Understanding Of Action Research Articles

Adapting and extending multimodal (inter)action analysis to investigate synchronous multimodal online language teaching

Abstract Multimodal (inter)action analysis offers a powerful and robust methodology for the study of action and interaction between social actors, their environment, and the objects and tools within. Yet its implementation in the analysis of synchronous multimodal online data sets, e.g. (inter)actions via videoconferencing, is limited. Drawing on our research in understanding teacher-learner (inter)actions in instruction-giving fragments in synchronous multimodal online language lessons, we describe and illustrate the ways in which we adapted and extended some of the methodological and analytical tools. These include (1) the use of a grounded theory approach in delineating and identifying higher-level actions, (2) the embodiment and disembodiment of frozen actions, (3) electronic print mode, (4) semiotic lag, (5) semiotic (mis)alignment, (6) modal density (mis)alignment, and (7) how modal density can be achieved by brisk modal shifts in addition to through modal intensity and complexity. We conclude by a call for further educational research in online teaching platforms using the framework to have richer understandings of the (inter)actions between social actors with particular roles and identities (teachers-learners), their environment, and the objects and tools within, which bring their “own material properties, feel and techniques of use, affordances and limitations” (Chun, Dorothy, Richard Kern & Bryan Smith. 2016. Technology in language use, language teaching, and language learning. The Modern Language Journal 100. 64–80: 65).

Exploring the predictive factors of heart disease using rare association rule mining

Cardiovascular diseases continue to be the leading cause of mortality worldwide, claiming a significant number of lives each year. Despite the advancements in predictive models, including logistic regression, neural networks, and random forests, these techniques often lack transparency and interpretability, limiting their practical application in clinical settings. To address this challenge, this research introduces EPFHD-RARMING, an innovative approach designed to enhance the understanding and predictability of heart disease through the discovery of rare and meaningful patterns. EPFHD-RARMING utilizes rare association rule mining to uncover hidden and unexpected rules that identify critical factors contributing to heart disease. This method is particularly adept at identifying high-risk patterns in individuals who appear healthy but may develop heart disease under certain conditions, thus facilitating early intervention and preventive measures. By integrating these insights with established feature engineering techniques, EPFHD-RARMING enhances its practical utility, enabling medical professionals to proactively manage patient care and tailor interventions to individual risk profiles. This study demonstrates the effectiveness of EPFHD-RARMING in providing a deeper, actionable understanding of the complex dynamics of heart disease. The model’s ability to identify and interpret rare patterns holds significant promise for advancing medical analytics and improving patient outcomes. Moreover, the applicability of EPFHD-RARMING extends beyond the healthcare domain, offering valuable insights in various fields where the discovery of rare patterns is critical, such as finance, marketing, and cybersecurity. This study conducts a comprehensive evaluation, which demonstrates the superior performance of EPFHD-RARMING compared to traditional predictive models in identifying key factors contributing to heart disease, in terms of interestingness, explainability, and comprehensiveness of insights. The results underscore the potential of this innovative approach to revolutionize our understanding and prediction of heart disease, ultimately contributing to more effective and personalized healthcare solutions. This research emphasizes the importance of rare association rule mining in medical analytics and paves the way for future studies to explore and utilize these techniques across diverse domains.

Alpha T-catenin: a crucial tumor suppressor in cancer pathogenesis.

Alpha T-catenin has recently been identified as a crucial tumor suppressor in various cancer types, with roles that go beyond just providing structural support in adherens junctions. This review brings together recent findings on alpha T-catenin's important involvement in key signaling pathways related to cancer progression. We present strong evidence of its regulatory role in Wnt signaling, a pathway often disrupted in colorectal cancer, and explain how it inhibits cell proliferation and tumor growth. We also discuss the significant downregulation of alpha T-catenin in colorectal cancers and its potential as a prognostic marker. Moreover, this review looks at how increasing alpha T-catenin levels can reduce tumor growth and spread, suggesting new therapeutic strategies. Additionally, we reveal alpha T-catenin's unexpected impact on NF-κB signaling in basal E-cadherin-negative breast cancer, expanding its importance across different cancer types. By bringing these findings together, we provide a thorough understanding of alpha T-catenin's tumor-suppressing actions, setting the stage for new targeted therapies and diagnostic tools in cancer treatment.

