Universite Paris-Sud Research Articles

Sub-millimeter fMRI Reveals Columnar Organization in Macaque Parietal Cortex

Sub-millimeter fMRI Reveals Columnar Organization in Macaque Parietal Cortex

Editorial Plasma and Cancer Treatment

The International Workshop on Plasma for Cancer Treatment, IWPCT, is an international workshop that focuses on basic and clinical research into the interaction of low temperature plasmas (LTP) with cancer cells and tumors. It was founded in 2014 by Prof. M. Keidar and Prof. M. Laroussi as a venue for researchers to present their cutting edge research on the application of LTP for cancer treatment, or “plasma oncology.” The first IWPCT was held in March 2014 in Washington, DC, USA, under the co-chairmanship of M. Laroussi (Old Dominion University, Norfolk, VA, USA) and M. Keidar (George Washington University, Washington, DC, USA). The second workshop, IWPCT-2, was held in March 2015 in Nagoya, Japan under the chairmanship of Prof. M. Hori (Nagoya University, Nagoya, Japan). IWPCT-3 was held again in Washington, DC, USA, in April 2016 under the co-chairmanship of Dr. J. Canady (Jerome Canady Research Institute, Takoma Park, MD, USA) and Dr. J. Sherman (George Washington University). The fourth workshop, IWPCT-4, was held on March 27–28, 2017 at the Institut Curie, Paris, France, under the co-chairmanship of Dr. J. Santos-Sousa (Universite Paris-Sud, Orsay, France) and Dr. P.-M. Girard (Institut Curie). IWPCT-4 was technically co-sponsored by the IEEE-NPSS and full papers based on the oral presentations given at the workshop were submitted and peer-reviewed for eventual inclusion in this issue of TRPMS.

Smart Polymeric Nanocarriers

1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China 2Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, USA 3Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA 4Institute of Molecular Sciences, CNRS, Universite Paris-Sud, Universite Paris Saclay, 91400 Orsay, France

A tribute to Philippe Rossi

Publication of this special volume of the Bulletin de la Societe geologique de France, dedicated to the evolution of the southern segment of the European Variscan chain, is an opportunity for the French community of Geosciences to pay a friendly honoring tribute to Philippe Rossi, a tireless promoter of geology within the important institution that is the Bureau de Recherches Geologiques et Minieres (BRGM). After his secondary studies at the Lycee J.B. Corot in Savigny-sur-Orge, Philippe Rossi discovered geology at the Universite Paris-Sud (Orsay), where he defended in 1975 a Doctorat thesis entitled: “ Geologie et gitologie du Cerro San Cristobal Logrosan, Caceres, Espagne”. In the wake of his thesis, Philippe joined the BRGM where he went, from the 1980s, to play a prominent role as both a geologist specialist of the Variscan chain in Europe, and a key player of the evolution and accomplishment of the French mapping program (Programme de la Carte Geologique de la France). First of all, Philippe is recognized in our community as a researcher enthusiast about the petrologic and geodynamic evolution of the European Variscan chain. In 1986, he defended a Doctorat d’Etat thesis at the Universite P. Sabatier (Toulouse) entitled: “ Organisation et genese d’un grand batholite orogenique : le batholite calco-alcalin de la Corse ”. In parallel, Philippe has led the cartographic synthesis of Corsica at 1/250 000 published in 1980, and was involved in the survey of 7 geological maps at 1/50 000 in Corsica, to be published between 1984 and 2012. In 2009, he and his colleagues published a remarkable synthesis of the Corso-Sardinian segment of the Variscan chain, updated in 2014 with regard to the place of Corsica in the Variscan “puzzle”. This work conducted in collaboration with A. Cocherie within the BRGM, but also with many French and …

