University Of Nantes Research Articles

Global research status and trends of enteric glia: a bibliometric analysis

BackgroundEnteric glia are essential components of the enteric nervous system. Previously believed to have a passive structural function, mounting evidence now suggests that these cells are indispensable for maintaining gastrointestinal homeostasis and exert pivotal influences on both wellbeing and pathological conditions. This study aimed to investigate the global status, research hotspots, and future directions of enteric glia.MethodsThe literature on enteric glia research was acquired from the Web of Science Core Collection. VOSviewer software (v1.6.19) was employed to visually represent co-operation networks among countries, institutions, and authors. The co-occurrence analysis of keywords and co-citation analysis of references were conducted using CiteSpace (v6.1.R6). Simultaneously, cluster analysis and burst detection of keywords and references were performed.ResultsA total of 514 publications from 36 countries were reviewed. The United States was identified as the most influential country. The top-ranked institutions were University of Nantes and Michigan State University. Michel Neunlist was the most cited author. “Purinergic signaling” was the largest co-cited reference cluster, while “enteric glial cells (EGCs)” was the cluster with the highest number of co-occurring keywords. As the keyword with the highest burst strength, Crohns disease was a hot topic in the early research on enteric glia. The burst detection of keywords revealed that inflammation, intestinal motility, and gut microbiota may be the research frontiers.ConclusionThis study provides a comprehensive bibliometric analysis of enteric glia research. EGCs have emerged as a crucial link between neurons and immune cells, attracting significant research attention in neurogastroenterology. Their fundamental and translational studies on inflammation, intestinal motility, and gut microbiota may promote the treatment of some gastrointestinal and parenteral disorders.

Open for All at ChemElectroChem

Open for All at <i>ChemElectroChem</i>

Next steps in the evolution of AAV vector characterization technologies

<div class="authors authors-lg"><div class="author"><div class="author-img"><img src="https://bioinsights.blob.core.windows.net/uploads/Eduard_picture copy.jpg" data-image="1"></div><div class="author-det"> <b>Eduard Ayuso</b> is Chief Technology Officer at DiNAQOR (Zürich, Switzerland), a genetic medicine platform company focused on addressing severe inherited cardiac diseases. Dr Ayuso is an expert in the field of gene therapy using viral vector platforms, including adenoviral vectors, helper-dependent adenoviral vectors, and adeno-associated vectors (AAV), as well as their design, manufacture, and purification. With over two decades of academic and industry consulting experience, he has made significant contributions to the field of in vivo gene transfer in small and large animal models of diseases, as well as AAV vector development and analytics. Dr Ayuso previously served as Head of Innovative Vectorology at the French National Institute of Health and Medical Research (INSERM), and as the Scientific Director of the Translational Vector Core unit at University of Nantes. Since 2018, he has served as vice president of the French Society for Gene and Cell Therapy. He is also a member of the Translational Science and Drug Product Development committee of the American Society for Gene and Cell Therapy. Dr Ayuso earned his PhD in Biochemistry and Molecular Biology and his degree in Veterinary Medicine from Autonomous University of Barcelona. </div></div></div>

Advances and Challenges for Model and Data Engineering

Advances and Challenges for Model and Data Engineering

Get in line: developing in-process analytical tools for gene therapy applications

