Units Of Blood Transfusion Research Articles

Psychological Problems and Coping Patterns among Mothers of Children with Thalassemia

Background: Mothers of children with thalassemia usually experience many psychological problems which negatively affect not only all quality of life domains but also, their coping patterns towards their children illness. Aim: This study aims to assess psychological problems and coping patterns among mothers of children with thalassemia. Research design: A descriptive design will be utilized to conduct this study. Setting: The study was conducted at blood transfusion unit in blood diseases department at Benha specialized children hospital, Qaliubiya Governorate. Sample: A purposive sample of (100) mothers of children with thalassemia were taken for the previously mentioned setting. Tools: Three tools were utilized to collect data; Tool (I): A structured Interviewing Questionnaire Sheet, Tool (II): Depression, Anxiety and Stress scale (DASS) and Tool (III): Coping patterns scale. Results: findings reflected that half of studied mothers had moderate level of depression and more than half of them had moderate level of anxiety and stress. In addition, more than half of them had low level of total coping patterns. Conclusion: Based on the results, there is a highly statistically significant positive correlation between total depression, anxiety and stress among the studied mothers. While, there is a highly statistically significant negative correlation between total depression, anxiety, stress and the total coping patterns among the studied mothers. Recommendations: Implementation an psycho educational training program for all mothers of children with thalassemia to decrease their psychological problems and enhance their coping patterns.

Prevention of postpartum haemorrhage: Economic evaluation of the novel butterfly device in a UK setting

ObjectivesTo explore the cost-effectiveness of a novel PPH device as compared with usual care. DesignA decision analytical model was used to explore the cost-effectiveness of the PPH Butterfly device compared with usual care. This was part of a United Kingdom, UK, clinical trial ISRCTN15452399 using a matched historical cohort who had standard PPH management without the use of the PPH Butterfly device. The economic evaluation was conducted from a UK National Health Service (NHS) perspective. SettingLiverpool Women’s Hospital, UK. Participants57 women with 113 matched controls. InterventionThe PPH Butterfly is a novel device that has been invented and developed in the UK to facilitate bimanual compression of the uterus in the treatment of PPH. Main outcome measuresMain outcome measures included healthcare costs, blood loss, and maternal morbidity events. ResultsMean treatment costs in the Butterfly cohort were £3,459.66 as compared with standard care £3,223.93. Treatment with the Butterfly device resulted in decreased total blood loss in comparison with standard care. The Butterfly device had an incremental cost-effectiveness ratio of £3,795.78 per PPH progression avoided (defined as ≤ 1000 ml additional blood loss from device insertion point). If the NHS is prepared to pay £8,500 per PPH progression avoided, then the Butterfly device is cost-effective with a probability of 87 percent. In the PPH Butterfly treatment arm there were 9% fewer cases of massive obstetric haemorrhage (severe PPH of more than 2000mls or more than 4 units of blood transfusion required) recorded as compared with the standard care historical cohort. As a low-cost device, the PPH Butterfly device is cost-effective but can be cost-saving to the NHS. ConclusionThe PPH pathway can result in high-cost resource use such as blood transfusion or high dependence unit hospital stays. The Butterfly device is a relative low-cost device in a UK NHS setting with a high probability of being cost-effective. The National Institute for Health and Care Excellence (NICE) can use this evidence in considering the adoption of innovative technologies such as the Butterfly device in the NHS. Extrapolation on an international scale to lower and middle-income countries could prevent mortality associated with PPH.

ANAESTHETIC MANAGEMENT OF A 26 YEARS OLD PREGNANT WOMEN WITH A KNOWN CASE OF SICKLE CELL DISEASE PLANNED FOR EMERGENCY CESAREAN SECTION

A26 years old pregnant women who is a known case sickle cell disease (ss) presented with respiratory distress and severe anemia planned for emergency cesarean section . After preoperative optimisation with 4 units of blood transfusion and oxygenation via facemask operative intervention was carried out under combine spinal epidural anaesthesia . A sensory block level of T6 is achieved with intrathecal injection 10 mg of hyperbaric bupivacaine with 25 microgram of injection fentanyl .Intraoperatively 1 units of blood transfusion was done under regular ABG monitoring to prevent acid -base inbalance, hypoxia, acidosis , hypothermia and hypercarbia . Postoperative analgesia was provided through the epidural catheter with 6 ml of ( inj 0.125% of bupivacaine + 25 microgram of inj fentanyl) every 12 hourly for 3 days. She was discharged from the postnatal ward on 5 th day following surgery with a healthy male baby . Pregnancy associated with sickle cell disease carries a high risk of maternal and neonatal mortality and morbidity. It provide a great challenge to anaesthesiologist during perioperative management. The uneventful course of anaesthesia in this case is managed with systemic evaluation and careful anaesthetic strategy

