Reference-frame-independent measurement-device-independent QKD (RFI-MDI-QKD), immune to both the slow unknown drift of reference frames and detector side channel attacks, can generate information-theoretic secure keys. Despite its natural resistance to the slow drift of reference frames, the performance of practical RFI-MDI-QKD systems descends with the increasing drift of reference frames. In this paper, we demonstrate the worst relative rotation of reference frames for practical RFI-MDI-QKD systems, and investigate their performance against the worst-case scenario, both of which are unclear to date. Simulation results show that, practical RFI-MDI-QKD systems can achieve quite good performance even against the worst-case scenario, which clearly demonstrates that it is possible to implement practical MDI-QKD systems with freely drifting reference frames.
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