University Of Bari Research Articles

Structural design and experimental tests on a model of tensegrity greenhouse prototype

The aim of this paper is the analysis, proposal and application of a structural tensegrity configuration for greenhouses supporting structures suitable for lightweight covering, based on principles of design coherence, material savings and building durability. By means of the FEM software, Sofistik®, a tensegral greenhouse prototype was modelled and designed in accordance with EN 13031-1:2019. In order to calibrate the results of the FEM analysis, experimental load tests and displacement measurements made with a tensegrity reduced scale model on a tensegrity reduced scale model, created at the Department laboratory of the University of Bari, were compared with the results of the calculation analysis. The displacements of the prototype selected nodes were detected by Target tracking Technology in two load configurations and a control transducer was positioned on the central structural node. The comparison among the displacements of the detected nodes with those resulting from the FEM software calculations, for two different load configurations, show average percentage errors of 7.1% and 12.55%. The results of the T test for the different load configuration point out that the two series of values experimentally detected and calculated by the software are not significantly different. Finally, results in terms of the structural steel weight and maximum stress of the tensegral structure were compared with those of commercial structures, both with vaulted roof and duopitched roof, of single span greenhouses having the same covered ground area of the greenhouse prototype. The proposed tensegrity greenhouse prototype showed a 9.6% and 35.2% reduction of the structural steel weight compared to the vaulted roof and to the duo-pitched roof greenhouse respectively.

Reduction of Sniff Nasal Inspiratory Pressure (SNIP) as an Early Indicator of the Need of Enteral Nutrition in Patients with Amyotrophic Lateral Sclerosis.

Percutaneous endoscopic gastrostomy (PEG) is the standard procedure for feeding severely dysphagic patients with amyotrophic lateral sclerosis (ALS). It is associated with prolonged survival and improvement in quality of life. Nasal inspiratory pressure during a sniff (SNIP) is a respiratory test used extensively in ALS for the assessment of inspiratory muscle strength. In this study, we aimed to investigate the role of SNIP at baseline to predict PEG placement in ALS. Data from a clinical incident cohort of 179 ALS cases attending the multidisciplinary ALS unit of the University of Bari between April 2006 and December 2012 were retrospectively analysed. At baseline, patients underwent detailed neurological, nutritional and respiratory assessments, including measurements of SNIP and forced vital capacity (FVC). Patients were therefore followed up approximately every three to six months until they were able to attend the centre. The censoring date for the survival analysis was 15 April 2014, with PEG placement as the main outcome. Cox proportional hazard regression models were used to examine the association between SNIP and PEG placement, adjusted for possible confounders. During the follow-up period, 75 participants (42%) received PEG implant. PEG placement was more frequent (57% vs. 31%; p = 0.001) and earlier (after 11.6 ± 14.0 months from the first visit, vs. 23.3 ± 15.5 months; p < 0.0001) in the group of patients with baseline SNIP ≤ 40 cm H2O. Baseline SNIP was a predictor of PEG placement even after correction for multiple potential confounders (HR 0.98; 95% CI: 0.96–0.99; p = 0.02). To conclude, the present study showed that SNIP at baseline is an early indicator of disease progression and therefore of the need for enteral nutrition in ALS.

Surgical, histological, and immunohistochemical approach to spontaneous malignant mammary tumor in a fancy rat (Rattus norvegicus domestica): a case report

A domestic rat (Rattus norvegicus domestica) was presented to the Department of Veterinary Medicine of the University of Bari “Aldo Moro” (Bari, Italy) for the presence of a progressive growing unilateral mass. The mass was completely surgically removed, and then histologically and immohistochemically evaluated. The lesion was diagnosed as mammary ductal carcinoma based on histopathological examination. Immunohistochemistry staining for estrogen receptor alpha (ERα) and proliferation marker Ki-67 were found to be positive. The rat was rechecked 3 months thereafter, with total body radiographs taken for metastatic assessment, and no macroscopic evidence of tumor recurrence was observed at the surgical site. Thus, the most effective weapon remains prevention, so owners should be advised to timely spay their pets to reduce the probability of mammary tumor appearance.

