Uninterrupted Production Research Articles

PRIORITIES FOR THE DEVELOPMENT OF MEDICINAL PLANT GROWING IN A POST-PANDEMIC ENVIRONMENT

The year 2020 was heavily influenced by the COVID-19 pandemic in all areas of human and social life. Today, it is difficult to imagine sectors of the economy that would not be affected by the pandemic, but the pharmaceutical industry and pharmaceutical companies are facing serious challenges. On the one hand, the pharmaceutical industry is forced to function in restrictions, like any other type of business in a pandemic, and on the other hand, it is forced to ensure uninterrupted production and supply of medicines, quickly increase their production, and strategically plan its activities in the post-pandemic world. All phases of pharmaceutical companies are affected by the pandemic, from the production and procurement of raw materials to research and development and doctor-patient interaction processes. The pharmaceutical industry, along with the health care system, has been at the epicenter of the global fight against the pandemic and its aftermath. In addition to new opportunities for the pharmaceutical industry in the fight against COVID-19, such as vaccine development and clinical trials of medical drugs to treat COVID-19, the pandemic has harmed the supply chain and production of herbal medicinal raw materials. The global pharmaceutical industry has faced the consequences of the closure of China’s customs borders for quarantine, as China is currently the leader in the production of medicinal pharmaceutical raw materials, accounting for about 40% of the world’s production of medicinal plant pharmaceutical raw materials. China has gained a leading position in the pharmaceutical raw materials industry due to its high production volume and low cost. Closed borders and quarantine-induced lockdown predetermined serious threats in the supply chain for the needs of pharmaceutical production, which was automatically reflected in rising logistics and freight prices. The presented study reviews the current state of the pharmaceutical herbal medicine industry and justifies the priorities of its development in post-pandemic conditions.

Deformation-based support design for highly stressed ground with a focus on rockburst damage mitigation

As mines go deeper, mine designs become more fragile and effective rock support becomes a strategic element for ground control to facilitate timely construction and cost-effective access for uninterrupted production. This article focuses on the design of integrated support systems for brittle ground when large displacements due to gradual bulking of stress-fractured rock or sudden violent bulking during rockbursts are induced by static and dynamic loading. It provides an overview of support design principles for a rational approach to ground control in deep mines when large deformations are anticipated near excavations. Such designs must not only account for load equilibrium but also for deformation compatibility. Most importantly, the design approach must account for the fact that the support's displacement capacity is being consumed as it is deformed after support installation. It is therefore necessary to design for the remnant support capacity, i.e. the capacity remaining when the support is needed. Furthermore, if the support capacity can be consumed, it can also be restored by means of preventive support maintenance (PSM). The PSM concept for cost-effective ground control is introduced and illustrated by quantitative and operational evidence. Contrary to other design approaches, the deformation-based support design (DBSD) approach provides the capacity of an integrated support system as a function of imposed displacements. Reduction in this support capacity due to mining-induced deformation renders excavations increasingly more vulnerable if located within the influence of active mining and seismic activity. Because deformation measurements are robust indicators of the decay in support capacity, scanning and other displacement monitoring technologies enable measurements to verify the DBSD approach, to assess the remnant safety margin of the deformed support, and to make operational support maintenance decisions.

Fully Automated Synthesis of Nitrogen-13-NH3 by SHIs HM-18 Cyclotron and Dedicated Module for Routine Clinical Studies

Aims:The production of nitrogen-13 (13N)-NH3 by ethanol method using automated synthesizer and accessing the production yield, quality control for clinical application.Context:13N, together with 18F, 15O, and 11C, is one of the positron emitters that can be produced on the multi-gigabecquerel scale in biomedical cyclotrons. (13N)-ammonia is frequently used for cardiac PET studies. It is widely applied for the evaluation of myocardial perfusion in the clinical assessment of cardiac disorders. Simple, fast, and reliable preparation methods have contributed to the routine application of this tracer. Although only two methods are available, a challenge remains to adopt a more efficient and consistent approach to its production. For clinical application, routine production of this tracer is mandatory in compliance with regulatory guidelines. Being at hospital radiopharmacy it is our responsibility to support the clinical service with uninterrupted production and supply of (13N)-NH3.Materials and Methods: The chemicals were used commercially available from Sigma Aldrich, India, Ltd., and Fisher Scientific, India, Ltd. (Mumbai, India), Sep-Pak CM cartridges (Waters India, Pvt., Ltd.,). Radio-thin layer chromatography was carried out using aluminum sheets precoated with silica gel 60 F254 (E. Merck, India).Results:The protocol developed with MPS-100 synthesizer yield (13N)-NH395–97% (EOB) with a synthesis time of around 7 min.Conclusions:With the installation of HM-18 cyclotron at our hospital, center is capable to produce (13N)-NH3 of good yield and purity through the ethanol method, for mycocardial perfusion studies. Our protocol is simple, reproducible, and robust.

