Unified Treatment Research Articles

Traditional versus virtual partial hospital programme for eating disorders: Feasibility and preliminary comparison of effects.

Minimal research has examined teletherapy for group or intensive eating disorder (ED) treatment, particularly partial hospital programme (PHP). This study compared treatment outcomes for individuals treated before and after a pandemic-driven implementation of virtual PHP. Patients received care at ED treatment centres using the Renfrew Unified Treatment for Eating Disorders and Comorbidity. Patients treated with virtual PHP were compared to patients treated with traditional PHP. Measures of ED symptomology and behaviours, depressive symptoms, anxiety severity, anxiety sensitivity, experiential avoidance, mindfulness, and body mass index (BMI; reported for anorexia nervosa [AN] patients only) were collected at intake and discharge. Multiple regression analyses were conducted to examine the effect of treatment group on outcomes, controlling for intake score, comorbidity, discharge status, AN diagnosis, and step-down status. Differences in treatment type were only found for binge eating frequency, with those in virtual PHP reporting significantly lower binge eating episodes at discharge than those in traditional PHP. Body mass index showed significantly less improvement in virtual PHP than in traditional PHP. Preliminary results suggest virtual PHP is feasible and effective, potentially increasing access to evidence-based, intensive ED treatment. However, additional research is needed to establish efficacious support for weight gain among individuals with AN in virtual programs.

Slip and Twinning in Bravais Lattices

A unified treatment of slip and twinning in Bravais lattices is given, focussing on the case of cubic symmetry, and using the Ericksen energy well formulation, so that interfaces correspond to rank-one connections between the infinitely many crystallographically equivalent energy wells. Twins are defined to be such rank-one connections involving a nontrivial reflection of the lattice across some plane. The slips and twins minimizing shear magnitude for cubic lattices are rigorously calculated, and the conjugates of these and other slips analyzed. It is observed that all rank-one connections between the energy wells for the dual of a Bravais lattice can be obtained explicitly from those for the original lattice, so that in particular the rank-one connections for fcc can be obtained explicitly from those for bcc.

Anharmonic electron-phonon coupling in ultrasoft and locally disordered perovskites

Anharmonicity and local disorder (polymorphism) are ubiquitous in perovskite physics, inducing various phenomena observed in scattering and spectroscopy experiments. Several of these phenomena still lack interpretation from first principles since, hitherto, no approach is available to account for anharmonicity and disorder in electron–phonon couplings. Here, relying on the special displacement method, we develop a unified treatment of both and demonstrate that electron–phonon coupling is strongly influenced when we employ polymorphous perovskite networks. We uncover that polymorphism in halide perovskites leads to vibrational dynamics far from the ideal noninteracting phonon picture and drives the gradual change in their band gap around phase transition temperatures. We also clarify that combined band gap corrections arising from disorder, spin-orbit coupling, exchange–correlation functionals of high accuracy, and electron–phonon coupling are all essential. Our findings agree with experiments, suggesting that polymorphism is the key to address pending questions on perovskites’ technological applications.

AdaTerm: Adaptive T-distribution estimated robust moments for Noise-Robust stochastic gradient optimization

With the increasing practicality of deep learning applications, practitioners are inevitably faced with datasets corrupted by noise from various sources such as measurement errors, mislabeling, and estimated surrogate inputs/outputs that can adversely impact the optimization results. It is a common practice to improve the optimization algorithm’s robustness to noise, since this algorithm is ultimately in charge of updating the network parameters. Previous studies revealed that the first-order moment used in Adam-like stochastic gradient descent optimizers can be modified based on the Student’s t-distribution. While this modification led to noise-resistant updates, the other associated statistics remained unchanged, resulting in inconsistencies in the assumed models. In this paper, we propose AdaTerm, a novel approach that incorporates the Student’s t-distribution to derive not only the first-order moment but also all the associated statistics. This provides a unified treatment of the optimization process, offering a comprehensive framework under the statistical model of the t-distribution for the first time. The proposed approach offers several advantages over previously proposed approaches, including reduced hyperparameters and improved robustness and adaptability. AdaTerm achieves this by considering the interdependence of gradient dimensions. In particular, upon detection, AdaTerm excludes aberrant gradients from the update process and enhances its robustness for subsequent updates. Conversely, it performs normal parameter updates when the gradients are statistically valid, allowing for flexibility in adapting its robustness. This noise-adaptive behavior contributes to AdaTerm’s exceptional learning performance, as demonstrated through various optimization problems with different and/or unknown noise ratios. Furthermore, we introduce a new technique for deriving a theoretical regret bound without relying on AMSGrad, providing a valuable contribution to the field.