Fossil calibration of Magnoliidae, an ancient lineage of angiosperms

In order to investigate the diversification of angiosperms, an accurate temporal framework is needed. Molecular dating methods thoroughly calibrated with the fossil record can provide estimates of this evolutionary time scale. Because of their position in the phylogenetic tree of angiosperms, Magnoliidae (10,000 species) are of primary importance for the investigation of the evolutionary history of flowering plants. The rich fossil record of the group, beginning in the Cretaceous, has a global distribution. Among the hundred extinct species of Magnoliidae described, several have been included in phylogenetic analyses alongside extant species, providing reliable calibration points for molecular dating studies. Until now, few fossils have been used as calibration points of Magnoliidae, and detailed justifications of their phylogenetic position and absolute age have been lacking. Here, we review the position and ages for 10 fossils of Magnoliidae, selected because of their previous inclusion in phylogenetic analyses of extant and fossil taxa. This study allows us to propose an updated calibration scheme for dating the evolutionary history of Magnoliidae. Julien Massoni. Laboratoire Ecologie, Systematique, Evolution, Universite Paris-Sud, CNRS UMR 8079, 91405 Orsay, France. massoni.julien@gmail.com James Doyle. Department of Evolution and Ecology, University of California, Davis, CA 95616, USA. jadoyle@ucdavis.edu Herve Sauquet. Laboratoire Ecologie, Systematique, Evolution, Universite Paris-Sud, CNRS UMR 8079, 91405 Orsay, France. herve.sauquet@u-psud.fr

Diffusion capacity and BMPR2 mutations in pulmonary arterial hypertension

To the Editor: Pulmonary arterial hypertension (PAH) is a disease in which remodelling of the small pulmonary arteries leads to an increase in pulmonary artery pressure (PAP). The most important genetic predisposing factor related to PAH is a mutation in the bone morphogenetic protein receptor type 2 gene ( BMPR2 ) [1, 2]. BMPR2 mutation carriers are known to present with disease at an earlier age and with worse haemodynamics [3]. We recently showed in a cohort of patients with idiopathic and hereditary PAH that a very low diffusion capacity for carbon monoxide ( D LCO) is exclusively found in some of the patients without identified BMPR2 mutations, whereas BMPR2 mutation carriers have a relatively preserved D LCO [4]. D LCO is a noninvasive marker of the quality of the alveolar capillary structure [5] and the observed difference in D LCO supports the hypothesis that distinct vascular disease processes are at play in BMPR2 mutation-related PAH and non BMPR2 mutation-related idiopathic PAH. Until recently, insufficient availability of lung samples has prohibited the performance of a detailed comparison of the pulmonary vascular pathologies in these two disease groups [6]. Therefore, we sought, in the present study, to confirm the previously found influence of BMPR2 mutations on diffusion capacity in a much larger multinational patient cohort. We performed a retrospective collaborative study at the VU University Medical Center in Amsterdam, the Netherlands and the Universite Paris-Sud, Assistance Publique Hopitaux de Paris, Le Kremlin-Bicetre, France. Patients were eligible for this study when classified in the database with idiopathic or familial PAH, and when the results from BMPR2 mutation analysis and D LCO measurements were available. Patients were diagnosed with idiopathic …

Correction: Potential Role of Estrogen Receptor Beta as a Tumor Suppressor of Epithelial Ovarian Cancer

There was an error in the Funding statement. The correct statement is: This work was supported by grants from ARC (Association pour la Recherche contre le Cancer, Grant No. 3582) (http://www.arc-cancer.net), The Ligue Nationale Contre le Cancer (http://www.ligue-cancer.net). Muriel Busson was supported by FRM (Fondation pour la Recherche Medicale) (http://www.frm.org). DV was a recipient of the Ligue Nationale contre le Cancer. CB was supported by a HFSP fellowship (http://www.hfsp.org/). The K. B. lab is supported by the Agence Nationale de la Recherche (ANR, grant number 2010 JCJC 1104 01) (http://www.agence-nationale-recherche.fr ​/), the Universite Paris-Sud, the Institut National de la Sante et de la Recherche Medicale (INSERM) and the Ligue Nationale Contre le Cancer (Comite Val d'Oise), and is a member of the Laboratory of Excellence LERMIT (Laboratory of Excellence in Research on Medication and Innovative Therapeutics) supported by a grant from ANR (Investissements d´Avenir). Dr Madly Brigitte was supported by the Fondation ARC and Dr Carine Jacquard by INCA (Institut National du Cancer). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Clinical Year in Review IV