Studies and Practice of Geometrical Test Procedures & Reconditioning of CNC Lathe Machine Tool

Machining Centres have been major production units for many decades with desired levels of accuracy, economy in costs of production and ease of control. Though new disruptive technologies such as rapid manufacturing, near net shape manufacturing technologies are replacing these machining units, still small and medium Indian Industries go with the conventional ways of large-scale production using conventional and classical machining approaches. With huge setups in place, such machines with high productivity demands, require stringent parts alignment tests frequently from time to time, referred to as Geometrical or Alignment tests to enable accurate finishing and machining of parts and smooth and uninterrupted production. This paper puts forth some basic Geometrical Tests performed on SB CNC 60 Lathe Machine Tool unit, identifying major deviations measurements and reconditioning the machine parts. The main objective of running such tests is to prevent breakdown of the machine and ensure safety working when handling older and heavier conventional machines.

Process safety management and process hazard analysis implementation progress in Pakistan chemical process industries

AbstractPakistan is a developing country and has various chemical process industries to fulfill the local demands of numerous chemical products. In order to maintain the uninterrupted production from these industries, safety protocols need to be implemented. Safety progress must be studied with passage of time to identify the gaps and to decide the future actions. In this article, process safety in various chemical process industries (CPIs) of Pakistan is investigated regarding process safety management (PSM) and process hazard analysis (PHA). The covered industries include mainly fertilizer complexes, food processing plants, gas and oil processing plants, oil refineries, petrochemical plants, polymer processing plants, paper industries, tire industries, and sugar industries. This research will help in addressing the weaknesses. A comparative analysis of all considered CPIs is provided graphically. Overall analysis of all industries depicts that more emphasis on three categories is required, namely (1) documents upgradation and staff communication, (2) PHA revision and auditing, (3) PHA recommendations documentation and implementation. Provided suggestions, the implementation of PSM and PHA in Pakistan CPIs is expected to enhance, which may lead to a substantial increase in productivity of these industries without accidents.

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats.

Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure. Meldonium is an anti-ischemic and anti-inflammatory agent which negatively interferes with lipid metabolism by shifting energy production from fatty acid oxidation to glycolysis, as a less oxygen-demanding pathway. Thus, we investigated the effects of a four-week meldonium pre-treatment on faecal-induced sepsis in Sprague-Dawley male rats. Surprisingly, under septic conditions, meldonium increased animal mortality rate compared with the meldonium non-treated group. However, analysis of the tissue oxidative status did not provide support for the detrimental effects of meldonium, nor did the analysis of the tissue inflammatory status showing anti-inflammatory, anti-apoptotic, and anti-necrotic effects of meldonium. After performing tissue lipidomic analysis, we concluded that the potential cause of the meldonium harmful effect is to be found in the overall decreased lipid metabolism. The present study underlines the importance of uninterrupted energy production in sepsis, closely drawing attention to the possible harmful effects of lipid-mobilization impairment caused by certain therapeutics. This could lead to the much-needed revision of the existing guidelines in the clinical treatment of sepsis while paving the way for discovering new therapeutic approaches.

