The existing methods for feature screening focus mainly on the mean function of regression models. The variance function, however, plays an important role in statistical theory and application. We thus investigate feature screening for mean and variance functions with multiple-index framework in high dimensional regression models. Notice that some information about predictors can be known in advance from previous investigations and experience, for example, a certain set of predictors is related to the response. Based on the conditional information, together with empirical likelihood, we propose conditional feature screening procedures. Our methods can consistently estimate the sets of active predictors in the mean and variance functions. It is interesting that the proposed screening procedures can avoid estimating the unknown link functions in the mean and variance functions, and moreover, can work well in the case of high correlation among the predictors without iterative algorithm. Therefore, our proposal is of computational simplicity. Furthermore, as a conditional method, our method is robust to the choice of the conditional set. The theoretical results reveal that the proposed procedures have sure screening properties. The attractive finite sample performance of our method is illustrated in simulations and a real data application.