Laboratorio di traduzione audiovisiva e accessibilità. L’esperienza degli studenti

Silvio De Toma, Fabio Di Bari, Dalila Monachino, Simona Specchio and Roberta Valenzano describe their experience as graduate students of the Audiovisual Tanslation and Accessibility course at the University of Bari (2017-18). More specifically, they focus on the challenges they faced during the workshop on the subtitling and audio description of the docufilm Varichina - La vera storia della finta vita di Lorenzo De Santis (2016).

Scedosporium apiospermum contact lens-related keratitis: a case report and literature review.

Scedosporium apiospermum (SA) is commonly present in temperate climates. It can induce cutaneous and subcutaneous tissue infections as well as disseminated infections in immunocompromised or immunocompetent hosts. The eye is rarely involved. Keratomycosis is usually caused by plant-related injuries. Here, we describe a patient with a severe and sight-threatening corneal abscess caused by SA, which was associated with contact lens wear and was successfully treated with a combination of surgical and medical therapies. An otherwise healthy 22-year-old woman, with history of contact lens wearing, was referred to the Ophthalmic Department of Bari University, Bari, Italy for evaluation of a corneal abscess and hypopyon in her left eye. Intensive topical and systemic antibiotic therapy was initiated after obtaining con- junctival swabs. Within 2 days, her ophthalmic condition had worsened, and her best-corrected visual acuity (BCVA) dropped to counting fingers. She underwent penetrating keratoplasty, after which her ophthalmic condition improved. Microbiological culture, obtained from the explanted cornea, revealed SA infection. This was addressed with specific topical and systemic therapy using voriconazole. Two weeks later, the con- dition of her left eye was stable, with mild corneal edema and no sign of acute graft rejection. Her BCVA improved to 20/25, and all medications were discontinued, except for the steroid eye drop. The patient was scheduled for a 1-month follow-up. Prompt identification of the etiological agent is mandatory to perform appropriate therapy in cases of keratomycosis. Surgery to remove the infected cornea is helpful in patients with deteriorating condition, in whom the initial medical therapy has failed. Topical and systemic antimycotic therapy, based on microbiological culture, is recommended as an adjunctive therapy for the surgical management of severe corneal mycotic abscesses.

Evaluation of prognostic histological parameters proposed for pleural mesothelioma in diffuse malignant peritoneal mesothelioma. A short report

IntroductionDiffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with poor survival that shares some similarities with the best-known pleural variant, pleural mesothelioma. The recent European Reference Network on Rare Adult Cancers (EURACAN)/International Association for the Study of Lung Cancer (IASLC) proposals attempted to improve the histological diagnosis and patient risk stratification. Herein, we investigated whether the pathology recommendations and suggestions of the pleural proposals were applicable to diffuse malignant peritoneal mesothelioma.MethodsFifty multiple laparoscopic biopsies of DMPM were consecutively collected at the Pathology Unit of the University of Bari. A two-tier system, i.e., low, and high grade, was used to categorize 34 epithelioid DMPMs. Architectural patterns, cytological features and stromal changes were also reported. Immunohistochemistry was performed for BRCA1-associated protein 1 (BAP1), programmed death-ligand 1 (PD-L1), and Ki67, while fluorescence in situ hybridization (FISH) was performed for p16/cyclin-dependent kinase inhibitor 2A (CDKN2A).ResultsHigh-grade epithelioid mesothelioma, high Ki67, and p16/CDKN2A deletion were significantly associated with short survival (p = 0.004, p < 0.0001, and p = 0.002, respectively). BAP1 loss and PD-L1 negativity were the most common findings. Multivariate analysis revealed that the nuclear grading system and p16 deletion significantly correlated with survival (p = 0.003 each).ConclusionsThe present study examined the prognostic significance of several factors proposed for pleural mesothelioma in an extra pleural site. Notably, the introduction of a grading system may provide better risk stratification in epithelioid DMPM. Ki67, BAP1 and p16/CDKN2A should also be measured whenever possible. A detailed report with all supportive data would allow us to collect sufficient information for use in further studies on larger case series.