Clear in advance to whom? Exploring ‘transparency’ of assessment practices in UK higher education institution assessment policy

ABSTRACT This study examines transparency in assessment practices within UK higher education institutions (HEIs), addressing a gap in how transparency is framed within policy documents. Employing content analysis on policy documents from 151 HEIs, we explore the multifaceted nature of transparency through techno-rational approaches, socio-cultural practices, and socio-material enactments to offer a nuanced understanding of transparency conceptualization and its intended audience. Findings indicate a predominant focus on techno-rational approaches – emphasizing clear documentation and information dissemination – while often overlooking the socio-cultural and socio-material dimensions crucial for thorough understanding and stakeholder engagement. We propose a nuanced framework integrating these three approaches, urging a shift beyond mere information disclosure to active stakeholder engagement with assessment criteria through dialogue and interaction. This research contributes to the discourse on transparency in assessment by offering theoretical and practical insights. Theoretically, it advances our understanding of transparency as a dynamic and contextually situated practice, challenging static conceptualizations. Practically, it provides a robust basis for refining assessment policies and practices, emphasizing clarity, comprehensibility, and inclusivity. By recognizing the diverse needs of stakeholders – students, educators, and assessors – the study advocates for policy enhancements that promote a deeper, actionable understanding of assessment practices. The findings lay the groundwork for future research on the conceptualization and impact of transparency in higher education, guiding more effective policy development and implementation. This study underscores the importance of comprehensive, well-articulated policies in fostering a shared understanding of transparent assessment practices within HEIs.

'Not a party to this crime': The reciprocal constitution of identity and morality by signatories of the Academics for Peace petition in Turkey.

In this paper, we examine how social identity, moral obligation and the relationship between the two shaped support for the 2016 Academics for Peace petition in Turkey. We examine the pre-trial statements of nine defendants charged for signing the petition and appearing in court on the same day in December 2018. We first conduct an inductive thematic analysis on one statement, and then, using the themes from this analysis, we conducted a deductive thematic analysis on the remaining eight statements. In line with the existing studies, we find considerable evidence that social identity and moral obligation are invoked as key reasons for signing in this highly repressive context. However, rather than these being separate factors, the two are reciprocally constitutive. That is, social identities define moral obligations and, at the same time, enacting moral obligations defines identity (both the position of the individual in the group and the nature of the group in the world). In discussion, we consider the broader implications of a moralized view of social identities for our understanding of both collective action and social identity processes more generally.

A dimensional analysis of experienced intensive care unit nurses' clinical decision-making for bleeding after cardiac surgery.

Bleeding following cardiac surgery is common and serious, yet a gap persists in understanding how experienced intensive care nurses identify and respond to such complications. To describe the clinical decision-making of experienced intensive care unit nurses in addressing bleeding after cardiac surgery. This qualitative study adopted the Recognition-Primed Decision Model as its theoretical framework. Thirty-nine experienced nurses from four adult intensive care units participated in semi-structured interviews based on the critical decision method. The interviews explored their clinical judgements and decisions in bleeding situations, and data were analysed through dimensional analysis, an alternative to grounded theory. Participants maintained consistent vigilance towards post-cardiac surgery bleeding, recognizing it through a haemorrhagic dimension associated with blood loss and chest drainage and a hypovolemic dimension focusing on the repercussions of reduced blood volume. These dimensions organized their understanding of bleeding types (i.e., normal, medical, surgical, tamponade) and necessary actions. Their decision-making encompassed monitoring bleeding, identifying the cause, stopping the bleeding, stabilizing haemodynamic and supporting the patient and family. Participants also adapted their actions to specific circumstances, including local practices, professional autonomy, interprofessional dynamics and resource availability. Nurses' decision-making was shaped by their personal attributes, the patient's condition and contextual circumstances, underscoring their expertise and pivotal role in anticipating actions and adapting to diverse conditions. The concept of actionability emerged as the central dimension explaining their decision-making, defined as the capability to implement actions towards specific goals within the possibilities and constraints of a situation. This study underscores the need for continual updates to care protocols to align with current evidence and for quality improvement initiatives to close existing practice gaps. Exploring the concept of actionability further, developing adaptability-focused educational programmes, and understanding decision-making intricacies are crucial for informing nursing education and decision-support systems.