The Ricci flow and the early universe

A framework of quantum spacetime reference frame is proposed and reviewed, in which the quantum spacetime at the Gaussian approximation is deformed by the Ricci flow. At sufficient large scale, the Ricci flow not only smooths out local small irregularities making the universe a homogeneous and isotropic Friedmann–Robertson–Walker metric, but also develops a local singularity at the physical-time origin. Due to the phenomenological suppression of the non-Gaussian primordial perturbations, we assume the validity of the Ricci flow applying to the high curvature region near the local singularity of the early universe. The no-local-collapsing theorem of Perelman ensures the existence of a canonical neighborhood around the large curvature pinching point, which resembles a gradient shrinking Ricci soliton (GSRS) solution of the Ricci flow. Without any inflaton field, the GSRS naturally reproduces an exact inflationary deSitter universe near the singularity at the leading order. Without any rolling-down behavior of inflaton, the deviation from exact deSitter described by the “slow roll parameters” can be calculated by a small deviation from the singular flow-time via the Ricci flow, and the primordial perturbations can also be studied on the GSRS background, the power spectrum of the scalar perturbation agrees with present observations, and the one of the tensor perturbation is predicted too small to be detectable than the standard inflation. The previous treatment of the cosmological constant and the effective gravity are also briefly reviewed in the framework. So we argue that the Ricci flow provides us a possible unified view and treatment of the late epoch accelerating expansion and early epoch inflation of the universe without introducing dark energy or inflaton (dark energy of the second kind).

A unified Monte Carlo approach for population balance simulation of particle coagulation and breakage

This paper proposes a unified Monte Carlo approach to model simultaneous particle coagulation and breakage processes. Based on the reconstruction of stochastic weighted particles, the present approach treats coagulation and breakage in a unified sense and resamples the weighted particle population globally. The prediction results are validated through several benchmark coagulation-breakage cases with known analytical solutions, and the performances are compared with those of conventional combination approaches. It is confirmed that, in terms of resolving particle size distribution and moments, the proposed reconstruction approach generally yields higher computational accuracy and efficiency, with especially reduced statistical noise for long-time simulations. The simple implementation, the unified treatment for different dynamic processes, and the well-balanced accuracy and efficiency make this new approach a promising candidate for solving general population balance problems of particles.

On the stability of homogeneous equilibria in the Vlasov–Poisson system on

The goal of this article is twofold. First, we investigate the linearized Vlasov–Poisson system around a family of spatially homogeneous equilibria in (the unconfined setting). Our analysis follows classical strategies from physics (Binney and Tremaine 2008 Galactic Dynamics (Princeton University Press); Landau 1946 Acad. Sci. USSR. J. Phys. 10 25–34; Penrose 1960 Phys. Fluids 3 258–65) and their subsequent mathematical extensions (Bedrossian et al 2022 SIAM J. Math. Anal. 54 4379–406; Degond 1986 Trans. Am. Math. Soc. 294 435–53; Glassey and Schaeffer 1994 Transp. Theory Stat. Phys. 23 411–53; Grenier et al 2021 Math. Res. Lett. 28 1679–702; Han-Kwan et al 2021 Commun. Math. Phys. 387 1405–40; Mouhot and Villani 2011 Acta Math. 207 29–201). The main novelties are a unified treatment of a broad class of analytic equilibria and the study of a class of generalized Poisson equilibria. For the former, this provides a detailed description of the associated Green’s functions, including in particular precise dissipation rates (which appear to be new), whereas for the latter we exhibit explicit formulas. Second, we review the main result and ideas in our recent work (Ionescu et al 2022 (arXiv:2205.04540)) on the full global nonlinear asymptotic stability of the Poisson equilibrium in .

Effects of coexisting zinc and nickel ions on crystallization behaviour and properties of spinel synthesised in chromium-containing wastewater

ABSTRACT Electroplating wastewater contains chromium ions, zinc ions, and nickel ions due to the emergence of a multi-layer plating process and unified treatment of mixed wastewater. The effects of coexisting zinc and nickel ions on crystallization behaviour and properties of spinel synthesised in chromium-containing wastewater by ferrite method were investigated in the study. The results indicated that the quality of the supernatant and the stability of synthetic products were barely affected. However, the magnetic property of the synthetic products was significantly increased when the concentration ratio of zinc and nickel ions was appropriate. With the extension of stirring time, the stability of the synthetic product increased, but the crystallinity gradually decreased. Chromium and zinc ions entered the synthetic products preferentially over nickel ions during ferrite synthesis. In addition, the morphology of the synthetic products was irregular and dense, and the lustre distribution was uniform. The distributions of iron, chromium, zinc, nickel and oxygen were overlapped, owing to a single spinel, and the molecular formula of synthetic products was speculated as (3.53 < x < 3.99, 0.2 < y < 0.36, 0.04 < z < 0.05, 0.03 < n < 0.05). Finally, the transport model of metal ions in the mixed wastewater was established, and the synthesis mechanism was revealed.