Department of Medicine, University of California San Francisco, San Francisco, California; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado; Department of Respiratory Medicine, Universite Paris-Sud, Assistance Publique Hopitaux de Paris, Inserm U999, Le Kremlin-Bicetre, France; and Department of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin

Editors’ preface for the topical issue “Finite dimensional integrable systems, dynamics, and Lie theoretic methods in Geometry and Mathematical Physics”

The articles collected in this issue are related to two workshops that took place in the summer of 2011. The workshop Cartan Connections, Geometry of Homogeneous Spaces, and Dynamics was organized by Andreas Cap (University of Vienna), Charles Frances (Universite Paris-Sud), and Karin Melnick (University of Maryland) from July 10–23, 2011, at the research platform International Erwin Schrodinger Institute for Mathematical Physics (ESI) of the University of Vienna. The conference FDIS2011 – Finite Dimensional Integrable Systems in Geometry and Physics, was organized by Vladimir Matveev, Christian Richter, and Konrad Schobel (all University of Jena) in Jena from July 26–29, 2011.

From Modern Mexican Microbialites, Insights into Ancient Metabolism

Living descendants of fossilized microbes in Lake Alchichica of Mexico are being characterized and their respective metabolic roles in microbialite construction described by Purificacion Lopez-Garcia at the Universite Paris-Sud in Orsay France, and her colleagues there and at other institutions in France, Poland, and Mexico. Details of their studies appear in the December 2011 PLoS ONE (6; 12:e28767; doi:10.1371/ journal.pone.0028767).

New hands at the helm

It is with great regret that I have to say good-bye to my CoChief Editor Professor Gerard Said, who after 3 years has decided to step down. His successors, of whom there are two, are Michael Strupp and Massimo Filippi. Gerard took on this role with myself and Thomas Brandt back in January 2009, and since then the journal has continued to grow in terms of the number of submissions it receives and its impact factor, in no small part because of Gerard’s skills and his well-established and leading role in the European Neurological Society (ENS), to which the journal is linked. Gerard qualified in neurology from the medical school of the Salpetriere back in 1971 and since then has become an international academic neurologist of great repute as well as being highly influential in many different areas of neurological practice and training, both nationally and internationally. Apart from being the Professor of Neurology and Chief of Service de Neurologie at the Centre Hospitalier Universitaire de Bicetre, Universite Paris-Sud from 1987 to 2007, he was also a co-founder of the ENS in 1986 with the late P.K. Thomas and Anita Harding. This new society was born out of a sense that there was nothing equivalent to the American Academy of Neurology in Europe. Gerard became the first Secretary General of the society until 2007 and has been instrumental in organising all of their yearly congresses. He became President of the ENS in 2010. His main field of investigation has been in the area of peripheral neuropathies, where he has made many seminal contributions, and he is perhaps best known for his work on diabetic and vasculitic neuropathy. However, his work extends to many aspects of the peripheral nervous system, with influential work on infectious causes of peripheral nerve dysfunction such as HIV-associated neuropathies. This work has led not only to a better description and recognition of these conditions, but also to better investigation and treatment. This ability to master the whole spectrum of peripheral nerve disease has led to him taking an international role in this field of neurology. He has been Director of the Research Group on Neuromuscular Disorders of the World Federation of Neurology, and between 1998 and 2000 he was also President of the Peripheral Nerve Society (PNS). During his 3 years at the helm of the Journal of Neurology Gerard has been instrumental in speeding up the review process, in bringing in new initiatives, and in R. A. Barker (&) Cambridge Centre for Brain Repair, University of Cambridge, The E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK e-mail: rab46@cam.ac.uk

Endogenous Retroviruses: Thierry Heidmann wins the 2009 Retrovirologyprize

Thierry Heidmann wins the 2009 Retrovirology prize.