"Effects of Lactobacillus Reuteri NBF 1 DSM 32203 Supplementation on Healthy Dog Performance"

Benedetta Belà1*, Giulia Pignataro1, Roberta Di Prinzio1, Daniele Di Simone2, Paolo Emidio Crisi1 and Alessandro Gramenzi1 Author Affiliations 1Faculty of Veterinary Medicine, University of Teramo, 64100 Piano d’Accio - Teramo, Italy 2Department of Economics and Finance, University of Bari, Largo Abbazia Santa Scolastica 53, 70124 Bari, Italy Received: July 07, 2021 | Published: July 13, 2021 Corresponding author: Benedetta Belà, Faculty of Veterinary Medicine, University of Teramo, 64100 Piano d’Accio - Teramo, Italy DOI: 10.26717/BJSTR.2021.37.005956

The Casuccio-Santacroce-Banfo knee arthroscope: an avant-garde Italian tale in the history of arthroscopy.

This brief historical note describes an arthroscopic instrument presented in Italy in 1950, and still preserved to this day at the library of the Rizzoli Orthopedic Institute in Bologna, Italy. A research on Casuccio, Santacroce, and Banfo prolific scientific collaboration was performed. The arthroscopic instrument was designed and utilized at the Orthopedic Clinic of the University of Bari, directed by Professor Casuccio, in collaboration with his assistant, Antonio Santacroce, and Giorgio Banfo, an orthopedist, entrepreneur, and owner of a modern establishment dedicated to the production of orthopaedic products and medical instruments. Much like America and Japan, 1950s Italy offered avant-garde arthroscopic instruments, which resulted from a masterful collaboration of research and development.

Long -term persistence of antibodies against varicella in fully immunized healthcare workers: an Italian retrospective cohort study

BackgroundChickenpox is a highly contagious disease caused by the varicella zoster virus (VZV), and in infants, adolescents, adults, pregnant women, and the immunocompromised it can be serious. The best way to prevent chickenpox is immunization with the varicella vaccine. Protective levels of antibodies induced by the varicella vaccine decline over time, but there is currently no formal recommendation for testing anti-varicella zoster virus (VZV) IgG levels in immunized healthcare workers (HCWs).MethodsThe aims of this study were to evaluate the seroprevalence of circulating anti-VZV IgG in a sample a sample of students and residents of the medical school of the University of Bari, the long-term immunogenicity of the varicella vaccine, and the effectiveness of a strategy consisting of a third vaccine booster dose. The study population was screened as part of a biological risk assessment conducted between April 2014 and October 2020. A strategy for the management of non-responders was also examined.ResultsThe 182 students and residents included in the study had a documented history of immunization (two doses of varicella vaccine). The absence of anti-VZV IgG was determined in 34% (62/182; 95%CI = 27.2–41.4%), with serosusceptibility more common among males than females (p < 0.05). After a third varicella dose, seroconversion was achieved in 100% of this previously seronegative group. No serious adverse events were recorded.ConclusionsOne-third of the study population immunized against VZV lacked a protective antibody titer, but a third dose of vaccine restored protection. Since it is highly unlikely that VZV will be eliminated in the immediate future, the loss of immunity in a substantial portion of the population implies a risk of varicella outbreaks in the coming years. Screening for varicella immunity in routine assessments of the biological risk of medical students and HCWs may help to prevent nosocomial VZV infections.

