This paper aims to study the initiatives taken by the private Universities through business Incubation centers for the development and promotion of Innovation and entrepreneurship. It also studies the linkages among University Incubation centers, young innovators, Industry and investors for ecosystem development. Traditional universities role has gradually evolved and changed now to redirect the new knowledge system for nation’s economic development through University Incubation centers. A model has been developed that illustrates how University Incubation center is functioning for the wellbeing of Society, Nation’s economy and youth employment. Current research paper is dealing various elements in understanding and analyzing the changing dynamics of University system in nurturing business Incubation and innovations through various initiatives and platform of developments. The Result shows that university provides a sound platform for young entrepreneurs for start-up’s with their innovative ideas and to help in startups at various levels. The model based innopreneurship framework will help to enhance university ecosystem and its functioning through Innovation and Entrepreneurial goals. Key words: Innovation, Incubation center, Entrepreneurship, Qualitative research. etc.