Unit Selection Research Articles

THE CONCEPTUALITY OF THE TEXT AS A MANIFESTATION OF THE ETHNO-CULTURAL CODE OF THE NATIONAL-AUTHOR PICTURE OF THE WORLD

The purpose of the article is to describe conceptuality as a subcategory of the textual category of informativeness, to focus on the linguistic means of expressing this typological feature of the verbal whole. The outlined goal involves the following tasks: to substantiate the existence of conceptuality as a subcategory of informativeness in the categorical hierarchy of the text; to focus attention on conceptuality in the aspect of revealing ethnocultural codes of national and individual author’s pictures of the world; describe key words, lexical repetitions, author’s aphorisms, as well as dedications, epigraphs, titles as linguistic means of realizing conceptuality. The source base of the research is Ukrainian-language artistic verbal objects, from which the selection of units (metaphors, epithets, periphrasis, oxymorons, etc.) was carried out, which reveal conceptuality as a textual subcategory of informativeness. The focus is on literary texts of both classical Ukrainian literature and modern ones — by Ihor-Bohdan Antonych, Ivan Bagryany, Oksana Zabuzhko, Maria Matios, Natalia Nazar, Roman Skiba, Hryhoriy Skovoroda, Vasyl Stus, Lesya Ukrainka, Hnat Khotkevich, Taras Shevchenko. The object of study is Ukrainian poetic discourse and its components (concepts), and the subject is artistic images of Ukrainian poetry and prose as expressions of conceptuality as a type of textual category of informativeness. The result of the scientific search was the deepening of the idea of hierarchical ordering of text categories and subcategories and the definition of conceptuality as an invariant characteristic of the verbal whole, which reflects a separate aspect of the typological feature of the verbal whole. We study artistic and poetic communication in the aspect of a discursive approach as a process in which the result of verbal interaction between its participants is a manifestation of the specificity of the linguistic and national picture of the world of Ukrainians. The conclusion is that the informativeness category represents the text as a communicative unit. The phenomenon of informativeness is caused by the presence of conceptual information in the artistic text, which is projected into the plane of the author — with the idea of the work, into the plane of the reader — with the process of perceiving the text as assimilation of new information and approaching the author’s idea. Ukrainian-language artistic texts are components of the world picture of the ethnos, they contain collective experience, the genetic and evolutionary basis of which is expressed by the textual subcategory of conceptuality. Conceptuality implements the aesthetic idea of the work, harmonizes the theme and plot, determines the selection of language means, etc. The concept is an axiological prism of worldview. Artistic communication is able to reveal the unique culture of the nation, its traditions, customs, mentality, reproduce people’s lives in national-historical originality, and also represent the worldview of the unique personality of the author-addressee. Linguistic means of implementing conceptuality as a subcategory of the text category of informativeness are keywords, lexical repetitions, author’s aphorisms, as well as dedications, epigraphs, titles.

ANALISIS PEMILIHAN UNIT PENGOLAHAN BIOLOGIS PADA IPAL DOMESTIK SOREANG, KABUPATEN BANDUNG

This study aims to design a household wastewater treatment facility that will serve the Soreang Subdistrict in the Bandung Regency. The Soreang Subdistrict area covers approximately 2,561 hectares. At the end of the planning period, this IPAL will cater to around 185,821 residents with a processing capacity of 19,500 cubic meters per day until the year 2041. The reference wastewater quality parameters for the planning include a BOD5 of 93.2 mg/L, COD of 98.1 mg/L, and TSS of 57.9 mg/L. The selection of wastewater treatment units at the Soreang IPAL is based on the efficiency of removing processed wastewater parameters and the standard limits of wastewater parameter loads for each treatment unit option. The chosen biological treatment unit is the Aerated Lagoon because it aligns with the characteristics of the treated wastewater and the availability of adequate land. The planned sequence of treatment units for the Soreang IPAL includes a collection well, bar screen, grit chamber, equalization tank, aerated lagoon, secondary clarifier, and sludge drying bed. The design of the Aerated Lagoon results in a volume of 43,060 cubic meters, with a retention time of 1.5 days. The required oxygen volume for this process is 151.8 kilograms per hour. The design projection for this IPAL indicates that the treated water will have a BOD5 of 9 mg/L, COD of 9.47 mg/L, and TSS of 2.33 mg/L, meeting the established quality standards.

