During the long rainless spells of the dry season, flows in medium and small streams get reduced to what is generally known as "low flow". For ungauged streams, the controlling "low flows" are determined using the regional analysis method. In the presently described exploration, the method applied was based on the assumption that dry weather discharges in medium and small rivers depended on the hydrogeological conditions. The controlling effect of hydrogeology on the natural low flow in medium and small streams of the hilly and mountainous part of Serbia was analyzed applying the theory of multiple linear regression. The thirty-day minimum mean 80 and 95 per cent exceedance flows were taken for dependent variables, and quantified hydrogeological elements as independent variables. The analysis covered streams that had small or medium size catchment areas. The treated example encompassed sixty-one gauged catchments. The resulting regional relations for the thirty day minimum mean 80 and 95 per cent exceedance flows are presented in this paper. The quality of the established relation was controlled by relevant statistic tests.