Experimental investigation of the roughness, freezing temperature and normal stress on the shear mechanical action of frozen saturated clay-rock interface

Recently, with the increase in global temperature, the permafrost degradation trend has intensified, and the soil-rock binary slope in permafrost regions has become more unstable. Therefore, this paper focuses on the shear strength of the clay-rock interface in the binary slope. The three-dimensional roughness, freezing temperature, and normal stress are key factors affecting the shear strength of the clay-rock interface. The influence of freezing temperature can be further quantified by using the unfrozen water content (UWC), which was measured by nuclear magnetic resonance (NMR) technology. By analyzing experimental results, it can be concluded that the three-dimensional roughness can effectively improve the shear strength of the clay-rock interface under freezing conditions, and the shear strength increases with the growth of the climbing angle (ic). The influence of temperature can be attributed to the effect of UWC on the internal friction angle and cohesion of saturated clay. Compared with the internal friction angle, the cohesion of saturated clay decreases faster with the increase of UWC. In addition, the shear strength of the clay-rock interface rises linearly as the normal stress increases, therefore the Mohr-Coulomb criterion also can be used to characterize the shear strength of the clay-rock interface. An interesting finding is that significant tensile cracks will appear in the clay part around the large bulge under low normal stress and high roughness. It further confirmed the contribution of large bulges to the prevention of shear slides of soft clay. The quantification understanding of the shear mechanical action of the clay-rock interface can provide a reference for scientific disaster reduction in cold regions.

When ideologies align: Progressive corporate activism and within‐firm ideological alignment

AbstractResearch SummaryThis article examines the association between ideology and firm participation in sociopolitical activism. In particular, it focuses on the ideological alignment between a firm's upper echelons and its general employees. We theorize that participation in progressive corporate activism reflects the ideological views of both the top management team and general employees. By examining firm participation in letter campaigns supporting progressive causes, our findings indicate that ideological alignment between a top management teams and general employees' liberal political leanings is associated with a firm's participation in progressive corporate activism. The CEO's own ideological preferences do not have an independent association with this kind of activism. This article concludes with a discussion of implications for our understanding of corporate political action and nonmarket strategy.Managerial SummaryThis article looks at the relationship between political ideology and firm participation in sociopolitical activism. Although some have argued that firms' activism reflects a CEO's ideological preferences or employee activism, we find that neither explanation fully accounts for the kinds of companies that engage in this kind of activism. We find that progressive corporate activism reflects the ideological views of both top management and general employees. Our findings suggest that companies that have ideological alignment on progressive issues are more likely to take public stands on those issues because the stands reinforce core values held by employees and the top management.

Leaven of Dough, Ferment of Gold: The Breadmaking Analogy in Medieval Metallic Transmutation

This paper traces the analogy between the making of bread with ferment (leaven or yeast) and theories of metallic transmutation throughout the Middle Ages. For this purpose it surveys several medieval alchemical writings, including Hortulanus’s influential Commentary on the Emerald Tablet. In this work, the ferment, an essential ingredient of the philosophers’ stone, is portrayed less as an active agent and more as the passive, nutritive earth (terra nutrix) which combines with the soul (anima) in order to yield the stone (lapis). I argue that the background of these theories has both a practical and a medical-theoretical dimension. The practical aspect derives from historical everyday practices of making bread from sourdough, and using old yeast “starter” as a kind of inoculum to speed up the fermentation of a new batch of fresh dough. The medical-theoretical framework for the understanding of ferment action was likely provided by the widely influential Galenic idea of whole substance action (Gr. καθ᾽ὅλην τὴν οὐσίαν, Lat. tota substantia), initially developed by Galen in pharmacology and later imported into alchemy via Arabic medicine. Together, these aspects converge into a successful model of “inoculation-emergence,” which underlies many medieval and early modern theories of fermentation, both medical and alchemical.