Optimized Double-Unit Cord Blood Transplantation Mitigates Transplant-Related Mortality Resulting in High Progression-Free Survival in Adults with Hematologic Malignancies

Background : Double-unit cord blood transplantation (dCBT) with intermediate intensity conditioning (Cy50/ Flu150/ Thio10/ TBI400cGy) and cyclosporine-A (CSA)/ mycophenolate mofetil (MMF) graft-versus-host disease (GVHD) prophylaxis has been associated with high progression-free survival (PFS) in adult patients (pts) with hematologic malignancies ( Barker JN et al, Blood Advances 2020). Now, our Center has investigated multiple refinements to further mitigate transplant-related mortality (TRM). Herein, we have analyzed transplant outcomes in these adult dCBT pts to establish an optimized dCBT platform. Methods : Consecutive adult first allograft pts with high-risk hematologic malignancies who underwent first allografts with intermediate intensity dCBT between 3/2018-8/2022 were analyzed. Optimizations involved further refined unit selection placing highest priority on unit quality (i.e. optimized banking practices) & CD34+ cell dose over HLA-match, ensuring therapeutic (CSA) levels (> 250 ng/mL) by day 0, prompt treatment of pre-engraftment syndrome (PES) & letermovir prophylaxis in CMV seropositive pts from day +7. Also, we have investigated 2 strategies to mitigate acute graft-versus-host disease (aGVHD): pts early in the study period received CSA, MMF & tocilizumab (8 mg/kg on day -1) prophylaxis ( Toci Group), whereas recent pts ( Recent Group) received CSA/ MMF with prompt therapy of clinically diagnosed aGVHD. Results : Of 74 patients (Table), 49 were in the Toci Group, & 25 in the Recent Group. Most pts were transplanted for acute leukemia (n = 55, 74%) & over half (n = 39, 53%) had non-European ancestry. Distribution of diagnoses, CMV serostatus, HCT-CI & graft characteristics were similar between the groups but Recent Group pts tended to be younger (38 vs. 47 years, p = 0.071). Toci Group pts had delayed neutrophil recovery [engraftment incidence 94% (95%CI: 87-99) at a median of 25 days (range 16-40), one graft failure], but low rates of PES (n = 19, 39%). The day-100 incidence of grade II-IV & III-IV aGVHD were 69% (95%CI: 56-82) & 10% (95%CI: 2-19), respectively. One pt (false negative CMV-serostatus) who did not receive letermovir had CMV infection. One-year TRM was 16% (95%CI: 6-27) with a 1-year relapse rate of 6% (95%CI: 3-13). TRM was due to infection (n = 3), aGVHD (n = 3, 1 with concurrent COVID-19 infection), multiorgan failure (n = 2) & graft failure (n = 1). With a median follow-up of 47 months (range 28-62), the 1-year OS was 84% (95%CI: 73-94) & 1-year PFS was 78% (95%CI: 66-89). By contrast, the engraftment incidence in Recent Group pts was 100% with a faster median neutrophil recovery of 19 days (range 11-36, p = 0.002) & all engrafted platelets at a median of 36 days (range 24-92). However, most Recent group pts developed PES [n = 20 (80%), p < 0.001] although this responded promptly to short course corticosteroids. Day 100 grade II-IV aGVHD was also higher [92% (95%CI: 81-99), p = 0.009], although grade III-IV aGVHD was low [8% (95%CI: <1-19)] & similar to tocilizumab pts. Day 100 incidence of CMV was 0%. With a median follow-up of 17 months (range 6-50), the 1-year TRM in Recent Group pts is 0% with a 1-year relapse incidence of 13% (95%CI: 7-27). Consequently, the 1-year OS & PFS are high at 96% (95%: 89-99) & 87% (95%CI: 74-99), respectively (Figure). Conclusions: Optimized dCBT with intermediate intensity conditioning, graft selection that prioritizes unit quality & CD34+ dose, CSA/ MMF prophylaxis with prompt therapy of PES & aGVHD, & letermovir CMV prophylaxis mitigates TRM in young & middle-aged adults. Thus, combined with relatively low relapse rates, the PFS & OS are high. Tocilizumab has been abandoned due to its notable association with delayed neutrophil engraftment & lack of survival advantage. Letermovir is highly effective completely preventing CMV infections & may contribute to the reduced aGVHD-related mortality recently (as compared to the pre-tocilizumab era), since avoidance of CMV antiviral therapy toxicities greatly facilitates aGVHD prevention & therapy. Given the rapid availability of cryopreserved unmanipulated CB grafts & frequent limitations of URD availability for minority populations, optimized dCBT is a highly attractive curative therapy for acute leukemias & other high-risk myeloid malignancies warranting prospective multi-center investigation.

