Understanding Of Vaccination Research Articles

Addressing the role of eHealth literacy in shaping popular attitudes towards post-COVID-19 vaccination among Chinese adults

This study examined the influence of eHealth literacy on Chinese individuals’ attitudes towards post-COVID-19 vaccination and explored methods to address obstacles related to eHealth literacy that could affect their comprehension and willingness to get vaccinated. In 2022, a web-based cross-sectional survey was conducted to assess the vaccination-related knowledge, attitudes and intentions of 950 participants. Vaccination knowledge was established by employing validated measures and conducting a Mokken scale analysis. Causal-directed acyclic graphs were used to illustrate the current comprehension of the correlation between eHealth literacy and the desire to receive vaccinations. This study utilised causal mediation and multiple linear regression analysis to determine the relationships between eHealth literacy, vaccination knowledge, vaccination willingness and subjective health status. The primary finding of this study was that an individual’s comprehension of vaccination was a robust indicator of their inclination to receive vaccination. Moreover, eHealth literacy has an indirect effect on the propensity to get vaccinated by enhancing one’s understanding of vaccines. This study emphasises the significant role of eHealth literacy in enhancing vaccination awareness and willingness, particularly among Chinese adults with poorer health in the post-COVID-19 period. The results affirm the efficacy of employing eHealth technologies to bolster immunisation initiatives, amplify vaccine consciousness, and promote compliance. Moreover, this study emphasises the significance of additional research to assess and record the function of eHealth literacy in immunisation practices.

Knowledge, attitude and practices of adult vaccine among the staff of vaccination units in Shandong Province

In order to understand the knowledge, attitude and practice (KAP) of vaccination against influenza, pneumonia, human papillomavirus (HPV), herpes zoster (HZ), COVID-19, and hepatitis B among staff of vaccination units in Shandong Province, a sample survey was conducted among 797 staffs of adult vaccination units in 12 counties (cities and districts) of Shandong Province from August to September 2022. The results showed that the respondents had the highest total score of knowledge and attitude for the COVID-19 vaccine, with the M (Q1, Q3) of 23 (20, 25) and 10 (10, 10), respectively, and had the lowest score of knowledge and attitude for the herpes zoster vaccine, with the M (Q1, Q3) of 19 (15, 22) and 8 (8, 10), respectively. The vaccine-related knowledge point"vaccine applicable population"had the highest score, with the M (Q1,Q3) of 26 (23, 30). The "contraindications/adverse reactions" and "adverse reaction management" had the lowest score, with the M (Q1, Q3) of 24 (20, 29) and 24 (20, 28), respectively. About 89.71% of respondents received one adult vaccine within two years at least. The principal driver for vaccination of 53.58% of recipients was their understanding of vaccines, which was"it was necessary to receive the vaccine". About 66.00% of respondents who had not received any adult vaccine in the past two years had insufficient awareness of the necessity of vaccination and believed that they were in good health and did not need to receive it. In summary, the staff of adult vaccination units in Shandong Province have a poor understanding of the herpes zoster vaccine in terms of vaccines and a relatively poor understanding of"contraindications/adverse reaction and management"in adult vaccination knowledge points.

Effectiveness of A Web-Based Course on Vaccination Competence in Higher Education: The Eduvac Erasmus+ Project

Immunization is a highly cost-effective investment in health, proven to be an effective tool in controlling and eliminating dangerous infectious diseases. Health science students require evidence-based knowledge to tackle challenges in healthcare, particularly in the field of vaccination. 
 
 The aim of the current study is to asses students’ knowledge on vaccinations and further explore their feedback after attending Educating Vaccination Competence web-based course (EDUVAC web-based course). 
 
 Students from five Higher Educational Institutes voluntarily participated in the EDUVAC web-based course. The course provided various study materials, including PowerPoint presentations, videos, quizzes, texts, and references to reputable websites. It also offered small assignments and self-tests for self-evaluation. An online questionnaire was available to students before and after they completed the EDUVAC web-based course. 
 