Versatile Graph Neural Networks Toward Intuitive Human Activity Understanding.

Benefiting from the advanced human visual system, humans naturally classify activities and predict motions in a short time. However, most existing computer vision studies consider those two tasks separately, resulting in an insufficient understanding of human actions. Moreover, the effects of view variations remain challenging for most existing skeleton-based methods, and the existing graph operators cannot fully explore multiscale relationship. In this article, a versatile graph-based model (Vers-GNN) is proposed to deal with those two tasks simultaneously. First, a skeleton representation self-regulated scheme is proposed. It is among the first trials that successfully integrate the idea of view adaptation into a graph-based human activity analysis system. Next, several novel graph operators are proposed to model the positional relationships and learn the abstract dynamics between different human joints and parts. Finally, a practical multitask learning framework and a multiobjective self-supervised learning scheme are proposed to promote both the tasks. The comparative experimental results show that Vers-GNN outperforms the recent state-of-the-art methods for both the tasks, with the to date highest recognition accuracies on the datasets of NTU RGB + D (CV: 97.2%), UWA3D (88.7%), and CMU (1000 ms: 1.13).

Examining Witness Interest: The Obstacles of Testimony in Islamic Jurisprudence and Positive Law

This study compares Islamic jurisprudence and positive law to explore the obstacles of testimony, focusing on the complexity and controversy surrounding witnesses' interests. Employing a legal comparative method, the research examines self-interest in testimony, emphasizing authoritative sources like fiqh books and Jordanian law, shedding light on the concept of self-interest as its primary focus. It highlights the differences between Islamic jurisprudence and contemporary legal frameworks, providing a nuanced understanding of witness actions in legal processes. This research's findings reveal that testimony's self-interest predominantly relates to lineage, siblinghood, marital relationships, hostility, and partisanship. The results show both Islamic jurisprudence and positive law recognize the prohibition of testimony due to self-interests is not absolute; there are many interpretations and exceptions to this restriction, with differences stemming from the reliance on religious texts in Islamic jurisprudence and legal reasoning in positive law. This gap arises from the ability of contemporary law to examine the interests of witnesses from various perspectives and through the use of different evidentiary tools. This research contributes practically that the application of law that is different from what has been formulated by fiqh scholars in Islamic jurisprudence does not necessarily indicate that the legal decision is at odds with Islamic law.

Networked sustainable lifestyle activism: growth and limits of zero waste movement in urban China

ABSTRACT How do citizens express environmentalism and lead sustainable change in an authoritarian country like China, where contentious political civic actions have limited saliency? Can we re-imagine what forms of citizen action build ’environmental movement’ in this socio-political context? Based on 41 in-depth interviews and seven months of participant observations in China’s zero waste community, this article proposes networked sustainable lifestyle activism as an important form of environmental movement in China’s socio-political context. Drawing on lifestyle movement (Haenfler et al. 2012) and sustainable materialism (Schlosberg 2019) theories, I analyze the growth, characteristics, and limitations of the zero waste movement in China. It consists of sustainable lifestyle activism that adopts lifestyle change for broader sustainability, pursues anti-consumerism authentic identity and well-being as a site of change, and grows through social media and informal networks. Meanwhile, the movement goes beyond individual lifestyle change as networks of secondhand material flow and collective, non-contentious environmental actions. Difficulties to promote widespread, thorough sustainable lifestyle change and constrained political engagement are important factors that limit the movement’s effects. My research contributes to the literature on new environmental movements, theoretical discussion of environmental movements in China, and empirical understanding of civic environmental actions in this socio-political context.