1D-Touch: NLP-Assisted Coarse Text Selection via a Semi-Direct Gesture

Existing text selection techniques on touchscreen focus on improving the control for moving the carets. Coarse-grained text selection on word and phrase levels has not received much support beyond word-snapping and entity recognition. We introduce 1D-Touch, a novel text selection method that complements the carets-based sub-word selection by facilitating the selection of semantic units of words and above. This method employs a simple vertical slide gesture to expand and contract a selection area from a word. The expansion can be by words or by semantic chunks ranging from sub-phrases to sentences. This technique shifts the concept of text selection, from defining a range by locating the first and last words, towards a dynamic process of expanding and contracting a textual semantic entity. To understand the effects of our approach, we prototyped and tested two variants: WordTouch, which offers a straightforward word-by-word expansion, and ChunkTouch, which leverages NLP to chunk text into syntactic units, allowing the selection to grow by semantically meaningful units in response to the sliding gesture. Our evaluation, focused on the coarse-grained selection tasks handled by 1D-Touch, shows a 20% improvement over the default word-snapping selection method on Android.

Insights into highly engraftable hematopoietic cells from 27-year cryopreserved umbilical cord blood

Umbilical cord blood transplantation is a life-saving treatment for malignant and non-malignant hematologic disorders. It remains unclear how long cryopreserved units remain functional, and the length of cryopreservation is often used as a criterion to exclude older units. We demonstrate that long-term cryopreserved cord blood retains similar numbers of hematopoietic stem and progenitor cells compared with fresh and recently cryopreserved cord blood units. Long-term cryopreserved units contain highly functional cells, yielding robust engraftment in mouse transplantation models. We also leverage differences between units to examine gene programs associated with better engraftment. Transcriptomic analyses reveal that gene programs associated with lineage determination and oxidative stress are enriched in high engrafting cord blood, revealing potential molecular markers to be used as potency markers for cord blood unit selection regardless of length of cryopreservation. In summary, cord blood units cryopreserved for extended periods retain engrafting potential and can potentially be used for patient treatment.

PHRASEOLOGICAL UNITS WITH THE ‘MYTHOLOGICAL BEING’ COMPONENT IN THE ENGLISH NATIONAL LANGUAGE WORLDVIEWS: PHRASEOSEMANTIC CLASSIFICATION

The article elaborates the typology of mythological beings that are actualized in phraseological units of the English language. The very essence of the representation of the mythological code of culture by means of English phraseology is defined. The object of research is phraseological units of the English language with the component ‘mythological creature’, the subject is the mythological code of culture, which is represented by mythological creatures. The research used the following methods: logical-conceptual method, generalization and systematization method, descriptive method. As special methods, the method of component analysis (for the identification and selection of phraseological units of the English language with the component ‘mythological creature’), the method of parametric analysis of the semantic structure (for the distribution of phraseological units according to the appropriate groups of ethno-subcodes) is used. The mythological code of culture is positioned in the study as a set of images of archaic, primitive religious ideas of people, arising from general provisions, which are the basis of theoretical mythology and serve as a kind of translator of worldviews of a person. In phraseology, the mythological ethnocode of the spiritual culture is correlated with the figurative basis of the primary word combination of the phraseological unit, formed under the influence of mythological thinking in the system of the spiritual culture of the ethnos. The systematization of types of ethnosubcodes in the space of the mythological ethnocode of culture is natural on the basis of mythological ideas about the universe and human existence in it. Within the mythological code of culture, 7 typological varieties are distinguished: animistic, fetish, totemic, cosmogonic, astral, eschatological, mythonymic. Two key typological varieties represented in the mythological code of culture are distinguished: the animistic ethnosubcode of culture, which denotes natural phenomena and objects of the surrounding world that have a soul or spirit; the cosmogonic ethnosubcode of culture, which is represented in the general world structure, the development of which goes in the direction from the initial chaos to the orderly one. The perspective of the research is defined in the sequential comparison of the expression of phraseological units with the component “mythological creature” in Ukrainian and English languages.

