University Of Kansas Research Articles

Reflections of a Citizen Scientist Educator

Reflections of a Citizen Scientist Educator

The Results of Four Recent Joint Expeditions to the Gobi Desert: Lacertids and Agamids

The National University of Mongolia, the Mongolian State University of Education, the University of Nebraska, and the University of Kansas conducted four collaborative expeditions between 2010 and 2014, resulting in accounts for all species of lacertid and agamid, except Phrynocephalus kulagini. These expeditions resulted in a range extension for Eremias arguta and the collection of specimens and tissues across 134 unique localities. In this paper we summarize the species of the Agamidae (Paralaudakia stoliczkana, Ph. hispidus, Ph. helioscopus, and Ph. versicolor) and Lacertidae (E. argus, E. arguta, E. dzungarica, E. multiocellata, E. przewalskii, and E. vermiculata) that were collected during these four expeditions. Further, we provide a summary of all species within these two families in Mongolia. Finally, we discuss issues of Wallacean and Linnaean shortfalls for the herpetofauna of the Mongolian Gobi Desert, and provide future directions for studies of community assemblages and population genetics of reptile species in the region.

News, Programs, Publications, and Awards

News, Programs, Publications, and Awards

Establishing low-density lipoprotein apheresis tolerability in patients with prior anaphylactoid reactions to lipoprotein apheresis using magnesium sulfate.

Lipoprotein apheresis (LA) tolerability is a key factor for the utilization of this therapy. Common reactions to LA are hypotension and nausea. Serious reactions include severe hypotension and anaphylactoid reactions (0.13%-1.3% and 0.2%-0.4%, respectively). The bradykinin response drives these reactions and can worsen with the use of angiotensin-converting-enzyme inhibitors. Efforts to mitigate these reactions are necessary for the tolerability of LA with a dextran sulfate-adsorption (DSA) system. In an effort to increase apheresis tolerability, seven patients at The University of Kansas, Department of Clinical Pharmacology, who had prior anaphylactoid reactions (defined as general cutaneous flushing, nausea/vomiting, tongue swelling, lightheadedness, and hypotension) to the DSA despite pharmacologic intervention, were treated with pre-LA intravenous magnesium adapted from a protocol developed by co-author Eliaz. This protocol consists of 1.5g of magnesium sulfate administered over 45 minutes. All seven patients were treated with intravenous magnesium sulfate immediately before LA. No episodes of anaphylactoid reactions during LA have been reported to date. Magnesium infusion before DSA can be utilized to establish tolerability in patients with prior anaphylactoid reactions to LA. Proposed mechanisms include temporary stabilization of the negative-positive interactions of the dextran sulfate filter leading to a reduction of circulating bradykinin, reduction of nitric oxide, and reduction of the sympathetic response to LA.

With Plenty of Elbow Room: Planning New and Upgraded Spaces for Library and Archives Conservation and Audiovisual Preservation

In 2018, the University of Kansas (KU) Libraries upgraded from a tired, twenty-year-old basement space to a new, purpose-built conservation lab for library and archives collections. The new conservation lab, which is housed in the special collections and archives library, quadrupled available lab space for its conservators and fleet of student employees. The move afforded Conservation space in the same library as the most vulnerable collection materials. In addition, rooms in the special collections and archives library were repurposed for audiovisual (AV) preservation, creating two new spaces for film and video workflows and upgrading an existing small audio room. This paper will discuss the conservation and preservation lab construction literature and will serve as a practical exemplar of the challenges and successes of the planning process, including lessons learned and unexpected benefits.