<div class="authors authors-lg"><div class="author"><div class="author-img"><img src="https://cdn.insights.bio/uploads/7e5b1831f3db4118af08131cb11c856b.png" data-image="1"></div><div class="author-det"><h3 class="author-name">René Gantier</h3><h5 class="author-title">Director of Technology for Gene Therapy, Repligen</h5> René Gantier is the Director of Technology for Gene Therapy at Repligen. He has almost 20 years of experience developing production and purification processes for biotherapies. René holds a MSc in Cell Biology from the University of Nantes (France) and a PhD in Biochemistry from the University of Rouen (France). He started his career in the biotechnology industry as a scientist developing long-lasting therapeutic cytokines at Nautilus Biotech (France), before joining Pall Life Sciences as a downstream processing field application specialist, and then expanded his role to lead the Biotech Process R&amp;D team developing end-to-end upstream-downstream continuous bioprocessing solutions for mAbs and cell/gene therapies. In his current role at Repligen, he provides technology guidance to develop high productivity next generation gene therapy manufacturing processes. </div></div></div><div class="authors authors-lg"><div class="author"><div class="author-img"><img src="https://cdn.insights.bio/uploads/293d59b48641407ab2c636baca03ea7c.png" data-image="1"></div><div class="author-det"><h3 class="author-name">Ramsey Shanbaky</h3><h5 class="author-title focus-visible" data-focus-visible-added="">Bioprocess Applications Manager, C Technologies Inc. - a Repligen Company</h5> Ramsey Shanbaky is the Bioprocess Applications Manger for C Technologies, Inc. He spent the first 8 years of his career working in R&amp;D, Manufacturing and Product Management designing and building fiber optic products for high powered laser delivery in the medical device industry. In the first part of his tenure at C Technologies, he worked alongside his customers to implement the SoloVPE product with biopharmaceutical accounts primarily in the western region. For the last 5 years, he has been partnering with customers to implement the FlowVPE system for inline concentration measurements both in the process development areas and GMP manufacturing areas for bioprocessing. He holds an BSEE from Purdue University and multiple patents and applications. </div></div></div><div class="authors authors-lg"><div class="author"><div class="author-img"><img src="https://cdn.insights.bio/uploads/Jay Headshot_200x200.png" data-image="1"></div><div class="author-det"><h3 class="author-name">Jay West</h3><h5 class="author-title">Principal Scientist at Bristol Myers Squibb</h5> Jay West is Principal Scientist at Bristol Myers Squibb in the Process Development Analytics group in Devens, MA. He obtained his BS in Chemistry from Rensselaer, MS in Chemistry from University at Albany, PhD in Biochemistry from Boston College, and performed postdoctoral research at Northeastern University. He has 8 years pharmaceutical industry experience, having worked at Regeneron Pharmaceuticals precious to BMS. His focus the past three years has been on Process Analytical Technology, particularly in downstream process development. </div></div></div>

The Impact of COVID-19 on the State of Clinical and Laboratory Research Globally in Transplantation in May 2020.

The Impact of COVID-19 on the State of Clinical and Laboratory Research Globally in Transplantation in May 2020.

Pregnancy and Delivery in Women with Lower Urinary Tract Reconstruction: A National Multicenter Retrospective Study from the French-Speaking Neuro-Urology Study Group (GENULF) and the Neuro-Urology Committee of the French Association of Urology.

Management of pregnancy and delivery in women with lower urinary tract reconstruction is challenging and the currently available literature is insufficient to guide clinical practice. We report pregnancy and delivery outcomes in this specific population. We conducted a national multicenter retrospective study (16 centers) including 68 women with 96 deliveries between 1998 and 2019. These women had at least 1 successful pregnancy and delivery after augmentation enterocystoplasty, catheterizable channel creation and/or artificial urinary sphincter implantation. Maternal and fetal complications during pregnancy and delivery were reported, as well as postpartum functional outcomes, according to the delivery mode. The chi-square test and Student's t-test were used to compare categorical and continuous variables, respectively. Overall 32% of reported pregnancies were complicated by febrile urinary tract infections, 13.5% by renal colic and 14.6% required upper urinary tract diversion. In addition, 10% of patients reported transient self-catheterization difficulties and 13.5% reported de novo or increased urinary incontinence. The preterm delivery rate was 35.3%. Elective C-section was performed in 61% of pregnancies. Twenty complications occurred during delivery (20%), including 19 during elective C-section. Urinary continence at 1 year was unchanged for 93.5% of deliveries. Delivery mode (p=0.293) and multiparity (p=0.572) had no impact on urinary continence. In this population C-section appeared to be associated with a high risk of complications. In the absence of any obstetric or neurological contraindications, vaginal delivery should be proposed as the first line option to the majority of these women.