Improvement of Sensor Technology for Monitoring Vocs in Harbour and Maritime Areas: Use Case and first Findings

Fugitive emissions of Volatile Organic Compounds (VOCs) resulting from industrial sources (e.g. storage tanks, gas pipelines or exhausted areas) are often sources of great concerns due to the release of unpleasant odors, irrespective if there is, or is not, a potential health impact (Manes et al., 2011). In this regard, trends of total VOCs are useful to detect the release of organic substances into the atmosphere for correlating them with potential odor harassments.Sensors based on photoionization principle have been successfully tested for continuous monitoring of the volatile organic compounds in ambient air: at the fence of productive plants; close to industrial factories or urban settlements (Locke et al., 1965). PID sensor is already proofed (University of Bari) for providing accurate data with detectable levels in the order of ppb, even in presence of high humidity conditions (Di Gilio et al., 2018). The aim of this study was the test of an innovative sensor technology (NetPID, Lab Service Analytica) capable of operating in hard weather conditions such as maritime environment, where equipment is exposed to high levels of moisture and condensate marine aerosols (droplet, not solubilized particles) (ref. MiniPID manual). The experimental design required the implementation of several PID detectors, placed on boats for dynamic monitoring of volatile organic compounds in an industrial harbour (Tsow et al., 2009). Electronic compensation for suppressing the non-specific contribution of moisture has been improved on these sensors: this led to a sensitivity below the ppb. In addition, flow chambers have been engineered and developed. Sensors have been also integrated on the dedicated smart network platform for collecting real-time data and trends with high resolution. Thanks to the data given by NetPID by the IoT platform, managers were so able to compare them with periodic information on port activities (storage, unloading, handling of raw and refined products). The setting of specific routines, based on the matching of multiple information levels (Port activities, total VOCs concentrations, weather conditions) (Choi et al., 2009), allowed to adopt the necessary corrective procedures for the mitigation of the impact of fugitive emissions in surrounded areas. Long-term tests have shown a high stability of instrumental responses, high robustness and reliability (Amodio et al., 2013).

Energy analysis of a green façade in summer: an experimental test in Mediterranean climate conditions

Energy performance of a double-skin green façade in Mediterranean climate was investigated. Experimental data were collected at a green façade prototype realized at the University of Bari. The green façade thermal behaviour was assessed under different summertime weather scenarios. To point out the plants influence, a comparison was carried out between microclimatic conditions and energy transfer at the covered wall, behind the vegetation, and at an un-vegetated wall. Experimental data concerning the walls surface, the air gap in the green façade and the external air were used to perform statistical analyses and to evaluate the heat fluxes. At daytime, the green façade provided a reduction of the wall surface temperature up to 9.9 °C, while air relative humidity behind the vegetation rose up to 18.7%. Surface and air warming were found at night-time. A time-shift was detected between the maximum surface temperature of the covered and of the bare wall. The analysis of the energy flux through the two walls highlighted a sensible reduction in the covered wall, equal to 62% during daytime. Solar and LWIR radiative and convective fluxes were generally lower in the covered wall. Latent heat due to evapotranspiration was evaluated, as well. Net radiation was found to be the most influencing parameter for latent heat transfer. A simplified relationship was proposed to quantify latent heat due to evapotranspiration. The formula based on the net radiation, as input parameter, was found to be the most suitable. The findings of this research contribute to the knowledge of the effects provided by green façades in terms of cooling and heating, influence on the proximity microclimatic conditions and overall energy transfer.

Peri-implantitis-like medication-related osteonecrosis of the jaw: Clinical considerations and histological evaluation with confocal laser scanning microscope.

ObjectiveIn the recent years, an increasing number of peri‐implant medication‐related osteonecrosis of the jaw (PI‐MRONJ) have been reported in literature, both in oncologic and osteoporotic patients. The aim of this study is to describe 19 cases of patients previously diagnosed as affected by peri‐implantitis, who were treated for PI‐MRONJ, with consideration on clinical and histopathological features.Materials and MethodsPatients included were affected by postmenopausal osteoporosis and were administered with different antiresorptive drugs. Due to the presence of clinical and radiological signs of peri‐implantitis not healed after non‐surgical periodontal treatment, they were referred to the Complex Operating Unit of Odontostomatology of the University of Bari. Then, after a drug holiday of at least 3 months and cycles of antibiotics, and after other cycles of periodontal treatment, patients underwent the surgical removal of implant fixtures and surrounding bone.ResultsAlthough the previous diagnosis of peri‐implantitis, the histopathological analysis with both conventional and confocal laser scanner microscopy confirmed the diagnosis of peri‐implantitis‐like MRONJ.ConclusionPeri‐implantitis not healed after conventional treatment in patients at risk on MRONJ occurrence should be considered as peri‐implantitis‐like PI‐MRONJ and treated as required in order to get complete healing of the pathological condition, thus avoiding delay in the diagnosis.

