Universidad De Research Articles

S114 Assessment of Corticosteroid Use as a Marker of Quality-of-Care in the Management of Inflammatory Bowel Disease

Background: Despite the development of new therapeutic strategies, corticosteroids still play a role in the induction of Inflammatory Bowel Disease (IBD) remission. However, often these drugs are misused. Methods: Descriptive, retrospective observational study of patients with IBD under follow-up in the Inflammatory Bowel Disease Program of Clínica Universidad de los Andes (Chile) during the period of January 2021-August 2022. The objectives were to assess the dose and duration of corticosteroid therapy, and the subsequent change in treatment in patients with IBD. The statistical analysis, descriptive and association statistics x2 with P< 0.05 were used. Results: Four hundred and thirty-two IBD patients were included, 63% of them women, with a median age of 42 years (14-94), 66% with ulcerative colitis (UC). Sixty-six percent of patients have received corticosteroids during the course of their disease (range 1-9 times) for a median of 12 weeks (2-48 weeks), prednisone being the most frequently used corticosteroid (53%). Seventy-seven percent of patients have received treatment for >3 months or in supratherapeutic doses (more than 1 mg/Kg, range 40-60 mg of prednisone). There was a change in treatment in 82% of these patients. During the Program’s follow-up, 10% have received corticosteroids (71% prednisone, 29% budesonide) with no differences according to IBD type, gender, age or type of treatment. No patient has received corticosteroids for >3 months or in supratherapeutic doses in our Inflammatory Bowel Disease Program. Two percent developed corticosteroid dependency and in 90% there was a change of treatment. Conclusion(s): This study validates the assessment of the use of corticosteroids as a marker of quality of care in IBD. The management of these patients through a specialized program could reduce the excessive use of corticosteroids.

Public ground as coastal defence: imagining the Mediterranean beachfront by the Atlantic

The article explores the role of public ground composition design as a defence element for coastal agglomerations vulnerable to mean sea level rise in extreme weather events scenarios. It addresses one of the pilot case studies of the [ENTRA]MAR Urban form intertwined with the sea research project, Quarteira, a coastal city located in the Algarve region of southern Portugal, which is vulnerable to flooding and erosion phenomena. The article provides an opportunity to systematise the reading and interpretation phases and also the research by design phase based on scenario development that was conducted during the fourth-year design studio at the Lisbon School of Architecture of the Universidade de Lisboa and therefore, to share its preliminary results on “imagining the Mediterranean beachfront by the Atlantic”. Attributing Mediterranean values and characteristics to Quarteira involves, as Braudel wrote in “Les Mémoires de la Méditerranée”, observing the coastal landscapes over and over again, until the physical and urban characteristics are eloquently revealed and named. Finally, it is underlined the need to design the space between land and sea based on the inherited memory of the coastal landscape and the operative role the public ground design &lt;may have as coastal defence. The article explores the role of public ground composition design as a defence element for coastal agglomerations vulnerable to sea level rise in extreme weather events scenarios. It addresses one of the pilot case studies of the [ENTRA]MAR Urban form intertwined with the sea research project, Quarteira, a coastal city located in the Algarve region of southern Portugal, which is vulnerable to flooding and erosion phenomena. The article provides an opportunity to systematise the reading and interpretation phases and also the research by-design phase based on scenario development that was conducted during the fourth-year design studio at the Lisbon School of Architecture of the Universidade de Lisboa and therefore, to share its preliminary results on "imagining the Mediterranean beachfront by the Atlantic". Attributing Mediterranean values and characteristics to Quarteira involves, as Braudel wrote in Les Mémoires de la Méditerranée, observing the coastal landscapes over and over again, until the physical and urban characteristics are eloquently revealed and named. Finally, it is underlined the need to design the space between land and sea based on the inherited memory of the coastal landscape and the operative role the public ground design may have as coastal defence.