Editorial: Scientific Advisors to the Editors

The continued success of the Journal of Pharmaceutical Sciences (JPharmSci®) in publishing the most original and significant scientific research findings in the pharmaceutical sciences is dependent in large part on the exceptional contributions of our Editorial Advisory Board (EAB) in the manuscript review process. The EAB members also participate in the annual selection of Ebert Prize candidates for the American Pharmacists Association and provide guidance to the Editorial Team on current and emerging trends in the pharmaceutical sciences. The JPharmSci® Editorial Team is pleased to announce the re-appointment to the EAB for another 3-year term (January 1, 2021 to December 31, 2023) of the following individuals: Carmen Alvarez-Lorenzo, Universidade de Santiago de Compostela; Cory Berkland, The University of Kansas; Akhilesh Bhambhani, Merck & Co., Inc.; Mino R. Caira, University of Cape Town; Carla M. Caramella, University of Pavia; Merry Christie, Voisin Consulting Life Sciences; Carsten Ehrhardt, Trinity College Dublin; David Elder, David P Elder Consultancy; Igor Gonda, Respidex LLC; Sarah Gordon, Liverpool John Moores University; Richard H. Guy, University of Bath; David J. Hauss, Regeneron Pharmaceuticals, Inc.; Rene Holm, Janssen Pharmaceutica; Munir A. Husssain, MAH Pharma Consulting LLC; Wim Jiskoot, Leiden University; Yukio Kato, Kanazawa University; Bruce Kerwin, Just-Evotec Biologics; Gregory Knipp, Purdue University; William J. Lambert, Module 3 Pharmaceutical Consulting; David Lechuga-Ballesteros, AstraZeneca Pharmaceuticals LP; S. Kevin Li, University of Cincinnati; Hanns-Christian Mahler, Lonza AG; Toru Maruyama, Kumamoto University; Gary McGeorge, Bristol-Myers Squibb; Patrick J. McNamara, University of Kentucky; Natalie Medlicott, University of Otago; José Ramón Moyano-Méndez, University of Seville; Eric Munson, Purdue University; Amber Haynes Raines, KBI Biopharma; Jukka Rantanen, University of Copenhagen; Larry Rosen, Venatorx Pharmaceuticals; Habil. Christoph Saal; Merck KGaA; Christian Schöneich, The University of Kansas; David Spencer, Ipsen; Robert M. Straubinger, University at Buffalo; Changquan Calvin Sun, University of Minnesota; Raj Suryanarayanan, University of Minnesota; Lynne Taylor, Purdue University; Frank-Peter Theil, UCB Biopharma; Masatoshi Tomi, Keio University; Nicolas Tsapis, Université Paris-Saclay; Guy Van den Mooter, University of Leuven; Michel Vert, CNRS – University of Montpellier; Nicholas W. Warne, Pfizer; and Kouichi Yoshinari, University of Shizuoka. The JPharmSci® Editorial Team would like to publicly thank the following individuals who have served on the JPharmSci® EAB and who will retire from the EAB effective December 31, 2020: Sunny Bhardwaj, Merck & Co.; Maria Jose Cocero Alonso, Universidad Valladolid; Xavier Decleves, Université Paris Descartes; Barrie C. Finnin, Monash University; Yatin Gokarn, Sanofi; Hiroyuki Kusuhara, University of Tokyo; Masanori Tachikawa, University of Tokushima; Mikihisa Takano, Hiroshima University; Yasuo Tsutsumi, Osaka University; Timothy Wiedmann, University of Minnesota; and Akira Yamamoto, Kyoto Pharmaceutical University. We are also pleased to announce the appointment of new EAB members for 3-year terms starting on January 1, 2021. These new members of the JPharmSci® EAB include: Shin-ichi Akanuma, University of Toyama; Marianne Ashford, AstraZeneca; Sudip K. Das, Butler University; Camilla Foged, University of Copenhagen; Akiko Ishii-Watabe, National Institute of Health Sciences; Wooin Lee, Seoul National University; Wilna Liebenberg. North-West University; Wei Qi, Amgen Inc.; and Natalie Trevaskis, Monash University. Together with the re-appointments and new appointments, the JPharmSci® EAB membership is now at 234 members. The JPharmSci®’s Editorial Team believes that the composition of the EAB appropriately reflects the diversity of scientific disciplines served by the journal and the diversity of its international audience. In addition, we feel that the EAB is sufficiently large to ensure that an adequate number of experts are available to conduct timely reviews of the approximately 1200 manuscripts per year that are submitted to JPharmSci®. Finally, as EIC I would like to take this opportunity to thank all of the EAB members, the Editors, and the Editorial Office Staff for their dedication to the success of JPharmSci® this past year and going forward into 2021. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Erratum to “Editorial: Scientific advisors to the editors” [J Pharm Sci 110 (2021) 988]Journal of Pharmaceutical SciencesVol. 110Issue 4PreviewThe title of the Editorial was mistakenly reversed with another Editorial in both the Table of Contents and on the papers themselves in the March 2021 issue of the Journal of Pharmaceutical Sciences. Full-Text PDF

ACRL candidates for 2021: A look at who’s running

Emily Daly is the head of assessment and user experience at Duke University Libraries, a position she has held since 2013. Prior to this, Daly served at Duke University Libraries as interim head of instruction and outreach (2012) and coordinator of upper-level instruction (2006–12). She also served as media coordinator at Southern High School in Durham, North Carolina (2005–06).Erin L. Ellis is the associate dean of research and learning services at Indiana University, a position she has held since 2018. Prior to this, Ellis held various positions at the University of Kansas, including associate dean of research and learning (2013–18), head of instructional services (2009–13), and social sciences librarian (2005–09).