 The mean knowledge score on vaccines increased significantly after the EDUVAC web-based course (p<0.001). The majority of the students (95%) felt that the web-based course has benefitted them for their future career and 96.4% would encourage other students to attend the EDUVAC web-based course. Overall, our findings suggest that EDUVAC is a valuable resource for those seeking to enhance their understanding of vaccination.

Maternal vaccination: shaping the neonatal response to pertussis.

Antepartum maternal vaccination can protect highly sensitive newborns before they are old enough to receive their own vaccines. Two vaccines are currently recommended during pregnancy: the flu vaccine and the Tdap vaccine against tetanus, diphtheria, and pertussis. Although there is strong evidence that maternal vaccination works to protect the offspring, limitations in the understanding of vaccines and of maternal transfer of immunity compound to obscure our understanding of how they work. Here we focus on the example of pertussis to explore the possible mechanisms involved in the transfer of protection to offspring and how these may impact the newborn's response to future exposure to pertussis. For example, Tdap vaccines induce pathogen specific antibodies, and those antibodies are known to be transferred from mother to the fetus in utero and to the newborn via milk. But antibodies alone have modest impact on pertussis disease, and even less effect on colonization/transmission. Maternal immune cells can also be transferred to offspring and may play a direct role in protection from disease and/or influence the developing neonatal immune system. However, some of the transferred immunity may also blunt the offspring's response to subsequent vaccination. In this review we will summarize the protection conferred to offspring by maternal vaccination against pertussis and the likely mechanisms by which protection is transferred, identifying the many knowledge gaps that limit our most effective application of this approach.

Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study.

Pakistan has subpar childhood immunization rates and immunization activities have faced several challenges over the past years. We evaluated the social-behavioral and cultural barriers and risk factors for refusal of polio, Routine Immunization (RI), or both in high-risk areas of poliovirus circulation. A matched case-control study was conducted from April to July 2017 in eight super high-risk Union Councils of five towns in Karachi, Pakistan. A total of 3 groups, each with 250 cases, including refusals for the Oral Polio Vaccine (OPV) in campaigns (national immunization days and supplementary immunization activities), RI, and both, were matched with 500 controls and identified using surveillance records. Sociodemographic characteristics, household information, and immunization history were assessed. Study outcomes included social-behavioral and cultural barriers and reasons for vaccine refusal. Data were analyzed in STATA using conditional logistic regression. RI refusal was associated with illiteracy and fear of the vaccine's adverse effects, while OPV refusals were linked to the mother's decision authority and the assumption that the OPV caused infertility. Conversely, higher socioeconomic status (SES) and knowledge of and willingness to vaccinate with Inactivated Polio Vaccine (IPV) were inversely associated with RI; and lower SES, walking to the vaccination point, knowledge of IPV, and an understanding of contracting polio were inversely associated with OPV refusals, with the latter two also inversely associated with complete vaccine refusal. Education, knowledge and understanding of vaccines, and socioeconomic determinants influenced OPV and RI refusals among children. Effective interventions are needed to address knowledge gaps and misconceptions among parents.

Simulated lab module to teach vaccine biology: From disease transmission to vaccine efficacy, all in a matter of three lab sessions.

Abstract Since the COVID-19 pandemic, it has become very important to teach undergraduate students at all levels, about disease transmission and vaccine biology. Just using lectures and reading assignments on these topics often will not be very effective for the student learning. In resource limited undergraduate teaching environment, it is often not possible to use advanced immunology lab techniques. To combat this problem, a lab-module was incorporated into the undergraduate immunology course. In this module, students will follow the process of vaccine development from the identification of a novel disease through the creation and clinical testing of a vaccine This hands-on module was run over the course of three-week lab period, including important concepts of disease transmission, disease diagnosis, mRNA vaccine development, vaccine efficacy and herd immunity. All the exercises included paper-simulations and simulated samples using sodium hydroxide pellets. Overall concepts of innate and adaptive immunity, and detailed concepts like antigenic epitopes, primary and secondary immune responses, and booster doses are emphasized. Students also learn to design mRNA vaccines using gene sequences of Coronavirus spike protein. They also learn principles of ELISA and phases of clinical trial of a novel vaccine. A survey was conducted at the end of the module to evaluate the student learning and student responses to this module. 90% of the students in class were very pleased with this module and stated that this module helped them consolidate their understanding of vaccines. This module can also be modified to be used in a molecular biology or upper-level microbiology courses, with minimum resources. None