Selection and Application of Beam Pumping Unit for Heavy Oil Production

Beam pumping units were among the first and are still among the most widely used artificial lift systems. This study investigates the components of beam pumping units and the manufacturing mechanism and design procedure recommended by Recommended Practice and the QRod simulator. The API provides API RP 11L Recommended Practice to obtain the values and operating characteristics for each component in dimensionless form. A trial-and-error method is used during the design procedures to determine the best surface and subsurface equipment for a given well's data. When completing a well, the artificial lift method must be considered to ensure that the well is able to be produced at a satisfactory rate. Besides, the procedures created nine cases to compare the requirements of different production rates and depths for a heavy oil well with 14 APIs. A depth of 5,000 ft with a rate of 300 bbl/day and a depth of 7,000 ft with a rate of 500 bbl/day is the specific production rate and depths at which the well will produce. For 300 BBL/Day the tubing size selected was 2-7/8” OD, for this size the suitable plunger size is 2”, and the suitable stroke length was 74in. In cases 6, 8, and 9, all the simulated rod strings were unable to handle the stress imposed by the combination of high depth and high production rate. As a result, all designed systems will fail during production.

The Challenges and Benefits of Co-Production Models in Public Services in Makkasar City

This study aimed to develop a recommendation model for the co-production of public services based on community shelters, involving collaboration between the government, community organizations, NGOs, shelter leaders, and the private sector in Makassar City. The objective was to improve the quality and accessibility of public services by utilizing the knowledge and networks of service users. The study utilized a qualitative approach, including observation, document review, and interviews with key informants from the local department of Women’s Empowerment and Child Protection and shelter administrators. The data analysis followed a qualitative method involving data organization, selection of analysis units, identification of categories and themes, analysis and interpretation, verification, and reporting. The results and discussions present a recommended model for the co-production of public services in community shelters in Makassar City, emphasizing the need for social readiness, effective communication, and trust-building among stakeholders. The study also highlights the challenges of implementing co-production, such as conflicting interests, complex coordination, and the importance of understanding the behavior and motivations of the involved actors. The proposed model aims to enhance collaboration between the government and community to provide sustainable solutions to shelter-related issues and improve the well-being of residents.
 Keywords: public services, collaboration, shared decision-making

Using LSTM neural networks for cross‐lingual phonetic speech segmentation with an iterative correction procedure

AbstractThis article describes experiments on speech segmentation using long short‐term memory recurrent neural networks. The main part of the paper deals with multi‐lingual and cross‐lingual segmentation, that is, it is performed on a language different from the one on which the model was trained. The experimental data involves large Czech, English, German, and Russian speech corpora designated for speech synthesis. For optimal multi‐lingual modeling, a compact phonetic alphabet was proposed by sharing and clustering phones of particular languages. Many experiments were performed exploring various experimental conditions and data combinations. We proposed a simple procedure that iteratively adapts the inaccurate default model to the new voice/language. The segmentation accuracy was evaluated by comparison with reference segmentation created by a well‐tuned hidden Markov model‐based framework with additional manual corrections. The resulting segmentation was also employed in a unit selection text‐to‐speech system. The generated speech quality was compared with the reference segmentation by a preference listening test.

Evidence that donors with variant RH genotypes are associated with unexpected Rh antibodies.