A Student-Led Approach to Integrate ASPEN Plus¬ in the Chemical Engineering Curriculum at The University of Kansas

Simulation software has experienced growing interest in chemical engineering curriculums for its usage in commercial engineering practices.  This article describes the ASPEN Plus® version 10 (V10) simulations and a student teach students approach to integrate ASPEN in the chemical engineering curriculum at the University of Kansas (KU). Videos, handouts, and lectures created by the first author, an undergraduate senior, effectively teaches ASPEN to other chemical engineering students and enhances the learning experience of the classroom.

John Wolfe Dardess: January 17, 1937–March 31, 2020

John Wolfe DardessJanuary 17, 1937–March 31, 2020 Ruth W. Dunnell On March 31, 2020, the community of Chinese historians lost a distinguished, pioneering, and prolific scholar of Yuan and Ming history with the passing of John Dardess. An active member of the University of Kansas Department of History from 1966 until his retirement in 2002, Dardess was an engaged scholar and mentor up to his death. His lifelong study of the Ming dynasty produced nine books on diverse topics across the centuries of Ming rule, the last of which was posthumously published,1 numerous substantive articles, and dozens of book reviews. Although Dardess cherished his privacy, he was generous with his gifts and his absence is felt keenly by former colleagues and students at the University of Kansas. One remarked, "I had tremendous respect for him and was always in awe of his ability to read Ming historical documents, which to me were not so easy to decipher, but which he could take and turn into rich, interesting, and very readable narrative."2 A graduate student whom Dardess agreed to tutor in nineteenth-century Qing sources confessed: "watching him read through Zuo Zongtang without need of a dictionary remains a thrilling memory."3 Dardess's career in Ming studies began with an exploration of its origins in the thirteenth and fourteenth centuries; these early publications on Yuan history remain essential references for scholars in the field today. Readers will find a detailed obituary by Sarah Schneewind, reviewing his Ming work, along with a bibliography of his publications compiled by Vickie Fu Doll, in Ming Studies 82 (2020). This remembrance will focus on Dardess's scholarship on the Yuan and the Yuan-Ming transition, and the legacy of his work to that field. [End Page ix] John Dardess unapologetically declared himself committed to exploring the political history of the Ming era, a choice not much in fashion in recent decades. Yet his body of work and impeccable scholarship demonstrate the capaciousness of the field and the rewards of tilling it. His commitment was a product of his own origins, coming of age at the beginning of the Cold War. As Dardess explained in a December 2011 interview, his life-long interest in political history and autocrats began at age seven or eight, when his father served as a surgeon under General Patton in France after D-Day.4 "Adolf Hitler and his god-awful political military machine" was something he could "feel, touch, and smell" from the battlefield souvenirs his hero-father sent home to him. Hitler died but Stalin lived, until 1953, while Mao was still too remote (it is difficult for scholars born after 1960 or so to grasp how utterly cut off Americans were from China from the late 1940s until the mid-1970s). So Dardess studied Russian language and history at Georgetown, earning a B.A. there in 1958. Then the U.S. Army Language School introduced him to Chinese and sent him to Taiwan in ca. 1959–60. Dardess's subsequent arrival at Columbia University, where he completed a Ph.D. in 1968, coincided with the birth of Ming studies and the Ming Biographical History Project, to which he contributed biographies of several late Yuan figures.5 His participation in Wm. Theodore de Bary's seminar on Chinese thought left an indelible impression on classmates such as historians Ted (Edward) Farmer and Morris Rossabi, who noted his qualities of modesty, humor, and extraordinary aptitude for the most impenetrable classical Chinese texts.6 In Dardess's view, Zhu Yuanzhang (Hongwu, Ming Taizu) bore striking similarities to the founding dictators of the twentieth century. To understand the Ming founder required probing the conditions from which he emerged. His early work on the Mongol-Yuan and the fourteenth-century transitional era illustrates the breadth of his scholarship: •. "The Transformations of Messianic Revolt and the Founding of the Ming Dynasty." Journal of Asian Studies 29.3 (May 1970): 539–558. •. "From Mongol Empire to Yüan Dynasty: Changing Forms of Imperial Rule [End Page x] in Mongolia and Central Asia." Monumenta Serica 30.1 (1972–73): 117–165. •. Conquerors and Confucians: Aspects of Political Change in Late Yuan...

