Expression of Concern: Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase.

Abstract

There are issues in J. Cell Sci. (2002) 115, 4671-4683 (doi:10.1242/jcs.00153).There are irregularities with the background in Fig. 3E and Fig. 9A. Also, in Fig. 4, several data points are unexpectedly similar between the two FACS plots in panel A, and the first two lanes of the blot in panel D are duplicated. The authors no longer have the original data, but state that the conclusions of the paper are not affected.A report by Instituto de Ciencias Biomédicas, Universidad de Chile, decided that there had been ‘to some extent data manipulation but not falsification’ of this and other papers authored by Claudio Hetz and concluded that the key findings of this paper are unaffected.Without the original data, it is difficult to determine how these issues arose, so the journal is publishing this note to alert readers to our concerns.