We previously reported unexpected Rh antibodies in the plasma of patients with sickle cell disease (SCD) that demonstrated common Rh specificities in the absence of transfusion of RBCs positive for that antigen. We hypothesize that these antibodies might result from transfusion of antigen-negative donor units with variant RH genotypes. Plasma testing by tube and IgG gel, extended RBC phenotyping, and HEA and RH genotyping were by standard methods. A 6-year-old female with SCD, phenotype D + C-c + E-e + K- undergoing exchange transfusion with CEK- and Fy(a-) units, presented with anti-C in the plasma, a + DAT and warm autoantibody (WAA) in the eluate. Her RH genotype was unremarkable: RHD*D/DAU0 and RHCE*ce/ce(48C). Units (n = 10) transfused over the prior 6 months were confirmed CEK- by serology and DNA testing. Most (n = 7) were Rh-negative. A unit with variant RH, RHD*DIIIa/weak partial 4.0, RHCE*ceVS.03/ceVS.02, was transfused 5 weeks prior. Anti-C and + DAT continued to demonstrate for 25 weeks. Total hemoglobin and % Hgb S did not deviate from her established baseline. We show direct association of plasma anti-C with transfusion of a C-negative unit with variant RH encoding partial D and uncommon V/VS+ hrB - phenotype. The antibody was transient, without evidence of compromised survival of transfused RBCs. The +DAT and WAA complicated workups and selection of units, and it is uncertain whether donors of the same genotype should be avoided. Minority donors are important for CEK-matching to avoid depleting Rh-negative supplies. Consideration of patient and donor RH genotypes may avoid unexpected antibodies and improve allocation of rare donations.

Hierarchical action encoding in prefrontal cortex of freely moving macaques

Our natural behavioral repertoires include coordinated actions of characteristic types. To better understand how neural activity relates to the expression of actions and action switches, we studied macaques performing a freely moving foraging task in an open environment. We developed a novel analysis pipeline that can identify meaningful units of behavior, corresponding to recognizable actions such as sitting, walking, jumping, and climbing. On the basis of transition probabilities between these actions, we found that behavior is organized in a modular and hierarchical fashion. We found that, after regressing out many potential confounders, actions are associated with specific patterns of firing in each of six prefrontal brain regions and that, overall, encoding of action category is progressively stronger in more dorsal and more caudal prefrontal regions. Together, these results establish a link between selection of units of primate behavior on one hand and neuronal activity in prefrontal regions on the other.

Understanding the spatio-temporally heterogeneous effects of built environment on urban travel emissions

Transportation has become one of the fastest-growing fields for greenhouse gas emissions. It is important to promote the coordinated development of cities and transportation. To deeply understand the emission distribution for urban travel, this study first applies a map matching algorithm to correct the vehicle Global Positioning System (GPS) trajectories on the road network and calculates the travel emissions by the COmputer Programme to calculate Emissions from Road Transport (COPERT) model. Most studies on the impact of built environment on travel emissions only consider the spatially heterogeneity of variables. Although the traditional GTWR can consider the spatio-temporally heterogeneous effects, the spatio-temporal bandwidth is selected at the same scale in the operation process, which limits the relationship analysis among diverse variables. Therefore, this study adopts a unilateral geographically and temporally weighted regression model (UGTWR) and its multiscale extended model (MUGTWR) to estimate the spatio-temporally heterogeneous effects of the built environment on urban travel emissions. In addition, considering the scale effect and zoning effect of the spatial geographical unit selection on the results, we conducted experiments separately on three spatial units: sub-district scale, Traffic Analysis Zones (TAZs) and grid scale to compare and obtain the most appropriate partitioning schemes. The results show that, the fitting effects of UGTWR and MUGTWR are better than that of GTWR, indicating that considering flexible bandwidth selection can effectively improve the accuracy of simulation. Moreover, the temporal and spatial bandwidth values of each independent variable calculated by MUGTWR reflect the heterogeneous characteristics in space and time of different built environment factors, which can provide scientific suggestions for formulating urban planning. The research results can provide planning strategies for optimizing the allocation of local transportation resources and guiding low-carbon travel behaviors.

