University Clinics Of Kinshasa Research Articles

Hemogram Abnormalities Associated with the Severity of COVID 19 in Patients at the University Clinics of Kinshasa

Hemogram Abnormalities Associated with the Severity of COVID 19 in Patients at the University Clinics of Kinshasa

Immuno-allergic dermatoses in children of 0-5years old in Kinshasa hospital environment.

The frequency of immuno-allergic dermatoses (IAD) is gradually overtaking that of infectious dermatoses in sub-Saharan Africa. The aim of this study was to identify the epidemioclinical profile and the determinants of IAD in children of 0-5years old at the University Clinics of Kinshasa (UCK). This was a documentary and descriptive study that focused on children from 0 to 5years old with IAD, over an 11-year period from 2011 to 2021. Included were children from 0 to 5years old received in consultation the first time for IAD. The parameters of interest were sociodemographic and clinical. Data was entered and analysed using Excel 2010 software. Ethical and deontological considerations were respected. The value of p<0.05 was the significance threshold. The frequency of IAD in children aged 0-5years in the UCK was 17.8%, with a high peak between 2 and 3years (41.9%) and a female predominance at 54.4%, which represents a sex ratio of 0.8. Prurigo strophulus (42.3%) and atopic dermatitis (22.8%) were the most common IAD. In multivariate analysis, the determinants were significantly the age group of 4-5years, the rainy season and the child's environment. Prurigo strophulus and atopic dermatitis were the most frequent IAD in children aged 0-5years. A holistic care (medical, ecological) of children and their parents may reduce morbidity related to IAD for this age.

Histopathological Profile of Germ Cell Tumors in Kinshasa: About a Series of 30 Cases at the University Clinics of Kinshasa and Review of the Literature

Histopathological Profile of Germ Cell Tumors in Kinshasa: About a Series of 30 Cases at the University Clinics of Kinshasa and Review of the Literature

Rationale of a Cross Sectional Analytic Study on Determinants of Recurrent Preeclampsia at University Clinics of Kinshasa (Democratic Republic of Congo) and at Victor Dupouy Hospital Center (France)

Rationale of a Cross Sectional Analytic Study on Determinants of Recurrent Preeclampsia at University Clinics of Kinshasa (Democratic Republic of Congo) and at Victor Dupouy Hospital Center (France)

Surgical Site Infection in Orthopedic and Trauma Surgery at Kinshasa University Clinics

Surgical Site Infection in Orthopedic and Trauma Surgery at Kinshasa University Clinics

Machine Learning based on Probabilistic Models Applied to Medical Data: The Case of Prostate Cancer

The growth in the amount of data in companies puts analysts in difficulties when extracting hidden knowledge from data. Several models have emerged that focus on the notion of distances while ignoring the notion of conditional probability density. This research study focuses on segmentation using mixture models and Bayesian networks for medical data mining. As enterprise data becomes large, there is a way to apply data mining methods to make sense of it using classification methods. We designed different models with different architectures and then applied these models to the medical database. The algorithms were implemented for the real data. The objective is to classify individuals according to the conditional probability density of random variables, in addition to identifying causalities between traits from tests of conditional independence and a correlation measure, both based on χ2. After a quick illustration of several models (decision tree, SVM, K-means, Bayes), we applied our method to data from an epidemiological study (done at the University of Kinshasa University clinics) of case-control of prostate cancer. Thus, we found after interpretation of the results followed by discussion that our model allows us to classify a new individual with an accuracy of 96%.

Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa

Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa

#6368 PLATELET TO LYMPHOCYTE RATIO AND SICKLE CELL NEPHROPATHY

Abstract Background and Aims Platelet-to-lymphocyte ratio (PLR) was introduced as cheap and readily assessed biologic markers of subclinical inflammation in sickle cell disease. Microalbuminuria and hyperfiltration, early markers of Sickle cell nephropathy (SCN) have been reported to be associated with platelet-to-lymphocyte ratio (PLR). This association has not yet been assessed in Congolese Sickle cell disease (SCD) children. Therefore, the aim of the present study was to assess the association between PLR and early markers of kidney disease in SCD children living in the Democratic Republic of Congo (DRC). Method In this cross-sectional study, we have investigated 175 SCD children from four centers (Kinshasa university clinics, CMMASS, CMD Diamand, and Biamba Marie Mutumbo Dikembe) that give a comprehensive care to SCD patients. The PLR were calculated from full blood count. Elevated albuminuria and hyperfiltration, as the main outcomes of the study, were defined by urinary albumin/creatinine ratio (ACR) ≥30 mg/g and estimated glomerular filtration ratio (eGFR) &amp;gt;130 ml/min per 1.73 m2 for females and &amp;gt;140 ml/min per 1.73 m2 for males, respectively. Logistic regression analysis was used to assess the relationship between RPL and early sickle cell nephropathy. Results Of the 175 SCD children enrolled, 41(23.4%) and 67(38.3%) of them presented with abnormal albuminuria and hyperfiltration, respectively. RPL &amp;gt;130 was observed in 90 (51.4%) patients. RPL was strongly, significantly and independently associated with both abnormal albuminuria (aOR 3,381; IC95% 2, 22-1, 63; p = 0,000) and hyperfiltration (aOR 2, 19; 95%IC 2, 98 - 22, 25; p = 0,010). Conclusion The present study has shown that nearly fifty two out of one hundred SCD children bear a high platelet to lymphocyte ratio that is strongly and significantly associated with early markers of kidney disease.