Editor’s Note

Editor’s Note Eero Laine, Assistant Professor I am hearing from friends and colleagues in various parts of the world that they are attending theatre again—in person. Of course, some never really stopped going to the theatre because of exceptional public health measures in their area or country and others still are now in the midst of the worst crises of the pandemic to date. Indeed, in light of these extremely uneven turns of the past year and as we labor over and through theories of drama and criticism, we might mark both the sometimes insignificance of theatre in the face of a virulent disease, and yet how much it means. That is, those everyday experiences from before the global sweep of the pandemic are anything but mundane today. Not that attending theatre was necessarily steeped in mundanity, but it was and is and will be part of the day-to-day life of the cities and communities we live in and around. The bulk of this issue is devoted to Michelle Liu Carriger’s edited special section “#PerformativeX,” which examines the uses and misuses of the term “performative” and the ways its definition may have changed through circulation. As theatre was disrupted by the pandemic (at least for most of the authors in the special section, from what I can tell of their geography), theatrical and performance studies language crept outward into popular discourse and on social media. This timely special section reframes central questions of theatre and performance theory and offers readers a number of entries into a term that is both common and complex. Together, the authors of the special section direct us toward the etymology and theoretical genealogy of performative actions, gestures, and utterances, while thinking through their current and potential future uses. The three original research articles in this issue examine a range of subjects and methodologies through which the journal considers dramatic theory and criticism. In “Against the Flows of Theory: Expanding the Ghost with Japanese Noh,” Jessica Nakamura reconsiders theories of ghosting and ghosts in the theatre. Furthering field-defining conversations on the directionality of knowledges and assumptions around epistemological centers, Nakamura’s article pushes the field to move beyond many of its assumptions about both its form and representation. Alison Walls’s “Black and White in Black and White: Branden Jacobs-Jenkins’s Sensation Scene in An Octoroon,” examines the key scenes in the critically acclaimed play and the ways that plays on theatrical genre opens the play to and implicates the audience. Finally, Patrick Scorese takes on longstanding questions of the field in “‘The Act of Sepulcher’: Effigies and Other Affects Toward a Theory of Historiographic Performance.” Here, Scorese draws on a comparative approach that places his own performance work among other theatre and performance artists and playwrights to show theory in practice. There are a number of other current and upcoming transitions at the journal. I want to first thank Chris Hall for his many years of service to the journal as the Managing Editor. Chris has been an invaluable member of the JDTC team during my [End Page i] time as Editor. Chris will be leaving JDTC as he recently defended his dissertation in the English Department at the University of Kansas and has accepted a tenure track job for the upcoming school year. Congratulations to Chris! We are quite happy to welcome Kaitlyn Tossie as the new Managing Editor, who has already begun work with this issue of the journal. Lastly, we’re incredibly pleased that Michelle Liu Carriger will be taking over the role of Editor from me at the beginning of 2022. If the special section in this issue is any indication, the journal is in very good hands and has a very bright future. That means that this is my penultimate issue with the journal—in the meantime, I am working with Kevin Brown and Felipe Cervera, the editors of Global Performance Studies, along with Kristof van Baarle and Kyoko Iwaki, to co-edit a joint issue of GPS and JDTC this fall. The joint issue will feature collaboratively written theatre and performance scholarship, a topic and methodology that has become especially dear to...

