With the scale-up of circulating fluidized bed (CFB) boilers, the size of the platen heating surface within the furnace increases. Deformation, crack, and tube explosion of the platen heating surface threaten the safe and stable operation of CFB boiler. Large wall temperature deviation and overtemperature of partial tubes of heating surfaces are two of main reasons resulting in above problems. To identify the causes of large wall temperature deviation and decrease them, the heat transfer characteristics and wall temperature distribution uniformity of platen superheaters in the furnace of a 350 MWe supercritical CFB boiler were studied by experimental tests, and the structure of the high temperature superheater was optimized by numerical simulation to improve the temperature distribution uniformity. The steam parameters and wall temperatures of the platen superheaters were measured at boiler loads of 50 % BMCR, 75 % BMCR, and 100 % BMCR. The heat transfer coefficient, heat flux, and wall temperature uniformity of the platen superheaters were analyzed. At 100 % BMCR boiler load, the average heat transfer coefficient and heat flux of the medium temperature superheater IIs were 165.5 W/(m2·°C) and 56 kW/m2, respectively; while those of the high temperature superheaters were 179.7 W/(m2·°C) and 53.2 kW/m2, respectively. The wall temperature distribution uniformity among six medium temperature superheater IIs or six high temperature superheaters was relative good, while the temperature distribution uniformity of a single platen superheater required improvement. An optimized structure of the high temperature superheater was obtained from eight structures by numerical simulation, achieving a steam temperature deviation of less than 8 °C at the boiler load of 100 % BMCR.