Long-term persistence of poliovirus neutralizing antibodies in the era of polio elimination: An Italian retrospective cohort study

IntroductionThe extensive use of oral and inactivated poliovirus (PV) vaccines has driven progress toward the global eradication of wild PV2 and PV3 and the elimination of PV1 in most countries, including Italy. Although the persistence of circulating neutralizing antibodies among the vaccinated is unclear, it is estimated that > 99% of the population vaccinated according to the recommended protocol should be protected for at least 18 years. MethodsThis study evaluated the seroprevalence of anti-PV neutralizing antibodies and the long-term immunogenicity of the oral poliovirus vaccine (OPV) in a sample of medical students and residents of the University of Bari who attended the Hygiene Department for a biological risk assessment between April 2014 and October 2020. ResultsThe prevalence of protected vaccinated individuals was > 90% for PV1, PV2, and PV3. Specifically, >99% of the study group was protected against PV1, > 98% against PV2, and almost 93% against PV3. Protective antibodies against all three viruses persisted for at least up to 18 years after administration of the last OPV dose, with PV1 and PV2 antibodies detected in > 95% of the participants > 30 years after the last OPV dose. ConclusionsThe childhood series of four doses of OPV guarantees a long duration of protection, despite the elimination of the virus and therefore the absence of a natural booster. However, until PV1 is completely eradicated, maximum vigilance on the part of public health institutions must be maintained.

Eye-related emergencies incidence at a tertiary referral center in Southern Italy during COVID-19 related lockdown

Background: In order to contain the community spread of coronavirus disease (COVID-19) in Italy, a stringent lockdown was imposed, which also impacted the healthcare services. The purpose of this study is to investigate the drop in the number of outpatients in the Ophthalmic Emergency Service (OES) in the Eye Clinic of University of Bari during the COVID-19 lockdown. Methods: A retrospective analysis of electronic medical records from a tertiary referral center in Southern Italy was performed. Demographics and medical characteristics of patients examined in the OES between March 10th, 2020 and May 3rd, 2020 were assessed and compared with records from the same period in 2019. We categorized the patients by sex, age group, and by the type of eye disease that was recorded as the principal diagnosis. The change (%) in the number of patients and diseases between the study periods was analyzed. Results: We observed a reduction in the number of OES visits during the lockdown (-63.4%) compared to the number of visits in 2019. The greatest changes were observed in the youngest (≤20 years; -76.6%) and the most elderly patients (≥81 years; -70.9%). The decrease in the number of patients presenting with each pathology ranged from -82% to -28.5%, depending on the pathology, and mainly involved the orbital and palpebral pathologies, anterior segment disorders, non-specific visual symptoms, and minor injuries. The diagnosis of chronic pathologies, rhegmatogenous retinal detachment, and vitreous haemorrhage increased by 134%, 100%, and 75%, respectively. Conclusions: Our results revealed the impact of the COVID-19 lockdown on OES activities in the Eye Clinic of University of Bari. A drop in number of visits across all age groups was observed. The number of patients presenting with minor and nonurgent conditions decreased, whereas the number of patients presenting with chronic diseases and urgent but deferrable conditions increased.

Corrections to “LOCUS: A Multi-Sensor Lidar-Centric Solution for High-Precision Odometry and 3D Mapping in Real-Time” [Apr 21 421-428

Authors Benjamin Morrell, Kamak Ebadi, Jeremy Nash and Aliakbar Agha-mohammadi in the above-named work [ibid., IEEE Robot. Automat. Lett., vol. 6, no. 2, pp. 421–428, Apr. 2020] were incorrectly affiliated with the Polytechnic University of Bari. The correct authors affiliations are reported in the present document.

