Unmet Demands Research Articles

Dual redox electrolytes for improving the performance of asymmetric supercapacitors constructed from heteroatom-doped green carbon spheres

Although supercapacitors benefit from both long-cycle durability and extraordinary power density, unmet energy demands still remain the key challenge on the path of their practical applications. Boosting energy densities without sacrificing the remarkable power densities and long cycle life is of special significance in developing high-performance energy storage systems. Herein, the synergy between reversible redox mediator addition and heteroatom-doping of carbon-based electrode active materials represents an enhanced electrochemical performance of the fabricated energy storage devices. Green carbon spheres (CSs) were synthesized through the eco-benign hydrothermal carbonization (HTC) approach. CSs were then chemically decorated by metal nanoparticles. A carbothermic reduction, in which metallic nano particles nanoparticles played a role as a sacrificial agent, was conducted to prepare highly porous CSs (PCSs). The carbothermic reduction process was followed by heteroatom doping of the PCSs. Nitrogen- and boron-doped PCSs were then utilized as positive and negative electrode active materials, respectively. A combination of potassium iodide (KI) and sodium anthraquinone-2-sulfonic acid (AQSA) was employed as dual-redox mediators to boost the electrochemical performance of the fabricated N-PCS//B-PCS ASC devices. The assembled ASCs coupled with AQSA/KI dual redox additives rendered not only remarkable energy density (86.3 W h kg−1) at a reasonable power density of 340 W kg−1 but also exhibited outstanding cyclic stability (only 22 % decay of initial capacitance observed after 5000 charge/discharge cycle). The encouraging features parallel to the remarkable capacitive performance of the fabricated ASCs make these supercapacitors immensely promising for practical applications.

Domination, social norms, and the idea of an emancipatory interest

Domination, social norms, and the idea of an emancipatory interest

From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology

AbstractProteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD) technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A PROTAC molecule specifically binds to its protein of interest (POI) and recruits an E3 ligase to assemble a ternary complex. The POI was subsequently ubiquitinated, followed by being degraded by proteasomes. After 20 years of development, PROTAC technology has made a significant progress, and quite some candidates have entered clinical trials. Along with the excitement of realizing that PROTAC technology can develop therapeutics toward those traditionally believed “undruggable” targets; there are still unmet demands in PROTAC design, screening, and intracellular availability. PROTAC technology is rapidly advancing from employing traditional medicinal chemistry methodologies to integrating state‐of‐the‐art chemical biology technologies, becoming a typical example of interdisciplinary medicine. This review summarizes the progress made in PROTAC technology in recent years, including expanding new targets, developing dual‐target PROTACs, rational design and screening strategies, regulatory activation, targeted delivery, and developing biological macromolecule‐contained PROTACs.

Populism of the Privileged: On the Use of Underdog Identities by Comparatively Privileged Groups

This article explores the use of populism by comparatively privileged groups, a specific type of populism we call the ‘populism of the privileged’. Our argument is not merely that ‘populisms of the privileged’ are also forms of populism, but that they warrant a specific label. We first identify intersections between populism and privilege on the levels of populist actors, support for populism and beneficiaries of populism, which we call populism by, with and for the privileged. We then present a discursive conceptualization of ‘populism of the privileged’. Building on this we develop analytical strategies for the study the ‘populism of the privileged’, zooming in on how ‘the people’ and ‘the elite’ are constructed in such populisms, their sociological directionality, the layeredness of privilege and un(der)privilege, the discursive construction of ‘crisis’ and ‘unmet demands’ and the role of discourses about populism in reproducing the claims of populisms of the privileged.

Advanced practice nurse education in its infancy: an exploratory study of Norwegian higher education institutions’ program descriptions

ABSTRACT There is a growing worldwide interest in educating nurses at an advanced level. Advanced practice nursing (APN) refers to an umbrella term for master-educated nurses working within expanded nursing practice. Previous APN research has primarily addressed comparative characteristics of education globally and several aspects related to practice after graduation. This study aimed to explore how higher education institutions position and legitimize APN as an education requisite for nurses, the health care system, and society. Program descriptions of relevant educational programs in the Norwegian context were analyzed using documentary reality construction. The findings point to how APNs are positioned to have a prominent contextual perspective, which are given precedence over direct patient care, legitimized through descriptions of societal problems and demands. This paper argues that APNs are positioned to hold individual responsibility to solve unmet societal demands.