Using Auxiliary Marginal Distributions in Imputations for Nonresponse while Accounting for Survey Weights, with Application to Estimating Voter Turnout

Abstract In many survey settings, population counts or percentages are available for some of the variables in the survey, for example, from censuses, administrative databases, or other high-quality surveys. We present a model-based approach to utilize such auxiliary marginal distributions in multiple imputation for unit and item nonresponse in complex surveys. In doing so, we ensure that the imputations produce design-based estimates that are plausible given the known margins. We introduce and utilize a hybrid missingness model comprising a pattern mixture model for unit nonresponse and selection models for item nonresponse. We also develop a computational strategy for estimating the parameters of and generating imputations with hybrid missingness models. We apply a hybrid missingness model to examine voter turnout by subgroups using the 2018 Current Population Survey for North Carolina. The hybrid missingness model also facilitates modeling measurement errors simultaneously with handling missing values. We illustrate this feature with the voter turnout application by examining how results change when we allow for overreporting, that is, individuals self-reporting that they voted when in fact they did not.

High-resolution bioenergetics correlates the length of continuous protonatable diaminoethane motif of four-armed oligo(ethanamino)amide transfectants to cytotoxicity

Recent clinical success with Onpattro and cationic ionizable lipid nanoparticle-based mRNA vaccines has rejuvenated research in the design and engineering of broader synthetic cationic vectors for nucleic acid compaction and transfection. However, perturbation of metabolic processes and cytotoxicity are still of concern with synthetic cationic vectors. Here, through an integrated bioenergetic and biomembrane integrity probing in three different human cell lines we reveal the dynamic effect of a library of sequence-defined four-arm oligo(ethanamino)amide transfectant on cell homeostasis, and identify metabolically safe building units over wide concentration ranges. The results show differential effects of the oligo(ethanamino)amide structure of comparable molecular weight on cell energetics. The severity of polycation effect on bioenergetic crisis follows with the length of continuous protonatable diaminoethane motif in the ascending order of glutaryl-triethylene tetramine, succinyl-tetraethylene pentamine and succinyl-pentaethylene hexamine. We further identify oligomeric structures that do not induce bioenergetic crisis even at high concentrations. Finally, transfection studies with a library of polyplexes carrying a reporter gene show no correlation between transfection efficiency and cytotoxicity. These observations demonstrate the usefulness of integrated high-resolution respirometry and plasma membrane integrity probing as a highly sensitive medium-throughput screening strategy for identification and selection of safe building units for transfectant engineering.

Geological-genetic structure of Irpin city, the role of lithological factors during engineering-geological zoning and construction assessment

The scheme of engineering-construction assessment created based on engineering-geological zoning of the city’s territory is desirable among additional graphic materials in the design of master plans projects as determined by building regulations. Engineering-geological zoning provides for different ranks’ selection of engineering-geological units (EG units), which have a particular range of common engineering-geological conditions that ultimately determine the construction sites’ affiliation to a specific suitability category. Geological-genetic structure of Irpin city of Kyiv region (Ukraine) is explored in this article. A variant of the creation of a large-scale engineering-geological map and corresponding geological-lithological sections by supporting boreholes in the borders of the city based on the engineering-geological survey conducted is presented. The obtained result allowed the selection of engineering geological zoning units – engineering geological districts by general conditions of geological development and subdistricts by engineering-geological complexes of Quaternary rocks’ thickness. The analysis of soils’ geomechanical properties (engineering-geological elements) lays the foundations for the selection of engineering-geological sites based on the comparison of this information with geomorphological, hydrogeological and geodynamic data. Accounting of geological-lithological factors in the preparation of the construction assessment scheme in the project of Irpin city’s master plan has become the ultimate result.

Selection of Cord Blood Unit by CD34+ Cell and GM-CFU Numbers and Allele-Level HLA Matching in Single Cord Blood Transplantation