ECONOMIC METHODS FOR STUDYING THE STATE AND EFFICIENCY OF USE OF MATERIAL RESOURCES OF INDUSTRIAL ENTERPRISES

The article the use of economic methods methods to study the state and efficiency of the use of material resources of industrial enterprises is proposed. The current state of the material resources of enterprises is analyzed on the basis of statistical data. It is proved that the following depends on the efficiency of material resources management: product quality; uninterrupted production support; resource efficiency; compliance with the deadlines for the execution of orders; the cost of production and, ultimately, the profitability of production. The analysis showed that the traditional mechanisms for managing the material resources of an enterprise do not meet new market requirements. In this regard, the stages of assessing the effectiveness of the use of material resources at the enterprise are proposed. Strategic priorities and tasks for each of the stages of the analysis have been identified. A diagnostic model of the efficiency of using material resources of industrial enterprises, obtained on the basis of discriminant analysis, is developed and proposed. The obtained discriminant functions are used to construct a map of differentiation of the efficiency of the use of material resources, statistical estimates of the synthesized models show high significance and adequacy.

Design and analysis of an off-grid PV plant for higher utilization efficiency in the field of pharmaceutical industry considering global pandemic state .

According to the concern of WHO the less association of people in an office may restrict the likelihood of spreading this COVID-19 infection. And it applies to all kinds of organizations. On the other hand, the pharmaceutical companies are working hard to maintain uninterrupted production of vaccine and medicines. This paper focuses on the main layer which is the power system management and its utilization through the less involvement of any individual. Automation and controlling the system remotely can be a good solution. In the design process the FDA proposed structure for the Pharmaceuticals needs to be maintained as well. One of the significant necessities is most of the energy should come from environment friendly system and in Bangladesh sunlight-based energy is the best solution right now. Solar energy utilization efficiency can be increased using the data logging system and machine learning algorithms from that archived data. In this paper, a SCADA operated Off-Grid Solar PV Automation System has been proposed to increase the utilization efficiency. To predict solar power availability over time and perform efficient energy trafficking, the automation system will analyze previous data and perform situational awareness operations for uninterrupted solar power generation. The proposed automation system has been designed focusing on pharmaceutical manufacturing utilities. A comprehensive analysis of the proposed automation system for pharmaceuticals industry applications has also been presented in this paper. The continuous monitoring system for this Off-Grid Solar PV power generating unit preserves multiple data entries, which increases with time and subjected to energy trafficking. And this energy trafficking based on machine learning increases the overall solar energy utilization efficiency.

Establishing the [18F]-FDG Production via Two Different Automated Synthesizers for Routine Clinical Studies: Our Institutional Experiences of 4 years.

Introduction:[18F]-Fluorodeoxyglucose ([18F]-FDG) is the most widely used positron-emission tomography tracer used for imaging in clinical studies such as early detection of cancer or its malignancies, quantifications, staging, and restaging of several malignancies. For clinical application, routine production of this tracer is mandatory in compliance to regulatory guidelines. Several dedicated commercial synthesizers are currently used for producing[18F]-FDG for clinical usage. Being at hospital radiopharmacy, it is our responsibility and duty to support the clinical service with uninterrupted production and supply of [18F]-FDG. This document describes the production of [18F]-FDG using two different automated synthesizers in terms of its production yield, time of synthesis, and analyze the quality control (QC) of the produced [18F]-FDG.Materials and Methods:The precursor, mannose triflate ultra-pure, authentic nonradioactive standard FDG and [18O]-water were obtained from ABX, Germany. Solvents and reagents were purchased from Sigma Aldrich India Ltd. and Fisher Scientific India Ltd., (Mumbai, Maharashtra, India).Results:The protocol developed for the synthesis with MPS-100 synthesizer yield of [18F]-FDG is approximate about 45% End of Bombardment (EOB) with synthesis time of around 35 min, whereas with F300E synthesizer it is around 60% with synthesis time of 25 min. The quality of the tracer produced by both synthesizers is at par with the QC parameter for clinical applications.Conclusions:Finally, we have developed the production using two automated synthesis modules which have the capability to produce [18F]-FDG, to do the patient studies in good yield and purity. Our protocol is simple, reproducible, and robust.

