The problem of social and labor relations in small businesses is relevant due to many circumstances: the priority of small business development is associated with its significant impact on employment, improvement of the socio-economic situation, reduction of tension in the labor market by creating additional jobs. In addition, small businesses should become a reliable taxable base for budgets of all levels. The object of the study is a social partnership as a mechanism for coordinating the interests of employees and employers in small businesses. The subject of the research is the regulation and improvement of social and labor relations within the framework of social partnership in small enterprises. The aim of the article is to improve social and labor relations in small enterprises based on the development of the social partnership. Methods of statistical analysis, data from a questionnaire survey of various categories of small business workers, analysis of materials provided by the FNPR, regions of the Russian Federation, the Russian Professional Union of Employees of Innovative and Small Enterprises, Internet sources served as the methodological basis for the study. The scientific novelty of the study lies in the development of the provisions of the social partnership system in the field of regulation of social and labor relations in small enterprises, proposals for the development of small business, proposals for building a mechanism for protecting the interests of SE employees. Based on the results of the study, in order to strengthen guarantees in the field of labor, recommendations were formulated and substantiated for concluding regional agreements at the level of Russian regions that apply to small enterprises and provide for the creation of appropriate associations of employers. They can be used to improve social partnership in the field of regulation of social and labor relations in the activities of small enterprises, as well as find application as aids in the educational process. The materials obtained during the study can be used by state bodies, the government, employers and trade unions to solve the country's economic, social and labor problems. The author concludes that it is necessary to establish guarantees in the system of social partnership in terms of indicators related to the regulation and protection of wages, ensuring stable employment and comfortable working conditions, and continuous training of personnel. In order to increase the employer's interest in creating proper working conditions at small businesses, it is proposed that the authorities, as one of the parties to social partnership, develop a system of measures, including government orders, grants, training, and state assistance in labor protection to cover expenses.