Abstract No. 39 Contemporary Management and Outcomes of Blunt Splenic Trauma: An Analysis of the Trauma Quality Improvement Program Registry

To evaluate the outcomes of management strategies among adult patients with blunt traumatic splenic injuries. Patients 18 years and older with a blunt splenic injury registered via the Trauma Quality Improvement Program (2007-2019) were identified. Those with concomitant, potentially life-threatening injuries were excluded. Management strategies implemented within 24 hours of presentation to hospital were classified as nonoperative management (NOM), embolization, surgery, or combination therapy (embolization and surgery). Outcomes evaluated were hospital length of stay (LOS), intensive care unit (ICU) LOS, ventilator-dependent days, mortality, and blood transfusion volume within 4 hours of hospital presentation. To minimize baseline confounding among management strategies by clinical and demographic attributes, entropy balancing was performed. To estimate each management strategy’s effect on the selected outcomes, generalized linear models were fit to balanced samples. Head-to-head sub-analysis of the effect of embolization compared with surgery, combination therapy, and NOM was performed. Of patients who met inclusion criteria (n = 75,770), 79.2%, 4.3%, 16.2%, and 0.3% received NOM, embolization, surgery, and combination therapy, respectively. Following entropy balancing and modeling, head-to-head sub-analysis revealed that the hospital LOS associated with embolization (10.4 days) was shorter than that of surgery (11.7 days, P < .001) and longer than that of NOM (8.0 days, P < .001). The ICU LOS associated with embolization (5.2 days) was shorter than that of surgery (6.4 days, P < .001) and longer than that of NOM (4.7 days, P < .001). The number of ventilator-dependent days associated with embolization (5.8 days) was higher than that associated with surgery (5.0 days, P < .001) and NOM (4.7 days, P < .001). Compared with embolization, NOM and surgery were associated with a greater likelihood of mortality (odds ratios [Ors] 1.23 [P < 0.05] and 3.56 [P < .001], respectively). The blood transfusion volume associated with embolization (576 mL) was lower than that associated with surgery (1,063 mL, P < .001) and NOM (842 mL, P < .001). Despite embolization’s low rate of utilization among adults with isolated blunt traumatic splenic injuries, it was associated with shorter hospital and ICU LOS, lower likelihood of mortality, and lower blood transfusion volume when compared with surgical management.

Topical tranexamic acid in intramedullary nailing for the treatment of intertrochanteric fractures in the elderly: A protocol for systematic review and meta-analysis.

Numerous studies have demonstrated that the use of tranexamic acid (TXA) intravenously minimizes bleeding, lowers transfusion rates, and does not raise the risk of complications during major orthopedic surgery. Concerning the effectiveness of the topical application, there are, nevertheless, inconsistent findings. We aimed to develop a protocol for systematic review and meta-analysis on the benefits and safety of topical TXA in intramedullary nailing for the treatment of intertrochanteric fractures in the elderly. PubMed, Embase, and the Cochrane Library will all be searched for randomized controlled trials published from the database inception to October 15, 2022. The primary outcomes will be intraoperative blood loss, hidden blood loss, total blood loss, transfusion rate, transfusion units, operative time, thromboembolic events, and mortality. The risk of bias will be evaluated using the Cochrane risk of bias assessment tool. Review Manager 5.3 will be used for the analysis. The effects and safety of topical TXA in intramedullary nailing for the treatment of intertrochanteric fractures in the elderly will be quantified in this study. The study's findings will assist doctors in determining if topical TXA use is secure and efficient.

