The main of the problems of the development of two-link manipulators with an angular coordinate system is the lack of effective and universal control systems capable of implementing energy-intensive modes of movement. This is due to the design features of the pointer system of such manipulators and the methods of their use. During the operation of the manipulator, significant dynamic loads occur in its drive system, which create oscillations of the mechanical system and reduce the accuracy of work. The control system must also effectively compensate for such dynamic variations. Dynamic equations of motion used to build manipulator control controllers, which allow taking into account various features of using manipulators. These mathematical models necessarily contain one of the characteristics in the form of the combined moment of inertia of the mechanical system, which is important in the calculation of differential equations and the determination of kinematic parameters of motion. In this article, the combined moments of inertia of the boom system of a two-link manipulator with an angular coordinate system are determined. A study was carry out and it shown that the nature of the change in the combined moments of inertia influenced by the modes of movement of the boom system links. The results of the study showed that the combined moment of inertia of the boom system of the manipulator is not a constant value, which does not change uniformly under special operating conditions of the machine. To determine the combined moments of inertia, the method of bringing the kinetic energy of the moving system to the drive mechanism was apply. This is relevant, because in the future it will be necessary to adjust the unevenness of the movement of the manipulator links by the drive itself. The study was conduct for a typical linear motion mode and a motion mode with a change in speed along a parabolic trajectory.