University Of Kuopio Research Articles

Plasma fibrinogen and wall thickness in carotid and femoral arteries: findings from the KIHD study

Objective : Previous epidemiologic studies have shown that high plasma fibrinogen concentration is associated with increased risk of cardiovascular events. However, there is less previous information about the impact of plasma fibrinogen on the severity of subclinical atherosclerosis in population samples. The purpose of this study was to test the association of plasma fibrinogen with the wall thickness of carotid and femoral arteries. Design : A sample of male participants in the ‘Kuopio Ischaemic Heart Disease Risk Factor Study’ (KIHD), aged 46–64, were examined in 1991–3 in a cross-sectional study. Setting : A study at the Research Institute of Public Health, University of Kuopio, Finland. Subjects and methods : For 1014 men, plasma fibrinogen was measured by fibrin clotting and the intima-media thickness (IMT) in distal common carotid arteries was assessed by high-resolution B-mode ultrasonography. Results : Variables with the strongest associations with plasma fibrinogen were cigarette-years, body fat percentage, exhaled carbon monoxide, t-PA antigen, age, serum apolipoprotein B, and waist to hip circumference ratio. The relative difference between the lowest and the highest fibrinogen quintile was 14% for unadjusted carotid IMT and 44% for femoral IMT. The respective differences for means adjusted for all the strongest risk factors for IMT, including smoking, were 8% for the carotid and 17% for the femoral IMT. Conclusion : Our data confirm previous findings indicating that the major non-genetic determinants of plasma fibrinogen are smoking and obesity and that elevated plasma fibrinogen levels are associated with increased arterial wall thickness in men. This association is stronger for femoral than common carotid arteries.

Flavonoids and phenolic acids in selected berries.

During the last decade, there has been a growing interest in naturally occurring anticarcinogenic substances in plant foods. Plant phenols, e.g. flavonoids and phenolic acids, are currently considered as one of the most promising groups of potential dietary anticarcinogens [ 11. The purpose of this study was to screen the major phenolic compounds in various edible berries growing wild or cultivated in Finland. The compounds of interest were: kaempferol, quercetin and myricetin (flavonoids); caffeic, p-coumaric and ferulic acids (hydroxycinnamic acids); p-hydroxybenzoic and gallit acids (hydroxybenzoic acids); and ellagic acid. These phenolics are suggested to have anticarcinogenie potential [I], and there were indications of their presence in some berries [2-41. This work is part of’ a larger project on flavonoids and phenolic acids in Finnish berries, their bioavailability and effects on carcinogen metabolism, conducted at the University of Kuopio. The berries studied were: strawberry (Frugariu x ananassu), red raspberry (Rubus idueus), arctic bramble (Rubus arcticus) and cloudberry (Rubus chumuemorus) of the family Rosuceue; black currant (Ribes

INCREASED GLUTAMATE RELEASE AND EXPRESSION OF FOS PROTEIN IN THE VTA BY ELECTRICAL STIMULATION OF THE PREFRONTAL CORTEX

*A.I. Virtanen Institute, †Department of Neurology, ‡Department of Pharmacology and Toxicology, University of Kuopio, P.O.Box 1627, FIN-70211, Kuopio, Finland

A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia.