Impairment of amacrine starburst cells and their synaptic contacts with dopaminergic cells could explain motion perception disturbances in Parkinson's disease

AbstractPurpose: Parkinson's disease (PD) patients suffer from visual deficiencies in the early stages of the disease. One of these visual symptoms is the impairment of the motion perception. In that sense, we wanted to determine if the starburst amacrine cells (the main cell type involved in motion perception) are degenerated in PD. Also, we sought to evaluate if this possible degeneration is related to the degeneration of the dopaminergic system.Methods: Post‐mortem human eyes from control and PD donors were used in this study. Immunohistochemistry and confocal microscopy were used in whole‐mount retinas to evaluate tyrosine hydroxylase‐positive cell density (dopaminergic amacrine cells), and choline acetyltransferase‐positive cell density (starburst amacrine cell). Moreover, we quantified the dopaminergic synaptic contacts with starburst amacrine cells using vesicular monoamine transporter‐2 (VMAT2) antibodies.Results: There is a decrease in the dopaminergic amacrine cell density in PD retinas. Furthermore, we found a decrease in the number of starburst amacrine cells. Importantly, we describe for the first time that dopaminergic amacrine cells contact with starburst amacrine cells in the retina and that these connections decrease in PD patients.Conclusions: This work shows the degeneration of starburst amacrine cells and their synaptic connections with dopaminergic cells, and this may explain the disturbances in motion perception present in PD. Importantly, these deficiencies can be used as a biomarker of this pathology performing functional tests for visual motion perception.Support: Ministerio de Ciencia e Innovación (FEDER‐ PID2019‐106230RB‐I00). Ministerio de Universidades (FPU16/04114). Instituto Carlos III (RETICS‐FEDER RD16/0008/0016). Generalitat Valenciana (IDIFEDER/2017/064, ACIF/2020/203). Michael J Fox Foundation for Parkinson's Research.

Numerical evaluation of intraocular lens decentration

AbstractPurpose: Numerical evaluation of the performance under decentering of an extended depth of focus (EDOF) bisegmented design intraocular lens (IOL).Methods: The optical assessment of The FEMTIS Comfort EDOF‐IOL was evaluated with a ray tracing software using the Atchison model eye (Atchison 2006). Under monochromatic illumination (555 nm) and 4.50 mm pupil, the Modulation Transfer Functions (MTFs) were calculated at the vergences range + 0.50 D to −2.50 D in both tangential and sagittal directions. They were calculated for IOL displacements of 0.25, 0.50 and 1.00 mm in the horizontal and vertical direction. The area under the MTFs (AMTFs) was calculated as the tangential and sagittal MTFs average for frequencies between 0 and 50 cycles/mm.Results: AMTF of the IOL has an EDOF profile. When it is decentered horizontally, the AMTF does not differ significantly from the AMTF of the centered IOL. But if it is decentered vertically the AMTF varies. This is due to the bisegmented design of the IOL.Conclusions: After surgery, decentration may occur due to posterior capsule opacification, capsule fibrosis, etc. (Ashena et al. 2020). Due to its design, this IOL is robust against horizontal decentration, but not for vertical decentration. D.M.‐M. acknowledges the Margarita Salas grant from the Ministerio de Universidades, Spain, funded by the European Union‐Next Generation EU.

Soft skills from the perspective of john dewey's problem-based learning for tenth semester psychologists in training at the villa del rosario campus of the university of pamplona

Higher Education Institutions (HEIs) are called upon to develop skills for work and life. That is to say, the formation of values and attitudes for every human being is of great importance for the development and balance between the professional, work, and social spheres. However, at present, higher education students have an education focused on work performance, leaving aside the development or training of soft skills or competences. This research set out to characterize the soft skills of tenth semester psychologists in training at the Villa del Rosario campus of the Universidad de Pamplona using John Dewey's Problem-Based Learning Theory (PBL). It was done under a qualitative, cross-sectional and phenomenological design approach, by means of interviews with psychologists in training and the application of a PBL. It can be concluded that Problem-Based Learning as a learning theory offers education a strategic framework for psychologists in training to develop competencies, as well as hard and soft skills from an experiential perspective. Regarding the latter, the evaluation identifies an imperative need, from this theoretical framework (PBL), to redefine the teaching-learning processes. As well, to promote values and traits that foster, in addition to communication, effective individual and collective relationships in the context in which the psychologist develops.

Public health education in Colombia: influence on public policies.

