Eka Sunarwidhi Prasedya, S.Si., M.Sc., Ph.D. Chairman of 4th ICBB 2021 This issue of IOP conference proceedings contains papers presented at the 4th International Conference on Bioscience and Biotechnology (ICBB) 2021. The ICBB is an annual international conference since 2018 that was initiated by Prof Ir H Sunarpi PhD. This year we are lucky to collaborate with Postgraduate-studies (Pascasarjana) University of Mataram thanks to the director Prof. Ir. H Muhamad Sarjan, M.Agr.,C.P. Ph.D and vice director Prof. Ir. Bambang Hari Kusumo, M.Agr.St., Ph.D. This meeting is hosted by Lab of Bioscience and Biotechnology Research, University of Mataram, Indonesia. It is held for three days, from 21 to 23 September 2021 by virtual conference with zoom platform due to COVID-19 pandemic.Interactive online presentations were arranged through Zoom Video Communications for the participants to present their ideas. The conference was divided into two main sessions: Main session for Keynote speakers and Panel Sessions for participants. A time of 30 minutes was given for Keynote speakers to present their fabulous work. For panel session, 10 minutes were given for participants to share their research and findings. A total of 204 participants (180 presenters and 24 non-presenters) from Universities, Research Institutes and also Government Departments joined the conference. All the selected papers were peer reviewed by expert reviewers in a double blind review system as per the review policy given by IOP Conference Series.On the first day of the conference (21st September) invited talks were presented by Prof. Julian Heyes, Ph.D. from Massey University New Zealand on “Deriving value from elite indigenous fruit and vegetable species”, Prof. Bambang Hari Kusumo, M.Agr.St., Ph.D. from University of Mataram on “Rapid measurement of soil carbon using near infrared technology”and Prof. Dr. Endang Semiarti, M.S., M.Sc. from Universitas Gadjah Mada Indonesia on “Biotechnology approach to improve the quality and quantity of orchids as potential agricultural commodities in Indonesia”. The second day of the conference presented talks by Prof. Lim Phaik Eem, Ph.D. from University of Malaya on “Importance of marine habitat conservation for utilization and discovery of new bioresources of seaweeds”, Prof. Mat Vanderklift, Ph.D. from Indian Ocean Marine Research Centre CSIRO Australia on “Opportunities for sustainable use of coastal ecosystems”, Assoc.Prof. Dr. Rapeeporn Ruangchuay from Prince of Songkla University Thailand on “ Seaweed resources in Thailand: cultivation and utilization” and Dr.rer.nat. Andri Frediansyah, M.Sc. from LIPI Indonesia on ”Microbial natural products: a discovery strategy”. The final day of the conference included talks by Prof. Akihiro Hazama, Ph.D. from Fukushima Medical University on “Investigation of cigarette smoke-induced cell hyperplasia mechanism using Induced Pluripotent Stem Cell (IPSCs)”, Prof. Kato Yasuhiro, Ph.D. from Keio University Japan on ”Water circulation of the earth and life” and Eka Sunarwidhi Prasedya, Ph.D. from University of Mataram Indonesia on “Microbiome implications for bioprospecting of seaweeds”.List of Conference Photograph, Conference Organizers are available in this pdf.