Large reservoir dams, which are carriers of energy and resources, have historically been the main targets of military conflict and terrorist attacks. A concrete-face rockfill dam (CFRD) is a competitive hydraulic structure widely used in large-scale water conservancy projects. However, the vibration response and damping paths of CFRDs under the influence of underwater explosion shock waves remains insufficiently understood. In this study, we created a theoretical model of slab vibration with four-sided free boundaries using Cole’s formula and the motion differential equation of a slab on an elastic foundation. Furthermore, a global sensitivity analysis of the vibration model parameters on the slab displacement was performed based on the Kriging surrogate model and Sobol method. The results showed that the antiseepage slabs experienced a void phenomenon, resulting in overall instability. The explosive distance and normal stiffness of the slab had the greatest influence on the void displacement of the slab, whereas the dam height and concrete density had insignificant effect. Moreover, increasing the dam height of the CFRD did not increase the risk of slab voids during underwater explosions, which was not the case under strong seismic loads. Therefore, the key factors for active and passive defense against blast resistance in CFRDs were identified, which can provide theoretical support for the blast-resistant design and research on CFRDs. In this study, the reliability of the theoretical model was verified by establishing a numerical analysis model.