Gateway community stakeholders’ perceived impacts of protected area management actions: The case of North Carolina (U.S.) state parks

Many protected area managers contend with increasing demand and insufficient funding (e.g., overcrowding, overuse, maintenance shortfalls, and staffing shortages). To combat these challenges, managers are exploring management actions (i.e., differential pricing, amenity pricing, reservation systems, and demand-based pricing) to increase revenue and distribute or reduce visitor use during peak times. However, implementation of these management actions may displace visitors, affecting gateway community stakeholders (e.g., park staff, affiliated nonprofits, tourism operators, destination management/marketing organizations (DMO), and elected officials) who benefit from state parks. Therefore, it is crucial to understand the effects these actions may have on gateway community stakeholders. Utilizing Weber's theory of formal and substantive rationality (WTFSR) coupled with the triple bottom line (economic, environmental, and social impacts), we conducted a concurrent, nested mixed methods study with 25 gateway community stakeholders of North Carolina State Parks (NCSP). Analysis of 25 semi-structured interviews and embedded rating and ranking questions provided a deeper understanding of stakeholders' preferred management actions, motivations for those preferences, and perceived impacts of NCSP management actions. Apart from demand-based pricing, gateway community stakeholders expressed overall positive economic, environmental, and social sentiments towards the proposed management actions, suggesting a suite of actions may be ideal for increasing revenue and distributing or reducing visitor use during peak times in protected areas. Management implications•Gateway community stakeholders can effectively differentiate between suites of management options to enhance environmental protections, community benefits, and profits.•State resident discounts, amenity pricing, and reservation systems were all highly ranked across multiple stakeholder groups, suggesting NCSP has multiple options to increase revenue and distribute or reduce visitor use during peak times. However, demand-based pricing had limited support from stakeholders suggesting NCSP should prioritize other management actions. The varying levels of support for management actions makes it crucial for NCSP to communicate their management action decisions with stakeholders.•Protected area managers must sustain relationships with gateway community stakeholders to be able to understand stakeholders' perspectives on the impacts of management actions.•Beyond NC, this study provides a strategy for protected areas facing similar challenges to assess how management actions may impact gateway community stakeholders or other key stakeholders (e.g., park users, underserved communities).

Research Characteristics and Approaches Taken to Follow up with Students Exposed to Bullying: A Scoping Review

AbstractThis scoping review enhances the understanding of follow-up actions taken to reduce consequences from bullying, in terms of both what such actions currently entail and what they can or should encompass. Based on a comprehensive literature search of six databases, the review examines 20 peer-reviewed articles. The results highlight that there has been little empirical research on follow-up actions towards students exposed to bullying, but the existing research has been conducted worldwide and at different educational levels. When synthesized, follow-up work is not a unified concept within the literature. The examined studies were predominantly quantitative and experimental, using richly diverse measurements primarily assessing different mental health outcomes through self-report questionnaires. No common timepoint for initiate follow-up actions was shared amongst the authors. The most commonly used approach within follow-up work was to offer psychosocial support to reduce the impact of bullying on students. Less attention has been given to systemic work, particularly in the classroom environment, and to studies combining systemic and individual support. Thus, this overview contributes to the knowledge on how follow-up actions are understood and used in research and identifies important areas of focus for further research aiming to prevent prolonged consequences from bullying.

Structural basis of rosmarinic acid inhibitory mechanism on SARS-CoV-2 main protease

The SARS-CoV-2 coronavirus is characterized by high mutation rates and significant infectivity, posing ongoing challenges for therapeutic intervention. To address potential challenges in the future, the continued development of effective drugs targeting SARS-CoV-2 remains an important task for the scientific as well as the pharmaceutical community. The main protease (Mpro) of SARS-CoV-2 is an ideal therapeutic target for COVID-19 drug development, leading to the introduction of various inhibitors, both covalent and non-covalent, each characterized by unique mechanisms of action and possessing inherent strengths and limitations. Natural products, being compounds naturally present in the environment, offer advantages such as low toxicity and diverse activities, presenting a viable source for antiviral drug development. Here, we identified a natural compound, rosmarinic acid, which exhibits significant inhibitory effects on the Mpro of the SARS-CoV-2. Through detailed structural biology analysis, we elucidated the precise crystal structure of the complex formed between rosmarinic acid and SARS-CoV-2 Mpro, revealing the molecular basis of its inhibitory mechanism. These findings not only enhance our understanding of the antiviral action of rosmarinic acid, but also provide valuable structural information and mechanistic insights for the further development of therapeutic strategies against SARS-CoV-2.