Can the Public-Private Business Model Provide a Sustainable Quality Pediatric Cardiac Surgery Program in Low- and Middle-Income Countries?

Over 90% of the world's children with congenital heart disease do not have access to cardiac care. Although many models provide pediatric cardiac surgery in low- and middle-income countries, sustainability poses a barrier. We explore one model providing care for the underserved in Chennai, India, that came into existence through trial and error over 30 years across three phases. Phase 1 was a Tamilnadu state government-sponsored program that soon became unsustainable with unmet demands. Phase 2 utilized a grassroots foundation of a public-private partnership (PPP) with few donors and a hospital with suboptimal infrastructure. Phase 3 is the ongoing fine-tuning of the PPP model, with upgraded infrastructure and a well-trained team. Through indigenization, an average cardiac surgery costs Rupees (Rs.) 1,80,000 ($2400). The government funds Rs. 60,000 to 80,000 ($800-$1066.67), and the rest is funded through the fund pool. The goal is to perform 100 free surgeries annually by maintaining a fund pool of Rs. 50 lakhs ($66,666.67), which supplements government funds. This ensures equitable distribution of funds with no compromise on resources (disposables, single-use cannulas, etc). Our model ensures the dignity of the patient, fair compensation for workers, and is practical, affordable, and easily adaptable. Thus far, this model provided free cardiac surgery for 357 children from Risk Adjusted Congenital Heart Surgery Score of 1 to 4, with an overall mortality of 2.73%. The prerequisites for this model are having a "spark plug," a dedicated surgical team, a partnership with state-of-the-art infrastructure, and a steady flow of funds.

Investigation of water allocation using integrated water resource management approaches in the Zayandehroud River basin, Iran

The Zayandehroud River is the largest river in the Gavkhouni basin, Iran. Water management in this basin is beset by poor water-allocation policies that do not adequately meet diverse demands (potable, agriculture, industry, and environmental demands). The Gavkhouni basin suffers from water scarcity and unmet water demands; especially with respect to environmental requirements. Water allocation considering appropriate priorities for all demands would be a major improvement for environmental protection in the Gavhouni basin. The application of the environmental flow in Integrated Water Resource Management offers practical options for water management in the Gavkhouni basin. Environmental flow describes the quantity, timing, and quality of water flow required to sustain freshwater, estuarine ecosystems, the human livelihoods, and well-being. A water resources management model is developed in this study for the purpose of improved water management in the Gavkhouni basin. The model involves six stages. The first stage implements a survey of resources and water use. The Environmental flow is calculated in the second stage with the hydraulic method and the Hydrologic Engineering Center- River Analysis System. The third stage applies the calculated environmental flow to the Integrated Water Resource Management approach by means of the Water Evaluation and Planning model. The fourth stage creates seven possible management scenarios in the Water Evaluation and Planning model to be applied in the period ending in the year 2041. These scenarios are ranked in the fifth stage with a multi-criteria decision-making method. The sixth stage applies the best management scenario in the study region. This study's results indicate that the annual drinking water demand under current conditions would rise from 547.6 to 760.2 Mm3 by 2041. The annual industrial water demand is estimated to increase from 213.7 to 400.5 Mm3, and the agricultural water demand is projected to remain constant at 1789.1 Mm3 per yr. The annual drinking water, environmental, industrial, and agricultural unmet demands are estimated to increase from 68.1, 106.5, 73.4, and 470 to 130.1, 186.1, 141.4, and 480 Mm3, respectively. The considered scenarios are (i) change in water supply priority, (ii) change in the population growth trend, (iii) change in return flow and water loss management utilization, (iv) change in the amount of water transferred to the Gavkhouni basin, (v) change of demand management (consumption per capita reduction), (vi) change of agricultural conditions, and (vii) change of industrial conditions. The change in water supply priority and the change in the volume of water transferred to the Gavkhouni basin scenarios are found to be of the highest priority. The best management alternative is chosen with four types of ranking (i.e., water allocation priorities) in which the ranking (i.e., drinking, Industrial, agricultural, environmental unmet water) and fourth ranking (i.e., environmental, drinking, industrial, agricultural Unmet water) are recommended as the best approach.