Children and young people's understanding of vaccines in the United Kingdom

Children and young people's understanding of vaccines in the United Kingdom

The Association between Health Protocol Compliance and Understanding of Vaccines with COVID-19 Immunization Status

COVID-19 case data as of January 16, 2021, in Indonesia reached 882,418 cases and in East Java reached 98,403 cases. In Surabaya, the total number of confirmed cases was 18,974 with 200 active cases, 17,500 recovered cases, and 1,274 deaths. Meanwhile, the level of community vulnerability is increasing due to the lack of community discipline toward the implementation of health protocols. It is critical to develop tailored strategies to reduce community vulnerability, namely through vaccination. We aimed to analyze the association between health protocol compliance and understanding of vaccines with COVID-19 immunization status. This cross-sectional study was conducted in Fishing Village, Kenjeran, Surabaya, East Java, Indonesia. The study was carried out in 2021 in people aged ≥ 18 years old and who lived in Fishing Village. Respondents were selected by simple random sampling. The chi-square test was used to analyze the data. The results showed health protocol compliance (p=0.785) and understanding of COVID-19 vaccination (p=0.819) did not have an association with COVID-19 immunization status. There was a significant association between understanding COVID-19 immunization and COVID-19 immunization status. Meanwhile, there was no significant association between health protocol compliance and COVID-19 immunization status.

What do adolescents think about vaccines? Systematic review of qualitative studies.

Adolescence presents a key opportunity to build vaccine-related health literacy and promote vaccine confidence and uptake. Although adolescents are central to vaccination programs, their views around vaccines are frequently underrepresented in qualitative literature. We reviewed qualitative studies to systematically identify and summarize existing evidence on adolescents' own understanding of vaccines and experiences with vaccine decision-making, including self-consent when applicable. CINAHL; Embase; Ovid Medline; and Psych Info database searches were last updated on May 28, 2022. Data pertaining to general study characteristics, participant demographics, and qualitative content were extracted independently by two reviewers and analyzed using textual narrative synthesis. Out of 3559 individual records, 59 studies were included. The majority of the studies were conducted in high-income countries and 75% focused on human papilloma virus vaccines, with the remaining studies looking at COVID-19, meningococcal, hepatitis B and influenza vaccines or adolescent experiences with vaccines in general. Adolescent self-consent was explored in 7 studies. Perspectives from sexual and gender minorities were lacking across studies. Adolescents often had limited understanding of different vaccines and commonly perceived vaccine information to be directed towards their parents rather than themselves. Many adolescents felt school-based vaccine education and information available through healthcare providers were insufficient to make informed decisions about vaccines. While adolescents described obtaining vaccine information from traditional and online media, face-to-face interactions and opinions from trusted adults remained important. Adolescents generally relied on their parents for vaccine-decision making, even when self-consent was an option. A notable exception to this included marginalized adolescents who could not rely on parents for health-related advice. Qualitative literature about adolescent vaccines would be enriched by studies examining vaccines other than the HPV vaccine, studies examining adolescent vaccine programs in low and middle-income countries, and by deliberately eliciting vaccine experiences of adolescent with diverse sexual orientation and gender identities.

Prevalence of Anti-SARS-CoV-2 Antibodies and Potential Determinants among the Belgian Adult Population: Baseline Results of a Prospective Cohort Study.