Implementation pilot study of community self-testing for COVID-19 among employees of manufacturing industries and their household members in 2022 to 2023.

COVID-19 self-testing is essential for enabling individuals to self-care, screen themselves and, if positive, isolate themselves. Since 2021, COVID-19 self-tests have been extensively used in high-income countries, however, their programmatic implementation in low- and middle-income countries has been delayed. An implementation pilot, mixed-methods study, was conducted in four industrial manufacturing companies, in Kedah State between November 2022 and May 2023. Participants were asked to take COVID-19 self-tests home for themselves and their household members and to use the tests according to national guidelines. At enrolment and at the end of the study, participants completed an online sociodemographic, knowledge and satisfaction survey. Data were cleaned and analysed using SPSS Statistics V28.0. Qualitative data were collected through semi-structured interviews and focus group discussions. Thematic analysis was conducted. A total of 1768 employees from four manufacturing industries enrolled in the pilot, representing 60% of the total employees and more than 50% of employees at each site. There were 40 COVID-19-positive cases detected in participants from the manufacturing industries, and 100 positive household members. Participants reported 27 invalid test results. Individuals aged 30 or less [adjusted odds ratio (AOR): 2.65; 95% CI: 1.63 to 4.31; p<0.001] and males (AOR: 1.54; 95% CI: 1.09 to 2.17; p = 0.014) showed a significant higher likelihood of self-testing compared to older and female participants. Additionally, individuals who received three or more doses of a COVID-19 vaccine had higher odds of using self-tests (OR 1.56 (95% CI: 1.03 to 2.36, p = 0.037)). There was a significant increase in participants' knowledge on how to correctly collect a self-sample using a nasal swab from 36,9% at baseline to 43,6% post-implementation (p = 0.004) and correct interpretation of a positive result from 80,5% at baseline to 87,6% post-implementation (p<0.001). Furthermore, there was a notable increase in the correct understanding of actions following a positive result, especially regarding self-isolation, which rose from 59.1% to 71.9% (p<0.001). A total of 44 SSIs, and 4 FGDs with a total of 14 participants, were performed. The five main themes explored were: 1) previous experiences with COVID-19, 2) COVID-19 ST experiences during the pilot study, 3) advantages of COVID-19 ST, 4) feelings related to COVID-19 ST, 5) willingness to use COVID-19 ST again, and 6) ST for other diseases. This research shows the feasibility of a self-testing model in the community through workplaces due to participants' high acceptability to enrol and high self-tests' uptake. Lessons learnt can inform operational aspects of the introduction and scale-up of self-care strategies in low- and middle-income countries, in particular the South-East Asia region.

Disney characters as moral role models: a discourse analysis of Coco and Encanto

Popular culture characters and narratives can influence people’s understanding of moral actions, and thus guide their behaviors accordingly. Films have proven to be strong anchors in people’s understanding of morality. We examine the perception of resilience as a moral characteristic in examining not just how people become resilient (thereby focusing on impact and action) but also to study “resilience” as a discourse and discussion in society as a moral message. We argue that popular culture narratives, particularly Disney films, help reinforce moral meanings of resilience. By conducting a discourse analysis of two films-Encanto and Coco and particularly focusing on resilience, we aim to contribute to a deepened understanding of Disney’s role in producing morality through diverse narratives and characters who serve as role models.

