The origin of irradiation and fluorescence of the 6.4 keV bright giant molecular clouds surrounding Sgr A*, the central supermassive black hole of our Galaxy, remains enigmatic. Testing the theory of a past active period of Sgr A* requires X-ray polarimetry. In this paper, we show how modern imaging polarimeters could revolutionize our understanding of the Galactic Center. Through Monte Carlo modeling, we produce a 4-8 keV polarization map of the Galactic Center, focusing on the polarimetric signature produced by Sgr B1, Sgr B2, G0.11-0.11, Bridge E, Bridge D, Bridge B2, MC2, MC1, Sgr C3, Sgr C2, and Sgr C1. We estimate the resulting polarization, include polarized flux dilution by the diffuse plasma emission detected toward the GC, and simulate the polarization map that modern polarimetric detectors would obtain assuming the performances of a mission prototype. The eleven reflection nebulae investigated in this paper present a variety of polarization signatures, ranging from nearly unpolarized to highly polarized (about 77%) fluxes. A major improvement in our simulation is the addition of a diffuse, unpolarized plasma emission that strongly impacts soft X-ray polarized fluxes. The dilution factor is in the range 50% - 70%, making the observation of the Bridge structure unlikely even in the context of modern polarimetry. The best targets are the Sgr B and Sgr C complexes, and the G0.11-0.11 cloud. An exploratory observation of a few hundred kilo-seconds of the Sgr B complex would allow a significant detection of the polarization and be sufficient to derive hints on the primary source of radiation. A more ambitious program (few Ms) of mapping the giant molecular clouds could then be carried out to probe with great precision the turbulent history of Sgr A*, and place important constraints on the composition and three-dimensional position of the surrounding gas.