Online Identification of Simplified CHP Models

The aim of this article is to develop a simplified equivalent dynamic model capable to capture the transient behavior of a gas-fueled co-generator. To comply with this exigency, an online identification methodology based on the sensitivity theory in conjunction with the Lyapunov function is adopted. By this methodology, stable solutions can be achieved in the online environment, renewing the parameters of the model at every change occurring on the physical system. In order to investigate the effectiveness of the proposed methodology in deriving a simplified dynamic model, several simulations and experimental tests were performed on the Prince Lab microgrid located at the Polytechnic University of Bari.

Meteorological and hydrodynamic data in the Mar Grande and Mar Piccolo, Italy, of the Coastal Engineering Laboratory (LIC) Survey, winter and summer 2015

Abstract. The Coastal Engineering Laboratory (LIC) of DICATECh of the Polytechnic University of Bari (Italy) maintains a place-based research programme in the Mar Grande and Mar Piccolo of Taranto (a coastal system in southern Italy), providing records of hydrodynamic and water-quality measurements. This site is one of the most complex marine ecosystem models in terms of ecological, social and economic activities. It is considered highly vulnerable because of the presence of a naval base, the biggest steel mill of Europe and an oil refinery. Two fixed stations have been installed, one in the Mar Grande (MG station) and another in Mar Piccolo (MP station). In the MG station constituents include wind speed and direction, air temperature and humidity, barometric pressure, net solar radiation, water salinity, water temperature, water pressure, dissolved oxygen, fluorescence, turbidity, CDOM, crude oil and refined fuels, sea currents, and waves. In the MP station constituents include water temperature, sea currents and waves. We provide a summary of how these data have been collected by the research group and how they can be used to deepen understanding of the hydrodynamic structures and characteristics of the basin. These data are available at https://doi.org/10.5281/zenodo.4449641 (Mossa et al., 2020).

COVID-19 lockdown and seasonal allergic rhinitis: our experience in 40 patients.

Introduction:The aim of this article was to study the course of seasonal allergic rhinitis during COVID-19 lockdown to understand if being quarantined at home for a long time can constitute a protective factor for allergic patients.Materials and methods:Telehealth consultations were performed by the departments of Otolaryngology of Foggia and Bari University Hospitals. Patients affected by cypress pollen allergy took part in a phone interview and were asked about their sinonasal symptoms during the COVID-19 lockdown, by answering the sinonasal outcome test (I-SNOT-22) questionnaire. Further data concerning the medications used to treat allergy and the number of days per month in which they were used were collected. The responses about the COVID-19 lockdown were compared to those obtained by the same patients in our clinics the previous year. The statistical analysis was executed by using the paired sample t-test and the Bartlett test considering as significant values with p values <0.05.Results:Forty patients affected by cypress pollen allergy visited at Foggia and Bari University Hospitals were enrolled in this study. All I-SNOT-22 scores concerning the COVID-19 lockdown were lower than those of the previous year; moreover, 18 (81.8%) clinical parameters were statistically significant (p<0.05). Also, in regard to the treatment, results about COVID-19 lockdown were overall better than those of 2019, with 50% (n=3) of the investigated drugs, reporting statistical significance (p<0.05).Conclusions:The present study was able to evidence the fundamental role of primary prevention in Allergology. Paradoxically, the home quarantine ordered by the Italian Government appeared to be an effective measure not only in the fight against COVID-19 but also against pollen exposure. (www.actabiomedica.it)

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series.