Deliberate underpricing and after-market mispricing in Indian IPO market: Stochastic frontier approach

Purpose This paper aims to study the underpricing phenomenon of initial public offerings (IPOs) of 355 Indian companies issued from 2007 to 2019. The research question this paper empirically examines is whether Indian corporate executives deliberately underprice IPOs from its fair value to attract investors, thereby causing an abnormal spike in the prices on the listing day. The findings of this study challenge a commonly held notion of leaving money on the table by IPO issuing companies. Of the overall average listing day returns of 17%, the deliberate premarket underpricing component is found to be mere 5.3%, while the remaining price fluctuation is, inter alia, a result of market momentum along with the unmet demands of impatient investors. Design/methodology/approach Following Koop and Li (2001), this study uses Stochastic frontier model (SFM) to study a routine anomaly of disparity between the primary market price (i.e. IPO issue price) and the secondary market price (listing price). The jump in the issue price observed on a listing day is decomposed into deliberate premarket underpricing component that reflects the extent of managerial manipulation and the after-market misvaluation component attributable to information asymmetry and prevailing market volatility. Findings This paper uses SFM to bifurcate initial returns into deliberate underpricing by managers and after-market mispricing by noise traders. This study finds that a significant part of the initial return is explained through after-market mispricing. This study finds that average initial returns are 17%, deliberate premarket underpricing is 5.3% and after-market mispricing averages 11.9%. Research limitations/implications This study can isolate underpricing done at the premarket by estimating a systematic one-sided error term that measures the maximum predicted issue price deviation from the offered price. Consequentially, the disaggregation of initial returns may be especially informative for retail investors in planning their exit strategy from an IPO by separating the strength of the firm's fundamentals and its causal relationship with the initial returns. Substantial proportion of after-market mispricing implies that future research should focus on factors causing after-market mispricing. As underlying causes are identified, tailor-made policy responses can be formulated to benefit investors. Practical implications This paper has empirically validated that initial return is a mix of both components, i.e. deliberate underpricing and aftermarket mispricing. This disaggregation of initial returns can prove helpful for investors in planning their exit strategy. This study can help investors to become more aware of the importance of the fundamentals of the firm and its causal relation with the initial returns. This information in turn can help reduce the information asymmetry amongst investors and help them lessen the costs of adverse selection. Originality/value A large number of research studies on IPO pricing find overwhelming evidence of underpricing in public issues. This research attempts to decompose the extent of underpricing into deliberate underpricing and after-market mispricing, thereby supplementing the existing literature on the IPO pricing puzzle. To the best of the authors’ knowledge, this study is the first contribution to the literature on initial return decomposition for the Indian capital markets.

Computational integration and meta-analysis of abandoned cardio-(vascular/renal/metabolic) therapeutics discontinued during clinical trials from 2011 to 2022.

Cardiovascular/renal/metabolic (CVRM) diseases collectively comprise the leading cause of death worldwide and disproportionally affect older demographics and historically underrepresented minority populations. Despite these critical unmet needs, pharmaceutical research and development (R&D) efforts have historically struggled with high drug failure rates, low approval rates, and other challenges. Drug repurposing is one approach to recovering R&D costs and meeting unmet demands in therapeutic markets. While there are multiple approaches to conducting drug repurposing, we recognize the importance of bringing together and consolidating discontinued drug information to help identify prospective repurposing candidates. In this study, we have harmonized and integrated information on all relevant CVRM drug assets from U.S. Securities and Exchange Commission (SEC) filings, clinical trial records, PharmGKB, Open Targets, and other platforms. A list of existing therapeutics discontinued or shelved by pharmaceutical/biotechnology companies in 2011-2022 were manually curated and interpreted for insights using information on each drug's genetic target, mechanism of action (MOA), clinical indication, and R&D information including highest phase of clinical development, year of discontinuation, previous repurposing attempts (if any), and other actionable metadata. This study also summarizes the profiles of CVRM drugs discontinued within the past decade and identifies the limitations of publicly available information on discontinued drug assets. The constructed database could serve as a tool for identifying candidates for drug repurposing and developing query methods for collecting R&D information.

Assessing climate change impacts on surface water availability using the WEAP model: A case study of the Buffalo river catchment, South Africa

