INTRODUCTION: Polycystic ovary syndrome (PCOS) is the most prevalent cause of endocrine disorders in teenagers. Hyperandrogenism affects brain maturation, especially in high plasticity periods (intrauterine and adolescence), potentially modulating the social-emotional status of affected adolescents (aPCOS). This study characterizes the consequences of hyperandrogenism in social-emotional status and social cognition on aPCOS. METHODS: This was an analytical cross-sectional study that included aPCOS between 12 and 25 years. Each patient underwent a clinical evaluation and measurements of the following: intrauterine androgen exposure markers (2D:4D, AGD), hormonal parameters, psychological questionnaires (PANAS, SDQ, EQ/SQ, RET, CAM), and Eye-Tracking (Tobii). This study was approved by Universidad de Chile's ethics commitee. RESULTS: Ninety participants were included: 43 cases and 47 controls. aPCOS presented more intrauterine exposure to androgens ([15/18] AGD: 9.7 versus 7.8; P=.014) and hyperandrogenemia ([15/18] FAI: 7.5 versus 4.1; P=.004). They exhibited a predominance of negative affects ([43/47] PANAS: 8.0 versus 2.0; P=.049), more socio-emotional problems ([43/47] SDQ: 2.5 versus 1.5; P=.047), less self-reported empathy ((43/47) EQ: 19.0 versus 25.1; P=.001), and differences in gaze patterns, such as longer time to first fixation in areas of interest (s) ([7/3] AOI(s): 0.35 versus 0.28; P=.037), which was associated with a worse score in emotional recognition (CAM; aR2=−0,920; f=19,48; Pr>|t|=|t|=0.049). CONCLUSION: aPCOS presented with predominance of negative affects, more social-emotional difficulties, and lower score on emotional recognition, associated with exposure to hyperandrogenism during the most critical neuroplasticity periods. These findings suggest that mental health should be evaluated on every PCOS patient, especially adolescents.