Outcomes of Patients Treated with Blood Transfusion in a Contemporary Tertiary Care Medical Center Intensive Cardiac Care Unit

Acutely ill patients treated with blood transfusion (BT) have unfavorable prognoses. Nevertheless, data regarding outcomes in patients treated with BT admitted into a contemporary tertiary care medical center intensive cardiac care unit (ICCU) are limited. The current study aimed to assess the mortality rate and outcomes of patients treated with BT in a modern ICCU. Prospective single center study where we evaluated mortality, in the short and long term, of patients treated with BT between the period of January 2020 and December 2021 in an ICCU. A total of 2132 consecutive patients were admitted to the ICCU during the study period and were followed-up for up to 2 years. In total, 108 (5%) patients were treated with BT (BT-group) during their admission, with 305 packed cell units. The mean age was 73.8 ± 14 years in the BT-group vs. 66.6 ± 16 years in the non-BT (NBT) group, p < 0.0001. Females were more likely to receive BT as compared with males (48.1% vs. 29.5%, respectively, p < 0.0001). The crude mortality rate was 29.6% in the BT-group and 9.2% in the NBT-group, p < 0.0001. Multivariate Cox analysis found that even one unit of BT was independently associated with more than two-fold the mortality rate [HR = 2.19 95% CI (1.47-3.62)] as compared with the NBT-group, p < 0.0001]. Receiver operating characteristic (ROC) curve was plotted for multivariable analysis and showed area under curve (AUC) of 0.8 [95% CI (0.760-0.852)]. BT continues to be a potent and independent predictor for both short- and long-term mortality even in a contemporary ICCU, despite the advanced technology, equipment and delivery of care. Further considerations for refining the strategy of BT administration in ICCU patients and guidelines for different subsets of high-risk patients may be warranted.

The Influence of Service Quality on Customer Satisfaction: Study in Blood Transfusion Service Units at RSCM

The best service quality is an important factor that must be owned by a company in order to be able to survive and still gain the trust of customers. Service quality is a performance indicator for health service providers such as hospitals. Hospitals will be more advanced if their performance can be maintained and improved according to patient demands. Therefore, hospital services must lead to market forces so that hospital orientation can retain customers so that the main goal can be carried out properly. Customer satisfaction is one of the determining factors and an indicator of quality and safety in UPTD RSCM. Customer satisfaction at UPTD RSCM is influenced by factors of reliability, responsiveness, assurance, empathy and tangible assets from the Blood Service Technician (TPD). The effect of service and performance of medical officers on customer satisfaction in the Blood Transfusion Unit of Dr. RSUPN. Cipto Mangunkusumo was carried out through the stages of research, namely: Analyzing the effect of service and performance of medical officers on patient satisfaction in the inpatient/or outpatient room at Dr. Cipto Mangunkusumo. From the results of data collection respondents, in this study the authors conclude a hypothesis; that customers are satisfied with the quality of service at the RSCM Blood Transfusion Unit on the factors of realibility, responsiveness, assurance, empathy and tangibles as a whole are at an index of 88.42% based on a Likert scale in the 'satisfied' category. The value of the consumer satisfaction index (CSI) lies in the 80% - 89.99% interval which indicates that the Customer Satisfaction Index is in the "satisfied" category

Racial and Ethnic Disparities among Pregnancies with Chronic Hypertension and Adverse Outcomes.

We aimed to ascertain whether the risk of adverse pregnancy outcomes in the United States among individuals with chronic hypertension differed by maternal race and ethnicity and to assess the temporal trend. Population-based retrospective study using the U.S. Vital Statistics datasets evaluated pregnancies with chronic hypertension, singleton live births that delivered at 24 to 41 weeks. The coprimary outcomes were a composite maternal adverse outcome (preeclampsia, primary cesarean delivery, intensive care unit admission, blood transfusion, uterine rupture, or unplanned hysterectomy) and a composite neonatal adverse outcome (preterm birth, small for gestational age, Apgar's score <5 at 5 minutes, assisted ventilation> 6 hours, seizure, or death). Multivariable Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% confidence intervals (CIs). Between 2014 and 2019, the rate of chronic hypertension in pregnancy increased from 1.6 to 2.2%. After multivariable adjustment, an increased risk for the composite maternal adverse outcome was found in Black (aRR = 1.10, 95% CI = 1.09-1.11), Hispanic (aRR = 1.04, 95% CI = 1.02-1.05), and Asian/Pacific Islander (aRR = 1.07, 95% CI = 1.05-1.10), compared with White individuals. Compared with White individuals, the risk of the composite neonatal adverse outcome was higher in Black (aRR = 1.39, 95% CI = 1.37-1.41), Hispanic (aRR = 1.15, 95% CI = 1.13-1.16), Asian/Pacific Islander (aRR = 1.34, 95% CI = 1.31-1.37), and American Indian (aRR = 1.12, 95% CI = 1.07-1.17). The racial and ethnic disparity remained unchanged during the study period. We found a racial and ethnic disparity with maternal and neonatal adverse outcomes in pregnancies with chronic hypertension that remained unchanged throughout the study period. · Between 2014 and 2019, the rate of chronic hypertension in pregnancy increased.. · Among people with chronic hypertension, there are racial and ethnic disparities in adverse outcomes.. · Black, Hispanic, and Asian/Pacific Islander have a higher risk of the adverse neonatal outcomes..