Ultra Sonographic Profile of Nephroblastoma at the University Clinics of Kinshasa

Objective: T o describe the ultrasonographic profile of nephroblastoma diagnosed at the university clinics of Kinshasa. Materials and methods: T his is a descriptive study; it concerns 45 patients with Wilms' tumor diagnosed by ultrasonography at the university clinics of Kinshasa from 2016 to 2021, i.e. an overall period of six years. Two ultrasound scanners branded Phillips u-22 and Mindray DC-30 were used.

Sociodemographic and Clinical Characteristics Associated with Early Detection of COVID-19 in Kinshasa: Democratic Republic of Congo

Objective: COVID-19 is a disease that, as of 2020, has affected the whole world. Its spread being rapid, early detection would contribute to its control. This study aims to determine the sociodemographic and clinical characteristics associated with this detection fast in Kinshasa. Material and methods: A cross-sectional, descriptive study with an analytical aim is carried out on 713 people suspected of COVID-19 upon their admission to the Covid Treatment Center of the University Clinics of Kinshasa (CTC / CUK) between 2020 and 2021 through the exploitation of the database registering these patients. Data are analyzed using jamovi software version 2.3.18. Frequencies, Fisher's Exact test then logistic regression with α = 0.05 are used. Results: In total, we recorded 713 cases, 459 or 64.4% tested positive at the first screening. The median age is 59.0 years. The sex ratio is 1.7 in favor of men. The following characteristics are associated with early detection of COVID-19: advanced age (OR = 2.9 *1.03 – 8.29+); arterial hypertension (OR = 1.7 *1.15 – 2.52]); diabetes mellitus (OR = 3.66 [1.92 – 6.98]); body aches (OR = 0.41 [0.20 – 0.83]) as well as signs of respiratory distress (OR = 2.4 [1.44 – 3.87]). Conclusion: This study shows that elderly patients, those with a history of hypertension, diabetes and signs of respiratory distress tested positive at the first screening upon arrival at the CTC/CUK, unlike those with body aches. These cases would therefore require special attention from all staff of the COVID-19 response team for appropriate care.

Pre-Anesthetic Consultation at the University Clinics of Kinshasa: Patient Profile, Type of Surgery, Anesthetic Protocol

<i>Introduction</i>: PAC is an element of anesthetic safety that makes it possible to collect information about the patient (history, physical examination), to assess the operative risk, to choose the technique of anesthesia and perioperative care best suited to the clinical condition of the patient. General objective was to describe the practice of PAC at the University Clinics of Kinshasa. <i>Methods</i>: This is a cross-sectional descriptive study carried out in Kinshasa from 1 January to 31 December 2021 (12 months), at the Department of Anesthesia and Resuscitation (ARD) of the University Clinics of Kinshasa. It involved all patients who had been consulted as part of a scheduled surgery, i.e. 443 patients. <i>Results</i>: The average age was 36.6 years with extremes of 7 days and 91 years. The female sex was predominant with 55.3%. Hypertension was the most found medical history in 13.5%. Gyneco-obstetric surgery (22.3%), otolaryngological surgery (13.8%) and neurosurgery (10.2%) were the most common of the surgical types. ASA I and ASA II patients were the most common (85.3%). General anesthesia accounted for 59% with Sevoflurane offered in 91% of general anesthesia. Spinal anesthesia accounted for 35.7%. <i>Conclusion</i>: The PAC is regularly performed in our environment in case of scheduled surgery and concerns all available surgical specialties.

Cohort Study on Benefit of Martial Supplementation with EDTA Sodium Iron in Management of Gravidic Anemia at the University Clinics of Kinshasa

Cohort Study on Benefit of Martial Supplementation with EDTA Sodium Iron in Management of Gravidic Anemia at the University Clinics of Kinshasa

Rationale of a Cross-Sectional Descriptive Study on Associated Factors and Prognosis Maternal-Fetal Links to Early Onset Preeclampsia at the University Clinics of Kinshasa, DR Congo

Rationale of a Cross-Sectional Descriptive Study on Associated Factors and Prognosis Maternal-Fetal Links to Early Onset Preeclampsia at the University Clinics of Kinshasa, DR Congo

Rationale of a Cross-Sectional Descriptive Study on Temporal Evolution of Frequency, Risk Factors and Complications of Preeclampsia in the University Clinics of Kinshasa, DR Congo

Rationale of a Cross-Sectional Descriptive Study on Temporal Evolution of Frequency, Risk Factors and Complications of Preeclampsia in the University Clinics of Kinshasa, DR Congo

Rationale of the Cross-Sectional Descriptive Study on Factors Associated with Failure of Vaginal Delivery Trial after Cesarean Section in the University Clinics of Kinshasa, DR Congo

