Accurate basin-level river discharge estimation is of vital importance across various fields, including water resources, climate change, natural hazards, biodiversity, and energy production. Normally, gauging stations are deemed the most reliable data source for measuring river discharge. However, a significant proportion of the world’s rivers remain ungauged due to a combination of technical, economic, and political constraints. Encouragingly, recent advancements in remote sensing and satellite observation have opened new avenues for global river discharge monitoring, even in ungauged basins, and the availability of extensive datasets and advancements in computing technologies have facilitated the development of numerous modern data-driven techniques. The general objective of this study is to estimate inflow discharge to Lake Baikal at upstream section from Upper Angara and Kichera River Basins using different satellite precipitation and runoff datasets. According to the calculation result, a higher discharge was observed for the power dataset. The obtained results were used to mitigate floods, droughts, bridge design, manage urban drainage systems, and manage the lake ecosystem.