Ruth Klüger on Vienna and Austria: An Interview

Ruth Klüger on Vienna and AustriaAn Interview Mark H. Gelber (bio) and Ruth Klüger Ruth Klüger (1931–2020) passed away on October 5, 2020, in the United States. Born in Vienna and deported to Theresienstadt, she survived Auschwitz and the Shoah together with her mother. After living in Germany for a short time after World War II, she immigrated to New York. She was educated in the United States and received degrees in English literature as well as her PhD in German literature from the University of California, Berkeley. She taught at several American universities, including Case Western Reserve University in Cleveland, the University of Kansas, the University of Virginia, the University of California, Irvine, and Princeton University. She finished her distinguished academic career at the University of California, Irvine. She has numerous scholarly publications to her credit, mainly in the fields of German and Austrian Literatures. She is also recognized widely as a poet, essayist, and feminist critic. She returned to Europe, where she was a guest professor in Göttingen and Vienna. Her memoir, entitled weiter leben (1991), a major bestseller, was a highly regarded autobiographical account and was subsequently translated into more than a dozen languages. It has also generated a vigorous critical discussion in its own right. Ruth Klüger received numerous prestigious literary prizes and other distinctions. In 2016 I was preparing a lecture that focused on Ruth Klüger's Zerreißproben (2013), to be delivered at a session on contemporary Austrian writing at an international conference in Europe. At one point I decided to ask her if she would agree to answer some questions about her relationship to Vienna and Austria, hoping that her replies would help me to understand her and perhaps [End Page 109] also her poetry better. I did not intend to publish the interview. After Ruth's recent death in 2020, I was going through some old correspondence and papers, and I came across that interview with her. I present it here in its entirety. ________ Mark Gelber: Please describe your feelings and relationship to Vienna and Austria today. If possible, please distinguish between the different periods of your life: childhood, after Anschluss, after deportations, during and after the war, in the U.S., after you returned to visit in Europe, and after your return to visit in Vienna, as well. My premise is that your relationship with Germany is much different from your relationship with Austria, and that your feelings about Vienna are complicated and conflicted. Ruth Klüger: Vienna was home only for the first years of my life. After I was six and a half, it became exile, a place one wanted to leave. That's significantly different from Walter Sokel and Egon Schwarz, who were older.1 They both had time to bond with classmates and come to know the city without restrictions. When I was about nine, I learned about Zionism, and from then on I was firmly committed to the idea and thought I knew where I belonged. After the war, before emigration to the U.S. in 1947, I visited Vienna briefly with my mother, and I didn't like it. I had an eerie feeling that I was visiting a graveyard and that the people living there didn't know it was a graveyard. MG: Walter Sokel wrote that he had nagging feelings of guilt when he took up the study of German literature in the U.S., given what had taken place in Europe during and after the Shoah. Did you have similar misgivings at any time? RK: When I decided to write a PhD in German literature, I already had an MA in English and a librarian's degree—and a job as a public librarian. But since I had little money and the German Department in Berkeley needed teaching assistants, it seemed to me to be a chance to spend a life doing something I would love. Still, it was like indulging a vice—the love of things German. And I lost friends as a result, specifically Jews to whom I became suspect. My mother never showed the slightest respect for my profession. And...

“Business as Usual,” But What Is Usual?

“Business as Usual,” But What Is Usual?

Redesigning a Journalism Course to Integrate IL: A Case Study

This case study discusses the integration of information literacy instruction and assessment in a required research course for students of journalism and strategic communication at the University of Kansas. The integration consisted of four components: (1) a unifying threshold concept, (2) an open textbook, (3) a sequence of five assignments, and (4) an early- and late-semester assessment of student information literacy attainment. Qualitative and quantitative data were used to evaluate course components and to guide ongoing course revisions. The course redesign addressed the challenge of creating a sustainable structure for IL instruction. Discipline-specific obstacles stemmed from divergent information values and distinct information-handling conventions in journalism-related professions.

A Curiosity of Cabinets: Collections Care as Community Care

As museum and library doors shuttered in response to COVID-19, digital portals opened new possibilities for centering collections as an antidote to social isolation. A joint effort between the University of Kansas’s (KU) Spencer Museum of Art and KU Libraries demonstrates how the constraints of physical distancing as a preventive health measure prompted the creation of a “hands-off,” yet interactive series of programs about preventive conservation strategies to apply to collections at home. The goal was to sustain a sense of community with Friends of the Museum and Friends of the Libraries by triangulating among institutional collections, examples from staff members’ homes, and the invitation for Friends to share their collections. As the series evolved with the pandemic, the role and messaging of collections care shifted as an act of community care. This article will discuss the process, challenges, and impact of this collaboration.