The prevalence of anti-SARS-CoV-2 antibodies and potential determinants were assessed in a random sample representative of the Belgian adult population. In total, 14,201 individuals (≥18 years) were invited by mail to provide saliva via an Oracol® swab. Survey weights were applied, and potential determinants were estimated using multivariable logistic regressions. Between March and August 2021, 2767 individuals participated in the first data collection. During this period, which coincided with the onset of the vaccination campaign, the seroprevalence in the population increased from 25.2% in March/April to 78.1% in July. Among the vaccinated there was an increase from 74,2% to 98.8%; among the unvaccinated, the seroprevalence remained stable (around 17%). Among the vaccinated, factors significantly associated with the presence of antibodies were: having at least one chronic disease (ORa 0.22 (95% CI 0.08–0.62)), having received an mRNA-type vaccine (ORa 5.38 (95% CI 1.72–16.80)), and having received an influenza vaccine in 2020–2021 (ORa 3.79 (95% CI 1.30–11.07)). Among the unvaccinated, having a non-O blood type (ORa 2.00 (95% CI 1.09–3.67)) and having one or more positive COVID-19 tests (ORa 11.04 (95% CI 4.69–26.02)) were significantly associated. This study provides a better understanding of vaccine- and/or natural-induced presence of anti-SARS-CoV-2 antibodies and factors that are associated with this presence.

Sosialisasi pentingnya vaksinasi terhadap masyarakat sari mulya guna mencegah penularan virus Covid-19

The COVID-19 pandemic has had an impact on all areas of human life. The Indonesian government's efforts to reduce the number of sufferers and transmission of Covid-19 continue to be carried out, one of which is through socialization of Covid-19 prevention. In the midst of the spread of the government's plan for vaccination, various hoaxes have sprung up which are spread by accounts that do not have the knowledge capacity. The understanding of vaccination among villagers is still unclear, so socialization about vaccination is needed. The development of the hoax is very dangerous. As an effort to handle this case, socialization and guidance about the Covid-19 vaccine was carried out to the people of Sari Mulya Village which coincided on July 15, 2021. This socialization was tried directly to the community. The socialization linked the residents of Sari Mulya Village and the Pangkalan Lesung Health Center. This activity was attempted as an effort to help socialize the importance of the Covid-19 vaccination program. The results of this socialization are expected to increase people's knowledge of how important vaccination is to correct lifestyles so that they can return to stability.

Evaluating the real-world vaccine effectiveness using a regression discontinuity design

Estimating the actual real-world effectiveness of the vaccine is an essential part of the post-marketing evaluation. This regression discontinuity design (RDD) using observational data is designed to quantify the effect of an intervention when eligibility for the intervention is based on a defined cutoff as age, making it suited to estimate vaccine effects. This approach can avoid the high cost and ethical issues; overcome difficulties in the organization and practice process in randomized controlled trials, which leads to a higher level of causal inference evidence and more realistic results. Here, we describe key features of RDD in general, and then specific scenarios, with examples, to illustrate that RDD are an essential tool for advancing our understanding of vaccine effects.

COVID-19 Vaccination: A Retrospective Observation and Sentiment Analysis of the Twitter Social Media Platform in Indonesia

Coronavirus (COVID-19) is a rapidly emerging and spreading infectious disease. To minimize the impact caused by the virus, it is necessary to have a vaccine. However, the existence of vaccinations for the Indonesian people has caused controversy so that it invites many people to give an opinion assessment, therefore people choose social media as a place to channel their opinions. In this study, a comparison was made with an observational infoveillance study by collecting data using a Python programming script (Python Software Foundation) to display posts related to the COVID-19 vaccine on Twitter as well as quantitative and qualitative analysis to identify trends and characterize the main themes discussed by twitter users on Twitter. Indonesia. Our research collects data through social media Twitter in the period August 2020 - March 2021. In this study we combine Retrospective Observation and Sentiment Analysis, with the aim of producing periodic timeline evaluations within a predetermined time frame. In this study author found that there was an interaction & increase in positive posts due to officially reported developments, on the other hand we were quite difficult to understand the factors behind the emergence of negative posts but we made a conclusion based on the results of sentiment analysis that most of the negative posts were caused by lack of information and understanding of vaccines and vaccines. the COVID-19 outbreak itself.