Ivanovo – city of labour valour: organisation of labour achievements of Ivanovo residents in the years of the Axis-USSR War (1941–1945)

The article is devoted to the study of labour achievements of Ivanovo residents during the participation of the USSR in World War II. This was preceded by a whole list of legal, managerial, social and economic decisions taken at the level of the centre and the region. Their main components were measures to organise labour and strengthen labour discipline, which, along with others, were based on the maximum mobilisation of regional resources. They were adequate to the military situation and in general they were so successful that the enterprises of the city and the region were able to achieve uninterrupted production of military and civilian products, and their teams during the war showed mass labour heroism and dedication. The article is based on the materials of the state archive of Ivanovo Region and the Russian state archive of socio-political history, as well as local and central periodicals. It summarises new information on the subject of most archival documents are introduced into scientific circulation, which allows to expand the knowledge of researchers and the public about the contribution of residents of Ivanovo and the region in achieving victory over Nazi Germany and its allies. The results of this study may be of interest to experts in the field of regional economy and the history of the World War II East Front.

Smart Home Energy Management System

Home energy management system has been selected as an attractive research issue due to its ability to enhance energy security by including devices, entertainment systems, security systems, environmental controls, etc. Home automation is incorporated as a potential technology to ensure efficient electricity performance without interruption, solve power demand problems and coordinate devices with innovative technologies. In this context, our proposal seeks to implement an accurate home energy management system. The proposed approach aims to improve uninterrupted electricity production and provide comfortable services to families. To implement correct system operations and meet each device's power demand, a Reel Time Energy Management System (RT-EMS) will be implemented and discussed through some required tasks using the Multi-Agent System (MAS). Each agent will be determined according to some criteria to implement the appropriate design and meet each device's power demand. The obtained results will show that the proposed system meets the general objectives of RT-EMS.

МЕТОДИКА РАСЧЕТА НОРМАТИВНОЙ ПОТРЕБНОСТИ НЕСНИЖАЕМЫХ ЗАПАСОВ КОМПЛЕКТУЮЩИХ И МАТЕРИАЛОВ НА СКЛАДАХ ПРОИЗВОДСТВЕННОЙ ОРГАНИЗАЦИИ

In the context of dynamic changes in environmental factors, the development and implementation of tools that allow for effective management of all work processes and ensure its competitiveness are of significant importance for production organizations. It is especially important to properly manage the organization's resources, including the irreducible stocks of materials and components in warehouses, to ensure uninterrupted production activities. The author's methodology presented in the article allows us to calculate the normative need of an organization for non-reduced stocks of components and materials in warehouses, allowing us to organize effective management of the organization's resources and their timely replenishment.

Hyperinsulinemia: A Metabolic Disease, the Quality of Life of its Patients and Treatment

Hyperinsulinemia is a metabolic condition that occurs mainly in people with increased body weight, which implies an increased body mass index (BMI) and the consequences it can have in long term. Many people suffer from hyperinsulinemia but do not know it, as they ignore their symptoms which are polycystic ovaries, hair loss, difficulty having children, sparse menstruation, etc. Hyperinsulinemia is a metabolic condition due to the fact that the body constantly produces an increased to excessive amount of insulin regardless of the amount of glucose present in the blood. Hyperinsulinemia should not be confused with and directly linked to diabetes, as type 2 diabetes may occur after several years of untreated hyperinsulinemia due to the natural fatigue of the pancreas due to its excessive and uninterrupted production of insulin. Usually people who show symptoms of hyperinsulinemia are predisposed as it can be diagnosed in newborns, it has arisen from other metabolic diseases such as isletoblastoma, liver disease, etc. It can also result from the administration of drugs such as contraceptives where after their cessation the body has returned to normal or unfortunately hyperinsulinemia may remain.

Review of the Current Laboratory Methods To Select Asphaltene Inhibitors

Asphaltene deposition is a long-standing problem that threatens the uninterrupted production of crude oil. Unlike other flow assurance problems, downhole asphaltene deposition is not well-understoo...