Colombia has a tradition on Public Health education since the mid years of 1950's. The first cohorts of Public Health academics and workers were trained at the National School of Public Health, which was established, with the support of the Rockefeller Foundation, at the Universidad Nacional de Colombia in Bogota, but later moved to the Universidad de Antioquia in Medellin. In the current context, Colombian Public Health academics have rallied against the neoliberal Health Reform implanted in 1993 that has failed to address the country's health priorities. Most of the interactions between Public Health academic leaders with government and other decision makers, revolve around the discussion on whether a new way to conceptualize and operate the national health system should be visualized and implemented. So far, the academic sector have been unable to overthrow the main aspects of the Reform -private insurance companies operating, and profiting, on public money- but they have demonstrated how inequalities in health access have widening under the Health Reform and how it have been unable to improve the health situation of the population.

The development of Brazilian women's and gender studies: a bibliometric diagnosis.

The online version contains supplementary material available at 10.1007/s11192-022-04545-w.

Patients with Sickle Cell Disease Treated with Hidroxiurea Have Higher Expression of PD-L1 in Monocytes

Background: Inflammation plays a key role in pathophysiology of sickle cell disease (SCD). Monocytes are important mediator cells in the inflammation pathway. Despite some evidence that monocytes are more activated in SCD and can trigger vaso-occlusion, there is a remarkable lack of knowledge about how monocytes behave in patients with SCD and whether they are modulated by different treatments. Objective: To assess possible changes in monocyte maturation and protein expression among sickle cell disease patients in different treatment modalities and compare them to healthy subjects. Methods: 25 patients with SCD followed at the outpatient service of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and 3 healthy controls were included. The inclusion criteria were: patients with sickle cell anemia (HbSS), over 18 years of age, without acute complications in the prior three months. Pregnancy was an exclusion criteria. Patients were divided in three groups: treatment with Hydroxyurea (HU) (n=10) using the same dose for at least three months; chronic exchange transfusion (n=9) (TP); and no specific treatment (NST) (n=6). We collected 3-5 ml of blood and performed peripheral blood mononuclear cells (PBMC) separation. Monocytes were analyzed by flow cytometry (Dx Flex, Beckman Coulter), using CD14 and CD16 as markers of subpopulations of monocytes as classical (CD14+/CD16-), intermediate (CD14+/CD16+) and non-classical (CD14-/CD16+). We also assessed the expression of CD 86 (a co-stimulation chemokine receptor), CD 163 (receptor for the conjugate hemoglobin-haptoglobin) and PD-L1 (an inhibitor receptor). Comparison between groups were made using ANOVA and Tukey test. Results: Gender distribution yielded no significant difference. Age varied as shown: HU 30 ± 8y, TP 37 ± 9y, NST 35 ± 11y and 42 ± 19y for the controls. The mean of total leukocytes and monocytes were, respectively: 8,816 ± 2,133/mm³ and 900 ± 563/mm³ (HU), 11,487 ± 3,813/mm³ and 1,343 ± 754/mm³ (TP), 9,081 ± 1879/mm³ and 1,373 ± 432/mm³ (NST), 7,080 ± 642/mm³ and 700 ± 0/mm³ (control).Among the total nucleated cells, the percentage of classical monocytes was lower in HU compared with. Controls (3.8 ± 2.1% vs. 7.7 ± 1.3%, p 0.008), lower in TP vs NST (2.4 ± 1.8% vs. 5.6 ± 2.8%, p 0.04) and in TP vs Controls (2.4 ± 1.8% vs. 7.7 ± 1.3%, p 0.001). No differences were shown in the intermediate monocytes population. In turn, nonclassical monocytes were higher in HU compared with TP (0.44 ± 0.3% vs. 0.22 ± 0.2%, p 0.013) and in controls vs TP ( 0.35 ± 0.07% vs 0.22 ± 0.2%, p 0.017). The expression of CD 86 and CD 163 was not significantly different between any of the subsets of monocytes. In classical monocytes, expression of PD-L1 was higher in HU compared with NST (86.1 ± 17.4% vs. 43.9 ± 31.0%, p 0.015 ) and HU vs Controls ( 86.1 ± 17.4% vs. 34.9 ± 8.9%, p 0.019). Expression of PD-L1 in intermediate monocytes and in non classical monocytes were also higher in HU compared with controls (88.9 ± 16.3% vs. 58.6 ± 8.6%, p 0.02 and 79.6 ± 30.2% vs. 37.1 ± 4.6% , p 0.02 respectively). These results are depicted in table and figure 1. Conclusion: Different treatments for sickle cell disease have affected the monocyte subsets distribution and PD-L1 expression in the population studied. HU and Transfusion Program induced a reduction in the Classical Monocyte subset, more pronounced in the latter. Classical monocytes are largely associated with a pro-inflammatory profile. The use of HU in SCD has been previously associated with less classical monocytes, and induction of monocyte maturation might help explain this finding; as for chronic transfusions, a migratory effect of monocytes to tissues has been proposed. The higher expression of PD-L1 in patients submitted to exchange transfusion and in use of HU indicate inhibition of inflammation, which is more pronounced in the HU group. Both treatments have immunomodulatory effects on SCD, however, to date, no inflammatory markers that assess response to treatment are available. Our findings might contribute to uncovering the role of PD-L1 in the chronic inflammation of SCD and to identify a potential biomarker. Nevertheless, further studies with larger cohorts are warranted in these settings. Figure 1View largeDownload PPTFigure 1View largeDownload PPT Close modal