KEGIATAN DONOR DARAH CIVITAS AKADEMIKA SEKOLAH TINGGI ILMU ADMINISTRASI BENGKULU

Blood donation is the activity of a person who voluntarily donates his blood for humanitarian purposes. The purpose of carrying out this blood donor activity is to create a sense of solidarity among people, increase satisfaction with health services, assist the government in providing blood needs for healthy people, and overcome the effects of the spread of disease. Blood donor activity conducted by a person is considered very important, because the blood needs in the Blood Transfusion Unit of Indonesia Red Cross then written UTD PMI in Bengkulu City, only fulfilled about 50% of the existing needs, especially for referrals from several Private Private Hospitals and Houses General Hospital. So that the blood donor activity that was originally done by someone, then done by community group which is in field of Sekolah Tinggi Ilmu Administrasi of Bengkulu.

DONOR DARAH DI MASA PANDEMI COVID-19

The principle of the Indonesian Red Cross service is the spirit of neutrality and independence, having a major role in providing safe, ready-to-use blood in sufficient quantities so that it can meet the demands of patients in need. The purpose of this activity is the implementation of blood donor activities in the community as an effort to maintain health. Activities in community service include health education and blood donation. The number of residents identified as registering to become blood donors was 61 people. After being screened by the Blood Transfusion Unit officers, 49 people were eligible to donate their blood. Public understanding of the importance of blood donation has increased and blood donation activities can be carried out smoothly as expected. People who cannot donate blood should be given an education

Predictors of Rebleeding in Non-variceal Upper Gastrointestinal Bleeding of Peptic Ulcer Etiology in Kashmiri Population.

Background Upper gastrointestinal bleeding (UGIB) represents a substantial clinical and economic burden and rebleeding is one of the most important predictors of morbidity and mortality. Identifying patients who are likely to rebleed is a critical component of effectively managing patients with bleeding peptic ulcers. So, the study was undertaken to look for predictors of rebleeding in patients with bleeding peptic ulcers and try to find out the new scoring system to predict rebleeding in our population. Material and methods A retrospective analysis of prospectively maintained hospital data of UGIB patients was done and 480 patients of endoscopically documented peptic ulcers whose complete data was available were taken for study. Results Among the studied patients, men constituted 84.6%, and most of the patients were in the third to sixth decade of life with a mean age of 40.9±15.9 years, 76% were from rural areas. Only males with a mean age of 38.4±19.8 rebled with a rebleeding rate of 2.9% only. Half of the patients who rebled were in shock at the time of presentation. Those who rebled received more units of blood transfusion (mean 3±1.8),had a large mean ulcer sizeof Forest class IIa and IIb and epinephrine injection monotherapy group with varied statistical significance. Among rebleeders (n=14), eight patients were managed by a second endoscopic therapy, and six (42.8%) rebleeders and 1.25% of patients in total needed surgery. Two patients ultimately died giving overall mortality of 0.4% and mortality of 14.3% among rebleeders. Conclusion Our study found a very low rebleeding rate and mortality which could be explained by a young population with fewer co-morbidities and better response to proton pump inhibitor therapy. The significant parameters related to rebleeding were shockat presentation, degree of smoking, units of blood transfused, ulcer size, and high-risk endoscopic stigmata.