Cover Fuel Cells 3/2020

Fuel CellsVolume 20, Issue 3 p. 229-229 Cover PictureFree Access Cover Fuel Cells 3/2020 First published: 10 June 2020 https://doi.org/10.1002/fuce.202070031AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract In the framework of the conference series, this Special Issue covers the 8th Fundamentals & Development of Fuel Cells Conference (FDFC2019), which was held in Nantes, France, from February 12th to 14th, 2019, and organized by the University of Nantes, France, by the LTEN (Laboratory of Thermal Sciences and Energy of Nantes), IMN (Institute of Materials of Nantes) and IREENA (Research Institute on Electrical Energy of Nantes-Atlantic). The technical program covered the topics from fuel cells and hydrogen, range from fundamentals of electrochemistry, cell and stack development, system design and control, to systems and field operation. At FDFC2019 most contributions were related to polymer electrolyte cells and solid oxide cells. All papers in this Special Issue were preselected by the Organizing Committee from the best conference contibutions. Volume20, Issue3Special Issue: 8th Fundamentals & Development of Fuel Cells Conference FDFC2019June 2020Pages 229-229 RelatedInformation

Fuel Cells and Hydrogen: a Further Step Towards Deployment.

AbstractNo abstract.

Julie Margaret Barker

Julie Margaret Barker spent her childhood in Canada and New Zealand. After a year at the University of Victoria, British Columbia, Canada, studying Classics and French, she spent a year travelling in Australasia before coming to Europe and enrolling in medicine at the University of Nantes. …

Educational gaming for dental students: Design and assessment of a pilot endodontic-themed escape game.

The concept of escape games dedicated to dental students is a new learning experience that has not yet been extensively explored. The aim of this pilot study was to assess the impact and perceived value of an endodontic-themed escape game as assessed by fourth-year dental students. This study was conducted at the University of Nantes,Facultyof Dental Surgery using a cross-sectional pre- and post-test research design to assess students' changes in performance. Students in the fourth year of dental surgery study (n=18) were divided in four groups for this study. The answers to the pre-test/post-test were 50 true/false questions. Moreover, a 20-question perception survey was given to all the participants after completion of the escape game. The study data were collected in May 2019. An unpaired t test analysed the mean differences between the groups. The results showed a statistically significant increase in post-test results (75.33%±10.17% of correct answers) compared to the pre-test results (67.33%±5.94% of correct answers) P<.05. Analysis of variance revealed that this change in score was not significantly different between the four groups. The students perceived the endodontic-themed escape game to be relevant. A one-sample t test indicated that students' mean (SD) perception 4.4 (0.7) was statistically significantly higher than the mean value of the evaluation scale P<.001. The students found this educational game to be a useful experience that helped them recall/apply knowledge whilst promoting teamwork. Therefore, this type of game can enhance students' learning and motivation.

Faces of Muhammad: Western Perceptions of the Prophet of Islam from the Middle Ages to Today by John V. Tolan (review)