Reference Gravity Frame in Latin America

With the development of the ballistic gravimeter in the late 80s, the efforts to establish reliable absolute gravity reference around the world became a reality. The need for the so-called International Terrestrial Gravity Reference Frame (ITGRF[1]) to substitute the IGSN 71 (International Gravity Standardization Net 1971) is one of the demands of modern Geodesy. In that context, the Laboratório de Topografia e Geodesia, Escola Politécnica da Universidade de São Paulo (LTG/EPUSP), Brazil, started in 2013, with the acquisition of the A10 no 32 (A10-032) absolute gravimeter, a large number of campaigns to measure gravity acceleration in the states of São Paulo, Minas Gerais, Paraná and abroad. The gravimeter was purchased by Instituto Geográfico e Cartográfico (IGC), state of São Paulo. After eight years of operation under the coordination of the Centro de Estudos de Geodesia(CENEGEO) and with the support of different institutions, a total of five national Gravity Reference (GR) was established: Argentina, Brazil, Costa Rica, Ecuador and Venezuela. The present efforts are the selection of a set of local GR in the different countries of Latin America and a possible contribution to the ITGRF.[1] The ITGRS/F acronyms were approved by IAG JWG 2.1.1 in April 2022, replacing the former IGRS/F acronyms.

Medicina tradicional como tratamiento de la COVID-19 en estudiantes y familiares en una universidad de la sierra del Perú

Medicina tradicional como tratamiento de la COVID-19 en estudiantes y familiares en una universidad de la sierra del Perú

Laboratory simulations of self-potential signals to assist groundwater studies

We present a brief history of experimental simulations with electrokinetic potential signals observed when common porous geological media are subjected to water flow regimes. The laboratory simulations at Instituto de Astronomia, Geofísica e Ciências Atmosféricas (IAG) of the Universidade de São Paulo (USP) had to overcome several challenges over years of research work, by developing experimental design, choice of materials, and software development to guide real data interpretation and definition of acquisition procedures to be implemented in practice. In this commemorative issue honouring the IAG/USP graduate program, we discuss some of our former results, including a set of original data for two laboratory experiments developed. The first experiment characterizes electrokinetic signals under controlled pumping regimes to illustrate the sensitivity of such potentials to structures with contrasting properties. The second study discusses model response for discrete fractures to guide field data interpretation to determine the hydraulic head in unconnected fractured systems by monitoring the variation of the electrokinetic potential after a borehole is pumped. In both cases, the experimental simulations are useful to understand the electric potentials of electrokinetic origin, pointing out their advantages in characterizing the subsurface hydraulic conditions when a borehole is pumped.

Editorial: Electrochemistry in Latin America

Editorial: Electrochemistry in Latin America

Factors related to sugar consumption by young people in Portugal: public policies and nutritional literacy

To reduce the burden of diet-related non-communicable diseases, promoting healthy eating habits has become a concern of modern societies. In this vein, in addition to trying to improve the health literacy of its population, the Portuguese authorities have recently levied taxes on food products that are deleterious to health. Despite the young exhibiting better health literacy, they also tend to overconsume these products. This research analyses the influence of public policies on healthy eating and of health literacy on the health management of young adults. We applied an online survey to young adults who were attending a university degree at Universidade de Lisboa. The collected data were processed by statistical analysis, using SPSS software. Although most of the young respondents recognize their importance in managing their individual health, a large majority are unaware of the public policies in place and frequently over consume sugar. Public policies on healthy eating thus need to reconsider the role of young people as agents of participation, promoting knowledge about the measures and providing them with tools to manage their own health.

