Research, testing and experimental substantiation of the possibility of using remote sensing data obtained from a spectrometer installed on an unmanned aerial vehicle (UAV) and satellite data to assess the presence of hydrocarbon deposits within geological structures has been carried out. The test area was chosen as the Vostochnorogintsevska area (Velikobubnivsky Val of the Dnipro-Donetsk Basin) with available hydrocarbon deposits (HC), productive and unproductive wells, the research route was laid between unproductive and productive wells. The main advantage of this territory is the availability of the results of processing primary data of ground measurements and remote sensing obtained by various types of equipment from 1999 to 2021. The study is devoted to the comparative analysis of vegetation indices, which are calculated from remote data obtained by a multispectral camera mounted on an UAV and Sentinel-2 satellite data. It was determined that these data have a high degree of correlation, reflect changes in the state of vegetation, caused by the presence of HC deposits, tectonically active fault zones, and have significant indicative value. The obtained results provide a basis for the effective use of UAVs in the structure of the methodology for solving oil and gas exploration tasks on land.