You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy III (MP50)1 Sep 2021MP50-14 THE IMPACT OF RACE/ETHNICITY ON UPSTAGING AND/OR UPGRADING RATES AMONG INTEREDIATE RISK PROSTATE CANCER PATIENTS TREATED WITH RADICAL PROSTATECTOMY Luigi Nocera, Mike Wenzel, Claudia Collà Ruvolo, Christoph Wurnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Francesco Pellegrino, Gabriele Sorce, Riccardo Leni, Daniele Robesti, Donato Cannoletta, Felix Chun, Vincenzo Mirone, Markus Graefen, Fred Saad, Shahrokh Shariat, Francesco Montorsi, Alberto Briganti, and Pierre Karakiewicz Luigi NoceraLuigi Nocera More articles by this author , Mike WenzelMike Wenzel More articles by this author , Claudia Collà RuvoloClaudia Collà Ruvolo More articles by this author , Christoph WurnschimmelChristoph Wurnschimmel More articles by this author , Zhe TianZhe Tian More articles by this author , Giorgio GandagliaGiorgio Gandaglia More articles by this author , Nicola FossatiNicola Fossati More articles by this author , Francesco PellegrinoFrancesco Pellegrino More articles by this author , Gabriele SorceGabriele Sorce More articles by this author , Riccardo LeniRiccardo Leni More articles by this author , Daniele RobestiDaniele Robesti More articles by this author , Donato CannolettaDonato Cannoletta More articles by this author , Felix ChunFelix Chun More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Markus GraefenMarkus Graefen More articles by this author , Fred SaadFred Saad More articles by this author , Shahrokh ShariatShahrokh Shariat More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , and Pierre KarakiewiczPierre Karakiewicz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002076.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Race/ethnicity may predispose to less favorable prostate cancer characteristics in intermediate risk prostate cancer (IR PCa) patients. We tested this hypothesis in a subgroup of IR PCa patients treated with radical prostatectomy (RP). METHODS: We relied on the Surveillance, Epidemiology and End Results 2004-2016. The effect of race/ethnicity was tested in univariable and multivariable logistic regression analyses predicting upstaging (pT3+/pN1) and/or upgrading (Gleason Grade Group [GGG] 4-5) at RP. RESULTS: Of 20,391 IR PCa patients, 15,050 (73.8%) were Caucasian, 2,857 (14.0%) African-American, 1,632 (8.0%) Hispanic/Latino and 852 (4.2%) Asian. Asian patients exhibited highest age (64 year), highest PSA (6.8 ng/ml) and highest rate of GGG3 (31.9%). African-Americans exhibited the highest percentage of positive cores at biopsy (41.7%) and the highest proportion of NCCN unfavorable risk group membership (54.6%). Conversely, Caucasians exhibited the highest proportion of cT2 stage (35.6%). In univariable analyses, Hispanic/Latinos exhibited the highest rates of upstaging/upgrading among all race/ethnicities, in both favorable and unfavorable groups, followed by Asians, Caucasians and African-Americans in that order. In multivariable analyses, Hispanic/Latino race/ethnicity represented an independent predictor of higher upstaging and/or upgrading in favorable IR PCa (Odds Ratio [OR] 1.27, p<0.01), while African-American race/ethnicity represented an independent predictor of lower upstaging and/or upgrading in unfavorable IR PCa (OR 0.79, p<0.001). CONCLUSIONS: Race/ethnicity predisposes to differences in clinical, as well as in pathological characteristics in IR PCa patients. Specifically, even after full statistical adjustment, Hispanic/Latinos are at higher and African-Americans are at lower risk of upstaging and/or upgrading. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e891-e892 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Luigi Nocera More articles by this author Mike Wenzel More articles by this author Claudia Collà Ruvolo More articles by this author Christoph Wurnschimmel More articles by this author Zhe Tian More articles by this author Giorgio Gandaglia More articles by this author Nicola Fossati More articles by this author Francesco Pellegrino More articles by this author Gabriele Sorce More articles by this author Riccardo Leni More articles by this author Daniele Robesti More articles by this author Donato Cannoletta More articles by this author Felix Chun More articles by this author Vincenzo Mirone More articles by this author Markus Graefen More articles by this author Fred Saad More articles by this author Shahrokh Shariat More articles by this author Francesco Montorsi More articles by this author Alberto Briganti More articles by this author Pierre Karakiewicz More articles by this author Expand All Advertisement PDF downloadLoading ...