Aquaporin-4 Expression in Meningioma Malignancy Progression

Abstract Objectives The aim of the present study is to analyze if aquaporin-4 (AQP4) may also be a tumor progression marker for meningiomas. Methods This is an immunohistochemistry study realized at the Universidade de São Paulo, São Paulo, state of São Paulo, Brazil: frozen meningioma samples from 81 patients (57 females and 24 males, age range from 22 to 81 years old, average 56.5 ± 14.1 years old), including 57 meningiomas World Health Organization (WHO) grade I (GI); 19 grade II (GII), and 5 grade III (GIII) were analyzed. The relative expression level of AQP4 was analyzed by quantitative polymerase chain reaction (qPCR), using the SYBR Green approach and for staining detection. Tissue sections were routinely processed and subjected to antigen retrieval. Results The expression of AQP4 in meningioma samples ranged from 0 to 10.26, with a median of 0.001 in GI cases, of 0.008 in GII cases, and of 0.006 in GIII cases. Although not statistically significant (p = 0.942), GI meningiomas have a lower median AQP4 expression level than higher malignant grade cases. Conclusion The AQP4 gene and protein expressions presented no association with meningioma malignant progression.

Variations in the origin of the anterior spinal artery in a Colombian population sample.

Based on most neuroanatomical descriptions, the anterior spinal artery (ASA) originates from two small vessels of the vertebral arteries, which are anastomosed just before forming the basilar artery. This study aimed to determine and quantify the possible variants of the origin of the ASA and its trajectory in samples of human brain stems. Male brain stems with the superior portion of the spinal cord until myelomera C3 of 23 adult human, and no evident morphological alterations were selected. The brain stems were collected for three years and fixed in a 10% formalin solution at the Anatomy Laboratory of the Universidad de Caldas (Colombia). Five samples (21.7%) had variations in the origin and trajectory of the anterior spinal artery. The variations in the origin of the ASA could generate morphofunctional advantages instead of leading to complications. That is the case when there are two anterior spinal arteries since it would increase tissue perfusion, thus protecting part of the spinal cord from ischemic pathologies. It is essential to consider the variations that may exist in the supply of the anterior region of the spinal cord for clinical and surgical assessments due to variations in its supplied territory.

Learning techniques that medical students use for long-term retention: A cross-sectional analysis

Background Reviews and meta-analysis conclude that distributed practice and practice testing are deemed the most effective learning techniques among undergraduate students, while rereading, underlining, and summarisation are the most known and less effective ones. However, this evidence is gathered from short-term retention studies prior to 2014, and there are other techniques with promising effect (metacognition, retrieval, concept mapping, setting learning goals) that were not included. Also, there is little real-settings evidence regarding what works best for long-term retention in medical students. Methods A cross-sectional analysis was carried out in a sample of 155 of second and third-year students of the Degree in Medicine at Universidad de Navarra in September 2020. The aim was to evaluate the impact the use of different learning techniques had on academic performance of undergraduate medical students, assessing up to three months of retention. A subgroup analysis was performed based on learning approach, spacing of the learning sessions, and academic results. Results Rereading, highlighting, and summarisation were the most known and used techniques among medical students, with detrimental effects on academic outcomes. Metacognition was the most effective technique, but up to 92% of the students didn’t know what it was. No single learning technique seemed to improve results in below-average students. Conclusions University curricula should promote the use of more efficient techniques, particularly metacognition, to help students become lifelong learners. More studies are needed to confirm these findings. Below-average students remain a challenging population.

Discussion: In Vivo Analysis of the Superficial and Deep Fascia.

São Paulo, Brazil From the Laboratory of Microsurgery and Plastic Surgery, School of Medicine, Universidade de São Paulo. Received for publication February 22, 2022; accepted July 6, 2022. Disclosure:The author’s laboratory received mini silicone protheses from Mentor. Cristina Pires Camargo, M.D., Ph.D., Av. Dr. Arnaldo 455, São Paulo, Brazil, [email protected]

Mediterranean Diet and Cardiovascular Prevention: Why Analytical Observational Designs Do Support Causality and Not Only Associations.

