lead to more investment or divestment during a crisis.Practical implicationsThe study offers insights for allocating resources to green marketing during recessions. Supporting GMSs during unpredictable times is important to successfully navigate performance both during and after a crisis. Six crisis response profiles are offered: green-nonbelievers, dis-investors, reluctants and cautious-, opportunistic- and strategic-green investors.Social implicationsThe study proposes a balanced approach to environmental sustainability, marketing strategy and firm performance during a crisis.Originality/valueThe study argues that GMSs enable firms to survive a crisis and recover from financial shocks.

The interplay among employee resilience, sustainable HRM and work engagement

BACKGROUND: Given the unpredictable and turbulent times, the concept of employee resilience is gaining increased recognition within numerous organisations, as resilient employees excel in adapting to continually altering situations and recovering more quickly. Additionally, they demonstrate higher work engagement. Since employee resilience, as a personal resource, can be developed, the question is about the ways through which it can be enhanced. Similarly, when arguing that engaged employees are able to perform better, the next question pertains to the antecedents of work engagement. The previous literature provided support that human resource management (HRM) plays an important role in fostering employee resilience and work engagement. However, the dimension of sustainability in people management has been somehow neglected. The paper tries to close the gap and, drawing on the JD-R model, explores the relationship among three constructs. OBJECTIVE: The aim of the paper is to reveal the interplay among sustainable HRM, employee resilience and work engagement. METHODS: Quantitative study. The data were collected using a survey. RESULTS: The core results revealed a positive link between sustainable HRM and work engagement. Additionally, employee resilience serves as a mediator. CONCLUSIONS: As an underlying mechanism, employee resilience influences the relationship between HRM practices and work engagement.

Disaster Capitalism and Social Policy: Social Work in the Aftermath of Natural Disasters

ABSTRACT Unpredictable timing, disruption of community and health services, severe economic impacts, and the deterioration of psychosocial well-being necessitate the evaluation of natural disasters from a social work perspective. Social workers play critical roles in these situations, such as connecting disadvantaged groups with necessary resources, protecting individuals’ well-being, assessing needs, and providing relief and support. The core roles and functions of the social work profession, which emphasize a people-centered, rights-based approach, become particularly significant after a disaster. Neoliberal policies and disaster capitalism exploit the fear and anxiety generated by natural disasters to gain public consent for practices that may not be in their best interests. In this context, fear appeals can be manipulated as a persuasive tool to make disaster-affected citizens accept policies and practices they would typically reject. This study outlines the issues that social workers should address at micro, meso, and macro levels to counteract the influence of neoliberal policies and disaster capitalism, which leverage the fear and anxiety induced by natural disasters to secure public consent for unfavorable practices.

Career Management in a VUCA World – An Ongoing Debate between Threats and Opportunities under the Technological Imperative

Abstract In today's VUCA world (acronym which stands for Volatile, Uncertain, Complex and Ambiguous), building up and managing a career can be extremely challenging, since society undergoes fundamental and irreversible transformations driven by the new technological wave. Technological developments have impacted all areas of an organization and all phases of a business process, from basic operations to sales to financial management and human resource management. In this framework, where new industries emerge, new skills are required and new professional roles are designed, career management is a syntagm which can no longer be viewed just as a social construct of personal significance, but rather as an active endeavor to grasp the future of professions, adapt to the new reality, and capitalize on the opportunities in order to thrive in the long run. The aim of this paper is to address career management within the VUCA world shaped by technological advancements, and the ongoing discussion surrounding the dual nature of technology as both a threat and an opportunity. Drawing on statistical data, we highlight the need for of a different and more effective approach to career management in the current complex and unpredictable times, and a more alert and purposefully designed work-life balance. As a qualitative study, the paper involved the collection and selection of the relevant literature in the field, the analytical inquiry and interpretation, as well as the use of statistical data and their analysis to defend the argument and conclude the results.

Reporting of immune-related adverse events (irAEs) in US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors.

e14693 Background: Evaluating immune checkpoint inhibitor (ICI) toxicity is complex given the interplay between the host immune system and tumor microenvironment leading to unpredictable timing and severity of irAEs. Monitoring of irAEs is critical as they can cause significant impact on morbidity and quality of life. Thus, we evaluated the consistency and pattern of reporting of irAEs in trials leading to FDA drug approvals. Methods: Using the FDA website, we identified 73 primary articles for ICI FDA approvals over a 10-year period (2011-2021). Data were collected independently by all authors as categorical variables for reporting of any grade and grade 3 or higher toxicity in the trial arm that led to FDA approval for 29 irAEs classified by the National Comprehensive Cancer Network Version 1.2024 guidelines. Our analyses were based on a binary classification of reported versus not reported, including the manuscript text, tables, and supplement, and reporting trends were analyzed based on the study year, phase, primary tumor, and monotherapy versus combination ICI therapy. Results: The majority of approvals were associated with Phase II (N=22) or Phase III (N=39) studies. Approvals included 14 primary tumors and 2 tumor agnostic approvals with the most common tumors including lung (N=22) and skin (N=14). irAE reporting ranged between 0% and 100% with a mean of 40% and a standard deviation of 35. Across the 29 irAEs, 45% were categorized as severely underreported with less than 25% reporting in trials, 17% were classified as underreported in 26-50% of trials, 17% were moderately reported in 51-75% of trials, and 21% were well reported in at least 75% of trials. For example, fatigue, diarrhea, and hypothyroidism were well reported at 100%, 99%, and 93%, respectively, while myocarditis, aseptic meningitis, and giant cell arteritis were severely underreported at 18%, 4%, and 1%, respectively. Additionally, certain systems were more reported than others, including gastrointestinal (100%) and endocrine (97%), while other systems were inconsistently reported such as cardiology (15%) and neurology (48%) (see Table). Conclusions: Our study identified significant inconsistencies in irAE reporting in clinical trials that led to ICI FDA approvals. In particular, rarer irAEs were reported infrequently while more common irAEs were well reported. Unified efforts are needed to standardize the irAE reporting in the primary literature to ensure reliable dissemination of information for timely recognition and treatment in clinical practice. [Table: see text]

'Normality in all the abnormality'-Older adults' experiences of holidays and celebrations from the COVID-19 pandemic.

The importance of holidays, traditions, and family celebrations to human culture and occupational engagement has been neglected. The aim of this study was to explore how older adults experienced holidays and celebrations with social and physical distancing during the COVID-19 pandemic. A secondary analysis was made on data from the At-Risk Study. Seventeen community-living adults (11 women and 6 men) aged 71-87 years, from Sweden participated. They were interviewed remotely four times during the first year of the pandemic. Data were analysed with qualitative content analysis. No consumer/community involvement occurred. Three categories on how the participants hoped for, planned, decided, adapted, avoided, and experienced holidays and celebrations with social and physical distancing included expectations and preparations in unpredictable times; the constant need for re-evaluation; and almost everything turned out differently. The desire to celebrate despite pandemic restrictions shows the importance and meaning holidays hold for older adults. Celebrations can be disrupted for many reasons, not only as extreme as the ongoing pandemic. For wellbeing in later life health care, social care, and society need to understand the inherent components and acknowledge ways of supporting participation in occasional events such as holidays, traditions, and family celebrations.