In Japan, only single-unit cord blood transplantations (CBTs) are typically performed, and their number has increased over the last 23 years, with ongoing improvement in results. In most cases, CBTs with multiple HLA mismatches are used, owing to a low HLA barrier, and lower engraftment rate is a problem that must be overcome. Here, as part of an effort to improve guidelines for the selection and processing of CB units for transplantation, we sought to assess the present status of CBT in Japan and to elucidate factors contributing to the favorable outcomes, focusing in particular on selection by cell components of CB unit and HLA allele matching. We conducted a nationwide study analyzing 13,443 patients who underwent first CBT between in Japan between December 1997 and December 2019 using multivariate regression analysis. Both patient- and transplantation-related variables, such as age and Hematopoietic Cell Transplantation Comorbidity Index, as well as selected CB unit characteristics, were included in the analysis. The interaction analysis elucidated that CB unit selection favoring higher counts of CD34+ cells and granulocyte macrophage colony-forming units (GM-CFU)/kg, but not of total nucleated cells, contributed to improved engraftment after transplantation. Moreover, a higher CD34+ cell dose was associated with improved overall survival (OS). Distinctive HLA allele matching was observed. A 0 or 1 HLA allele mismatch between patient and donor had favorable engraftment and carried significantly lower risks of acute GVHD and chronic GVHD but had a significantly higher leukemia relapse rate, compared with a 3-HLA allele mismatch. HLA-DRB1 mismatches were associated with reduced risk of leukemia relapse. Notably, the number of HLA allele mismatches had no incremental effect on engraftment, acute and chronic GVHD, or relapse incidence. As a result, 5-year overall survival did not differ significantly among patients receiving CB units with 0 to 7 HLA allele mismatches. The main points of CB unit selection are as follows. First, selection according to a higher number of CD34+ cells/kg and then of CFU-GM/kg is recommended to obtain favorable engraftment. A unit with .5 × 105 CD34+ cells/kg is minimally acceptable. For units with a CD34+ cell dose of .5 to 1.0 × 105 cells/kg, applying the parameter of ≥20 to 50 × 103 GM-CFU/kg (66.5% of transplanted CB units in this cohort) is associated with a neutrophil engraftment rate of approximately 90%. A unit with ≥1.0 × 105 CD34+ cells/kg can achieve a ≥90% mean neutrophil engraftment rate. Subsequently, HLA allele matching of HLA-A, -B, -C, and -DRB1 at the 2-field level should be searched for units with 0 or 1 HLA allele mismatch in the host-versus-graft direction for favorable engraftment. Units with 2 to 6 HLA allele mismatches are acceptable in patients age ≥15 years and units with 2 to 4 HLA allele mismatches are acceptable in patients age ≤14 years. Units with HLA-DRB1 and/or -B allele mismatch(es) might not be preferable owing to an increased GVHD risk. Our analysis demonstrates that single-unit CBT with the selection of adequate CD34+/kg and GM-CFU/kg and HLA allele matching showed favorable outcomes in both pediatric and adult patients.

Energy-Efficient Optimization in Distributed Massive MIMO Systems for Slicing eMBB and URLLC Services

The fifth generation (5G) communication system aims to support diverse services such as enhanced mobile broadband (eMBB) and ultra-reliable and low-latency communication (URLLC). In order to enable the coexistence of eMBB and URLLC services on a common physical infrastructure, network slicing incorporated in the distributed massive multiple-input multiple-output (DM-MIMO) system is regarded as a promising solution. In this paper, a non-orthogonal slicing scheme is proposed to improve the spectral efficiency, and the short packet transmission is adopted for URLLC to meet the low latency requirement. Through a joint optimization of beamforming and remote radio unit (RRU) selection, we investigate the energy efficiency (EE) maximization problem for the downlink DM-MIMO system. The formulated problem is a mixed integer nonlinear program (MINLP) that we solve by applying some efficient approaches, such as the Dinkelbach method, the reweighted <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\ell _{1}$</tex-math></inline-formula> -norm and difference of convex (DC) programming. By combining these approaches in one iteration, a double-loop procedure based on semi-definite relaxation (SDR) and successive convex approximation (SCA) is employed to find the suboptimal solution of the problem. Simulation results show that the proposed scheme significantly improves the EE of the DM-MIMO system and efficiently manages resource allocation.