How Religious and Cultural Doctrines Affect Child Vaccination: An Analysis of Parents’ Understanding of Child Vaccination in Khyber Pakhtunkhwa, Pakistan

ABSTRACT In developing countries, children die each year from vaccine-preventable diseases. This study examines the public’s understanding of vaccination and the impact of social pressures and religious influences on parents who avoid vaccinating their children. Results showed that the illiteracy of the population endangers the safety of health workers in the form of terrorist attacks during vaccination campaigns. In addition, the concept of banned substances in vaccines has influenced the vaccination of children. Moreover, senior religious leaders supported the vaccination campaign, while opponents faced public pressure to vaccinate their children.

Binding Strength and Hydrogen Bond Numbers between COVID-19 RBD and HVR of Antibody

The global battle against the COVID-19 pandemic relies strongly on the human defense of antibody, which is assumed to bind the antigen’s receptor binding domain (RBD) with its hypervariable region (HVR). Due to the similarity to other viruses such as SARS, however, our understanding of the antibody-virus interaction has been largely limited to the genomic sequencing, which poses serious challenges to containment and rapid serum testing. Based on the physical/chemical nature of the interaction, infrared spectroscopy was employed to reveal the binding disparity, the real cause of the antibody-virus specificity at the molecular level, which is inconceivable to be investigated otherwise. Temperature dependence was discovered in the absorption value from the 1550 cm−1 absorption band, attributed to the hydrogen bonds by carboxyl/amino groups, binding the SARS-CoV-2 spike protein and closely resembled SARS-CoV-2 or SARS-CoV-1 antibodies. The infrared absorption intensity, associated with the number of hydrogen bonds, was found to increase sharply between 27 °C and 31 °C, with the relative absorbance matching the hydrogen bonding numbers of the two antibody types (19 vs. 12) at 37 °C. Meanwhile, the ratio of bonds at 27 °C, calculated by thermodynamic exponentials, produces at least 5% inaccuracy. Beyond genomic sequencing, the temperature dependence, as well as the bond number match at 37 °C between relative absorbance and the hydrogen bonding numbers of the two antibody types, is not only of clinical significance in particular but also as a sample for the physical/chemical understanding of vaccine–antibody interactions in general.

Determination of COVID-19 Vaccine Hesitancy Among University Students.

IntroductionWith the sudden outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), vaccines appear to be the most efficient measure in combating spread. However, vaccines are only effective if a community collectively uptakes vaccination. This approach is growing increasingly difficult with the emergence of ‘Vaccine Hesitancy.’ This paper aims to determine the association between university curricula and the degree of hesitancy for the COVID-19 vaccine.MethodsThe online questionnaire assessed demographic data, prior knowledge of vaccines, attitude towards COVID-19 vaccines using an adapted version of the WHO Strategic Advisory Group of Experts (SAGE) Working Group’s Vaccine Hesitancy Survey (VHS) and factors likely to motivate vaccine uptake. By using binary scoring, the degree of hesitancy among students was determined. Exploratory Factor Analysis (EFA) on VHS revealed underlying causes of hesitancy. To analyze the dependence between hesitancy and curriculum, a chi-squared test was conducted.ResultsMedical students scored higher for prior knowledge of vaccines (M = 3.54) as opposed to non-medical students (M = 3.49). Medical students responded favorably to COVID-19 vaccines with only 1.37% showing hesitancy for all nine items of VHS, compared to 2.55% of non-medical students. EFA produced three subscales within the VHS: lack of confidence, risk factor concern, and misinformation. The lack of confidence factor accounted for 65% of the data obtained. The chi-square test solidified that vaccine hesitancy is dependent on curriculum.ConclusionThe majority of non-medical students showed hesitancy towards obtaining COVID-19 vaccines compared to medical students who were more willing, largely owing to their knowledge and understanding of vaccines.

