Diclofenac, known as diclone in Syria, is the most widely used drug in multiple medical conditions. This research was conducted to assess the use and awareness of diclofenac in Syria through a survey. 601 responses were included in this research.Most participants were female (67.7%), between the ages of 18 and 30 years (82.9%), and did not have a chronic disease (86.3%). More than half of the participants were university students (53.4%). A high proportion of the participants had a university education level (87.7%). The most commonly used dosage form for diclofenac was tablets among participants(70.9%). 43.8% chose 50mg as the dose of diclofenac. Most participants improved after using diclofenac (73.7%). Participants were satisfied after diclofenac treatment (66.56%). Most had no side effects after treatment with diclofenac (79.5%). 81.3% of the participants who experienced side effects suffered from stomach pain. Fortunately, 84.4% of the participants did not use the injection combining diclofenac with cortisone and an antibiotic. 56.38% used this combination to treat respiratory infections. A minority of the participants experienced allergic reactions after taking this medication (4%). More than two-thirds of the participants will continue to use diclofenac for pain management in the future (65.9%).77.9% of the participants used diclofenac without a prescription. Most participants used this medicine after a meal (82%). 36.6% of the participants recorded half an hour as the onset of diclofenac. The participants reported an action duration of 6 hours (24.5%) and 8 hours (31%). This study confirmed the high use of diclofenac among the Syrians. A good level of awareness was observed among the surveyed participants.