Profile of female blood donors in the blood transfusion units of Dr. Sardjito Central General Hospital Yogyakarta

Introduction: Blood transfusion has been widely used in various medical services due to its benefits. Blood transfusion units (UTD) in Indonesia remain to experience a shortage of 972,552 blood units, or amounted to 18.8%. The percentage of female donors in Indonesia is 27.5%, while that of male donors is 72.5%. This large difference in proportion is caused by various erroneous assumptions, including that women are considered to have donated blood naturally every month through the menstrual process. This study aims to prove the low proportion of female donors and discovering the profile of female donors in the Blood Transfusion Unit (hereinafter referred to as UTD) of Dr. Sardjito General Hospital (hereinafter referred to as RSUP Dr. Sardjito) Yogyakarta. Methods: This descriptive study utilized data from 62,221 blood donors in 2017–2019 taken from the donor database of the UTD of RSUP Dr. Sardjito Yogyakarta. Results: Female donors at RSUP Dr. Sardjito in 2017-2019 reached 13,873 (22.3%) donors, 71.6% of them having an age range of 17-30 and 38.31% of them having blood type O. Rhesus positive was found in 99.58% of donors, while rhesus negative was found in 0.42% of donors. Female donors with a Hb range of 12.5-14 g/dL reached 69.16%, while those with a Hb range of 14.1-15.5 g/dL reached 26.97%. Whole blood component was found in 99.97% of donors, and voluntary donor status was found in 94.25% of donors. Conclusion: The proportion of female donors is much smaller than that of males, with the majority being whole-blood donors. The most common blood type found in female donors is O, and the highest age range is 17 to 30. The highest Hb range is 12.5-14 g/dL. Most of them are voluntary donors.

Widespread adoption of AI risk models for maternal hemorrhage requires mitigation of bias

Accurate risk stratification for maternal hemorrhage could lead to improved outcomes. However, the performance of risk stratification tools across populations has not been extensively explored. Therefore, we aim to examine the fairness of machine learning methods for predicting the risk of maternal hemorrhage. A retrospective study was performed using the U.S. Consortium for Safe Labor (2002–2008) dataset. Severe maternal hemorrhage was defined based on receiving at least 1 unit of blood transfusion. The Random Forest algorithm was adopted to model a patient’s risk using eighty-six clinical variables. Model training was done using patients’ data from 2002 - 2006 and was tested on the following two years while excluding patients with missing transfusion records. The model evaluation was conducted using the area under the receiver operating characteristic (AUROC) and precision-recall curves(AUPRC). In addition, following the recommendations from the Aequitas fairness group, we assessed the bias using: (1) equality of opportunity criteria that aims to match errors in the hemorrhage predictions outcomes for the different subgroups, (2) positive predictive value rate that aims to evaluate whether the predicted outcome equally matches the observed outcome for all subgroups. Of the 142,137 births, 3.7% required at least 1 unit of blood transfusion. The model had good performance concerning AUROC (0.80) and AUPRC (0.11), representing a nearly three-fold improvement compared to the prior. However, when comparing the model performance and fairness metrics with respect to race (AUROC: W:.75, B:0.83, H:0.75, A:0.85, AUPRC: W:0.11 B:0.11, H:0.08, A:0.06), the model underperformed in minority populations compared to the white patients as the reference(Figure 1). The Widespread adoption of machine learning-based risk assessments requires careful evaluation of their performance across various sub-populations, choosing appropriate decision thresholds and developing methods for mitigating potential bias.View Large Image Figure ViewerDownload Hi-res image Download (PPT)

Management Information System Web-Base on Blood Donation Service

Blood donation is an activity of sharing blood from a person to others in need. This activity was carried out because of the large number of patients in the hospital who needed blood for their illness. The amount of blood needed is not proportional to the amount of blood stock in the hospital, so it is deficient and requires a lot of blood from donors. The scarcity of blood stocks does not occur only in hospitals but also in PMI (Indonesian Red Cross) so that patients or families have difficulty finding blood to meet the needs of patients. The method used in these crisis conditions is to contact a few random people, or create information on personal social media about who can donate blood. This method is less efficient and effective because the data of potential donors is often also not qualified and data collection is also still done manually by the blood transfusion unit. Information technology is one of the solutions in providing information and data collection as well as management in the blood transfusion unit PMI Deli Serdang. In this case the R&amp;D method ( Research And Development) can help develop a management information system to collect data in blood donation services at PMI Deli Serdang.