Study regionThe Buffalo River (BR) catchment, KwaZulu-Natal, South Africa. Study focusDue to the vast majority of the BR catchment’s water demands not being fully satisfied in recent years, studies investigating potential climate change impacts on the catchment's water supply availability are needed. The study’s objective was to therefore assess climate change-induced surface water availability (SWA) variations in the BR catchment from 2020 to 2100. To achieve this, the hydrologic Water Evaluation and Planning model was forced with the catchment's physical and hydrological data, and projected climate data from an ensemble of GCMs under RCP4.5 and RCP8.5 scenarios from CMIP5. New hydrological insights for the regionThe study findings projected increased precipitation, especially in the far future (2070–2100) whereby mean annual precipitation increased by 5 % to 8286 Mm3/annum under the worst-case climate change scenario (RCP8.5). With evapotranspiration and water abstractions averaging 4500 Mm3/annum and 115 Mm3/annum, respectively, surface runoff and SWA increased by 8 % and 10 %, yielding averages of 3265 Mm3/annum and 287 Mm3/annum, respectively. Even with the increased SWA, unmet demands also increased by 113 % towards the end of the 21st century. As the study established that climate change might exacerbate the BR catchment's water supply system's insufficiency to meet growing demands, such findings present an opportunity for the integrated Water-Energy-Food nexus approach to be further utilised for formulating sustainable water management strategies.

Internet Search Trends on Breast Cancer Between 2017 and 2021 in Brazil: an Infoveillance Investigation

Introduction: Internet users frequently search for information on health issues. The behavior of Internet users may be related to health contexts experienced in their communities, reflecting unmet demands. Objective: To analyze the interest of Internet users on breast cancer in Brazil between 2017 and 2021. Method: An infodemiological study was carried out using the relative search volume (ranging from 0 to 100) for the term “câncer de mama” (breast cancer) in Brazil, retrieved from the Google Trends tool. The annual relative search volume was compared with a non-parametric approach and significance value (p) of 5%. Results: Except between 2019 and 2020 (p-value>0.05), there was a significant increase in Internet searches for the term “câncer de mama” in Brazil (all p-values <0.05). The peak of interest (relative search volume=100) was found in October 2020. Internet users who searched for the term “câncer de mama” often searched for signs and symptoms of breast cancer. Conclusion: The interest of Internet users on breast cancer has increased in recent years in Brazil.

Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as antiproliferative and apoptotic agents

Hepatocellular carcinoma (HCC), also known as hepatoma, is the most prevalent type of primary liver cancer. It begins in the hepatocytes, the liver’s major cell type. Cancer that began in another region of the body but has spread to the liver is known as secondary cancer of life; several still unmet demands for better, less toxic therapy to treat this malignant tumor. Several novel pyrazolo[1,5-a]pyrimidine derivatives were synthesized as part of our goal to develop promising anticancer drugs. All the synthesized hybrids have been screened for their cytotoxicity effect against three cancer cell lines which are; HepG-2, HCT-116, and MCF-7. The liver cancer cells were found to be the most sensitive to the effect of the new molecules. A subsequent set of in vitro biological evaluation studies has been conducted on the most promising derivatives to identify their effect on such a cancer type. In HepG-2 cells, four derivatives (8a, 8b, 10c, and 11b) demonstrated good anticancer activity. The most efficacious compounds were 8b and 10c, which had IC50 values of 2.36 ± 0.14 and 1.14 ± 0.063 μM, respectively, higher than the reference medication Imatinib. The latter’s putative molecular effect has been investigated further by looking at its influence on the cell cycle, EGFR, and specific apoptotic and anti-apoptotic markers in HepG-2 cells. These findings indicated that 8b and 10c could trigger apoptosis by upregulating BAX and caspase-3 and cell cycle at the Pre-G1 and G2-M stages. The compounds 8b and 10c showed high potency for EGFR with IC50 equal to 0.098 and 0.079 μM, respectively. Compound 10c had the most effective inhibitory activity for EGFR L858R-TK with IC50 (36.79 nM). Additionally, in silico ADMET and docking studies were done for the most active hits, representing good results.Graphical Novel Fluorinated Pyrazole-Based Heterocycles Scaffold: Cytotoxicity, In Silico Studies and Molecular Modelling Targeting Double Mutant EGFR L858R/T790M as Antiproliferative and Apoptotic Agents

Intellectual Property Rights

Healthcare is one industry where intellectual property (IP) is a valuable resource. The creation of medications to meet medical requirements and the discovery of new therapies necessitate the preservation of inventions. Protection of scientific and technological advancements inspires researchers and the business community to develop new and improved treatments and medications, extending and improving people’s lives. Healthcare businesses may recoup their investments and continue to invest in fresh research because of IP protection. IP has raised the bar for medical and health research, and it will keep finding solutions to today’s unmet demands. As it supports the financing scheme for R&D, IP is a crucial cornerstone of our healthcare system. This article discusses that in a variety of industries, including the healthcare industry, IP is a valuable asset. It is imperative to safeguard ideas and discoveries to find new cures and create drugs to meet medical needs. Protection of scientific and technological advancements motivates researchers and the business community to discover new and improved treatment options and medications, thereby enabling people to live longer and better lives [1].