NEWER TECHNOLOGIES FOR THE DELIVERY AND MANAGEMENT OF DISTANCE AND E-LEARNING

Distance learning through e-learning courses has become the most important and commonly requested mode of learning in the higher education system over the past decade. Many aspects of our lives have been upended by COVID-19 including education. Distance education became a requirement at lightning speed, due to the pandemic and worldwide shutdown. According to the University of Kansas, at the height of the COVID-19 outbreak in early April, more than 1.5 billion students, or 91.3 percent of global enrolment, were directly affected by school closures. The question of whether or not to migrate from physical classroom is no more the priority but how quick and efficiently we can adopt distance learning. This paper evaluates the incorporation of the emerging technologies into the concepts of distance learning in terms of efficiency in the teaching and learning environment at universities, polytechnics and colleges.

«ПРОСТО МОЛОДОЙ ТУРИСТ В НАШЕЙ СТРАНЕ»: ЛИНГВИСТ И АНТРОПОЛОГ НЕЗ-ПЕРС АРЧИ ФИННИ

Born in Culdesac, ID, Archie Phinney, a Nez Percé, was the first Native American to receive an undergraduate degree from the University of Kansas. He collaborated with prominent Smithsonian anthropologists J. N. B. Hewitt and T. Michelson as well as the great Franz Boas; visited Leningrad after being invited by Vladimir Bogoras in the context of an academic exchange program; defended his candidate thesis at the Institute of Anthropology, Archeology and Ethnography (MAE); and returned to serve as an Indian agent in different reservations in the USA. The USSR scholarship of Phinney fell on a difficult yet crucial period in the history of Soviet ethnography, when it was not yet completely closed and remained receptive to the influences of Boas’ School. Through Phinney and other American researchers like him, who visited the Soviet Union at that time, the Soviet practice of “indigenization” had a reverse effect on J. Collier’s liberal Indian New Deal. Phinney collaborated with the Bureau of Indian Affairs, when the latter was on the Indian Commissioner’s post. Today, Phinney’s figure again attracts interest after some oblivion. The department of anthropology at the University of Idaho, Moscow, occupies a building named in his honor. The scope of the paper is based on the Boas Paper collection — his correspondence with Phinney, Bogoras, Averkieva, Barton and others, stored at the American Philosophical Society, Philadelphia. The analyzed materials, representing the general atmosphere in the 1930s Soviet academic community, are still little-known to the Russian-speaking reader.

Mosunetuzumab, a Novel CD20/CD3 Bispecific Antibody, in Combination with CHOP Confers High Response Rates in Patients with Diffuse Large B-Cell Lymphoma

Mosunetuzumab, a Novel CD20/CD3 Bispecific Antibody, in Combination with CHOP Confers High Response Rates in Patients with Diffuse Large B-Cell Lymphoma

First-in-Human Phase I Trial of Adoptive Immunotherapy with Ex Vivo Expanded and Activated Γδ T Cells Following Haploidentical Bone Marrow Transplantation and Post-BMT Cyclophosphamide