Causal reductions in cardiovascular disease (CVD) with the Mediterranean diet (MedDiet) are supported by randomized trials, but the ability of nonrandomized studies to provide causal inferences in nutritional epidemiology is questioned. The “Seguimiento Universidad de Navarra” (SUN) project, conducted during 1999–2019 with 18,419 participants, was used to try to refute non-causal explanations for the inverse association found between adherence to the MedDiet and reduced CVD risk. A framework of different analytical strategies is proposed: alternative definitions of the exposure, exploration of residual confounding, resampling methods, depiction of absolute risks across the follow-up period, trial emulation, and negative controls. Additionally, we calculated the rate advancement period (RAP). We found that one standard deviation increase in the most frequently used MedDiet score was associated with a 29% relative reduction in CVD risk (95% Confidence Interval [CI] 14–41%), which is almost identical to that found in 2 randomized trials. The RAP of CVD would be postponed by an average of 7.9 years (95% CI: 1.6 to 14.2 years) by switching from low (MDS = 0 to2) to high (MDS = 7 to 9) adherence to the MedDiet in the fully adjusted model. Sensitivity analyses, graphical representations of absolute risks, trial emulation, and negative controls also supported causality. In conclusion, a framework of analytical approaches supported the causal effect of the MedDiet on CVD prevention using observational data. Similar methodology could be applied for causal inferences regarding other hypotheses.

A scientific methodology course for advanced medical students: an eight-year perspective

Background: Exponential increases in the development of medical knowledge, the expansion of areas where medicine develops its activities, the emergence of new pathologies (e.g., COVID-19), novel diagnostic methods and therapeutic strategies, together with the appearance of multiple communication and information technologies, determined that the education of future physicians required targeted training in scientific methodology. Methods: The design and execution of a course in scientific methodology in the curriculum of Facultad de Medicina, Universidad de la República, Uruguay, is described. The course is carried out at an advanced stage of the medical studies for all the students, in which they develop a 10-month research project supervised by the medical school faculty. Students undergo all stages of a research endeavor: generation of hypothesis or general aim, elaboration of a research protocol, submission to the Research Ethics and Animal Welfare Committees, data recollection, analysis, interpretation and publication of the results. Results: The course is undertaken at the Facultad de Medicina, Universidad de la República, Uruguay, the main university of the country, with high numbers of students enrolled. The course involves the participation of 600 students and up to 300 professors per year, which implies a huge institutional effort. Conclusions: The scientific methodology course resulted in one of the most important incorporations of the current 2008 curriculum. Local students, faculty and international evaluators have qualified this activity as an educational breakthrough, being a gratifying and productive experience. The course represented the first exposure of medical students to the research methodology, scientific literature and publication rules, and emphasized the dynamic nature of medical knowledge within modern medical education. Moreover, for some students it constituted the onset of academic research careers. An additional positive outcome was the reactivation of some faculty research projects, in a way that largely exceeded the boundaries of the course.

The Traspena meteorite: heliocentric orbit, atmospheric trajectory, strewn field, and petrography of a new L5 ordinary chondrite

ABSTRACTThe Traspena meteorite fell on 2021 January 18 about 20 km south-east of the city of Lugo (Galiza, Spain), shortly after a huge and bright fireball crossed the sky for 4.84 s. Astrometric measurements obtained from the fireball cameras of the Universidade de Santiago de Compostela (USC) as well as from many casual videos were used to determine the atmospheric trajectory of this meteoroid which penetrated the atmosphere and generated sound waves that were detected at three seismic stations. The original meteoroid had a diameter of about 1.15 m and a mass around 2620 kg. It impacted the Earth’s atmosphere with a steep entry angle of about 76${_{.}^{\circ}}$7 from a height of 75.10 km until fading away at 15.75 km with a velocity of 2.38 km s−1. Before the impact, this small asteroid was orbiting the Sun with a semimajor axis of 1.125 au, a moderate eccentricity of 0.386, and a low inclination of 4${_{.}^{\circ}}$55. A weak evidence of dynamic link with the PHA (Potential Hazardous Asteroid) Minos was investigated. During the atmospheric entry, two major fragmentation events occurred between heights of 35 and 29 km at aerodynamic pressures between 1 and 5 MPa. The strewn field was computed after calculating the individual dark flights of the main body along with two smaller fragments. Fortunately, 2 month after the superbolide, a 527-g meteorite was found. It was examined using several geochemical and petrographic analyses which allowed us to classify it as a moderately shocked (S3) L5 ordinary chondrite with a bulk density of 3.25 g cm−3.