To examine the clinical course of age-associated memory impairment (AAMI) and to evaluate the value of neuropsychological tests in predicting cognitive decline in AAMI subjects in a follow-up period of more than 3 years. Prospective cohort study. The outpatient Memory Research Unit of the Department of Neurology at the University of Kuopio in Eastern Finland. A sample of 229 subjects (mean age 71.7 years) identified in two screening studies as having AAMI. A battery of neuropsychological tests and a structured inquiry for health status and subjective memory complaints were performed at baseline and follow-up to diagnose AAMI according to the criteria proposed by a National Institute of Mental Health work group. Of the 229 subjects, 176 (76.9%) participated in the follow-up for, on average, 3.6 years after the baseline. Of the participants, 104 (59.1%) still met the AAMI criteria. Other subjects were classified into five subgroups: (1) subjects showing decline in cognition meeting dementia diagnosis (16, 9.1% (13 of them AD)); (2) subjects with mild cognitive decline meeting neither dementia nor AAMI criteria (13, 7.4%); (3) subjects with memory performance now superior to AAMI criteria (17, 9.7%); (4) subjects having a disease classified as exclusion in the criteria (15, 8.5%); (5) subjects not now reporting subjective memory loss in everyday life (9, 5.1%). Two subjects (1.1%) were not classified because of incomplete data. Neuropsychological tests predicted which subjects would develop dementia during the follow-up period. The best discriminators between these subjects and those who remained AAMI were memory and verbal fluency tests. The study suggests that, in general, AAMI is nonprogressive, but the AAMI population also includes subjects with early dementia and subjects without genuine memory loss. However, these subjects can be differentiated with a more detailed neuropsychological evaluation.

Partogram of a Grand Multipara

Department of Obstetrics and Gynecology, University of Oulu; and Department of Obstetrics and Gynecology, University of Kuopio, Finland. J Perinat Med 1994;22:213-218

Determinants of femoral and carotid artery atherosclerosis

The aim of the study was to find the most important determinants of early atherosclerosis in the carotid and femoral arteries. Carotid and femoral maximal intima media thickness (IMT) was measured 19 months after the first of 4 risk factor measurements. Department of Community Health and General Practice, University of Kuopio, and Occupational Health Care in Pyhäsalmi Mine, Finland. The subjects comprised 60 male volunteers aged from 32 to 65 years from amongst 277 workers at the Pyhäsalmi Mine, Finland. Subjects were invited for an ultrasound examination, in order of serum total cholesterol content, until the required figure of 60 cases was achieved. Carotid and femoral maximal intima media thickness. Systolic blood pressure (P < 0.01), serum total cholesterol (P < 0.01), age (P = 0.01) and pack-years smoked (P = 0.02) were independent determinants of maximal carotid artery IMT, and total cholesterol (P = 0.01), age (P = 0.03) and pack-years smoked (P = 0.01) for maximal femoral artery IMT. For the latter, plasma fibrinogen concentration (P = 0.10) was the next factor to enter the multiple regression model. Body mass index, heart rate, serum HDL cholesterol, triglycerides, urate, apolipoprotein A1, antithrombin III, lipid peroxides, vitamin E and plasma vitamin C had no significant association with either maximal carotid or femoral IMT or the mean of the carotid and femoral IMT. Systolic blood pressure, serum total cholesterol, age and pack-years smoked are the most important determinants of early atherosclerosis in the carotid artery and total cholesterol, age and pack-years smoked in the femoral artery. Prevention should take into consideration these findings. The role of plasma fibrinogen and oxidized low density lipoprotein would require re-evaluation in larger populations studied longitudinally.

Volumes of hippocampus and amygdala in the MRI-based diagnosis of early Alzheimer's disease : H. Soininen, M.P. Laakso, E-L. Helkala, P. Hartikainen, K. Partanen, P. Vainio, and P.J. Riekkinen Sr. Depts. Neurology and Radiology, University Hospital and University of Kuopio, Kuopio, 70211, Finland

Volumes of hippocampus and amygdala in the MRI-based diagnosis of early Alzheimer's disease : H. Soininen, M.P. Laakso, E-L. Helkala, P. Hartikainen, K. Partanen, P. Vainio, and P.J. Riekkinen Sr. Depts. Neurology and Radiology, University Hospital and University of Kuopio, Kuopio, 70211, Finland

Occupational exposure to electromagnetic fields is associated with increased risk of alzheimer's disease : E. Sobel (University of Southern California, USA), Z. Davanipour (Loma Linda University, USA), R. Sulkava (University of Kuopio, Finland), J.D. Bowman (Cincianti, OH, USA), T. Erkinjuntti (University of Helsinki, Finland), V. Henderson, J.G. Buckwalter (University of Southern California, USA)