Roundtable Discussion of the Impact of the 4th World Symposium on Pulmonary Hypertension

A discussion among attendees of the 4th World Symposium on Pulmonary Hypertension took place to share “an insider's look” into the current and future research and treatment implications in pulmonary hypertension. Myung H. Park, MD, guest editor of this issue of Advances in Pulmonary Hypertension, Assistant Professor of Medicine and Director, Pulmonary Vascular Diseases Program, Division of Cardiology, University of Maryland School of Medicine, Baltimore, moderated the discussion. Participants included Robyn Barst, MD, Professor Emerita, Columbia University, New York; Marc Humbert, MD, PhD, Universite Paris-Sud, French Referal Center for Pulmonary Hypertension, Hopital Antoine-Beclere, Assistance Publique Hopitaux de Paris, Clamart, France; Ivan Robbins, MD, Associate Professor of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; and Lewis J. Rubin, MD, Clinical Professor, Department of Medicine, University of California, San Diego.

Bayesian Core: A Practical Approach to Bayesian Computational Statistics

The authors, Marin from Universite Paris-Sud, and Robert, from Universite Paris-Dauphine, have attempted to produce an intermediate level text on Bayesian statistics aimed for use by graduate students who need to have a fundamental understanding of Bayesian methods for their research. The authors also intend the book to be useful to scientists in all disciplines who may need to use Bayesian statistics. For several years both authors have taught a course corresponding to the text as part of a second year masters program for students in data processing as well as in statistics. The aim is to have readers learn to think about the purpose of a Bayesian analysis and to develop an intuition of what their analytic results should look like. Exercises are found throughout the text, rather than at the end of each chapter. The hope is to have readers get a more immediate feedback about what they are learning as they progress through the material. This way, inaccuracies in thinking can be caught early in the learning process. My impression of the text is that it is more of a handbook on Bayesian methods than a traditional textbook. The writing style is generally clear and to the point. The subject matter is for the most part developed in a step by step manner, with an effort taken to clarify major concepts and equations as they develop in the discussion. The authors have chosen to employ R for all examples, and even have a section in the text entitled, “A short introduction to R.” However, the use of examples showing R code in the text is for the most part dropped after Chapter 4.

The 3rd Worldwide Network Conference (HPWN-3): ?Strengthening the connection between fundamental research and its biotechnological applications?, Alghero, Sardinia, Italy, 25?29 September 2004

The Hansenula polymorpha Worldwide Network (HPWN) Conference is a biannual meeting at which fundamental research groups and industrial groups come together. The participating groups utilize the thermotolerant methylotrophic yeast H. polymorpha (syn. Pichia angusta ) as host during their studies. This organism is one of the most useful model organisms to study the intertwined processes of methanol metabolism and peroxisome homeostasis. Additionally, H. polymorpha has become a very powerful micro-organism for the production of heterologous proteins. After meetings in Dusseldorf, Germany (2000) and La Laguna, Tenerife, Spain (2002), the 3rd HPWN meeting was organized by members of the lab of Enrico Berardi (University of Ancona, Italy) in the conference centre of Porto Conte Ricerche, Alghero, Sardinia, Italy, 25–29 September 2004. Approximately 65 participants attended the conference, which included 27 scheduled presentations. Very importantly, the conference schedule allowed much time for informal interactions between the various participants, which is the strength of such small and specialized meetings. One-third of the participants were from biotechnological companies, reflecting the interest of H. polymorpha as a platform for heterologous protein production. ### 2.1 Nitrogen metabolism The conference got started with a comparative approach between the transcriptional regulation of nitrogen utilization in different ascomycetes by the invited speaker Claudio Scazzocchio (Universite Paris-Sud, France). His thorough comparison focussed on nitrogen utilization in Aspergillus nidulans and H. polymorpha . Unlike other yeast species, H. polymorpha has the ability to assimilate nitrate as sole nitrogen source. The main conclusion that could be drawn from this comparison is that there has been a convergent evolution between these fungal species that has led to distinct systems of regulation of nitrogen utilization in H. polymorpha and filamentous fungi. During recent years, nitrate/nitrite assimilation has become one of the main topics in the lab of E. Berardi , the host of the meeting. Federica Serrani from his …