Peripheral giant cell granulomas (PGCG) associated with hyperparathyroidism (HPT) are rare clinical entities. The aim of this study is to report on 21 PGCGs of the oral cavity as the first clinical sign of unknown primary HPT (PHPT) referred to the Complex Operating Unit of Odontostomatology of Aldo Moro University of Bari from 2009 to 2019. Surgical treatment consisted in conservative enucleation of the lesion, if possible, with contextual bone rim osteoplasty with piezosurgical tools and following histological examination. After histological diagnosis of PGCG, PHPT screening was performed dosing parathyroid hormone and serum calcium. In all the patients haematological investigation demonstrated elevated values of parathyroid hormone and serum calcium ruling out an unknown PHPT. Specifically, after endocrinological evaluation, patients showed PHPT related to: parathyroid adenoma (13), parathyroid hyperplasia (two, one of which occurred in a intra-thyroidal parathyroid), and parathyroid carcinoma (1) and were scheduled for surgical treatment. Considering that PGCGs could represent the first clinical sign of an undiagnosed PHPT and the screening of PHPT is a non-invasive and cheap exam, in case of histological diagnosis of a giant cell lesion, both central and peripheral, especially in patients with synchronous or history of methacronous giant cell lesions, parathyroidal screening should be mandatory.

New Insights in Laboratory Testing for COVID-19 Patients: Looking for the Role and Predictive Value of Human epididymis secretory protein 4 (HE4) and the Innate Immunity of the Oral Cavity and Respiratory Tract.

COVID-19 is a viral pandemic caused by the new coronavirus SARS-CoV-2, an enveloped positive stranded RNA virus. The mechanisms of innate immunity, considered as the first line of antiviral defense, is essential towards viruses. A significant role in host defense of the lung, nasal and oral cavities is played by Human epididymis secretory protein 4 (HE4) HE4 has been demonstrated to be serum inflammatory biomarker and to show a role in natural immunity at the level of oral cavity, nasopharynx and respiratory tract with both antimicrobial/antiviral and anti-inflammatory activity. Several biomarkers like IL-6, presepsin (PSP), procalcitonin (PCT), CRP, D-Dimer have showed a good function as predictor factors for the clinical evolution of COVID-19 patients (mild, severe and critical). The aim of this study was to correlate the blood levels of CRP, IL-6, PSP, PCT, D-Dimer with He4, to identify the predictive values of these biomarkers for the evolution of the disease and to evaluate the possible role of HE4 in the defense mechanisms of innate immunity at the level of oral cavity, nasopharynx and respiratory tract. Of 134 patients admitted at COVID hospital of Policlinico—University of Bari, 86 (58 men age 67.6 ± 12.4 and 28 women age 65.7 ± 15.4) fulfilled the inclusion criteria: in particular, 80 patients (93%) showed prodromal symptoms (smell and/or taste dysfunctions) and other typical clinical manifestations and 19 died (13 men age 73.4 ± 7.7 and 6 women age 74.8 ± 6.7). 48 patients were excluded because 13 finished chemotherapy and 6 radiotherapy recently, 5 presented suspected breast carcinoma, 5 suspected lung carcinoma, 6 suspected ovarian carcinoma or ovary cyst, 1 cystic fibrosis, 3 renal fibrosis and 9 were affected by autoimmune diseases in treatment with monoclonal antibodies. The venous sample was taken for each patient on the admission and during the hospital stay. For each patient, six measurements relating to considered parameters were performed. Significant correlations between He4 and IL-6 levels (r = 0.797), between He4 and PSP (r = 0.621), between He4 and PCT (r = 0.447), between He4 and D-Dimer (r = 0.367), between He4 and RCP (r = 0.327) have been found. ROC curves analysis showed an excellent accuracy for He4 (AUC = 0.92) and IL-6 (AUC = 0.91), a very good accuracy for PSP (AUC = 0.81), a good accuracy for PCT (AUC = 0.701) and D-Dimer (AUC = 0.721) and sufficient accuracy for RCP (AUC = 0.616). These results demonstrated the important correlation between He4, IL6 and PSP, an excellent accuracy of He4 and IL6 and showed a probable role of He4 in the innate immunity in particularly at the level of oral cavity, nasopharynx and respiratory tract. Besides He4 together with IL6 might be involved in the onset of smell and/or taste disorders and it might be used as innovative biomarker to monitor clinical evolution of COVID-19 because He4 could indicate a multi-organ involvement.