Entropy and Energy Profiles of Chemical Reactions.

The description of chemical processes at the molecular level is often facilitated by the use of reaction coordinates or collective variables (CVs). The CV measures the progress of the reaction and allows the construction of profiles that track how specific properties evolve as the reaction progresses. Whereas CVs are routinely used, especially alongside enhanced sampling techniques, the links among reaction profiles, thermodynamic state functions, and reaction rate constants are not rigorously exploited. Here, we report a unified treatment of such reaction profiles. Tractable expressions are derived for the free-energy, internal-energy, and entropy profiles as functions of only the CV. We demonstrate the ability of this treatment to extract quantitative insight from the entropy and internal-energy profiles of various real-world physicochemical processes, including intramolecular organic reactions, ionic transport in superionic electrolytes, and molecular transport in nanoporous materials.

Upstream–Downstream Asymmetry in Multiscale Interaction Underlying the Northern Hemisphere Atmospheric Blockings

Abstract The typical blockings over the Pacific, Atlantic, and Ural Mountain regions are investigated for an understanding of their dynamical interactions in a unified treatment with their respective basic flows and high-frequency processes, respectively. Thanks to the localized nature of the new methodology as used in this study, for the first time we identify a dipolar structure (for each of the three regions) in the map of the interscale energy transfer from the basic flow to the composite blocking, with a positive center upstream and a negative center downstream. This indicates the crucial role of the instability of the basic flow in the maintenance of blockings, which has been overlooked due to the bulk nature of the spatially integrated energetics (by summing the transfer over the whole blocking, the two centers essentially cancel out, leaving an insignificant bulk transfer). For the interaction between the blocking and the high-frequency storms, the well-known critical role of the upscale forcing in blocking development is confirmed. But, unexpectedly, except for that over the Atlantic where the forcing exists throughout, over the other two regions the forcing is found to occur mainly downstream. This is quite different from what the classical theory, e.g., the famous eddy strain mechanism of Shutts, would predict.

Modeling impedance boundary conditions and acoustic barriers using the immersed boundary method: The three-dimensional case.

One of the main challenges in time domain wave-based acoustics is the accurate simulation of both boundary conditions and barriers capable of reflecting and transmitting energy. Such scattering structures are generally of irregular geometry and characterised in terms of frequency-dependent reflectances and transittances. Conditions for numerical stability can be difficult to obtain in either case. Immersed boundary methods, which are heavily used in computational fluid dynamics applications, replace boundaries by discrete driving terms, avoiding volumetric meshing and staircasing approaches altogether. The main contribution of this article is a unified numerical treatment of both impedance boundary conditions and barriers capable of transmitting energy and suitable for use in the setting of wave-based acoustics. It is framed in terms of the immersed boundary method within a finite difference time domain scheme, using a dual set of matched discrete driving terms in both the conservation of mass and momentum equations that can be tuned against a desired reflectance or transmittance. Numerical results in three dimensions are presented, illustrating non-porous barriers and impedance boundary conditions, and highlight important features such as spurious leakage through an immersed boundary. A brief demonstration of conditions for numerical stability of the immersed boundary method in this context is provided in an appendix.

Clinical Characteristics of Aggressive NK-Cell Leukemia

To explore and summarize the clinical characteristics and treatment of aggressive NK-cell leukemia (ANKL), and provide new insights for clinical diagnosis and treatment of this disease. The clinical data of 7 patients with ANKL admitted to the First Affiliated Hospital of Wannan Medical College from March 2014 to July 2021 were retrospectively analyzed, and their clinical characteristics, laboratory and imaging results, treatment and outcomes were analyzed. Among the 7 patients, 5 were males and 2 were females, with a median age of 47 (33-69) years old. The morphology of bone marrow cells in 7 patients showed similar large granular lymphocytes. Immunophenotyping revealed abnormal NK cells in 5 cases. By the end of follow-up, 6 cases died and 1 case survived, with a median survival time of 76.9 (4-347) days. ANKL is a rare disease with short course and poor prognosis. If combined with hemophagocytic syndrome (HPS), the prognosis is even worse. There is no unified treatment method at present, and the use of PD-1 inhibitors may prolong the survival in some patients.