Occupational exposure to electromagnetic fields is associated with increased risk of alzheimer's disease : E. Sobel (University of Southern California, USA), Z. Davanipour (Loma Linda University, USA), R. Sulkava (University of Kuopio, Finland), J.D. Bowman (Cincianti, OH, USA), T. Erkinjuntti (University of Helsinki, Finland), V. Henderson, J.G. Buckwalter (University of Southern California, USA)

The effects of THA and nicotine on cognition in experimental models of Alzheimer's disease : P. Riekkinen Jr. and M. Riekkinen. University of Kuopio, Dept. of Neurology, Kuopio, Finland

The effects of THA and nicotine on cognition in experimental models of Alzheimer's disease : P. Riekkinen Jr. and M. Riekkinen. University of Kuopio, Dept. of Neurology, Kuopio, Finland

Long-term, double-blind trial of selegiline in Alzheimer's disease : P.J.Riekkinen, K.Koivisto, E-L.Helkala, T.Hänninen, M.Vanhanen, H.Aaltonen, O.Kilkku and E.Heinonen. Dep. Neurology, University of Kuopio, Kuopio and Orion Corp., Orion-Farmos Pharmac., Turku, Finland

Long-term, double-blind trial of selegiline in Alzheimer's disease : P.J.Riekkinen, K.Koivisto, E-L.Helkala, T.Hänninen, M.Vanhanen, H.Aaltonen, O.Kilkku and E.Heinonen. Dep. Neurology, University of Kuopio, Kuopio and Orion Corp., Orion-Farmos Pharmac., Turku, Finland

Volumes of hippocampus, amygdala, and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes : M. Lehtovirta, M.P. Laakso, H. Soininen, S. Helisalmi, A. Mannermaa, E-L. Helkala, K. Partanen, M. Ryynänen, P. Vainio, P. Hartikainen and P.J. Riekkinen Sr. Department of Neurology, Unit of Clinical Genetics of the Department of Gynaecology and Obstetrics, Department of Radiology, Kuopio University Hospital,

Volumes of hippocampus, amygdala, and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes : M. Lehtovirta, M.P. Laakso, H. Soininen, S. Helisalmi, A. Mannermaa, E-L. Helkala, K. Partanen, M. Ryynänen, P. Vainio, P. Hartikainen and P.J. Riekkinen Sr. Department of Neurology, Unit of Clinical Genetics of the Department of Gynaecology and Obstetrics, Department of Radiology, Kuopio University Hospital,

Drug Information from Pharmacies

AIRAKSINEN, MARJA MSC*; AHONEN, RIITTA; LIE, PHARM*; ENLUND, HANNES PHD* Author Information

Testing sensitive dentine in man

International Endodontic JournalVolume 26, Issue 1 p. 4-4 Testing sensitive dentine in man V. KONTTURI-NÄRHI, V. KONTTURI-NÄRHI Department of Periodontology, University of Kuopio, Kuopio, FinlandSearch for more papers by this authorM. NÄRHI, M. NÄRHI Department of Physiology, University of Kuopio, Kuopio, FinlandSearch for more papers by this author V. KONTTURI-NÄRHI, V. KONTTURI-NÄRHI Department of Periodontology, University of Kuopio, Kuopio, FinlandSearch for more papers by this authorM. NÄRHI, M. NÄRHI Department of Physiology, University of Kuopio, Kuopio, FinlandSearch for more papers by this author First published: January 1993 https://doi.org/10.1111/j.1365-2591.1993.tb00525.xCitations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume26, Issue1January 1993Pages 4-4 RelatedInformation

The relationship of the CSF monoamine metabolites with clinical response to THA in Alzheimer's disease: K. Alhainen, E.-L. Helkala, K. Reinikainen, T. Hänninen and P. Riekkinen. Department of Neurology, University of Kuopio; POB 1627, SF-70211 Kuopio, Finland

The relationship of the CSF monoamine metabolites with clinical response to THA in Alzheimer's disease: K. Alhainen, E.-L. Helkala, K. Reinikainen, T. Hänninen and P. Riekkinen. Department of Neurology, University of Kuopio; POB 1627, SF-70211 Kuopio, Finland