Adverse outcomes among pregnancies with large for gestational age neonates: stratified by diabetes status

While the association of maternal diabetes and large for gestational age (LGA; birth weight above 90% based on Duryea et al nomogram) neonates is recognized, there is paucity of data regarding whether adverse outcomes of laboring people with an LGA neonate are related to maternal diabetes (DM). We aimed to describe the trend in the rate of LGA and compare adverse outcomes in laboring people with LGA neonates by maternal DM status (pregestational or gestational diabetes versus no diabetes). A population-based retrospective cohort study using the U.S. Vital Statistics data set (2014-2020) evaluated individuals with a non-anomalous LGA neonate, who labored and delivered at 24–41 weeks. The co-primary outcomes were composite maternal adverse outcome (cesarean delivery, intensive care unit admission, blood transfusion, uterine rupture or unplanned hysterectomy) and composite neonatal adverse outcome (Apgar score < 5 at 5 minutes, assisted ventilation >6h, seizure or death). Multivariable Poisson regression models were used to estimate adjusted relative risks (aRR) and 95% confidence intervals (CI). Average annual percent change (AAPC) was obtained using JointPoint Regression to assess changes over time. Among 1.8 million singletons with LGA neonates, maternal DM was identified in 186,579 people (10%). There was a downward trend in the rate of LGA in people with DM compared to a stable rate among people without (Figure 1). An increased risk of composite maternal adverse outcome (aRR1.37, 95% CI 1.36-1.38) and composite neonatal adverse outcome (aRR1.57, 95% CI 1.53-1.62) was found in those with DM compared to those without (Table 1). An upward trend in the rate of composite neonatal adverse outcomes among both groups was observed(Figure 1). Using a nationally representative sample of the U.S., 1 out of 10 LGA neonates were born to people with DM. The risk of composite adverse maternal and neonatal outcomes was significantly higher in those with DM and LGA neonate. Interventional trials are needed to identify and reduce the adverse outcomes among people with DM and LGA.View Large Image Figure ViewerDownload Hi-res image Download (PPT)

A comparison of neurological event and mortality rates between transcatheter aortic valve implantation and surgical aortic valve replacement.

Transcatheter aortic valve implantation (TAVI) is the treatment of choice for patients with symptomatic severe aortic stenosis. To evaluate the neurological event and mortality rates of TAVI in comparison with those of surgical aortic valve replacement (SAVR). A systematic literature search identified pertinent full-text journal articles published from 2000 to 2022 that were taken as the study materials. Patients were at the age of 79.3 ±2.8 years and 79.9 ±2.9 years at the time of intervention/open surgery in the TAVI and SAVR groups, respectively. Patients' age and preoperative comorbidity rates were similar in both groups. A self-expanding valve prosthesis and a percutaneous transfemoral route were the most commonly used in patients receiving TAVI. The duration of the procedure and the hospital stay were much shorter, and the number of transfused blood units was much lower in the TAVI group than in the SAVR group. No significant intergroup difference was found in the prevalence of postoperative stroke, 1-month all-cause mortality, and 1-month and 1-year cardiovascular mortality rates. However, 1-year all-cause mortality was much lower in the TAVI than the SAVR group. The subgroups of risk stratification showed better outcomes for non-high-risk patients compared with high-risk patients. Irrespective of other postoperative complications of TAVI, this study emphasizes the postoperative major neurological events and mortality. TAVI appears to be superior to SAVR with regard to 1-year all-cause mortality. TAVI is thus recommended for elderly patients with symptomatic severe aortic stenosis at very high surgical risk contraindicated for SAVR.

Haematology Parameters of Apparently Healthy Prospective Whole Blood Donors in a Nigerian Hospital Setting