Comparative Analysis of the Most Used Versus the Recently Developed Vitiligo Activity and Extent Scores and Their Change with Treatment.

There are diverse assessment tools for vitiligo, with no standardized approach that helps unify treatment outcome measures. Thus, comparing different treatment modalities and developing evidence-based recommendations for vitiligo management has been quite challenging. We compared the most commonly used tools assessing both vitiligo activity and extent, namely, Vitiligo Disease Activity Score (VIDA) and Vitiligo Area and Severity Index (VASI) score to their newly developed counterparts, namely, Vitiligo Extent Score Plus (VES plus) and Vitiligo Signs of Activity score (VSAS), to provide insights that would help set recommendations for a unified outcome assessment protocol for vitiligo patients. Thirty-six active non-segmental vitiligo cases were recruited, 30 of whom completed 48 sessions of narrow band ultraviolet B (NB-UVB). Patients were assessed for both extent and activity both before and after treatment with NB-UVB. Scores were correlated. Additionally, VES plus was assessed for its reliability in comparison to VASI score. Both extent (VASI and VES plus) and activity scores (VIDA and VSAS) showed significant improvement following treatment. Additionally, VES plus and VASI were positively correlating both before and after treatment as well as their percent change. Furthermore, VES plus proved as reliable as VASI. Regarding activity scores, total, hypochromic and Koebner VSAS only correlated with VIDA following treatment. Confetti VSAS neither correlated with VIDA before nor after treatment. VES plus and VASI scores have proven of comparable reliability. While examination-based VSAS score comes as an additive tool to the history-based VIDA score.

Entanglement and indistinguishability: facing some challenges from a new perspective.

While entanglement in the case of distinguishable particles is clearly understood, in the case of indistinguishable particles, there is still a wide debate regarding basic conceptual issues. Here, I will address two such issues. First, the debate almost always rests on a differentiated treatment of the cases of distinguishability and indistinguishability, even with respect to the definition of the concept of entanglement. Second, the fact that symmetrized and antisymmetrized states of indistinguishable particles are non-factorizable leads to certain perplexities about the very nature of entanglement. In the present work, both issues will be addressed from the perspective of an ontology of properties, which finds its natural expression in the algebraic formalism of quantum mechanics. The final goal will be to show that the proposed ontology allows a unified treatment of entanglement in the distinguishability and indistinguishability cases and offers a straightforward way out to perplexities. This article is part of the theme issue 'Identity, individuality and indistinguishability in physics and mathematics'.

Spanish Bare Interrogatives and Number

Abstract Dayal (1996) makes two predictions on the interaction of number and wh-phrases: (i) that questions with singular wh-phrases yield a uniqueness inference, and (ii) that questions with plural wh-phrases yield an antiuniqueness inference. Maldonado (2020) shows that Spanish bare wh-phrases do not conform to Dayal’s predictions. From this, she argues against a unified treatment of number across wh-expressions. Elliott et al. (2022) argue that a unified treatment of number can be maintained if bare wh-phrases are capable of ranging over generalized quantifiers. We weigh in on this discussion by arguing for an intermediate position: though independent evidence suggests that wh-phrases can range over generalized quantifiers, an assumption that we adopt for bare wh-phrases, the unified treatment of number presented in Elliott et al. (2022) faces challenges that can be avoided under Maldonado’s assumptions about number marking on bare wh-phrases.

Quantum-Classical Hybrid Systems and their Quasifree Transformations

We study continuous variable systems, in which quantum and classical degrees of freedom are combined and treated on the same footing. Thus all systems, including the inputs or outputs to a channel, may be quantum-classical hybrids. This allows a unified treatment of a large variety of quantum operations involving measurements or dependence on classical parameters. The basic variables are given by canonical operators with scalar commutators. Some variables may commute with all others and hence generate a classical subsystem. We systematically study the class of "quasifree" operations, which are characterized equivalently either by an intertwining condition for phase-space translations or by the requirement that, in the Heisenberg picture, Weyl operators are mapped to multiples of Weyl operators. This includes the well-known Gaussian operations, evolutions with quadratic Hamiltonians, and "linear Bosonic channels", but allows for much more general kinds of noise. For example, all states are quasifree. We sketch the analysis of quasifree preparation, measurement, repeated observation, cloning, teleportation, dense coding, the setup for the classical limit, and some aspects of irreversible dynamics, together with the precise salient tradeoffs of uncertainty, error, and disturbance. Although the spaces of observables and states are infinite dimensional for every non-trivial system that we consider, we treat the technicalities related to this in a uniform and conclusive way, providing a calculus that is both easy to use and fully rigorous.

