Abstract. Since Global Navigation Satellite System may be unavailable in complex dynamic environments, visual SLAM systems have gained importance in robotics and its applications in recent years. The SLAM system based on point feature tracking shows strong robustness in many scenarios. Nevertheless, point features over images might be limited in quantity or not well distributed in low-textured scenes, which makes the behaviour of these approaches deteriorate. Compared with point features, line features as higher-dimensional features can provide more environmental information in complex scenes. As a matter of fact, line segments are usually sufficient in any human-made environment, which suggests that scene characteristics remarkably affect the performance of point-line feature based visual SLAM systems. Therefore, this paper develops a scene-assisted point-line feature based visual SLAM method for autonomous flight in unknown indoor environments. First, ORB point features and Line Segment Detector (LSD)-based line features are extracted and matched respectively to build two types of projection models. Second, in order to effectively combine point and line features, a Convolutional Neural Network (CNN)-based model is pre-trained based on the scene characteristics for weighting their associated projection errors. Finally, camera motion is estimated through non-linear minimization of the weighted projection errors between the correspondent observed features and those projected from previous frames. To evaluate the performance of the proposed method, experiments were conducted on the public EuRoc dataset. Experimental results indicate that the proposed method outperforms the conventional point-line feature based visual SLAM method in localization accuracy, especially in low-textured scenes.