After high-temperature treatment, both nano-titanium dioxide-modified concrete and ordinary concrete exhibit typical splitting failure. High-temperature heating reduces the mechanical properties and brittleness of concrete and improves the ductility of concrete. The stress-strain relationship of the specimens was obtained through the uniaxial compression test of ordinary concrete and nano-titanium dioxide-modified concrete cube specimens under normal temperature and high-temperature conditions. In addition, the relationship between temperature and damage variables was established, and the unified constitutive model containing damage variables after room temperature and high-temperature treatment of ordinary concrete and nano-titanium dioxide-modified concrete were established. It provides a reference for future research on the mechanical properties of high-performance concrete structures after high temperatures (fire).