On using stratified two-stage sampling for large-scale multispecies surveys

Designing a large-scale multispecies survey presents significant challenges due to its multivariate, multiscale, and often multiobjective nature. Because it is impractical to measure or observe all variables of interest at every location in the survey area, spatial sampling is crucial. To ensure a statistically sound survey, free of assumptions, randomization of the selection of spatial sampling units is required.In a large-scale survey, minimizing travel costs requires multistage sampling in which nearby sampling units are grouped within higher-level sampling units. The design may be supplemented by one or more strata systems — possibly nested — that intervene at specific sampling stages. This article focuses on stratified two-stage sampling that balances statistical efficiency and travel cost minimization.As presurvey knowledge, we assume that the spatial distribution of the species of interest is available for the sampled spatial domain, either from a spatial database or a published species distribution atlas. The multispecies nature of the survey sampling plan relies on these data. The primary sampling units are defined by the spatial grid resolution of the distribution data, while the presence data are used to stratify the PSUs to ensure that the sampling effort is concentrated where most species occur.In this article, we formally define the sampling coverage probability of a species distribution when the selection of samples is randomized according to a given probability mass function (i.e., a probability sampling plan or sampling design, in the statistical sense of the term). By maximizing the sampling coverage probability averaged over the species, the stratification and allocation of spatial sampling units concentrate observer effort where most species occur and minimize effort elsewhere.To guide and illustrate our ideas, we present as an example a multispecies waterbird program at the national scale in European France within the framework of probability sampling from finite populations.

Analysis of Intensive Care Unit Nursing Clinical Judgment and Selection of Nursing Diagnosis for Cerebral Hemorrhage.

Few nursing informatics studies focus on selecting nursing diagnoses for critical patients. The absence of data about nursing clinical judgment in the care of patients with cerebral hemorrhage greatly hinders research progress in evidence-based care. A stratified, retrospective study analyzed 115 electronic "intelligent" nursing information system nurse assessments and nursing diagnoses. Data were documented from April 2019 to November 2020 for critically ill patients admitted with cerebral hemorrhage in a 10-bed medical ICU at a 1500-bed tertiary facility, Henan Honliv Hospital, in Henan Province, China. In the selection of nursing diagnoses among nurses of stratified competencies (novice to expert), novice and experienced nurses were found to have significant variances in selecting nursing diagnoses for critically ill patients with cerebral hemorrhage. Novice nurses more frequently selected the Activity Intolerance Risk diagnosis as an initial diagnosis ( P = .025). Experienced nurses selected the Fluid Volume Excess Risk diagnosis more frequently ( P = .003). Consequently, nursing information systems are important in evaluating professional practice. The access to structured, standardized nursing data for the complete nursing process enables nurse managers to comprehensively analyze the nursing care given to patients, the distribution of patient nursing diagnoses, and the status of patient care risks.

ЕЛЕКТРОННА ОСВІТА: СОЦІАЛЬНО-ЕКОНОМІЧНИЙ КОНТЕКСТ

This research can be treated as a kind of pilot, due to the relatively small population of respondents. However, according to the definition of the selection of typical units, such a small population of respondents is sufficient to draw conclusions from the research presented in this text. The purpose of the article is analysis of the main problems and positive aspects of the introduction of electronic educational tools. The methodological basis of the research was the logical methods of information processing, statistical analysis, comparison. The main hypothesis of the study. Teaching and learning with the use of modern telecommunications and information technologies is already a permanent component of the reality of education in and around the world most countries Teaching via the Internet, which is one of the forms of distance education, breaks certain stereotypes regarding the so-called knowledge transfer process. Presenting main material. Innovation is the main driver of economic and social progress. Its absence results in stagnation both in the economy and in various spheres of social life. Economists emphasize the importance of large-scale investments in innovative programs, including education, which will not only help revive the economy in the near term, but also in the long term.. Originality and practical significance of the research. The selected research results presented here were related, as already indicated, to the declarations of current and future employees of the Schools. Undoubtedly, the crisis caused by the COVID-19 pandemic has once again revealed the need for innovation and innovation in education and other areas of social life. Meeting this need requires well-thought-out changes in teacher education and professional development. In preparing teachers for work, it is necessary to move away from the narrowly understood didactic effectiveness in favor of, among others, developing teachers' attitudes in the field of introducing changes in education and their innovative behavior. Conclusions. Conclusions are presented in the form of answers to research problems: Respondents know many remote learning applications and programs, the most popular of which is Teams; The biggest disadvantage of e-education is the lack of direct contact with the teacher and other pupils/students, although these data are not clearly significant; The greatest advantage of e-education is its low organizational, time and financial costs; Respondents have the possibility of using various methods in e-education and are in favor of using activating methods. Unfortunately, they have little knowledge of the existence of a variety of applications.