A surface plasmon resonance based approach for measuring response to pneumococcal vaccine

Incidence of pneumococcal disease has increased worldwide in recent years. Response to pneumococcal vaccine is usually measured using the multiserotype enzyme-linked immunosorbent assay (ELISA) pneumococcal test. However, this approach presents several limitations. Therefore, the introduction of new and more robust analytical approaches able to provide information on the efficacy of the pneumococcal vaccine would be very beneficial for the clinical management of patients. Surface plasmon resonance (SPR) has been shown to offer a valuable understanding of vaccines’ properties over the last years. The aim of this study is to evaluate the reliability of SPR for the anti-pneumococcal capsular polysaccharides (anti-PnPs) IgGs quantification in vaccinated. Fast protein liquid chromatography (FPLC) was used for the isolation of total IgGs from serum samples of vaccinated patients. Binding-SPR assays were performed to study the interaction between anti-PnPs IgGs and PCV13. A robust correlation was found between serum levels of anti-PnPs IgGs, measured by ELISA, and the SPR signal. Moreover, it was possible to correctly classify patients into “non-responder”, “responder” and “high-responder” groups according to their specific SPR PCV13 response profiles. SPR technology provides a valuable tool for reliably characterize the interaction between anti-PnPs IgGs and PCV13 in a very short experimental time.

Medical Myths Affecting Public Health

Miracle cures for diabetes, hypertension and end stage renal failure. One wonder drug that can heal cancer that can be bought via e-commerce sites. Fake articles which skews the public’s understanding of vaccine. These are just a few of the medical myths that’s been spreading within the community. For the medical community, some of these myths are outrageously ridiculous. But to the uninformed, the effects can be disastrous. With the advent of social media such as Facebook, Twitter and Instagram, the spread of these myths goes far and wide. Take a peek at the cases and you will see patients with uncontrolled blood sugar with chronic kidney diseases deteriorate because they read somewhere that anti-diabetics causes kidney damage. Have a look at the surgical department and see how patients with breast cancer default treatment to seek a miracle drug from quack doctors. Unabated, these false beliefs and myths will take a toll on the current health care system. More individuals will refuse treatment for chronic diseases and will only seek treatment once they deteriorate. More children will be subjected to vaccine preventable diseases as the herd immunity crumble due to false information on vaccine. If we don’t start doing something about these myths, the health care system will crumble.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 26

Vaccinating outside Section 7a immunisation programmes: who, how and why?

On 23 April 2019, the authors of this roundtable discussion met to deliberate the vaccinations that fall outside of the Section 7A immunisation programme. The 3-hour meeting resulted in the production of this article. Funding for vaccinations that fall outside of the Section 7a programme is mired in confusion. Who is responsible for the payments? What are the outliers? What are the loopholes in vaccination commissioning? What are the regional differences? Where can best practice be found? When will these issues be resolved? These questions and more were discussed at length and in great detail. This article explains where these discrepancies lie, analyses specific issues that require clear guidance, and discusses the competing interests of health professionals. This discussion aims to inform the national vaccination review and hopes to shed light on areas that cause GPs and practice nurses confusion during their daily tasks. We all enjoyed the meeting, and its discussion and transformation into a working document. We hope you find this article useful and that it impacts your understanding of vaccinations that fall outside of the Section 7A programme.

Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus.

The human respiratory syncytial virus (hRSV) is the main etiologic agent of severe lower respiratory tract infections that affect young children throughout the world, associated with significant morbidity and mortality, becoming a serious public health problem globally. Up to date, no licensed vaccines are available to prevent severe hRSV-induced disease, and the generation of safe-effective vaccines has been a challenging task, requiring constant biomedical research aimed to overcome this ailment. Among the difficulties presented by the study of this pathogen, it arises the fact that there is no single animal model that resembles all aspects of the human pathology, which is due to the specificity that this pathogen has for the human host. Thus, for the study of hRSV, different animal models might be employed, depending on the goal of the study. Of all the existing models, the murine model has been the most frequent model of choice for biomedical studies worldwide and has been of great importance at contributing to the development and understanding of vaccines and therapies against hRSV. The most notable use of the murine model is that it is very useful as a first approach in the development of vaccines or therapies such as monoclonal antibodies, suggesting in this way the direction that research could have in other preclinical models that have higher maintenance costs and more complex requirements in its management. However, several additional different models for studying hRSV, such as other rodents, mustelids, ruminants, and non-human primates, have been explored, offering advantages over the murine model. In this review, we discuss the various applications of animal models to the study of hRSV-induced disease and the advantages and disadvantages of each model, highlighting the potential of each model to elucidate different features of the pathology caused by the hRSV infection.