Faces of Muhammad: Western Perceptions of the Prophet of Islam from the Middle Ages to Today by John V. Tolan Peter Heinegg Faces of Muhammad: Western Perceptions of the Prophet of Islam from the Middle Ages to Today. By John V. Tolan. Princeton, NJ: Princeton University Press, 2019. xii + 309 pp. $29.95. There are many stories told about, and words attributed to, the great religious founders, the Buddha, say, and Jesus, and Muhammad, although very little of all this material is verifiable history in the strict sense. Professor Tolan teaches history at the University of Nantes; but in any case his subject is not the actual person of Muhammad, but “Mahomet,” the construct or fantasy or caricature created by western writers from roughly the twelfth to the twenty‐first century. It's safe to say that no other major religious figure has been as distorted and vilified as the Prophet—though there are some important exceptions to this wrongheaded record. But Tolan's dense, briskly moving summary (which could well have been far longer) tells us not about Islam, but the various cultural agendas of Europeans reacting to what they thought Islam was or looking to gain some sort of polemical mileage out of their misguided notions. For medieval crusade chroniclers, “Mahomet” was a golden idol, a false god worshiped by the “Saracens” (= Arabs, but connected by a folk etymology to Sarah), a term Muslims never used to describe themselves. Or else, he was a master heretic who seduced Christians into the toils of a false faith, and was thus consigned by Dante to the ninth trench of Hell in a gory scene that Tolan oddly skims over. Such gross distortions lingered on for ages, but in the sixteenth century Miguel Servet (1509 or 1511–1553), better known as Michael Servetus, like later “Unitarians,” drew upon the Qur'an for arguments against the Trinity, only to be burned at the stake in Geneva for his troubles. As wars between Catholics and Protestants began to tear Europe apart, some critics cited the tolerant view of religious diversity in the Qur'an and the Ottoman Empire. In the seventeenth and eighteenth centuries, anti‐clerical writers praised Muhammad as a “reformer who abolished the privileges of a corrupt and superstitious clergy.” In the eighteenth and nineteenth centuries, Muhammad was sometimes treated as “a sort of Arab national hero, bringing law, religion, and glory to his people.” Voltaire (1694–1778) tried to have it both ways. In Fanaticism, or Mahomet the Prophet: A Tragedy (1736), he uses the old cliché of Muhammad the imposter as a stalking horse to attack targets closer to home. But in his huge Essay on the Manners and Thinking of the Nations (begun in 1756), he takes a much more broad‐minded view, comparing him favorably to Alexander the Great, calling him not a fanatic, but an “enthusiast.” “As a conqueror, legislator, monarch, and pontiff, he played the greatest role that can be played on earth in the eyes of the common people.” Note the culminating swipe, which Voltaire couldn't resist. To be sure, Voltaire prefers Confucius to Muhammad because Confucius was a purely rational sage who foreswore the Prophet's modes of worldly power, just as he prefers the Chinese to the Arabs because he thought they were more “civilized.” Still, though parts of the Qur'an may be contradictory, absurd, or confused, other passages are “sublime.” All things considered, Voltaire considers Muhammad a great man and a hero. Figures as disparate as Goethe, Napoleon, and Thomas Carlyle would strongly agree. Eventually, as time went on, the work of scholars, translators, and other western experts, sometimes unfairly tarred as “Orientalists,” made it possible to arrive at a fairer assessment of Muhammad. In the English‐speaking world, ground‐working was done when George Sale produced a serviceable, unbiased translation of the Qur'an (1734), with a prefix validating the Prophet as a righteous enemy of superstition and overweening clerical privilege. Before Sale, in 1671 Henry Stubbe, who knew no Arabic and read most Islamic documents in Latin translation, published his Originall & Progress of Mahometanism with a preface that hails Muhammad as “a religious reformer, beloved and admired...

Система навчання як соціальна провокація: за романом Р. Мерля “За склом”

This article is dedicated to the crisis situation in the French system of higher education of the 1960-ies. In particular, main grounds for students’ protests in 1968 have been considered: opposition to political regimes, strikes against the war in Vietnam, demonstrations against improper conditions for study and censor. The attention is focused on the background of the May Revolution in France. The novel by R. Merle “Behind the Glass” (1970) within the curriculum of the higher educational institution has been studied. It has been determined that the author distinguishes a number of typical characters of the students’ and teachers’ media. The cause and effect course of social events within the archaic teaching tradition in the system of higher education in France in XX century has been defined. It has been traced that the necessity of еру emergency renovation of curricula, lectures and tutorials caused rebellious mood among the students. The investigation shows that financial instability, conservative scientific and technical opportunities of education, expressive conflicts between the assistants and professors of the University of Nantes, unfavorable conditions for the students’ education and existence, lack of creative cooperation with the teachers, unwillingness to come to an understanding with the students in Paris resulted in the rebellious mood among the students. Under the analysis results it has been found that еру students’ rebellions in 1968 not only changed social and economic sector of the French society, but also significantly renewed higher education system of teaching.

The Effect of Magnification Loupes on Spontaneous Posture Change of Dental Students During Preclinical Restorative Training.

Scientific evidence validating the beneficial effect of loupes in preventing musculoskeletal disorders is very scarce. The aim of this study was to assess the impact of dental loupes on dental students' posture during a preclinical restorative dentistry course. Using a randomized crossover design, this study was conducted at the School of Dentistry, University of Nantes, France, in 2017. Forty students in their second year of dental study were randomly divided into two groups of 20 each: group A used loupes, whereas group B did not. The week after, students reversed configurations (each subject served as his or her own treatment and control group). Students were video-recorded during cavity preparation. Trunk, head and neck, and upper arm positions were analyzed using continuous scores based on the modified Posture Assessment Instrument. Additionally, cavities were rated, and students completed a questionnaire on their perceptions of the loupes. On a scale on which lower scores indicated better posture, the results showed significantly higher posture ergonomic scores per minute for students without loupes (146.3±6.64 points/min) than with loupes (123.2±6.77 points/min; p<0.05). The majority of the students (32/39, 82%) showed improvements in ergonomic postures with the use of loupes. Trunk, head, and neck were positively impacted by the use of loupes, but not the upper arms. Cavity preparations were not improved by the use of loupes. The questionnaire revealed negative aspects (pain and difficulty adapting) but underlined the perceived positive impact on posture. This study documented the ergonomic advantages and challenges of introducing magnification near the beginning of the dental training program.