Rationale of the Cross-Sectional Descriptive Study on Factors Associated with Failure of Vaginal Delivery Trial after Cesarean Section in the University Clinics of Kinshasa, DR Congo

Use of Drugs During Pregnancy at the Kinshasa University Clinics, Democratic Republic of the Congo

Use of Drugs During Pregnancy at the Kinshasa University Clinics, Democratic Republic of the Congo

Bioclinical Performance of Liver Cirrhosis and Hepatocarcinoma Diagnosis versus Abdominal Ultrasound-Hepatic Histopathology at Kinshasa University Clinics between 1990 and 2004

Bioclinical Performance of Liver Cirrhosis and Hepatocarcinoma Diagnosis versus Abdominal Ultrasound-Hepatic Histopathology at Kinshasa University Clinics between 1990 and 2004

Epidemio-Clinical Profile of Newborns Transfereed to University Clinics of Kinshasa and Poor Prognosis Factors

Epidemio-Clinical Profile of Newborns Transfereed to University Clinics of Kinshasa and Poor Prognosis Factors

Interventional study on Dolutegravir and other antiretrovirals in patients with subclinical atherosclerosis in the Kinshasa Hospital

After 2016, the World Health Organization (WHO) proposed Dolutegravir (DTG) as an alternative first-line treatment for adults. Thus, the purpose of this study was to identify biomarkers of cardiometabolic risk capable of demonstrating the beneficial effect of Dolutegravir (DTG) compared to other antiretrovirals in predicting atherosclerosis in people living with HIV (PLHIV) and hospitalized in Kinshasa Hospital. we conducted an interventional study of people living with HIV who had received antiretroviral therapy (ART) for at least 6 months and were treated in the structures of the network coordinated by the Catholic Church (BDOM-Bureau Diocésain des Oeuvres Médicales) and of the University Clinics of Kinshasa (CUK) between January 2017 and December 2021. Subclinical atherosclerosis was defined as Pulsed Pressure (PP) ≥60 mm Hg; Carotid Intima-Media Thickness (CIMT) > 0.8 mm; and Systolic Pressure Index (SPI) < 0.9. Logistic regression was used in the statistical analysis of associations. a total of 334 PLHIV were recruited, of whom 96.1% (n=321) were on ART and 13.9% (n=13) were ART naïve patients. The mean age of PLHIV was 51±12 years with a female predominance (70.4%; n=235); the independent determinants of subclinical atherosclerosis were marital status (aOR: 4. 95% CI 1.5-10.5; p<0.006), low socioeconomic level (aOR: 10.7, 95% CI 2.3-48.7 p<0.002), duration of HIV infection (aOR: 6.6, 95% CI 2.8-16; p<0.0001), duration of antiretroviral therapy ≥9 years (aOR: 0.3, 95% CI 0.2-0.7; p<0.005) and total cholesterol ratio/high-density lipoprotein-cholesterol (CT/HDL-c)(aOR: 2, 95% CI 1.1-3.6; p= 0.034). The mean values of traditional and emergent variables were significantly higher in the previous ART regimen without DTG than in the new regimen with DTG. However, dyslipidemia was detected during the new DTG-based regimen. dyslipidemia was common during the DTG-based regimen. Marital status, low socioeconomic level, duration of HIV infection, duration of antiretroviral treatment beyond 9 years and the TC/HDL-c ratio were identified as determinants of subclinical atherosclerosis in PLHIV on ART hospitalized in the Kinshasa hospital.

Anatomical and Clinical Profile of Thyroid Diseases at the University Clinics of Kinshasa from 1989 to 2009

Le but de cette étude est de dresser le profil anatomo-clinique des pathologies thyroïdiennes. Pour réaliser cette étude descriptive et rétrospective de 167 cas sélectionnés de pathologies thyroïdiennes diagnostiqués entre 1989 et 2009 au service d’anatomie pathologique des cliniques universitaires de Kinshasa, avec comme variable retenu la fréquence relative de la pathologie thyroïdienne par rapport à l’ensemble des biopsies de cette période, le sexe et l’âge. 167 cas des pathologies thyroïdiennes diagnostiquées entre 1989 et 2009 au service d’anatomie pathologique des cliniques universitaires de Kinshasa sur 22 474 biopsies ont été sélectionnés. Cette étude montre que les pathologies thyroïdiennes représentaient 0.7% de biopsies. La tranche d’âge de 31 à 40 ans représentait 23% de cas ; le sexe féminin représentait 81% de cas ; le goitre simple constituait 47.93% des cas, l’adénome représentait 8.38% et le carcinome représentait 7.78% sur l’ensemble des tumeurs thyroïdiennes. La pathologie thyroïdienne représentait 0.74% de toutes les biopsies, elle est donc moins fréquente avec une prédominance féminine à 81.44% ; touchant beaucoup des jeunes entre 31-40 ans. Le goitre simple constituait 47.93% des cas, l’adénome représentait 8.38% et le carcinome représentait 7.78% sur l’ensemble des tumeurs thyroïdiennes. Mots clés: Pathologie thyroïdienne, biopsie, goitre, adénome, carcinome