ПРОГРАМНО-ЦІЛЬОВИЙ ПІДХІД В УПРАВЛІННІ ЕКОНОМІЧНОЮ БЕЗПЕКОЮ ПІДПРИЄМСТВ

Статтю присвячено узагальненню та обґрунтуванню доцільності застосування програмно-цільового підходу в управлінні економічною безпекою підприємств, встановленню цільових його орієнтирів та відповідних програмних заходів їх досягнення. Визначено програмні заходи для досягнення цілей управління фінансовою безпекою підприємства, у тому числі для зниження кредитозалежності, підвищення ефективності інвестицій. Розкрито програмні заходи для забезпечення техніко-технологічної безпеки, зокрема для забезпечення досягнення безперебійності процесу виробництва. Обґрунтовано програмні заходи цілей управління інформаційною безпекою (захист розробок та ноу-хау; захист від конкурентної розвідки) та програмні заходи цілей кадрової безпеки. Запропоновано відповідні цілі та програмні заходи безпеки економічних відносин.

Steel making cities of labor prowess: historical memory and new opportunities

In the beginning of 2020 in Russia an honorary title “Сity of labor prowess” was established, which was awarded to the cities, citizens of which made a significant contribution to reaching the Victory of the USSR in the Great Patriotic War of 1941– 1945. The cities to receive the new title ensured an uninterrupted production of war and civil products at plants during the war time and the citizens showed mass labor heroism and selflessness, confirmed by awarding of plants and workers by state rewards as well as presentation of challenge Red Flags of State Defense Committee. On July 2, 2020 the new title was awarded to 20 cities, among which were many centers of steel industry, in particular, Magnitogorsk, Chelyabinsk, Nizhny Tagil, Novosibirsk, Izhevsk, Novokuznetsk. Steel industry in war years provided the needs of the country and the Red Army by all kinds of metals. Steel plants within a short time managed to arrange a wide-scale production of armor plates, gun, shell, armor-piercer steels and other new for them high quality alloyed steels , necessary for production of armament and war machinery. Besides, at the steel plants a production of ammunition and utilities for weapon and war machinery was mastered. The title “City of labor prowess” is a “civil” analogue of the title “City of military velour”. Despite this status does not envisages any material stimulation of citizens and additional financing of a city, receiving of it will enable not only to preserve the historical memory and to show respect to heroic forefathers, but also give a new pulse to development of regions, as well as will attract attention of mass media, business and federal authorities and will increase the tourist attractiveness.

RETRACTED: An efficient grasshopper optimization with recurrent neural network controller-based induction motor to replace flywheel of the process machine

This paper proposes a convenient power electronic circuitry with a control approach for the flywheel replacement of an induction motor. The proposed control approach is the joined execution of grasshopper optimization algorithm and recurrent neural network based on duty ratio controller and hence the proposed work is named grasshopper optimization with recurrent neural network. The main contribution of this work is, the power electronic circuitry gets the input voltage samples and limits the deviation to appraise the instantaneous torque demand. The required voltage for the instantaneous torque demand is produced by the proposed control technique. In the proposed grasshopper optimization with recurrent neural network technique, the grasshopper optimization algorithm is a meta-heuristic population-based algorithm, which works from the perspective of the swarming behavior of grasshoppers in nature. In the proposed system, the recurrent neural network learning procedure is improved by the grasshopper optimization algorithm in the perspective of the minimum error objective function. the proposed grasshopper optimization with recurrent neural network technique optimizes the inverter switching states by limiting the error between the setpoint torque and the demand torque regarding objective function. With this proposed technique, the unbalance between demand torque and generated torque is found with high precision and the quicker execution to pull back out the torsional pulsation insensitive load linked transmission systems. By utilizing the proposed methodology, the extreme fluctuation of load torque due to peaky loads in an induction motor will be detected accurately. Also, the proposed technique reduces the torsional vibrations, weakness in components and minimizes the outages of uninterrupted production leading to higher profits. The proposed strategy is actualized in the MATLAB/Simulink platform and evaluated their performance. The performances are appeared differently compared with the existing methods.