Intellectual Property Rights

Healthcare is one industry where intellectual property (IP) is a valuable resource. The creation of medications to meet medical requirements and the discovery of new therapies necessitate the preservation of inventions. Protection of scientific and technological advancements inspires researchers and the business community to develop new and improved treatments and medications, extending and improving people’s lives. Healthcare businesses may recoup their investments and continue to invest in fresh research because of IP protection. IP has raised the bar for medical and health research, and it will keep finding solutions to today’s unmet demands. As it supports the financing scheme for R&D, IP is a crucial cornerstone of our healthcare system. This article discusses that in a variety of industries, including the healthcare industry, IP is a valuable asset. It is imperative to safeguard ideas and discoveries to find new cures and create drugs to meet medical needs. Protection of scientific and technological advancements motivates researchers and the business community to discover new and improved treatment options and medications, thereby enabling people to live longer and better lives [1].

Intellectual Property Rights

Healthcare is one industry where intellectual property (IP) is a valuable resource. The creation of medications to meet medical requirements and the discovery of new therapies necessitate the preservation of inventions. Protection of scientific and technological advancements inspires researchers and the business community to develop new and improved treatments and medications, extending and improving people’s lives. Healthcare businesses may recoup their investments and continue to invest in fresh research because of IP protection. IP has raised the bar for medical and health research, and it will keep finding solutions to today’s unmet demands. As it supports the financing scheme for R&D, IP is a crucial cornerstone of our healthcare system. This article discusses that in a variety of industries, including the healthcare industry, IP is a valuable asset. It is imperative to safeguard ideas and discoveries to find new cures and create drugs to meet medical needs. Protection of scientific and technological advancements motivates researchers and the business community to discover new and improved treatment options and medications, thereby enabling people to live longer and better lives [1].

Necropolitics and Scarce Resource Allocation: Letting Die in Death-worlds within the Framework of Lifeboat Ethics

The debate about the allocation of scarce healthcare resources was one of the most heated during the COVID-19 pandemic. The main ethical concern is what should we do in crisis periods when there are unmet demands for specific health goods, products, and services. One of the assumptions for the authors in this field is to take scarcity as a given neutral fact. Following this, literature mostly focuses on preference scales and optimal allocation measures, obliterating substantive discussions on how scarcity is produced and differentially distributed. Such an obliteration is what took Tom Koch (2013) to criticize “lifeboat ethics” – for him, we should not be focusing on how to distribute places in the lifeboat, but rather on why we ever allowed ourselves to navigate in such circumstances. His argument can be used to defend a duty to plan, which, if fulfilled, would prevent tragic choices. Here, I follow a different argument, related to how scarcity plays a role in the maintenance of status quo in necropolitical frameworks. In those settings, scarcity is not an accident of crisis periods, but a permanent structural factor and a means of governing. While we keep our ethical lens away from how scarcity is produced in these countries, we run the risk of leaving aside antecedent public choices that prioritize certain interests over the life of the ultimately killable ones – i.e., the decisions that reify and naturalize scarcity.

Recursive decomposition probability model for demand estimation of street-hailing taxis utilizing GPS trajectory data

The flexible and personalized street-hailing taxi service constitutes an indispensable component of urban mobility. However, most studies have focused only on the observed demand (pickup record) while ignoring the unmet demand. If based only on such analysis, the effectiveness of demand management policies and taxi searching strategies will be undermined. Motivated by this, we develop a recursive decomposition probability (RDP) model to efficiently estimate the demand (the summation of observed and unmet demands) of street-hailing taxis based on GPS trajectory data. In detail, we first partition the chronologically ordered passing records of taxis in individual road segments into several observations. Then, we utilize the proposed RDP model to derive the probability of each observation. Finally, the likelihood function is established, and the demand parameters for each road are estimated by maximum likelihood estimation. A simulation analysis is conducted to validate the performance of the proposed RDP model. It is shown that the demand estimated by the proposed model is much closer to the set demand than the observed demand under all testing scenarios. In addition, by comparing with benchmarks, the proposed RDP model needs no assumptions about the taxi arrival process and the numerical results show that it performs well. Finally, empirical studies are conducted with field data, the demand during the morning peak hour in 626 roads in Xi'an, China, is estimated by the proposed RDP model and the extended geographically weighted RDP model. The result indicates that the demand is obviously higher than the observed demand, emphasizing the importance of estimating demand in demand management.