Entretien avec Christian Baudelot

Christian Baudelot (1938) is a well-known French sociologist, disciple of Pierre Bourdieu, and author of important studies that explore social inequalities in education and work, and the topic of suicide. He is Emeritus Professor at the Ecole Normale Superieure (ENS) in Paris, and former Dean of the Department of Social Sciences (1990-2003). He has also taught Sociology at the University of Nantes, where he was Director of the department of Sociology (1984-1993), and at the University of Lille 1 (1966-1978); other positions he has held include assistant professor at the University of Yale, and visiting professor at the Institute of French Studies in New York, at the Federal University of Rio de Janeiro and in various Chinese universities. In the interview, Baudelot traces the key developments in his academic career: from his chance – lucky – meeting with Pierre Bourdieu, to the years of his sociological formation. He is a worthy successor of the generations of French sociologists which have given the Ecole Normale Superieure its international prestige: from Durkheim to Halbwachs, Bougle, Aron, Touraine, Boudon, Bourdieu, Passeron and, more recently, Baudelot’s own generation. The ENS has always been fertile terrain for those interested in questions that emerge on the dividing lines between different disciplines: the point where scientific breakthroughs and discoveries are much more likely to occur, according to Christian Baudelot.

Editorial introductions

Current Opinion in Critical Care was launched in 1995. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of critical care is divided into 13 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the journal's Section Editors for this issue. SECTION EDITORS Thomas RimmeléThomas RimmeléProf. Thomas Rimmelé is the Chairman of the Department of Anaesthesiology and Intensive Care Medicine at Edouard Herriot Hospital, Lyon, France, and Chairman of the Department of Organ Harvest Coordination for the Hospices Civils de Lyon, France. He gained his medical degree in 2004, specialising in anaesthesiology and intensive care, from the Claude Bernard University, Lyon, France, and subsequently completed a PhD on extracorporeal blood purification therapies in sepsis. In addition to blood purification for sepsis, Prof. Rimmelé's academic interests include acute kidney injury, renal replacement therapy in the intensive care unit, and simulation in healthcare as he is also the co-director of the simulation center at Lyon University, France. Prof. Rimmelé is the author or co-author of more than 150 peer-reviewed articles or book chapters and regularly delivers lectures at international meetings. Wesley H. SelfWesley H. SelfDr Wesley H. Self, MD, MPH, is the Vice Chair for Research in the Department of Emergency Medicine at Vanderbilt University Medical Center in Nashville, Tennessee, USA. He is an emergency physician and clinical researcher focused on the intersection of emergency and critical care medicine. He has authored over 100 peer-reviewed publications and widely lectured and presented research findings on the early management of pneumonia, sepsis, and related emergencies. Dr Self was the principal investigator for the Saline Against Lactated Ringer's or Plasmalyte in the Emergency Department (SALT-ED) trial (N Engl J Med 2018), which demonstrated a lower incidence of major adverse kidney events following IV fluid resuscitation with balanced crystalloids compared with saline. He was also a lead investigator in the Etiology of Pneumonia in the Community (EPIC) study (N Engl J Med 2015), which demonstrated a high disease burden from respiratory viruses among patients hospitalized with community-acquired pneumonia in the United States. Dr Self serves as the co-principal investigator of the Vanderbilt Clinical Center in the Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network (www.petalnet.org) funded by the National Heart, Lung and Blood Institute (NHLBI). His current work focuses on embedding pragmatic comparative effectiveness trials into ongoing clinical care to learn how to improve early resuscitation. Dr Self completed medical school at the University of Virginia, USA, residency training in emergency medicine at Northwestern University, USA, and a clinical research fellowship at Vanderbilt University, USA. He is currently an Associate Professor of Emergency Medicine at Vanderbilt University Medical Center, where he leads the Division of Emergency Medicine Research. Karim AsehnouneKarim AsehnouneProf. Karim Asehnoune got his degree as an MD in 1999 at University René Descartes Paris, France. After completing his PhD in immunology in 2001, he spent one year in the lab of Prof. Edward Abraham in the University of Colorado, Denver, USA (2002). He was appointed Professor of Anaesthesiology and Critical Care Medicine in the University of Nantes, France, in 2009. Prof. Asehnoune is the head of the Anaesthesiology department of Hospital Hotel-Dieu, and the director of the 30-bed surgical Intensive Care Unit at the University hospital of Nantes, France. He is currently a member of the scientific committee of the French Society of Anaesthesiology and Critical Care Medicine, and the director of a French network of ICUs (www.ATLANREA.org). Professor Asehnoune was involved as the coordinator of several multi-centre trials, and he was the primary investigator of 2 multicentre double blind randomised studies evaluating corticosteroids in severe trauma patients. He is the director of a lab dedicated to the study of host-pathogen interactions (http://www.ea3826.univ-nantes.fr/). He has published more than 180 peer-reviewed articles.