INFORMATION SYSTEM FOR CONTROL OF RAW MATERIAL TRANSPORTATION OF AN IRON AND STEEL PLANT

Today, the creation and use of powerful information systems for managing the raw material flows of a metallurgical enterprise transported by the railways allow to diminish turn-round of wagons on the house tracks of the enterprise, to reduce the stock of raw materials in wagons, to create conditions for uninterrupted production, as well as to increase the level of maturity of cross-functional interaction of divisions.This necessitates the development of a system of rapid collection, analysis, and visualization of information on the supply of raw materials, which will act as a single information space to coordinate the actions of all parties involved. Such an information system should support decisions at both the operational and tactical levels. Operational decisions in this case include changing plans for the current period, purchasing missing volumes, redirecting raw materials to other consumers, prioritization of relevant shipments and wagons’ rearrangement. Tactical level includes revision of reserve and consumption standards, elaboration of special agreements with carriers.The objective of the study is to investigate the possibility of using an information system for controlling raw material transportation to reduce the turn-round of wagons on the house tracks of a metallurgical enterprise. The authors use general scientific methods, comparative analysis, mathematical methods. The article studies the main functionality of such a system, presents a methodology for calculating the investment attractiveness of a project, and suggests further directions for development in the field of information interaction between enterprises and rolling stock operators.

4-E (Energy-Exergy-Environment-Economic) analyses of integrated solar powered jaggery production plant with different pan configurations

Conventional jaggery making process utilizes the bagasse for boiling of sugar cane juice which releases pollutants into the atmosphere and high particulate matter from these emissions causes air pollution. In this article, solar powered jaggery industry with freeze pre-concentration is proposed with conventional and modified heating pans. The system performance, environmental impacts and economic feasibility were assessed by carrying out 4E (Energy-Exergy-Environment-Economic) analyses using the developed mathematical model. These systems were designed to produce 300 kg of jaggery per day when operated for 7.5 h in 3 batches with average solar direct normal irradation of 662 W/m2 and 343 °C. These systems are integrated with auxiliary heating for uninterrupted production in the absence of sunlight. These systems can mitigate nearly 2015.95 to 3062.15 tons of CO2 emission during its 25 years of lifespan under 300 clear days of operation each year. Jaggery produced by this technique is rich in its colour and completely safe for human consumption as no artificial clarificants are used. Amount invested in these systems can be recovered in a span of 12.03 to 13.45 years for jaggery selling price of USD.0.514/kg or INR.36/kg.

Heliceculture as a promising area of agricultural production

Purpose. The aim of the article is research of theoretical, organizational and economic aspects of functioning and effective development of farms for growing and processing of snails and substantiation of prospects of heliceculture as a branch of agriculture on the basis of analysis of world experience. Methodology of research. In the course of the research the methods of general scientific (analysis, synthesis, abstraction) and empirical methods (observations, questionnaires, conversations) of economic science are used, which are based on a systematic approach, which allowed to characterize the current state of production and export of heliceculture products, as well as identify key issues in this area of agricultural production. Findings. The concept of “heliceculture” is substantiated and its content is analysed in terms of prospects as a new direction of agricultural production. The historical genesis of the development of traditions of snail products consumption has been studied, as a result of which the first mentions in the history of Ancient Rome, as well as France and Italy have been revealed. An analysis of the dynamics and current state of development of domestic heliculture entrepreneurship, which showed a rapid increase in the number of snail farms and increasing exports of snails to Europe. An overview of the world market for edible snails is made, where there is a noticeable tendency to a gradual annual increase in the consumption of heliculture products. The key elements of the technological process of growing edible snails are analysed, which allowed to systematize a number of basic technological processes and to conclude about the complexity and complexity of this production. The commodity assortment of heliculture has been determined, which includes meat, caviar and snail secretion. The key advantages of Ukraine as a producer and exporter of heliculture products are highlighted, including the availability of labour, proximity to markets, high land supply and dissatisfaction with global demand for these products, which makes it significant for the development of heliculture as an agricultural production. The key problems that hinder the development of snail farming are summarized, namely: legislative unregulation, limited industrial production capacity, lack of diversified processing, limited information and scientific research. The key directions of development of the heliceculture industry are determined, among which: organization of production and marketing heliceculture cooperatives, provision of in-depth processing and year-round uninterrupted production, development of agro-tourism on the basis of snail farms. Originality. A systematic approach to clarifying the definition of “heliceculture” is proposed. On the basis of a thorough study of official statistical information on the state of production of snail products, the importance of heliculture as a promising area of agricultural production is substantiated. Practical value. The obtained research results can be used in the development of an effective concept for the development of the heliculture industry. Key words: heliceculture, heliceculture market, snail farming, small business, family farm.