Since 2011, an increasing incidence of sexually transmitted infections and risky sexual practices has been reported among young adults in Canada. However, research on sexual risk behaviours of international students in North America is limited, despite an increasing number of students from abroad attending higher education institutions on this continent. This article shares research findings comparing the sexual practices of international and domestic students in five postsecondary institutions in three Canadian provinces (Manitoba, Ontario, Quebec). Two hundred forty-two international students and 1220 domestic students took part in the bilingual online and paper-based survey. Female international students were less likely to be sexually active than international male, domestic male, and domestic female students. International students were significantly less likely to partake in many risky sexual behaviours, such as inconsistent condom use and unplanned sex after consuming alcohol or drugs. However, male international students were more likely to report having multiple sexual partners than male domestic students. These findings are relevant to those who counsel and advise postsecondary students on Canadian campuses and for healthcare practitioners to better understand postsecondary students’ sexual practices. Strategies to enhance sexual health and knowledge include targeted promotion of safe sexual practices and sexual education in postsecondary institutions.