Recent observations of topological meron textures in two-dimensional (2D) van der Waals (vdW) magnetic materials have attracted considerable research interest for both fundamental physics and spintronic applications. However, manipulating the meron textures and realizing the topological transformations, which allow for exploring emergent electromagnetic behaviors, remain largely unexplored in 2D magnets. In this work, utilizing real-space imaging and micromagnetic simulations, we reveal temperature- and thickness-dependent topological magnetic transformations among domain walls, meron textures, and stripe domain in Fe5GeTe2 (FGT) lamellae. The key mechanism of the magnetic transformations can be attributed to the temperature-induced change of exchange stiffness constant within layers and uniaxial magnetic anisotropy, while the magnetic dipole interaction as governed by sample thickness is crucial to affect the critical transformation temperature and stripe period. Our findings provide reliable insights into the origin and manipulation of topological spin textures in 2D vdW ferromagnets.