INTRODUCTION: HAPLO BMT combined with cyclophosphamide infusion on days +3 and +4 following BMT (PTCy) for patients that lack an HLA-matched donor provides effective graft versus host disease (GVHD) prophylaxis but with a heightened risk of disease recurrence likely due to prolonged immunodeficiency. Multiple studies have shown that increases in circulating donor-derived gamma delta (γδ) T cells during the early post-transplant period is strongly associated with significant improvement in disease-free survival (DFS). We developed a clinical protocol to engineer this effect by infusing escalating doses of ex vivo expanded and activated donor γδ T cells (EAGD) during this period of immunodeficiency as prophylaxis against disease recurrence. As innate immune effectors γδ T cells immediately recognize and kill malignant cells in a broad-based non-MHC restricted manner and do not initiate GVHD. STUDY DESIGN AND METHODS: This single-center Phase I clinical trial of allogeneic haploidentical BMT + EAGD (NCT03533816), currently underway at the Kansas University Cancer Center, represents the first time BMT patients have received a large infusion of EAGD from a haploidentical donor during the early post-transplant time period. Subjects ≥18 years of age with AML, ALL, CML or MDS either in morphologic complete remission with high risk features, in first complete remission, or chronic phase (CML) eligible for BMT are enrolled in a 3 x 3 design with escalating EAGD doses from 1 x 106/kg to 3 x 106/kg to 1 x 107/kg. Subjects must have adequate organ function and a KPS ≥70. Any subjects with central nervous system neoplastic involvement, HIV infection, or a life expectancy <12 weeks are excluded. Haploidentical donors provide an initial non-mobilized leukapheresis product from which EAGD are manufactured and an unmanipulated bone marrow harvest as the source of hematopoietic stem cells. Closed system EAGD manufacturing is performed in the Miltenyi Prodigy® bioreactor by expansion of γδ T cells in conjunction with αβ T cell depletion. Specimens for composition, viability, sterility, identity, and purity are obtained prior to cryopreservation and results obtained prior to infusion. Subjects undergo standard of care conditioning therapy with fludarabine and cyclophosphamide followed by BMT and post-BMT cyclophosphamide (Cy). The EAGD product is thawed and infused directly within 5 days of neutrophil engraftment (ANC >500/mL for 3 consecutive days). Peripheral blood is collected at screening, pre and post EAGD infusion, then monthly thereafter through Day 100 with additional samples collected every 6 months through 1 year and annually thereafter. Biologic parameters include leukemia phenotype and genomics, multiparameter peripheral blood immunophenotyping, single-cell and serum Th1/Th2/Th17 cytokine analysis, and immunogenomics for both peripheral blood and the EAGD cell product. Primary endpoints include the following safety assessments; laboratory parameters, viral monitoring, physical exams, acute and chronic GVHD, as well as biopsy pathology. Relapse and overall survival will be measured as secondary endpoints. Descriptive statistics under each specific dose will be used to summarize baseline characteristics, safety variables and efficacy outcomes. Kaplan-Meier curves and summary statistics will be used to summarize time-to-event outcomes. STATUS: To date, 3 female subjects (age range, 44 - 54) with AML have been enrolled with 2 subjects receiving the EAGD infusion. To have no treatment-related adverse events have been recorded Disclosures Lamb: In8bio: Current Employment, Current equity holder in private company. Beelen:In8bio: Current Employment, Current equity holder in publicly-traded company. Youngblood:In8bio: Current Employment, Current equity holder in publicly-traded company. McGuirk:Pluristem Ltd: Research Funding; Allo Vir: Consultancy, Honoraria, Research Funding; Kite Pharmaceuticals: Consultancy, Honoraria, Research Funding, Speakers Bureau; Bellicum Pharmaceutical: Research Funding; Astellas: Research Funding; Fresenius Biotech: Research Funding; Novartis: Research Funding; Gamida Cell: Research Funding; Juno Therapeutics: Consultancy, Honoraria, Research Funding.

H. George Frederickson, HOT TICKETS, Crimes, Championships, and Big Time Sports at the University of Kansas (Jefferson, NC: McFarland Books, 2019). 256 pp. $25.00 (soft cover), pISBN: 978‐1‐4766‐7787‐3; eISBN: 978‐1‐4766‐3748‐8

<i>H. George Frederickson</i>, HOT TICKETS, Crimes, Championships, and Big Time Sports at the University of Kansas (<i>Jefferson, NC: McFarland Books, 2019). 256 pp. $25.00 (soft cover), pISBN: 978‐1‐4766‐7787‐3; eISBN: 978‐1‐4766‐3748‐</i>8

Editorial Letter

Editorial| November 01 2020 Editorial Letter Eric C. Rath Eric C. Rath Eric C. Rath is Professor of History at the University of Kansas, where he teaches courses on food history and premodern Japan. A specialist in Japanese food, his books include Food and Fantasy in Early Modern Japan (University of California Press, 2010), Japan's Cuisines: Food, Place and Identity (Reaktion Books, 2016), and the forthcoming Oishii: The History of Sushi (Reaktion Books, 2021). Search for other works by this author on: This Site PubMed Google Scholar Gastronomica (2020) 20 (4): iv–vi. https://doi.org/10.1525/gfc.2020.20.4.iv Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Eric C. Rath; Editorial Letter. Gastronomica 1 November 2020; 20 (4): iv–vi. doi: https://doi.org/10.1525/gfc.2020.20.4.iv Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentGastronomica Search This content is only available via PDF. © 2020 by the Regents of the University of California. All rights reserved. Please direct all requests for permission to photocopy or reproduce article content through the University of California Press's Reprints and Permissions web page, http://www.ucpress.edu/journals.php?p=reprints.2020 Article PDF first page preview Close Modal You do not currently have access to this content.