Abstract Introduction: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC) is a National Cancer Institute comprehensive cancer partnership led by the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northeastern Illinois University, and the University of Illinois at Chicago. The mission of ChicagoCHEC is to advance cancer health equity through meaningful scientific discovery, education, training, and community engagement. The current number of individuals in research and cancer health equity-related careers does not mirror the nation's demographics. While there are several gains in health status among racial and ethnic minority groups, disparities in health status have widened for certain indicators. At the culmination of the eight weeks, Research Fellows learned fundamental research practices and methodologies, pertinent research content topics (e.g., cancer inequity and recruitment of underserved minorities in clinical trials), social contexts for health inequity across the cancer continuum, and critical professional development practices and networks. Methods: Eligible participants were all undergraduate and post-baccalaureate students without graduate education from Northwestern University, Northeastern Illinois University, the University of Illinois at Chicago, and City Colleges of Chicago. Quantitative and qualitative data were collected and entered into RedCap via responses to module evaluations and a baseline survey with questions on self-efficacy in cancer disparity research. We applied modules around overarching core competencies envisioned by the ChicagoCHEC Research Education Core: (1) research practices, (2) research content, (3) social context/ interaction and personal development, and (4) professionalization. We recruited an intentional selected sample of underrepresented minorities to achieve representation across various definitions of “underrepresented” not limited to race/ethnicity, citizenship status, gender identification, sexual orientation, first-generation college student, and more. To achieve a high number of competitive candidates, the Research Education Core, one of four cores of the overarching U54 ChicagoCHEC, utilized existing cross-institutional inventories of student programs and groups, and corresponding recruitment strategies. This included Research Education Core staff collaborative presentations at career fairs, with student organizations, and in classes. The program leveraged the expertise of leading scholars and cancer researchers, health professionals, institutional leadership, and community leaders across Chicago taking part as guest lecturers, project mentors, and site visit hosts. The program served as an opportunity to move the needle on health by expanding opportunities to the next generation in a way that also changes the architecture of collaboration, community engagement, and the culture of research education to address health inequities. Core components of the intervention include individual and personal reflection, group exercises, didactic lecture, and classroom-based, and immersion and hands on experiences. These learning vehicles aimed to advance core values and competencies. Core values include teamwork, mentorship, critical thinking, value alignment, professionalism, intellectual curiosity, social justice, and reflective dialogue. Citation Format: Shaneah Taylor, Melinda Monge. Bridging the gap through a targeted research fellowship: Introduction and recruitment of under-represented minority students to the cancer research physician scientist pipeline [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C25.