Muscle-tendon behaviour during sprint in road cyclists: effect of the force-velocity condition

Muscle-tendon behaviour during sprint in road cyclists: effect of the force-velocity condition

Apprentissage de l’anatomo-cyto-pathologie par les étudiants en médecine : comprendre le rôle de la motivation

The motivations of medical students for Pathologic Anatomy are little known although they can strongly influence their academic performance. Our work focused on the analysis of the relationship between performance and motivation for Pathologic Anatomy. Second-year students (n=268) from the University of Nantes were contacted to complete a motivation questionnaire and to provide indicators of performance and attendance. The responses were analyzed in order to establish the psychometric reliability and the factorial structure of the questionnaire. The relationship between motivation and performance was explored by correlation and by linear regression studies. A cluster analysis was performed to specify the distribution of the two variables in our sample. The sample corresponded to 168respondents with a F/M ratio similar to that of our population. Our data demonstrated the reliability of the questionnaire and a structure described by 5motivation factors (self-determination, self-efficacy, career, grade and intrinsic motivation). The academic performance was not significantly correlated with the overall motivation or with student attendance. However, it was predicted by self-determination and self-efficacy. Our work revealed gender differences as well as the existence of two distinct clusters defined by the motivation and performance of the students. This work constitutes the first study of the motivations of French medical students for cyto-pathology. It validates a quantitative assessment tool for motivation. Finally, it explores the heterogeneity of the distribution of motivation and academic performance within a population of learners.

On site deployment of 3D printing for the building construction – The case of YhnovaTM

The University of Nantes has developed a 3D printing technique (BatiPrint3DTM) dedicated to the construction of the walls of a house. This innovative on site construction technique is based on the deposition of two layers of expansive foam used as a formwork for a third concrete layer. It allows to build at the same time the structure and the insulation. This new construction technology has first been developed at the laboratory, but rapidly, we decided to deploy it on site, in order to demonstrate its technical viability. We present the technology Batiprint3DTM and the demonstrator YhnovaTM, a 95m2 social dwelling built for the social landlord Nantes Métropole Habitat (NMH).

Advances in transgenic animal models and techniques.

On May 11th and 12th 2017 was held in Nantes, France, the international meeting "Advances in transgenic animal models and techniques" ( http://www.trm.univ-nantes.fr/ ). This biennial meeting is the fifth one of its kind to be organized by the Transgenic Rats ImmunoPhenomic (TRIP) Nantes facility ( http://www.tgr.nantes.inserm.fr/ ). The meeting was supported by private companies (SONIDEL, Scionics computer innovation, New England Biolabs, MERCK, genOway, Journal Disease Models and Mechanisms) and by public institutions (International Society for Transgenic Technology, University of Nantes, INSERM UMR 1064, SFR François Bonamy, CNRS, Région Pays de la Loire, Biogenouest, TEFOR infrastructure, ITUN, IHU-CESTI and DHU-Oncogeffe and Labex IGO). Around 100 participants, from France but also from different European countries, Japan and USA, attended the meeting.