In this study, the time and spatial variability of perceptible conditions, determined on the basis of effective temperature in the area of the Szczecin agglomeration are presented. The study was based on air temperature, relative humidity and wind speed data acquired during 2005–2007 from three emissions stations located in the centre and on the outskirts of the city of Szczecin, Poland. The differences in the values of the measured meteorological components between the studied city locations, in terms of their magnitude and daily structure, were analysed by month and calendar season. The results demonstrate that the temperatures in the city centre were considerably higher throughout the daily cycle, which was most evident during the summer in contrast to winter when the differences were the lowest. Mainly June and July, at 17–24 UTC (Coordinated Universal Time), were characterized by the average highest intensity of the urban heat island. Reduced relative humidity in the centre of Szczecin, as compared to the suburban areas, was observed particularly during summer. Throughout the daily cycle, this trend was also observed during spring, primarily during the night. Wind speed within the congested housing in the centre of Szczecin was over two-fold lower as compared to the unbuilt-up areas of the outskirts, irrespective of the time of the day and season of the year. Modification of the air humidity, thermal and anemometric conditions was reflected in a considerable variation in heat perception. In summer and spring, between 1300 and 2100 UTC, the most burdening biometeorological conditions, sensed as ‘hot’ and ‘very hot’ weather, prevailed in the city centre. During winter, on the other hand, the unbuilt-up areas on the city outskirts were the most unfavourable in terms of biothermal conditions, with the predominant categories of perceptible weather conditions throughout the daily cycle being ‘cold’ and ‘very cold’.