Electron energy-loss spectrum of an electron passing near a locally anisotropic nanotube

a ´´ ˆ Laboratoire de Physique des Solides , Associe au CNRS ,( UMR 8502) Universite Paris-Sud, Batiment 510, Orsay 91405, France b ´ Laboratoire de Physique du Solide , Facultes Universitaires Notre-Dame de la Paix ,6 1rue de Bruxelles, 5000 Namur, Belgium Abstract Electron Energy-Loss Spectroscopy (EELS) is a very well adapted tool to study the dielectric response of nanotubes. Due to the 'curved anisotropy' of such nano-objects, the interpretation of the EEL spectra is far from being straightforward and an adapted theoretical framework is then required. In this contribution, we extend the continuum dielectric approach to hollow anisotropic cylindrical nanoparticles, showing that the energy-loss probability can be handled both analytically and numerically.

Atomic geometry and the probability distribution of self-assembled Cs nanowires at the InAs(110) surface

Laboratoire pour l’Utilisation du Rayonnement Electromagne ´tique (LURE), Bat. 209D, Universite Paris-Sud, F-91405 Orsay, France~Received 28 September 2001; revised manuscript received 13 December 2001; published 30 August 2002!Cesium adsorbs on the InAs~110! surface in the form of long chains extending for several hundreds ang-stroms along the @11I0# direction, leading to a (23n) periodicity, with n depending on the mean distancebetween the alkali chains. We have investigated the evolution of the (23n) superstructure as a function ofcoverage and the statistical distribution of the Cs chains by means of grazing-incidence x-ray diffraction andlow-energy electron diffraction. The atomic geometry has been fully determined: each Cs chain is constitutedby two Cs adatoms with different adsorption sites. The minimum Cs-Cs distance within the chain is 6.9 A,much larger than the Cs-Cs bond length in bcc bulk metallic Cs.DOI: 10.1103/PhysRevB.66.085335 PACS number~s!: 68.43.Hn, 61.10.2i, 68.65.2kI. INTRODUCTION

Call for papers: Special issue on “Molecular physics of building blocks of life under isolated or defined conditions”

