Background: The objective of this study was to investigate the pattern of craniofacial injuries in victims of fatal road traffic accidents, observed through autopsies conducted at Midnapore Medical College, West Midnapore from January 2021 to December 2023. Methods: It is a retrospective, cross- sectional observational study. Data was collected by thorough analysis of the injuries documented in post-mortem reports of all the alleged road traffic accident cases where victim sustained Cranio- facial injuries within a time span of 3 years, from 1st January 2021 to 31st December, 2023. Data was analysed using Microsoft Excel. Conclusion: The study highlights the necessity of context-specific interventions to address the unique injury patterns observed in West Midnapore's road traffic accidents. Improving road infrastructure, raising traffic safety awareness, and promoting protective measures like seat belts and helmets can reduce severe craniofacial injuries. The prevalence of maxillofacial fractures underscores the face's vulnerability, with long-term physical and psychological impacts. Effective prevention strategies, such as strict traffic regulations and awareness campaigns on the dangers of distracted or impaired driving, are essential. Despite limitations, the study provides valuable insights into craniofacial injury patterns in fatal accidents, stressing the need for enhanced road safety, stronger traffic laws, and better post-accident care. Interdisciplinary collaboration among healthcare professionals, law enforcement, and policymakers is crucial for developing comprehensive strategies to manage and prevent these injuries. By examining regional injury characteristics and comparing them with other studies, this research contributes to the broader understanding of craniofacial trauma, offering significant implications for improving road safety, trauma care, and forensic practices.