Trail making test in the screening of dementia: An introduction of a new version: M. Vanhanen, T. Hänninen, E.-L. Helkala, K. Koivisto, L. Mykkänen, M. Laakso, K. Pyörälä, PJ. Riekkinen. Departments of neurology and Medicine, University of Kuopio, 70210 Kuopio, Finland

Trail making test in the screening of dementia: An introduction of a new version: M. Vanhanen, T. Hänninen, E.-L. Helkala, K. Koivisto, L. Mykkänen, M. Laakso, K. Pyörälä, PJ. Riekkinen. Departments of neurology and Medicine, University of Kuopio, 70210 Kuopio, Finland

The road to antemortem biochemical tests for Alzheimer's disease (AD): H. Ghanbari 1, B. Miller 1, J. Chong 1, D. Bennette 2, N. Azad 3, J. Wilmer 3, C. Risch 4, C. Nemeroff 4, K. Ericksons 5, K. Reinikainen 6, K. Koivisto 5 and P. Riekkinen 6. 1 Abbott Laboratories, Abbott Park, IL, USA, 2 Rush Alzheimer's Center, Chicago, IL,

The road to antemortem biochemical tests for Alzheimer's disease (AD): H. Ghanbari 1, B. Miller 1, J. Chong 1, D. Bennette 2, N. Azad 3, J. Wilmer 3, C. Risch 4, C. Nemeroff 4, K. Ericksons 5, K. Reinikainen 6, K. Koivisto 5 and P. Riekkinen 6. 1 Abbott Laboratories, Abbott Park, IL, USA, 2 Rush Alzheimer's Center, Chicago, IL,

Alzheimer's disease: A systemic autoimmune disorder with immune complex deposits in peripheral tissues?: H. Soininen, K. Syrjänen, S. Syrjänen, O. Helnonen, R. Miettinen, H. Neittzanmäki, and P. Riekkinen. Depts of Neurology; Pathology; Dermatology; University of Kuopio, SF-70211 Kuopio, Finland

Alzheimer's disease: A systemic autoimmune disorder with immune complex deposits in peripheral tissues?: H. Soininen, K. Syrjänen, S. Syrjänen, O. Helnonen, R. Miettinen, H. Neittzanmäki, and P. Riekkinen. Depts of Neurology; Pathology; Dermatology; University of Kuopio, SF-70211 Kuopio, Finland

D-cycloserine alleviates learning deficit induced by muscarinic blockade in rats: J. Sirviü, T. Ekonsalo, P. Riekkinen, Jr., and P.J. Riekkinen. Dept of Neurology, University of Kuopio, Kuopio, Finland

D-cycloserine alleviates learning deficit induced by muscarinic blockade in rats: J. Sirviü, T. Ekonsalo, P. Riekkinen, Jr., and P.J. Riekkinen. Dept of Neurology, University of Kuopio, Kuopio, Finland

Discrimination of THA responders by short neuropsychological tests in Alzheimer's disease: K. Alhainen, E.-L. Helkala and P. Riekkinen. Dept. of Neurology, University of Kuopio; POB 1627, SF-70211 Kuopio, Finland

Discrimination of THA responders by short neuropsychological tests in Alzheimer's disease: K. Alhainen, E.-L. Helkala and P. Riekkinen. Dept. of Neurology, University of Kuopio; POB 1627, SF-70211 Kuopio, Finland

Neurotransmitter markers in the cerebrospinal fluid of patients with histologically verified Alzheimer's disease : ∗K.J. Reinikainen, H. Soininen, L. Paljärvi §, P.J. Riekkinen. Departments of Neurology and Pathology §, University of Kuopio, 70211 Kuopio, Finland

Neurotransmitter markers in the cerebrospinal fluid of patients with histologically verified Alzheimer's disease : ∗K.J. Reinikainen, H. Soininen, L. Paljärvi §, P.J. Riekkinen. Departments of Neurology and Pathology §, University of Kuopio, 70211 Kuopio, Finland