Natural scenes reveal diverse representations of 2D and 3D body pose in the human brain

Human pose, defined as the spatial relationships between body parts, carries instrumental information supporting the understanding of motion and action of a person. A substantial body of previous work has identified cortical areas responsive to images of bodies and different body parts. However, the neural basis underlying the visual perception of body part relationships has received less attention. To broaden our understanding of body perception, we analyzed high-resolution fMRI responses to a wide range of poses from over 4,000 complex natural scenes. Using ground-truth annotations and an application of three-dimensional (3D) pose reconstruction algorithms, we compared similarity patterns of cortical activity with similarity patterns built from human pose models with different levels of depth availability and viewpoint dependency. Targeting the challenge of explaining variance in complex natural image responses with interpretable models, we achieved statistically significant correlations between pose models and cortical activity patterns (though performance levels are substantially lower than the noise ceiling). We found that the 3D view-independent pose model, compared with two-dimensional models, better captures the activation from distinct cortical areas, including the right posterior superior temporal sulcus (pSTS). These areas, together with other pose-selective regions in the LOTC, form a broader, distributed cortical network with greater view-tolerance in more anterior patches. We interpret these findings in light of the computational complexity of natural body images, the wide range of visual tasks supported by pose structures, and possible shared principles for view-invariant processing between articulated objects and ordinary, rigid objects.

Everyone can draw: An inclusive and transformative activity for conceptualization of topographic anatomy.

Anatomical drawing traditionally involves illustration of labeled diagrams on two-dimensional surfaces to represent topographical features. Despite the visual nature of anatomy, many learners perceive that they lack drawing skills and do not engage in art-based learning. Recent advances in the capabilities of technology-enhanced learning have enabled the rapid and inexpensive production of three-dimensional anatomical models. This work describes a "drawing on model" activity in which learners observe and draw specific structures onto three-dimensional models. Sport and exercise sciences (SES, n = 79) and medical (MED, n = 156) students at a United Kingdom medical school completed this activity using heart and femur models, respectively. Learner demographics, their perceptions of anatomy learning approaches, the value of the activity, and their confidence in understanding anatomical features, were obtained via validated questionnaire. Responses to 7-point Likert-type and free-text items were analyzed by descriptive statistics and semi-quantitative content analysis. Learners valued art-based study (SES mean = 5.94 SD ±0.98; MED = 5.92 ± 1.05) and the "drawing on model" activity (SES = 6.33 ± 0.93; MED = 6.21 ± 0.94) and reported enhanced confidence in understanding of cardiac anatomy (5.61 ± 1.11), coronary arteries (6.03 ± 0.83), femur osteology (6.07 ± 1.07), and hip joint muscle actions (5.80 ± 1.20). Perceptions of learners were independent of both their sex and their art-based study preferences (p < 0.05). Themes constructed from free-text responses identified "interactivity," "topography," "transformative," and "visualization," as key elements of the approach, in addition to revealing some limitations. This work will have implications for anatomy educators seeking to engage learners in an inclusive, interactive, and effective learning activity for supporting three-dimensional anatomical understanding.

Extra-nuclear and cytoplasmic steroid receptor signalling in hormone dependent cancers

Steroid hormone receptors are key mediators in the execution of hormone action through a combination of genomic and non-genomic action. Since their isolation and characterisation in the early 20th Century much of our understanding of the biological actions of steroid hormones are underpinned by their activated receptor activity. Over the past two decades there has been an acceleration of more omics-based research which has resulted in a major uptick in our comprehension of genomic steroid action. However, it is well understood that steroid hormones can induce very rapid signalling events in tandem with their genomic actions wherein they exert their influence through alterations in gene expression. Thus the totality of genomic and non-genomic steroid action occurs in a simultaneous and reciprocal manner and a greater appreciation of whole cell action is required to fully evaluate steroid hormone activity in vivo. In this mini-review we outline the most recent developments in non-genomic steroid action and cytoplasmic steroid hormone receptor biology in endocrine-related cancers with a focus on the 3-keto steroid receptors, in particular the androgen receptor.