Background: Adequate selection of a prospective whole blood donor protects his health and safety of the recipient. Objectives: The main objective of this study was to determine the haematology parameters of apparently healthy prospective whole blood donors. Participants and Methods: This was a hospital based prospective study carried out from August to October 2020 at the blood transfusion unit of the Lagos State University Teaching Hospital (LASUTH), Ikeja, Nigeria. A structured pretested questionnaire was used for data collection. The socio demographic status and the haematology parameters of apparently healthy prospective whole blood donors who tested negative for HIV, hepatitis B and C markers were captured. Obtained data were analysed with the statistical package for the social scientist software version 20. Results: One hundred male (97.1%) and three female (2.9%) apparently healthy prospective whole blood donors were studied. The median age of study subjects was 30 years. Obtained median haematology parameter values were 13 g/dl, 40%, 4.9/nl and 203.9/nl for haemoglobin concentration, haematocrit, total white cell and platelet counts respectively. The median values for the mean corpuscular haemoglobin concentration (MCHC), mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV) of participants were 32.6 g/dl, 27.7 pg and 85.7 fl respectively. Observed prevalence of subnormal haematology parameters for haemoglobin concentration, total white cells, platelets were 12.6%, 25.2%, and 13.6% respectively. Also subnormal values for MCHC, MCH, MCV were 11.7%, 26.2%, and 16.5% respectively among prospective whole blood donors in this study. No higher than normal haematology parameter values were observed. Median values for erythrocyte sedimentation rate was 8.4 mm/hr. Conclusion: A significant percentage of apparently healthy prospective whole blood donors had subnormal haematology parameters values. Obtained normal values in our study are comparable with local reference range reports from previous studies in Nigeria and other parts of Africa. 124947

Skrining parasit malaria pada kantong darah di Unit Transfusi Darah Palang Merah Indonesia (PMI) Cabang Kota Banda Aceh

Background: Blood screening of donors has been routinely conducted to anticipate various infectious diseases transmitted through blood transfusion. However, screening for malaria has not been a top priority at the Blood Transfusion Unit (BTU), despite Banda Aceh City being a malaria-endemic area. Screening for malaria is essential to reduce transmission risk and ensure recipient transfusion safety.Objectives: The study aimed to determine the results of the Rapid Diagnostic Test (RDT) examination of malaria in blood bags at the BTU in the Indonesian Red Cross (IRC) branch in Banda Aceh.Methods: The study used an experimental design with the RDT method, which was conducted at the IRC Banda Aceh in December 2021. This study uses a descriptive research design through a cross-sectional approach. The total sample in this study was 30 donor blood bags taken by simple random sampling.Results: The results showed that malaria was found positive in 1 donor blood sample (3.33%) and 29 (96.67%) negative for malaria.Conclusion: The frequency of malaria screening results is predominantly negative. However, there are some positive ones in donor blood at the Banda Aceh branch of the Indonesian Red Cross Blood Transfusion Unit.

Horizontal collaboration in a decentralised system: Indonesian blood supply chain

ABSTRACT This paper examines the impacts of horizontal collaboration among blood transfusion units (BTUs) in the Indonesian blood supply chain to anticipate problems such as uncertainty of supply and demand. The conceptual model developed in this study, as well as its implementation, considers the uncertainty. A discrete event simulation is used to evaluate the horizontal collaboration with three main performance indicators: the rate of blood shortages, the rate of outdated blood bags, and the total profits. Two blood transfusion units (BTUs) in Indonesia are examined as case studies in this research. Based on data from the two case studies in one year, a set of experiments, results, and sensitivity analyses were conducted to test the benefits of horizontal collaboration. The results show that the horizontal collaboration decreases blood shortages, outdated blood bags, and inventory costs and increases the total profits. The total revenues increased, and there was additional income from selling blood bags to partner collaboration.

An evaluation of a volumetric method for the flow cytometric determination of residual leukocytes in blood transfusion units.

The removal of leukocytes from blood components helps to prevent or reduce some adverse reactions that occur after blood transfusions. The implementation of the leukodepletion process in the preparation of blood units requires quality control, consisting of a reliable cell counting method to determine residual leukocytes in blood components. The most widely used methodology is a flow cytometric bead-based counting method. To avoid the need for commercial counting beads, we evaluated a volumetric counting method of leukocyte enumeration. A total of 160 specimens of leukodepleted plasma, red cell and platelet units, as well as 58 samples of commercially available controls containing different concentration levels of leukocytes, were included in the study. The conventional quality control method using the bead-based counting method performed with the FACSCalibur flow cytometer was compared to the bead-based counting method and the volumetric counting method performed with the MACSQuant 10 flow cytometer. Our results show that the MACSQuant bead-based method, as well as the volumetric MACSQuant method, meet the sensitivity requirements of residual leukocyte enumeration when compared to the gold standard, bead-based FACSCalibur method. We conclude that the volumetric method can be a substitute for the bead-based counting of residual leukocytes in a variety of blood components.