Diabetic cardiac autonomic neuropathy: insulin resistance, lipid profile, and omega-3 polyunsaturated fatty acids

The significance of cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM) has been not fully appreciated and there is no unified treatment algorithm. Aim: The aim of study was to investigate the effects of -3 polyunsaturated fatty acids (-3 PUFAs) on blood lipid profile and insulin resistance (IR) parameters in patients with T2DM and definite CAN. The study involved 33 patients with T2DM and definite CAN. Patients were allocated into two treatment groups: 1st group - 15 patients received standard hypoglycaemic therapy - control (n = 15); 2nd group (n = 18) - standard hypoglycaemic therapy and 1 capsule/day of the ω-3 PUFAs (1 g, including 90 % ω-3 PUFAs) for three months. The concentrations of glucose, glycated haemoglobin A1c, immunoreactive insulin in the blood were determined. Lipid metabolism was assessed by the concentration of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) measurements. The insulin resistance Homeostasis model assessment, atherogenic coefficient (AC), TG/LDL-C, TG/TC, TG/LDL-C and TG glucose (TyG) index were calculated. Obtained results of our study could witness that the prescription of -3 PUFAs was accompanied by a statistically significant decrease in TG concentration; AC, TG/LDL-C, TG/TC, TG/LDL-C, TyG index parameters and increase in HDL-C levels (compared to control). Conclusions. Obtained results justify the appropriateness of -3 PUFAs prescriptions to patients with T2DM and definite CAN.

An Overview of Safety and Security Analysis Frameworks for the Internet of Things

The rapid progress of the Internet of Things (IoT) has continued to offer humanity numerous benefits, including many security and safety-critical applications. However, unlocking the full potential of IoT applications, especially in high-consequence domains, requires the assurance that IoT devices will not constitute risk hazards to the users or the environment. To design safe, secure, and reliable IoT systems, numerous frameworks have been proposed to analyse the safety and security, among other properties. This paper reviews some of the prominent classical and model-based system engineering (MBSE) approaches for IoT systems’ safety and security analysis. The review established that most analysis frameworks are based on classical manual approaches, which independently evaluate the two properties. The manual frameworks tend to inherit the natural limitations of informal system modelling, such as human error, a cumbersome processes, time consumption, and a lack of support for reusability. Model-based approaches have been incorporated into the safety and security analysis process to simplify the analysis process and improve the system design’s efficiency and manageability. Conversely, the existing MBSE safety and security analysis approaches in the IoT environment are still in their infancy. The limited number of proposed MBSE approaches have only considered limited and simple scenarios, which are yet to adequately evaluate the complex interactions between the two properties in the IoT domain. The findings of this survey are that the existing methods have not adequately addressed the analysis of safety/security interdependencies, detailed cyber security quantification analysis, and the unified treatment of safety and security properties. The existing classical and MBSE frameworks’ limitations obviously create gaps for a meaningful assessment of IoT dependability. To address some of the gaps, we proposed a possible research direction for developing a novel MBSE approach for the IoT domain’s safety and security coanalysis framework.

Multisystem inflammatory syndrome in children: another COVID-19 sequel.

With the rapid expansion of the COVID-19 pandemic, the disease burden and its consequences on the paediatric population has been progressively recognised. Although COVID-19 infection in children presents as asymptomatic to mild illness, instances of hyperinflammation and multi-organ involvement following the viral infection have been described. This condition, known as the multisystem inflammatory syndrome in children (MIS-C), has gained a wide global attention. Despite the global efforts to uncover the disease characteristics and management, a clear pathogenesis and a unified treatment regimen have not been reached yet. This paper tackles the epidemiology of the MIS-C, discusses its suggested pathogenesis, drives through its varying clinical presentations, and evaluates the different treatment regimens employed in managing MIS-C.

Universal derivation of the asymptotic charges of bosonic massless particles

We present a unified treatment of the conserved asymptotic charges associated with any bosonic massless particle in any spacetime dimension. In particular we provide master formulae for the asymptotic charges and the central extensions in the corresponding charge algebras. These formulae can be explicitly evaluated for any given theory. For illustration we apply them to electromagnetism and gravity, thereby recovering earlier results.