Submission until end of 2001 Scheduled for publication in Sept./Oct. 2002 The new research field studying “Building blocks of life under isolated or defined conditions” is showing rapid growth. New technical and experimental developments have stimulated recent progress in the investigation of biologically relevant, but thermally unstable, molecules in well defined environments. At the same time, enormous progress in computer power and the development of more efficient computational methods now make it possible to calculate large, flexible systems, such as small peptides and nucleobase pairs, at unprecedented levels of theory. While this approach does not claim to try and understand biological systems in situ, it does aim to explore their detailed intramolecular properties, otherwise hidden in the averaging of states, structures, conformers and sites, inherent in the solution phase and under other undefined conditions.[-2.5mm] Special conditions, such as low temperatures, defined environments or the observation of isolated and selected or even single molecules, can generate high resolution data which, combined with theory, can provide fundamental insights into the detailed properties of biomolecules. This approach reveals their dipole moments, ionization energies, electron affinities, proton affinities, structural shape, electronic structure, photodynamics and reactivity, but also their structural arrangement and binding strength to themselfs, to other building blocks of life or to solvent molecules.[-2.5mm] Our focus for this special issue is on the most fundamental biomolecular building blocks, including, but not limited to nucleic acid bases, nucleotides, amino acids and small as well as large peptides or proteins and complexes thereof. Investigations may include, for example, rotationally, vibrationally and electronically resolved spectroscopy with different excitation schemes, such as multiphoton ionization, laser induced fluorescence, photodissociation, photoelectron spectroscopy techniques and variety of mass spectrometric methods, such as ion-drift and ICR based approaches. New double resonance techniques allow assignments of conformer, isomer and tautomer structures which often coexist in molecules and complexes of biological interest. A great advantage of specific and detailed experimental results under well-defined conditions is the possibility of direct comparisons with theoretical calculations. This makes it possible to explore the shape of the potential energy surface, atomic charge densities, and contributions of individual forces to binding energies and solvation. We invite all molecular physicists, chemists and biochemists, experimentalists and theoreticians alike, who study molecular systems of biological interest under well defined conditions, to contribute to this special issue. Please send your manuscripts to the EPJ Editorial Office, Universite Paris-Sud, Bâtiment 510, F-91405 Orsay Cedex, France or to one of the guest editors below Karl Kleinermanns Heinrich-Heine-Universitat Dusseldorf Institut fur Physikalische Chemie I Universitatsstrase 1 40225 Dusseldorf – Germany Tel. (49) 211 811 3691 – Fax: (49) 211 811 5195 e-mail: kleinermanns@uni-duesseldorf.de Jean-Pierre Schermann Universite Paris-Nord Institut Galilee Laboratoire de Physique des Lasers 93430 Villetaneuse – France Tel. (33) 1 4940 3816 – Fax. (33) 1 4940 3200 e-mail: schermann@lpl.univ-paris13.fr Mattanjah S. de Vries Department of Chemistry and Biochemistry University of California Santa Barbara, CA 93106 – USA Tel: (805) 893-5921 – Fax: (805) 893-4120 e-mail: devries@chem.ucsb.edu Dr. Rainer Weinkauf Heinrich-Heine-Universitat Dusseldorf Institut fur Physikalische Chemie I Universitatsstrase 1 40225 Dusseldorf – Germany Tel. (49) 211 81 11729 – Fax: (49) 211 81 11730 e-mail: weinkauf@uni-duesseldorf.de For a faster assessment electronic submission is highly encouraged (e-mail: epjd@edpsciences.org). Instruction for preparing the manuscripts are given at http://www.edpsciences.org Karl Kleinermanns, Jean-Pierre Schermann, Mattanjah S. de Vries, Rainer Weinkauf

Mössbauer spectrometry ofA2FeMoO6(A=Ca,Sr,Ba): Search for antiphase domains

J. M. Greneche, M. Venkatesan, R. Suryanarayanan, and J. M. D. Coey Laboratoire de Physique de L’Etat Condense UPRESA CNRS 6087, Universite du Maine, 72085 Le Mans, France Physics Department, Trinity College, Dublin 2, Ireland Laboratoire de Physico-Chimie de l’Etat Solide CNRS, UMR 8648, Bat. 414, Universite Paris-Sud, 91405 Orsay, France ~Received 18 August 2000; revised manuscript received 7 November 2000; published 29 March 2001!

French participation in the International Equatorial Electrojet Year

Abstract. Without abstractAcknowledgements. The IEEY studies in the African sector were made possible by the participation of a large number of institutes. Funding was provided by the Ministère Français de la Coopération (Département de la Recherche et des Formations, and Département Télécommunications); ORSTOM (Département Terre Océan Atmosphère); CNET (France-Telecom Centre Lannion); the Ministère Français de la Recherche et de la Technologie; Centre National de la Recherche Scientifique (Département Sciences de l'Univers); the Centre à l'Energie Atomique; the Université Paris-Sud; Abidjan University, Ivory Coast; Dakar University, Senegal. We would like to express our deep gratitude to the many colleagues who have participated in the success of this experiment through their enormous personal commitment, to the Editorial Board of Annales Geophysicae and particularly to Sylviane Perret for producing this special issue.