Associations between serum soluble transferrin receptor and the prevalence of cancers.

As increasing experimental evidence suggests that iron metabolism play crucial roles in cancer and non-cancer conditions, there is a lack of data on serum soluble transferrin receptor (sTfR), a promising marker representing unmet cellular iron demands, between cancer risk from epidemiological studies. Here, we aimed to evaluate the predictive value of sTfR and cancer prevalence. We analyzed on 5,480 adult participants from 2015 to 2018 National Health and Nutrition Examination Survey (NHANES). Spearman correlation analysis was performed to investigate the correlations between sTfR and other characteristics. To identify the associations between sTfR and the prevalence of cancers, stratified multivariable logistic regression models, subgroup and sensitivity analyses were also performed. In tertile analyses, participants in the highest level of sTfR were significantly associated with increased prevalence of total cancers [odds ratio (OR) = 1.53, 95% confidence interval (CI): 1.15-2.02] as compared with those at the lowest tertile. Each unit increment in ln-transformed sTfR concentration was shown to be associated with 39% increased risks of total cancers. Similar associations were found in males rather than females. Further subgroup and sensitivity analyses indicated that, in continuous and tertile analyses, sTfR was more closely associated with male- and female-specific cancers of prostate and testis (2.35: 1.03-5.40; 2.03: 1.00-4.09; respectively), and breast, cervix, ovary and uterus (1.92: 1.11-3.35; 1.66: 1.02-2.69; respectively). Our findings suggested that elevated level of sTfR was associated with the prevalence of cancers, especially in sex-specific cancers. In order to better determine them, further research in humans will be required.

Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options.

Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It is yet to be fully clarified how the disease becomes so deadly in some patients. However, it is proven that a condition called "cytokine storm" is involved in the deterioration of COVID-19. Although beneficial, sustained production of cytokines and overabundance of inflammatory mediators causing cytokine storm can lead to collateral vital organ damages. Furthermore, cytokine storm can cause post-COVID-19 syndrome (PCS), an important cause of morbidity after the acute phase of COVID-19. Herein, we aim to explain the possible pathophysiology mechanisms involved in COVID-19-related cytokine storm and its association with multi-organ failure and PCS. We also discuss the latest advances in finding the potential therapeutic targets to control cytokine storm wishing to answer unmet clinical demands for treatment of COVID-19.

Assessment of future water demand and supply using WEAP model in Dhasan River Basin, Madhya Pradesh, India.

Understanding the available resources and the needs of those who use them is necessary for the evaluation and allocation of water resources. The main sectors utilizing the basin water resources are agriculture, drinking water, animal husbandry, and industries, and the efficient and rational management of water resources to be distributed among those different sectors of activity is vital. This study attempts to develop an integrated water resource management system for the Dhasan River Basin (DRB) by employing a scenario analysis approach in conjunction with Water Evaluation and Planning Model(WEAP) to analyze trends in water use and anticipated demand between 2015 and 2050, simulating five possible scenarios (I, II, III, IV, and V) as for external driving factors. For the WEAP modeling framework, 2015 was chosen as a current (base) year for which all available information and input data were given to the model and the future demand situation was analyzed for the period 2016-2050 (forecasting period). From the findings, it was observed that for the forecasting period, total water demand, unmet demand, and streamflow were 185.29 Bm3, 117.35 Bm3, and 58.26 Bm3, respectively, in the case of scenario I; 232.34 Bm3, 162.17 Bm3, and 59.87 Bm3 in case of scenario II; 139.40 Bm3, 84.37 Bm3, and 58.15 Bm3 in case of scenario III; 186.15 Bm3, 118.76 Bm3, and 56.98 Bm3 in case of scenario IV; and 181.89 Bm3, 96.87 Bm3, and 53.11 Bm3 in case of scenario V. Results of the study indicated that by 2050, increasing population growth, industrial development, and an increase in the agricultural area will rise the water demand dramatically, posing threats to the environment and humans. Therefore, implementing improved irrigation technologies, advancing agricultural practices on farms, and constructing water conservation and retaining structures could significantly reduce the unmet demands and shortfalls in DRB. Overall findings reveal that the pressure on the Dhasan water resources would increase in the future, and thus several suggestions have been provided to assist decision-makers in sustainable planning and management of water resources to meet future demands.